ライフサイエンスコーパス: macroglobulin

1 n) and inflammation (e.g., leptin and alpha2-macroglobulin).

2 g. serpins, regulating cell death, and alpha-macroglobulins).

3 and cleave both antithrombin III and alpha2-macroglobulin.

4 ecipitated C4 complement protein and alpha-2-macroglobulin.

5 greatly enhanced in the presence of alpha(2)-macroglobulin.

6 d by a chase with mouse laminin-1 and alpha2-macroglobulin.

7 erum that contains C1-inhibitor and alpha(2)-macroglobulin.

8 bitory concentration close to that of alpha2-macroglobulin.

9 he receptor binding domain of human alpha(2)-macroglobulin.

10 tor, alpha(1)-antichymotrypsin, and alpha(2)-macroglobulin.

11 esence of eukaryotic proteins such as alpha2-macroglobulin.

12 he presence or absence of activated alpha(2)-macroglobulin.

13 duced acute-phase response protein, alpha(2)-macroglobulin.

14 ing Pro-Phe-Arg-pNA, independently of alpha2-macroglobulin.

15 ound environment becomes complexed to alpha2-macroglobulin.

16 otein RidA, and the mammalian protein alpha2-macroglobulin.

17 cetylated low density lipoprotein and alpha2-macroglobulin.

18 nhibitor of metalloproteinases-1 and alpha 2-macroglobulin.

19 rin, alpha-lactalbumin, insulin, and alpha-2-macroglobulin.

20 on probably includes both albumin and alpha2-macroglobulin.

21 mic inflammation as measured by plasma alpha-macroglobulin.

22 ncer cells by a proteinase inhibitor, alpha2-macroglobulin.

23 ch as tissue inhibitors of MMPs and alpha(2)-macroglobulins.

24 e C3b crystal structure in which its TED and macroglobulin 1 (MG1) domains were connected through the

25 UB (complement C1r-C1s, Uegf, Bmp1) and MG2 (macroglobulin-2) domains of C3b.

26 , ADAM9 (54%), vitronectin (54%), and alpha2-macroglobulin (55%), as well as some cell surface protei

27 Five CDRs contact the C5 macroglobulin 7 domain, which contains the entire epitop

28 positively correlated with levels of alpha2-macroglobulin, a marker of epithelial leak, in localized

29 The ability of cells to bind alpha(2) macroglobulin, a previously known CD91 ligand, or HSP gp

30 Alpha2-macroglobulin, a protease inhibitor secreted as part of

31 , nephelometry, and Western blot for alpha-2-macroglobulin (A2M) and activated partial thromboplastin

32 tion in the evolutionarily conserved alpha-2-macroglobulin (A2M) domain of CPAMD8, c.4351T>C (p. Ser1

33 Alpha-2-Macroglobulin (A2M) is a highly plausible candidate gene

34 alpha2-Macroglobulin (A2M) is a proteinase inhibitor found in a

35 ned whether the acute-phase protein, alpha-2 macroglobulin (A2M), a major component of the innate imm

36 apolipoprotein A-2 [APOA2], 9.7-fold; alpha2-macroglobulin [A2M], 4.5-fold; apolipoprotein A-1 [APOA1

37 Eight genes (alpha-2-macroglobulin [A2M], creatine kinase [CKB], angiotensin-

38 to serpins, canonical inhibitors and alpha-2-macroglobulins (A2Ms).

