ライフサイエンスコーパス: macrocycle

1 , as well as the peripheral positions of the macrocycle.

2 absorption spectra measured for the tetramer macrocycle.

3 g has been chosen to cyclize the 14-membered macrocycle.

4 tion of the linear tripeptide to the desired macrocycle.

5 tramolecular Passerini MCR used to close the macrocycle.

6 h two polyyne chains locked through the same macrocycle.

7 d not change the overall conformation of the macrocycle.

8 n to form a trithiazole-substituted pyridine macrocycle.

9 en investigated and compared with the [8]CPP macrocycle.

10 th precise control over the position of each macrocycle.

11 lecules are buried inside a container-shaped macrocycle.

12 r the functionalization of the calix[6]arene macrocycle.

13 onic behavior of the resulting tetracationic macrocycle.

14 ll shaped squaraine dye inside a tetralactam macrocycle.

15 ditions yields the "precursor" porphyrinogen macrocycle.

16 hyll a presenting a slight distortion to its macrocycle.

17 to expanded derivatives of this antiaromatic macrocycle.

18 e antiaromatic character of a porphyrin-like macrocycle.

19 desirable single plateau for the triangular macrocycle.

20 of strained and conformationally restricted macrocycles.

21 of the first air-stable and chiral inorganic macrocycles.

22 tion of the new phosphorus-sulfur-containing macrocycles.

23 carbon atoms, threaded through a variety of macrocycles.

24 ns of natural product-like oligodepsipeptide macrocycles.

25 esized to be the site of binding for peptide macrocycles.

26 activity and physical properties of peptidic macrocycles.

27 thesizing passively permeable peptidomimetic macrocycles.

28 ented synthesis, and its application towards macrocycles.

29 ed via the synthesis of >20 diverse oligoTEA macrocycles.

30 uit of synthesizing therapeutically relevant macrocycles.

31 by encapsulation inside a pair of cyanostar macrocycles.

32 a magic number rule for the family of {Pdx } macrocycles.

33 duction of CO2 to CO by cobalt aminopyridine macrocycles.

34 face of highly flexible yet shape-persistent macrocycles.

35 the corresponding phenanthrylene-thienylene macrocycles.

36 lection of functionalized spiroligomer-based macrocycles.

37 lectronic interactions between the porphyrin macrocycles.

38 groups in the self-assembly of these chiral macrocycles.

39 dentifies a molecular bridge between the two macrocycles.

40 le class of aromatic foldamers, into twisted macrocycles.

41 of the highly toxic amanitin toxin family of macrocycles.

42 icochemical properties of tetrapyrrolic-like macrocycles.

43 otonation of the inner protons of individual macrocycles.

44 Macrocycle 1 can bind to one cation such as potassium or

45 Moreover, macrocycle 1 forms a self-assembled tetrameric aggregate

46 mong the eight macrocycles studied, only the macrocycle 1 has a porous structure.

47 When the modeling of whole macrocycles 1 and 2 was performed, a huge difference in

48 ]rotaxanes with varying sizes of crown ether macrocycles ([22]crown-6, 22C6; [24]crown-6, 24C6; [26]c

49 l 3 can occur by both routes of entering the macrocycle 3 in the cone conformation: passage through t

50 nthesis of the larger resorcin[5 and 6]arene macrocycles [5](OMe) and [6](OMe) has been realized by a

51 tously, is the only reported giant palladium macrocycle-a unique structure that spontaneously assembl

52 ntly and renders the resulting bis-bispidine macrocycles achiral.

53 The T2DIR spectra indicate that the macrocycle adopts a boat-like conformation at the final

54 the ends of the thread and the cavity of the macrocycle allowed us to set up the best substituents fo

55 ii, incorporating 11 steric centres into the macrocycle, although the pathway must involve chelation,

56 tion of oligo(ethylene glycol) diacids gives macrocycles analogous to crown ethers, representing mini

57 Dihydromotuporamine C contains a large macrocycle and an appended polyamine component and was s

58 n connecting positions 17 and 36 to create a macrocycle and an intramolecular disulfide linkage betwe

59 different combinations of chiral and achiral macrocycle and axle components, the dominant influence o

60 -fold relative to the unsubstituted, racemic macrocycle and improved selectivity.