39 sue-type plasminogen activator, and alpha(2)-macroglobulin activated Rac1 in LRP1-expressing Schwann

40 mixture of pure C1-inhibitor and/or alpha(2)-macroglobulin added together with MBL-MASP, all at physi

41 roteinase inhibitor (alpha 1-PI) and alpha 2-macroglobulin (alpha 2-M) are reduced, especially in the

42 ivated factor X (factor Xa) binds to alpha 2-macroglobulin (alpha 2M) and is rapidly cleared from the

43 We have characterized four human alpha 2-macroglobulin (alpha 2M) bait region variants (G679C, M6

44 alpha 2-Macroglobulin (alpha 2M) is a complex tetrameric protein

45 alpha 2-Macroglobulin (alpha 2M) is a high-affinity, broad-spect

46 alpha 2-Macroglobulin (alpha 2m) is a major plasma proteinase in

47 Receptor-recognized forms of alpha 2-macroglobulin (alpha 2M*) bind to two macrophage recepto

48 Alpha(2)-macroglobulin (alpha(2)M) and its receptor, low density

49 In the present studies we identify alpha(2)-macroglobulin (alpha(2)M) as an additional endogenous in

50 alpha(2)-Macroglobulin (alpha(2)M) binds transforming growth fact

51 oscopy reconstructions of the human alpha(2)-macroglobulin (alpha(2)M) dimer and chymotrypsin-transfo

52 alpha(2)-Macroglobulin (alpha(2)M) functions as a proteinase inhi

53 alpha(2)-Macroglobulin (alpha(2)M) is a highly conserved proteina

54 alpha(2)-Macroglobulin (alpha(2)M) is a plasma protease inhibitor

55 alpha(2) macroglobulin (alpha(2)M) or serum is sufficient to inhi

56 e human plasma proteinase inhibitor alpha(2)-macroglobulin (alpha(2)M) regulates cellular growth by b

57 associated protein and by activated alpha(2)-macroglobulin (alpha(2)M), suggesting the participation

58 In the current study, we employed alpha(2)-macroglobulin (alpha(2)M)-agarose column chromatography

59 ntified initially as a receptor for alpha(2)-macroglobulin (alpha(2)M).

60 ntified this co-purified protein as alpha(2)-macroglobulin (alpha(2)M).

61 (1,2)) are known to be modulated by alpha(2)-macroglobulin (alpha(2)M).

62 eptor-related protein-1 (LRP-1) and alpha(2)-macroglobulin (alpha(2)M).

63 ors by receptor-recognized forms of alpha(2)-macroglobulin (alpha(2)M*) activates various signaling c

64 orm of the pan-proteinase inhibitor alpha(2)-macroglobulin (alpha(2)M*) and amyloid precursor protein

65 Receptor-recognized forms of alpha(2)-Macroglobulin (alpha(2)M*) bind to LRP, but the pattern

66 to the receptor-recognized form of alpha(2)-macroglobulin (alpha(2)M*) demonstrate enhanced immune r

67 sed to receptor-recognized forms of alpha(2)-macroglobulin (alpha(2)M*) demonstrate increased DNA syn

68 port that the LRP ligand, activated alpha(2)-macroglobulin (alpha(2)M*), induces robust calcium influ

69 78 by its natural ligand, activated alpha(2)-macroglobulin (alpha(2)M*), results in a 2-3-fold up-reg

70 its physiologic agonist, activated alpha(2)-macroglobulin (alpha(2)M*).

71 receptors for transferrin (Tf) and alpha(2)-macroglobulin (alpha-2-M; LRP-1) were compared using qua

72 plement factor H (CFH) precursor and alpha-2-macroglobulin (alpha-2M).

73 Alpha-2-macroglobulin (alpha-2M; encoded by the gene A2M) is a s

74 dy [EndoCAb]), acute-phase proteins (alpha-2 macroglobulin [alpha-2M], C-reactive protein [CRP], hapt

75 cleavage of the proteinase inhibitors alpha2-macroglobulin (alpha2-M) and alpha 1-proteinase inhibito

76 oid-supplemented enhanceosome for the alpha2-macroglobulin (alpha2-M) gene and compare this with a de

77 (ATIII), heparin cofactor II (HCII), alpha2-macroglobulin (alpha2-M), protease nexin I, and plasmino

78 alpha2-Macroglobulin (alpha2M) activated with methylamine binds

79 d from human plasma and identified as alpha2-macroglobulin (alpha2M) and pregnancy zone protein.