61 The [40]annulenoid macrocycle and its [38]annulenoid oxidized form display

62 e transfer interactions between the H12SubPc macrocycle and the electron-withdrawing TCBD unit direct

63 Depending on the size of the macrocycle and the reaction conditions (solution versus

64 h the generation of N-terminus to side chain macrocycles and a new approach for generating fused macr

65 gent synthetic approach to this new class of macrocycles and demonstrate that the conformational prop

66 , phosphole, and silole are highly promising macrocycles and exhibit quite different physicochemical

67 h sufficient affinity to their targets, with macrocycles and nonmacrocycles being found to have simil

68 ay structures confirm the formation of these macrocycles and show the presence of a number of the int

69 cts of the different sizes and shapes of the macrocycles and the character and length of their side c

70 ace of structures possible for short peptide macrocycles and vastly increase the available starting s

71 o pyrroline ring B forms the bacteriochlorin macrocycle, and (ii) Nazarov cyclization of the beta-(pr

72 und approximately in the center of the 3 + 3 macrocycle, and two chloride anions are deeply buried in

73 rs feature van der Waals contact between the macrocycles, and demonstrate excitonic splitting due to

74 uctures of 9 of 12 designed 7- to 10-residue macrocycles, and three 11- to 14-residue bicyclic design

75 rce a relatively wide separation between the macrocycle anthracene sidewalls.

76 on in the confined space of a benzylic amide macrocycle are attributed to its anchimeric assistance.

77 oxidation and ring expansion of the corrole macrocycle are described comprehensively.

78 Synthetic macrocycles are an attractive area in drug discovery.

79 Macrocycles are appealing drug candidates due to their h

80 Shape-persistent macrocycles are attractive functional targets for synthe

81 The macrocycles are freely soluble in common organic solvent

82 tional dispositions of redox-active units in macrocycles are key to achieving high energy density and

83 Macrocycles are molecular entities that display a combin

84 Such macrocycles are noncollapsible and geometrically well-de

85 Peptide macrocycles are promising therapeutic molecules because

86 ity and host-guest chemistry of the original macrocycles are well-known, new derivatives of them are

87 ur peripheries of eclipse-arranged porphyrin macrocycles, are successfully constructed through a top-

88 hat directs the assembly of a benzylic amide macrocycle around the axle to form [2]rotaxanes in up to

89 we use the binding of diglyme to the single macrocycle as guest-induced stimulation.

90 We use a rigid, conjugated macrocycle as the electron acceptor in devices to obtain

91 so explored nanometer-sized shape-persistent macrocycles as novel multitopic organic linkers to prepa

92 various substituents at the periphery of the macrocycle at both the beta and meso positions.

93 The arrival of the shuttling macrocycle at the final station is visible from a newly

94 actions that ratchet the displacement of the macrocycle away from the reactive sites on the track.

95 ucturally diverse, and highly-functionalized macrocycles based around a broad range of scaffolds and

96 ic and hexameric S- and Se-bridged inorganic macrocycles based on cyclophosphazane frameworks, using

97 Inorganic macrocycles, based on non-carbon backbones, present exci

98 These macrocycles bear large and flexible substituents that us

99 cteriochlorophylls contain a bacteriochlorin macrocycle bearing an annulated fifth ring.

100 cles and a new approach for generating fused macrocycles (bicycles).

101 ty on the axle as a photo/thermal-switchable macrocycle binding site.

102 Nevertheless, in the absence of competitive macrocycle-binding sites, realization of a replicating n

103 onformationally mobile motifs, but forging a macrocycle bond typically becomes more difficult at larg

104 hat insert cobalt/iron into the tetrapyrrole macrocycle but are thought to be distinctly located in t

105 le describes not only the synthesis of these macrocycles but also the encountered difficulties during

106 t a global ring current can be promoted in a macrocycle by adjusting its oxidation state to suppress

107 that are derived from opening of the chlorin macrocycle by the Rieske-type oxygenase PHEOPHORBIDE a O

108 pi-Extension of the porphyrin macrocycle by way of syn-fusion with two external aromat

109 thod provides access to structurally diverse macrocycles by exploiting the reactivity of transient ma

110 Furthermore, modifying 12-membered macrocycles by heteroatom substitution and utilizing alk

111 We do this with a star-shaped macrocycle called cyanostar that is flexible as well as

112 In the second mechanism, the macrocycle can be elongated after completion of the rota

113 t mechanism, the translational motion of the macrocycle can be triggered or halted at either terminus

114 natively, affinity capture beads coated with macrocycle can be used to immobilize the liberated squar

115 Artificial macrocycles can be convergently synthesized by a sequenc

116 lar units of alpha-graphyne ('carbo-benzene' macrocycles) can be inserted between two anilinyl (4-NH2

117 that the chalcogen atoms oriented within the macrocycle cavity are able to chelate copper(I) endotopi

118 as near the end of a flanking chain, and (b) macrocycle cavity size, which was enhanced when the cavi

119 f this beta value is modulated via porphyrin macrocycle central metal atom substitution [beta(PZn(n);

120 (n) wire, which were modulated via porphyrin macrocycle central metal atom substitution.

121 giant ca. 220 nm(3) unit cell containing 16 macrocycles clustered into eight face-shared tetrahedral

122 -free" assembly can be achieved, whereby the macrocycle components can also form a template in situ a

123 ompared to the non-interlocked free axle and macrocycle components.

124 C3deOAmB possesses the same macrocycle conformation as AmB and retains the capacity

125 place largely independently from the overall macrocycle conformation.

126 , we describe the synthesis of the desmethyl macrocycles, conformational studies on the atropisomers,

127 rotonated derivatives show a rich variety of macrocycle conformations ranging from a stepped 2 + 2 ma

128 A series of macrocycles consisting of 9,10-substituted phenanthrenes

129 These macrocycles contain 14 independently controllable stereo

130 Even though these two macrocycles contain 22pi electrons and five pyrrole/hete

131 lecular chains consist solely of interlocked macrocycles, contain one of the highest concentrations o

132 A series of p-terphenyl-based macrocycles, containing highly distorted p-phenylene uni

133 es forming hetero-ternary complexes with the macrocycle cucurbit[8]uril (CB[8]) and an auxiliary gues

134 d that supports the glyco-conjugate: organic macrocycles, dendrimers, nanomaterials, and polymers are

135 Synthetic macrocycles derived from sequence-defined oligomers are

136 onstrate the biological activity of oligoTEA macrocycles designed to mimic facially amphiphilic antim

137 In addition to the synthesis of novel macrocycles (dimers through hexamers), this process prov

138 tion of a 2:1 sandwich complex involving two macrocycles enhances rigidity and dramatically shifts th

139 been exploited for preparing benzylic amide macrocycles enhancing, in most cases, the results of the

140 These new macrocycles exhibit simultaneously tunable visible and n

141 Independent of ring size, all macrocycles exhibit stepwise, light-induced, ring-openin

142 Upon protonation, the macrocycles exhibited bathochromically shifted absorptio

143 tetrazines thread inside a pair of cyanostar macrocycles following voltage-driven reduction (+e(-)) o

144 led a striking requirement for a low-entropy macrocycle for activity.

145 ntury ago, the chemistry of wholly synthetic macrocycles for structure-specific, highly selective, ho

146 II, Ser/Thr dehydration (TclKL) and peptide macrocycle formation (TclM) occurs.

147 positions have been prepared, with yields of macrocycle formation of up to 39%.

148 The kinetics and yields of macrocycle formation respond to cation guests, with the

149 (CAT) assembly of a {CAT} subset{Mo24 Fe12 } macrocycle forms a giant ca. 220 nm(3) unit cell contain

150 d macrocycle inside the MOF pores, while the macrocycle-free linker is bent and yields a MOF with a n

151 h 37- and 38-membered 2,2':6',2''-terpyridyl macrocycles generate triply threaded [4]rotaxanes in up

152 The 18-membered macrocycle H2 macropa was investigated for (225) Ac chel

153 hermal bath as a stimulus, we found a single macrocycle has 332 accessible conformers with olefins un

154 tic protocol for the synthesis of 1,4-diketo macrocycles has been developed, using only 2.5 mol % of

155 th one of the macrocycles indicated that the macrocycles have a weak tendency to form coordination co

156 Porphyrins and related macrocycles have been intensively exploited as sensing m

157 gen bonding in pi-stacked pairs of cyanostar macrocycles having large cavities.