80 es of the plasma proteinase inhibitor alpha2-macroglobulin (alpha2M) demonstrated that alpha2M-protei

81 alpha2-Macroglobulin (alpha2M) functions as a major carrier of

82 alpha2-Macroglobulin (alpha2M) inhibits diverse extracellular p

83 alpha2-Macroglobulin (alpha2M) is a broad spectrum proteinase i

84 lorite-induced modifications of human alpha2-macroglobulin (alpha2M) markedly increase its chaperone

85 Ligation of the alpha2-macroglobulin (alpha2M) signaling receptor by receptor-r

86 resent study, we demonstrate that the alpha2-macroglobulin (alpha2M) signaling receptor is up-regulat

87 Surprisingly, oxidation of native alpha2-macroglobulin (alpha2M) with 125 microM hypochlorite res

88 The carboxy terminus of alpha2-macroglobulin (alpha2M), a proteinase inhibitor released

89 thiol ester-containing protein human alpha2-macroglobulin (alpha2M), asparagine 1065, plays a simila

90 amounts of the LRP ligand, activated alpha2-macroglobulin (alpha2M), at 4 degrees C.

91 y 700-kDa complex with the inhibitor, alpha2-macroglobulin (alpha2M), that retains activity against s

92 gets to early/recycling endosomes, or alpha2-macroglobulin (alpha2M), which targets to late endosomes

93 ptor for many protein ligands, and of alpha2-macroglobulin (alpha2M)-proteinase complexes as one such

94 uences that were identical to that of alpha2 macroglobulin (alpha2M).

95 From this screen, we identified alpha-2-macroglobulin (alpha2M).

96 of the human endopeptidase inhibitor, alpha2-macroglobulin (alpha2M).

97 lexed to the blood transport protein, alpha2-macroglobulin (alpha2M).

98 Receptor-recognized forms of alpha2-macroglobulin (alpha2M*) bind to two classes of cellular

99 ous study demonstrated that activated alpha2-macroglobulin (alpha2M*) binding to the low-density rece

100 on of cell surface GRP78 by activated alpha2-macroglobulin (alpha2M*) promotes cell proliferation and

101 n in response to EI-tPA and activated alpha2-macroglobulin (alpha2M*) required the NMDA receptor and

102 Activated alpha2-macroglobulin (alpha2M*) signals predominantly through c

103 ted forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*) to cell surface-associated GRP7

104 zed forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*) to GRP78 on the cell surface of

105 e examined the effects of activated alpha(2)-macroglobulin (alpha2M*), a ligand of LRP, on intracellu

106 containing lipoproteins and activated alpha2-macroglobulin (alpha2M*), promote neurite outgrowth, sug

107 D91/LRP ligand, the activated form of alpha2-macroglobulin (alpha2M*).

108 layer (LbL) microcapsules to deliver alpha-2-macroglobulin (alpha2MG), a protein with modulatory prop

109 ve, half-transformed, and transformed alpha2-macroglobulins (alpha2Ms) labeled with a monoclonal Fab

110 alpha-Macroglobulins (alphaMs) are large glycoproteins that ha

111 otease as demonstrated by cleavage of alpha2-macroglobulin, although physiological substrates are pre

112 igher molecular weight complexes with alpha2-macroglobulin, an inhibitor of MMPs.

113 and had very low capacities to cleave alpha2-macroglobulin and a peptide substrate.

114 ific manner to the promoters of the alpha(2)-macroglobulin and Aalpha-fibrinogen genes and to an intr

115 peared to result from binding between alpha2-macroglobulin and activated MMP-1.

116 in the clearance of plasma-activated alpha 2-macroglobulin and apolipoprotein E-enriched lipoproteins

117 pression of the rat acute phase genes alpha2-macroglobulin and beta-fibrinogen.

118 nalyses confirmed the upregulation of alpha2-macroglobulin and ceruloplasmin in the diabetic retina,

119 T, whereas it significantly decreased alpha2-macroglobulin and complement C3, P < 0.05.

120 ealed foci of albumin, transferrin, alpha(2)-macroglobulin and IgG transudation around blood vessels

121 xicity in the presence of activated alpha(2)-macroglobulin and its down-regulation via inhibition by

122 Ad7 partially colocalized with alpha(2)-macroglobulin and late endosomal and lysosomal marker pr

123 tor-associated protein or activated alpha(2)-macroglobulin and occurred primarily via a fluid-phase,

124 n (LRP), a cell surface receptor for alpha 2-macroglobulin and other ligands.

125 30 still stimulates the expression of alpha2-macroglobulin and synergizes with IL-1 to up-regulate al

126 contains the genes that encode both alpha(2)-macroglobulin and the low-density lipoprotein receptor-r

127 The LRP1 agonists, alpha2-macroglobulin and tissue-type plasminogen activator, att

128 Other LRP1 ligands, including alpha2-macroglobulin and tissue-type plasminogen activator, fai

129 , beta-fibrinogen, paralleled that of alpha2-macroglobulin and was significantly reduced following la

130 ncludes the pan-protease inhibitors alpha(2)-macroglobulins and vertebrate complement factors.

131 of one potential acute phase protein (alpha2 macroglobulin), and albumin concentration is inversely p

132 and of amyloid deposition (clusterin, alpha2-macroglobulin, and ADAM9).

133 Apolipoprotein E, alpha2-macroglobulin, and amyloid precursor protein (APP) are i

134 LRP and its ligands apolipoprotein E, alpha2-macroglobulin, and beta-amyloid precursor protein (APP),

135 n of 15 of 42 genes including MART-1, alpha2-macroglobulin, and CD59.

136 ng fluorescently labeled transferrin, alpha2-macroglobulin, and cholera toxin B-subunit conjugated wi

137 a receptor for the peptide PKRGFQD, alpha-2-macroglobulin, and for SNTRVAP, 78-kDa glucose-regulated

138 PA), apolipoprotein E/lipoproteins, alpha(2)-macroglobulin, and the beta-amyloid precursor protein, h

139 nly the active enzyme bound to the two alpha-macroglobulins, and the interaction was specific for alp

140 s were found for C1-INH protein, C1q, alpha2-macroglobulin, antithrombin III, and angiotensin-convert

141 siological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor prot

142 ses: alpha1-antiproteinase inhibitor, alpha2-macroglobulin, aprotinin, and soybean inhibitor, using t

143 hese results indicate that GRP78 and alpha-2-macroglobulin are highly active in osteoblastic, androge

144 BMP1 is shown to cleave the alpha(2)-macroglobulin "bait" region, at a single specific site,

145 Whereas a clear role for CD91 in alpha(2)-macroglobulin binding and uptake was readily obtained, t

146 though fucoidin was without effect on alpha2-macroglobulin binding or uptake.

147 e inhibitor-binding protein-G-related alpha2-macroglobulin-binding (GRAB) protein, and the antiphagoc

148 y 7-fold) and the protein G-related alpha(2)-macroglobulin-binding protein (grab; approximately 29-fo

149 Clusterin and alpha2-macroglobulin bound to PGPFs to significantly ameliorate

150 Murinoglobulin, the second murine alpha-macroglobulin, bound both TGF-beta isoforms with 30-fold

151 alpha(2)-Macroglobulin-bound chymase generates angiotensin II in

152 The present work shows that alpha(2)-macroglobulin-bound chymase remains accessible to small

153 on of murine macrophage receptors for alpha2-macroglobulin, bradykinin, epidermal growth factor, and

154 r a Ser increased the reactivity with alpha2-macroglobulin but not with casein or Cm-Tf.