158 e-persistent macrocycles to include flexible macrocycles if, and only if, their conformers have simil

159 Initial addition of DABCO to the porphyrin macrocycle in chloroform solution leads to the formation

160 onents, the dominant influence of the chiral macrocycle in our rotaxane design for determining the ef

161 defined structure could be assigned to each macrocycle in the homologous series, most likely as a re

162 apidly polymerize alkynes to form conjugated macrocycles in high yield.

163 The S,S-tetrazine macrocycles in turn provide a convenient handle for prob

164 ding protection of threaded functions by the macrocycle, in this case promoting an unusual and disfav

165 delocalization over more than two porphyrin macrocycles, in contrast to meso-to-meso ethyne or butad

166 l to generate structurally diverse arrays of macrocycles, including those with nonproteinogenic eleme

167 the synthesis and properties of a series of macrocycles incorporating two dihydroazulene (DHA) photo

168 Therefore, a series of 12- to 18-membered macrocycles incorporating two phosphorus and six sulfur

169 The triangular macrocycle, incorporating three PMDI units in close prox

170 liminary studies carried out with one of the macrocycles indicated that the macrocycles have a weak t

171 ce that allows for motion of the interlocked macrocycle inside the MOF pores, while the macrocycle-fr

172 ibutable to the folding of the even-membered macrocycles into exciton-vibrational coupled dimer pairs

173 ly template the folding of even-membered PBI macrocycles into ropelike folded conformations that give

174 The macrocycle IR spectra of the [Co(I)N4H](+)-CO2(-) comple

175 formational diastereoisomers of a homochiral macrocycle is a rare, if not unique, occurrence.

176 The macrocycle is an interesting scaffold for ion-transport

177 sites on the cyclic track is faster when the macrocycle is far from the reactive site than when it is

178 The macrocycle is highly anion-selective and transports ions

179 o CH-hydrogen-bond to halide anions when the macrocycle is located on an alternative (ammonium) bindi

180 l on the metal centres incorporated into the macrocycle is of utmost importance to achieve tailored p

181 introduction of non-peptidic scaffolds into macrocycles is highly desirable in tuning the activity a

182 be a system in which a small molecular ring (macrocycle) is continuously transported directionally ar

183 (H2 L)] (L="Pacman" Schiff-base polypyrrolic macrocycle), is found and explained.

184 d with two smaller isophthalamide-containing macrocycles, is constructed using an anion template synt

185 teins do not provide a useful guide: Peptide macrocycles lack regular secondary structures and hydrop

186 ion of structurally (and thus shape) diverse macrocycle libraries.

187 age reaction occurs at a rate independent of macrocycle location, net directional rotation of the mol

188 lators of CXCR7 have been reported, peptidic macrocycles may provide advantages in terms of potency,

189 We designed aryl-triazole-ether macrocycles (MC) to be semiflexible, which allows ion pa

190 form, oxaliplatin, when co-incubated with a macrocycle metallotexaphyrin (i.e., Motexafin Gadolinium

191 on of template clusters within the inorganic macrocycle {Mo24 Fe12 } allows the self-generation of an

192 e synthesis of the right-hand heteroaromatic macrocycle of diazonamide A features C16-C18 bond format

193 2 + 2 macrocycle to a multiply folded 8 + 8 macrocycle of globular shape.

194 extrin, an inexpensive, sustainably produced macrocycle of glucose, are likewise of interest for remo

195 demonstrated that this perfluoroarene-based macrocycle of TP10 exhibits increased penetration of the

196 We describe 21 macrocycles of a size of 15-20.

197 he stimuli-induced change of position of the macrocycle on the rotaxane thread.

198 binding sites, the change of position of the macrocycle on the thread can be achieved through a serie

199 one-electron reduced state of the NDI-based macrocycle on the time scale of these techniques.