155 e as shown by its ability to cleave alpha(2)-macroglobulin, but it does not cleave specific peptide b

156 mice, whereas the rate of removal of alpha2-macroglobulin by the LDLR-related protein, which also in

157 of unlabeled gp96 or the CD91 ligand alpha2-macroglobulin, by anti-CD91 Ab and by the specific CD91

158 a novel member of the complement 3/alpha(2)-macroglobulin (C3/alpha(2)M) family named CPAMD8 (comple

159 in II-generating activity, and that alpha(2)-macroglobulin capture may be exploited in assessing syst

160 We used alpha(2)-macroglobulin capture to develop a sensitive, microtiter

161 es) of acute-phase response proteins: alpha2-macroglobulin, ceruloplasmin, complement components, lip

162 xpression of the rat acute phase gene alpha2-macroglobulin compared to both laparoscopic CLP using he

163 Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ort

164 Here we demonstrate that Macroglobulin complement-related (Mcr), a gene previousl

165 onships of CD109, a member of the the alpha2-macroglobulin/complement (AMCOM) gene family.

166 a novel and independent branch of the alpha2-macroglobulin/complement gene family (AMCOM) and may be

167 TGF-beta2.alpha2-macroglobulin complexes are more refractory to heparin/h

168 HGF increased alpha2-macroglobulin concentrations on postburn days 2, 5, and

169 tudies with the LRP ligand, activated alpha2-macroglobulin, confirmed that LRP was present and functi

170 tors phenylmethylsulfonyl fluoride and alpha-macroglobulin could reverse the sigB biofilm defect.

171 lysosomal function, since the rate of alpha2-macroglobulin degradation was not affected by the presen

172 GRP78 also serves as the receptor for alpha2-macroglobulin-dependent signaling and for uptake of cert

173 that the mutation disturbs the integrity of macroglobulin domain 4 and induces conformational change

174 The M373T mutation was localized to the macroglobulin domain 4 of C3, which contains a binding s

175 es within C3, including the rearrangement of macroglobulin domain 6 enabling binding of S77 to the ad

176 in 6 enabling binding of S77 to the adjacent macroglobulin domain 7 domain.

177 linker between the thioester domain and the macroglobulin domain ring of C3.

178 nt 3 and pregnancy zone protein-like, alpha2-macroglobulin domain-containing 8).

179 mutations in CPAMD8 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8) as the cause

180 vealed a domain configuration, including six macroglobulin domains (MG1-MG6) arranged in a ring, term

181 gene response (GAS) element in the alpha(2)-macroglobulin enhancer, Stat1 did not stimulate transcri

182 t-transfection experiments with the alpha(2)-macroglobulin enhancer, Stat3 and c-Jun cooperated to yi

183 ing transcription controlled by the alpha(2)-macroglobulin enhancer.

184 duced transcription directed by the alpha(2)-macroglobulin enhancer.

185 , which is not redundant in the murine alpha-macroglobulin family or in murine plasma.

186 which is the only known member of the alpha-macroglobulin family that does not bind TGF-beta, also f

187 hibitor, alpha1-antichymotrypsin, and alpha2-macroglobulin function as critical antiapoptotic factors

188 Therefore, genetic variability in the alpha2-macroglobulin gene is a risk factor associated with neur

189 e reported an association between the alpha2-macroglobulin gene on chromosome 12 and late-onset Alzhe

190 interleukin-6-inducible activation of alpha2-macroglobulin gene promoter.

191 The A/A genotype in exon 24 of the alpha2-macroglobulin gene was associated with neuropathological

192 rane conductance regulator and rodent alpha2-macroglobulin, growth hormone receptors, and insulin-lik

193 ions of an intermediate form of human alpha2-macroglobulin (half-transformed alpha2M) in which two of

194 levels of five acute-phase proteins (alpha-2 macroglobulin, haptoglobin, serum amyloid P, procalciton

195 s confirmed by cross-competition with alpha2-macroglobulin IL-6RE and specific interactions with anti

196 ow compared with Stat3 binding to the alpha2-macroglobulin IL-6RE.

197 nd the eventual depletion of antiplasmin and macroglobulin in an advancing (approximately 0.25 mm thi

198 Levels of the proteinase inhibitor alpha2-macroglobulin in burn fluid and chronic ulcer wound flui

199 albumin, fibrinogen, transferrin, and alpha-macroglobulin in hepatocytes.