200 mergence of a unprecedentedly large range of macrocycles or to molecular specificity, i.e., the autoc

201 we find that the superior performance of the macrocycle originates from its rigid, conjugated, and cy

202 ive fruits maturation is the cleavage of the macrocycle pheophorbide a to a primary fluorescent chl c

203 A series of macrocycle-polyamine conjugates were prepared, and the s

204 In dichloromethane, the macrocycles prevail in wide-stretched conformations and

205 An analogous 39-membered macrocycle produced no rotaxane products under similar c

206 The possibility of finely tuning the macrocycle properties by synthetic modification of the d

207 These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclines, and

208 es a more efficient and selective route to Z-macrocycles relative to previously reported systems.

209 ite numerous attempts, these double-stranded macrocycles remain outstanding synthetic challenges.

210 The macrocycle resembles a five-membered cucurbituril in whi

211 itions, the most electron-deficient of these macrocycles revealed reversible formation of eight charg

212 The macrocycle reveals complex conformational dynamics depen

213 The macrocycle's rigid structure reduces the number of charg

214 t examination of the relationships between a macrocycle's shape persistence, its conformational space

215 Among a variety of chains appended onto the macrocycle scaffold, cholesterol is found to be the best

216 ation and its coassembly with cyanostar (CS) macrocycles selected to modify tetrafluoroborate (BF4(-)

217 cal studies on solid-state thin films of the macrocycle show that they exhibit semiconducting propert

218 These macrocycles show solvent-dependent conformational equili

219 The macrocycles showed one sharp Soret-type band at approxim

220 anism where upon nitrate anion binding, both macrocycles shuttle from the naphthalene diimide station

221 le of the thread preventing a benzylic amide macrocycle shuttling between different sides of a prochi

222 recognition sites produces a small-amplitude macrocycle shuttling motion, from the viologen to the me

223 rary with different replicators of different macrocycle size (hexamers and octamers), we observed the

224 and agonism/antagonism varied upon enlarging macrocycle size, giving the mu-agonist 9 or the delta-an

225 oups in all the alpha-benzo positions of the macrocycle skeleton, MPc(OBu)8, have strong near-infrare

226 Substrates included strained polyphenylene macrocycles, strained cycloalkynes, and a key macrocycli

227 umber of currently available unbound peptide macrocycle structures.

228 Among the eight macrocycles studied, only the macrocycle 1 has a porous

229 Mixed-chirality peptide macrocycles such as cyclosporine are among the most pote

230 Structure and properties of the macrocycles, such as self-association in solution and op

231 onal distribution for the p-phenylene-linked macrocycle suggests that the o-phenylene units are large

232 This macrocycle symbolizes the antiaromatic character of a po

233 These AIPs feature a thiolactone macrocycle that connects the peptide C terminus to the s

234 hore of a chlorophyll, is a dihydroporphyrin macrocycle that contains one pyrroline ring and three py

235 on band with deformation of its tetrapyrrole macrocycle that is induced by changing the position of a

236 singly threaded rotaxane can slip through a macrocycle that is sufficiently large to accommodate thr

237 tive FXIIa inhibitor by optimizing a peptide macrocycle that was recently evolved by phage display (K

238 Herein, we report triamide macrocycles that are easily synthesized and externally f

239 We describe the synthesis of two conjugated macrocycles that are formed from the end-to-end linking

240 th a variety of synthetic flexible and rigid macrocycles that have drawn their inspiration from Peder

241 We produced a series of peptidic macrocycles that incorporate an N-linked peptoid functio

242 ps of diiodide 6 pass through the calixarene macrocycle; the activation free energy for the conversio

243 is topologically reminiscent of tetrapyrrole macrocycles though electronically distinct, has allowed

244 Values of Ka and kon for macrocycle threading in water are reported for a series

245 end of the squaraine core that ensures fast macrocycle threading kinetics, and (c) sialic acid block

246 e squaraine dyes are large enough to prevent macrocycle threading or rotaxane unthreading.

247 s been demonstrated in rotaxane shuttles and macrocycle threading systems, the sensitivity of speed b

248 (c) sialic acid blocking groups that prevent macrocycle threading until they are removed by viral neu

249 The resulting [3 + 3] macrocycles (three o-phenylenes and three linkers) are s

250 ows a fine-tuning of the properties of these macrocycles through a selective and mild introduction of

251 e conformations ranging from a stepped 2 + 2 macrocycle to a multiply folded 8 + 8 macrocycle of glob

252 A computational study reveals the smallest macrocycle to have the most energetic VHF-VHF state and

253 form a template in situ allowing template to macrocycle to superstructure formation and the ability t

254 ly, the capability of these surface-confined macrocycles to host lanthanide elements is assessed, int

255 study expands the scope of shape-persistent macrocycles to include flexible macrocycles if, and only

256 Subsequently, L2 underwent macrocycle transformations to give singly and doubly N-C

257 With a decreasing hydrogen content, the macrocycles undergo a stepwise transition from a cylindr

258 tructure cannot be threaded by a tetralactam macrocycle until the blocking groups are removed by enzy

259 ement of the steroids in the presence of the macrocycles (up to 100 times, for drug delivery) and the

260 enes to alter the shape of the cavity of the macrocycle upon absorption of light.

261 cter, which is understood to destabilize the macrocycle upon conjugation.

262 chemical modifications to a natural product macrocycle upon its activity, 3D geometry, and conformat

263 ttracted much attention for the synthesis of macrocycles used to construct porous materials.

264 osing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based cat

265 modules that produce the 16-membered tylosin macrocycle, using them as biocatalysts in the chemoenzym

266 synthesis of oligothioetheramide (oligoTEA) macrocycles via a one-pot acid-catalysed cascade reactio

267 r [SP( horizontal lineS)S moiety]-containing macrocycles via a one-pot and three-component domino rea

268 The optimal 16-membered macrocycle was 60-fold more potent than an acyclic analo

269 ved from each configurationally enantiomeric macrocycle was investigated in CD3SOCD3 solution by vari

270 homodimers of organophosphates and cyanostar macrocycles was investigated for the first time.

271 The knots and their isomeric unknot macrocycles were characterized by NMR spectroscopy, mass

272 As a result, two new palladium macrocycles were discovered: a structural analogue of th

273 However, macrocycles were more disk- and spherelike, which may co

274 , or benzene, new families of porphyrin-like macrocycles were produced.

275 erved for a multiply folded protonated 8 + 8 macrocycle which binds six sulfate anions; two of them a

276 We report the synthesis of a tetracationic macrocycle which contains two N,N'-bis(methylene)naphtha

277 e consisting of a large four-station central macrocycle which incorporates a bay tetrachloro-function

278 hile inactive mutants showed a more flexible macrocycle which is unfavorable for binding.

279 embered bicyclic ring fused to a 14-membered macrocycle, which has been described extensively in the

280 Our initial macrocycles, which were double-digit nanomolar FXIa inhi

281 uried inside a folded container-shaped 4 + 4 macrocycle, while in the case of the previously reported

282 Cyclo[6]aramides, a type of macrocycle with a hydrogen-bond-constrained backbone, ex

283 lex supported by the tetramethylcyclam (TMC) macrocycle with a tethered thiolate.

284 In addition, a key macrocycle with orthogonal functionalities was designed

285 ceeded in the concomitant metallation of the macrocycle with substrate atoms and the axial ligation o

286 ontrast, in aromatic solvents folding of the macrocycles with a distinct odd-even effect regarding th

287 e linking is generally applicable to peptide macrocycles with a specific utility in the synthesis of

288 (speed bumps) on the flanking chains and two macrocycles with different cavity sizes.

289 Expanded porphyrins are large-cavity macrocycles with enormous potential in coordination chem

290 atment with BBr3 to obtain the corresponding macrocycles with free OH groups.

291 al pH to form peptide-peptide intermolecular macrocycles with highly tunable ring sizes.

292 An unprecedented class of macrocycles with intrinsic fluorescence consisting of ph

293 red through the coupling of arylenethynylene macrocycles with ODNs, which were used to mediate the as

294 Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited fo

295 itely) with other linear fragments, allowing macrocycles with precise substitution patterns to be "gr

296 eability exhibited by multicomponent-derived macrocycles with respect to their homodetic counterparts

297 series of semirigid perylene bisimide (PBI) macrocycles with varied ring size containing two to nine

298 Electronic communication between concentric macrocycles with wave functions that extend around their

299 A bifunctional macrocycle, with hydrogen bond donors at one end and acc

300 The diheteroporphyrins, which are neutral macrocycles without ionizable protons, also showed inter