200 expression of modified versions of alpha(2)-macroglobulin in the treatment of fibrotic conditions.

201 onstrated that genetically modified alpha(2)-macroglobulin, in which the native bait region is replac

202 the blood biomarkers only decorin and alpha2-macroglobulin increased predictive value for future seve

203 y competitively inhibited by excess alpha(2)-macroglobulin, indicating that hspRs in addition to CD91

204 vated and receptor-recognized form of alpha2-macroglobulin-induced calcium signaling was abolished in

205 The previously known CD91 ligand, alpha 2-macroglobulin, inhibits re-presentation of gp96-chaperon

206 dings suggest that chymase bound to alpha(2)-macroglobulin is active, that the complex is an angioten

207 alpha(2)-Macroglobulin is an irreversible inhibitor that is shown

208 thic dilated cardiomyopathy, whereas alpha 2-macroglobulin is high.

209 pression of the acute phase protein alpha(2)-macroglobulin is induced in vivo by interleukin-6 (IL-6)

210 een reported that the serum protein alpha(2)-macroglobulin is unable to inhibit the astacin-like prot

211 red to immobilized fetuin-A and not alpha(2)-macroglobulin, its major contaminant.

212 [Cl-] in alpha2-macroglobulin-labeled endosomes, which enter a late comp

213 s of bacterial genomes identified many alpha-macroglobulin-like sequences that appear to have been ac

214 1) was found near D12S98 close to the alpha2-macroglobulin locus in the affected pairs in which both

215 d alpha(1)-proteinase inhibitor and alpha(2)-macroglobulin lose the spreading activity, indicating th

216 , alpha 1-antichymotrypsin (ACT) and alpha 2-macroglobulin (MAC), and cognitive impairment in the ver

217 Finally, we show TFPI inhibits 125I-alpha2-macroglobulin-methylamine binding to hepatoma cells and

218 sites: a major site at the interface between macroglobulin (MG) 3 and MG4 domains, and a less frequen

219 MLS 2.16), 5 (MLS 2.00), 12, close to alpha2-macroglobulin (MLS 1.91), and 21, close to amyloid precu

220 alpha2-Macroglobulin null mice demonstrate increased resistance

221 ls but precipitated only with human alpha(2)-macroglobulin, of many glycoproteins and polysaccharides

222 ists (the receptor binding domain of alpha-2-macroglobulin or the hemopexin domain of matrix metallop

223 on of excess CD91 ligand, activated alpha(2)-macroglobulin, or receptor-associated protein, an antago

224 gy between STAT3-C and c-Jun at the alpha(2)-macroglobulin promoter in HepG2 cells, suggesting that S

225 nts contribute to activation of the alpha(2)-macroglobulin promoter in response to IL-6 family member

226 re members of the thioester-containing alpha-macroglobulin protein superfamily.

227 Human alpha(2)-macroglobulin-proteinase complexes bind to their recepto

228 nt-like repeats, CR3 and CR8, from an alpha2-macroglobulin-proteinase ligand binding region of LRP, a

229 ding and inactivation of TGF-beta1 by alpha2-macroglobulin, rather than by modulation of growth facto

230 The alpha(2-)macroglobulin receptor (alpha(2)MR) has been reported to

231 ipoprotein receptor-related protein/alpha(2)-macroglobulin receptor (LRP) antibodies.

232 lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP).

233 low-density receptor-related protein/alpha2-macroglobulin receptor (LRP/alpha2MR) is blocked by Ni2+

234 lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP/alpha2MR) mediates the inter

235 M), interaction between CR3 and human alpha2-macroglobulin receptor binding domain that involves a co

236 The alpha2-macroglobulin receptor LRP1 cycles with Glut4 and the Tf

237 The CD91 molecule (also called alpha 2-macroglobulin receptor or the low density lipoprotein-re

238 Previously, CD91, the alpha2-macroglobulin receptor, was identified as the heat shock

239 obtained for another ligand of LDLR, alpha-2-macroglobulin receptor-associated protein (RAP), a commo

240 rotein receptor-related protein (LRP)/alpha2-macroglobulin receptor-mediated endocytosis of 125I-Th-P

241 ptor protein CD91, also known as the alpha-2-macroglobulin receptor.

242 ipoprotein receptor-related protein/alpha(2)-macroglobulin receptor.

243 A bound to suPAR, a binding site for alpha 2-macroglobulin receptor/LDL receptor-related protein (alp

244 xin (PE) binds the heavy chain of the alpha2-macroglobulin receptor/low density lipoprotein receptor-

245 s and enters mammalian cells via the alpha 2-macroglobulin receptor/low density lipoprotein receptor-

246 ciation with the endocytic receptor alpha(2)-macroglobulin receptor/low density lipoprotein receptor-

247 asminogen activator (uPA) through the alpha2-macroglobulin receptor/low density lipoprotein-related r

248 vitronectin, thombospondin, and the alpha 2-macroglobulin receptor/low-density lipoprotein-related r

249 Ligation of alpha(2)-macroglobulin receptors by receptor-recognized forms of

250 ound the receptor-binding domain of alpha(2)-macroglobulin (residues 1304-1451).

251 le related to the protease inhibitor alpha-2-macroglobulin responded strongly to malaria parasite inf

252 undergone a remarkable movement through the macroglobulin ring.

253 ced by laminin-2 or collagen IV, whereas the macroglobulin served as a collagenase inhibitor that did

254 amily, which includes C3, C4, C5, and alpha2-macroglobulin, shows that SpC3 is the first divergent co

255 -dependent regulation of macrophage alpha(2)-macroglobulin signaling receptors (alpha(2)MSR) and low

256 The specific binding of plasma CPB to alpha-macroglobulins suggest that these proteins may function

257 ng leupeptin, aprotinin, serpins, and alpha2-macroglobulin, suggesting the presence of non-canonical

258 ificant increases in serum levels of alpha-2-macroglobulin that correspond to changes in its mRNA lev

259 Malpha2M is the only murine alpha-macroglobulin that promotes NO synthesis.

260 d characterization of such a bacterial alpha-macroglobulin, that from Escherichia coli.

261 Three ligands were chemorepulsive: alpha-2-macroglobulin, tissue plasminogen activator, and metallo

262 meprin beta, we herein demonstrate alpha(2)-macroglobulin to be a potent inhibitor of the similar BM

263 This is also the first alpha-macroglobulin to be characterized that is predicted to b

264 or MMP-1 and MMP-3 determined using alpha(2)-macroglobulin to capture MMP dissociating from MMP-TIMP

265 vated and receptor-recognized form of alpha2-macroglobulin to macrophages was greatly reduced, and ac

266 y to process peptides chaperoned by alpha(2) macroglobulin, undergo identical variations.

267 f transforming growth factor beta 1, alpha 2 macroglobulin, vascular endothelial growth factor A, con

268 acetylated low density lipoprotein or alpha2-macroglobulin was degraded and released from cells in tr

269 OET-11, an alpha(2) macroglobulin, was expressed by the receptor neurons and

270 or another gene, encoding a putative alpha-2-macroglobulin, we found evidence of positive selection,

271 ment of DCs with mannan or LRP ligand alpha2-macroglobulin, we observed only a minor decrease in FVII

272 gen MART-1 and the protease inhibitor alpha2-macroglobulin were detected in the melanocyte cell line

273 psin inhibitor, antithrombin III, and alpha2-macroglobulin, whereas active tetramers are resistant to

274 showed specific binding to a protein, alpha2-macroglobulin, which may be the reason that IL-2 display

275 ptidases, but is mostly captured by alpha(2)-macroglobulin, which sequesters peptidases in a cage-lik

276 , of RAP inhibited the interaction of alpha2-macroglobulin with LRP.