ライフサイエンスコーパス: macrolide antibiotic

1 11-member cyclic peptide, whereas FK506 is a macrolide antibiotic.

2 rophylactic treatment with clarithromycin, a macrolide antibiotic.

3 e novel form of proarrhythmia seen with this macrolide antibiotic.

4 to the first total synthesis of this complex macrolide antibiotic.

5 hylamino)-3,4,6-trideoxyhexose found in some macrolide antibiotics.

6 ents with acute coronary syndrome when given macrolide antibiotics.

7 duct ions of explosives, acylcarnitines, and macrolide antibiotics.

8 ed activity of the broader spectrum group of macrolide antibiotics.

9 ng antibiotic resistance against a number of macrolide antibiotics.

10 Ketolides represent a new generation of macrolide antibiotics.

11 contributes to its ability to generate four macrolide antibiotics.

12 odular PKSs, which catalyze the synthesis of macrolide antibiotics.

13 ts ability to produce two distinct groups of macrolide antibiotics.

14 hrough genetic analysis to be susceptible to macrolide antibiotics.

15 nthesis may modulate site-specific action of macrolide antibiotics.

16 al cells treated with high concentrations of macrolide antibiotics.

17 tunnel is the target of clinically important macrolide antibiotics.

18 tcomes in a mouse model with beta-lactam and macrolide antibiotics.

19 increasingly resistant to currently marketed macrolide antibiotics.

20 s such as cyclosporin, statins, taxanes, and macrolide antibiotics.

21 clav, clindamycin, and fluoroquinolones) and macrolide antibiotics; a hand hygiene campaign; hospital

22 trE efflux pump system confers resistance to macrolide antibiotics and antimicrobial substances of th

23 iation pathways of a variety of ions such as macrolide antibiotics and hydrogen-bonded complexes.

24 rrent use of terfenadine and contraindicated macrolide antibiotics and imidazole antifungals continue

25 provides a platform for the discovery of new macrolide antibiotics and may also serve as the basis fo

26 atal cases were less likely to have received macrolide antibiotics and more likely to have received s

27 transporter has been implicated in efflux of macrolide antibiotics and secretion of enterotoxin STII.

28 S) genes: derivatives of medically important macrolide antibiotics and unusual polycyclic aromatic co

29 ition of carbamazepine metabolism by certain macrolide antibiotics, antifungals, verapamil, diltiazem

30 Prior treatment with macrolide antibiotics appeared to be protective against

31 Beta-lactam and macrolide antibiotics are considered safe in pregnancy a

32 The efficacies of these macrolide antibiotics are markedly reduced in the absenc

33 Polyene macrolide antibiotics are naturally occurring antifungal

34 Although several macrolide antibiotics are proarrhythmic and associated w

35 natives to erythromycin, including the newer macrolide antibiotics, are now part of the recommendatio

36 6-trideoxyhexose found, for example, in such macrolide antibiotics as erthyromycin, azithromycin, and

37 The macrolide antibiotic azithromycin has anti-inflammatory

38 udy was to assess whether treatment with the macrolide antibiotic azithromycin improves endothelial f

39 The widely used macrolide antibiotic azithromycin increases risk of card

40 We show that the macrolide antibiotic azithromycin reduced viral prolifer

41 assess whether short-term treatment with the macrolide antibiotic azithromycin reduces recurrent isch

42 The macrolide antibiotic bafilomycin A1 inhibited CS-induced

43 Treatment of cells with the macrolide antibiotic bafilomycin A1, an inhibitor of vac

44 Macrolide antibiotics benefit patients with a variety of

45 giogenesis stimulation can be blocked by the macrolide antibiotic borrelidin (BN), which exhibits a b

46 resent a practical, fully synthetic route to macrolide antibiotics by the convergent assembly of simp

47 nt data challenged this view by showing that macrolide antibiotics can differentially affect synthesi

48 More than 300 new macrolide antibiotic candidates, as well as the clinical

49 he potential anti-inflammatory activity of 3 macrolide antibiotics, clarithromycin, roxithromycin, an

50 The macrolide antibiotic concanamycin is a potent and specif

51 Glycosylation of macrolide antibiotics confers host cell immunity from en

52 somes, (ii) inhibition of CD4 degradation by macrolide antibiotics does not restore surface expressio

53 an antifungal drug of the family of polyene macrolide antibiotics, elevated YFP expression by the re

54 The macrolide antibiotic erythromycin A and its semisyntheti

55 The macrolide antibiotic erythromycin also interacted with t

56 megalomicea and differs from the well-known macrolide antibiotic erythromycin by the addition of a u

57 oxyglucose, is an unusual sugar found on the macrolide antibiotic erythromycin, and it has been shown

58 ), the parent aglycone of the broad spectrum macrolide antibiotic erythromycin.

59 Further, our structures of the macrolide antibiotics erythromycin and azithromycin in c

60 these proteins can confer resistance to the macrolide antibiotic, erythromycin.

61 intriguing class of mutants is resistant to macrolide antibiotics even though these drugs still bind

62 Macrolide antibiotics, exemplified by erythromycin, bind

63 This new class of macrolide antibiotics exhibited potent activity against

64 During antibiotic stewardship, use of 4C and macrolide antibiotics fell by 47% (mean decrease 224 def

65 Macrolide antibiotic for 3 months was associated with im

66 ation and disease progression, we tested two macrolide antibiotics for their ability to inhibit Nef f

67 Macrolide antibiotics have been shown beneficial in cyst

68 reviously to be involved in interaction with macrolide antibiotics, have been modeled in the crystall

69 The cladinose-containing macrolide antibiotic in the tunnel positions the nascent

70 confer resistance to erythromycin and other macrolide antibiotics in a variety of bacteria.

71 site-specific oxidation of the precursors to macrolide antibiotics in the genus Streptomyces introduc

72 o)-3,4,6-trideoxyhexose found in a number of macrolide antibiotics including methymycin (2), neomethy

73 Macrolide antibiotics, including azithromycin, have been

74 Macrolide antibiotics, including erythromycin, clarithro

75 induced lethality and identified a series of macrolide antibiotics, including roxithromycin, that pot

76 ion leading to the production of a series of macrolide antibiotics, including the natural ketolides n

77 ptide sequence and the chemical structure of macrolide antibiotic, indicating possible interaction be

78 Rapamycin, a lipophilic, macrolide antibiotic, induces autophagy by inactivating

79 ing "plug-in-the-bottle" model suggests that macrolide antibiotics inhibit translation by binding ins

80 Ceftriaxone with or without a macrolide antibiotic is a recommended treatment for pati

81 Resistance to macrolide antibiotics is conferred by mutation of A2058

82 resistance of group A Streptococcus (GAS) to macrolide antibiotics is now a worldwide problem.

83 A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleoti

84 A new class of macrolide antibiotics, known as ketolides, show improved

85 Macrolide antibiotics, like erythromycin, clarithromycin

86 A prolonged course (3 months) of macrolide antibiotic may be considered for patients with

87 Previous studies show that macrolide antibiotics may be efficacious in the treatmen

88 - and 14-membered aglycone precursors of the macrolide antibiotics methymycin and picromycin, respect

89 nsferase involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomy

90 Increasing evidence suggests that macrolide antibiotics might be beneficial in patients wi

91 Rapamycin, an antifungal macrolide antibiotic, mimics starvation conditions in Sa

92 oxidative tailoring of the 16-membered ring macrolide antibiotic mycinamicin II in the actinomycete

93 or the production of hybrid glycopeptide and macrolide antibiotics, novel anthelminthic agents and no

94 These include macrolide antibiotics, omalizumab, tumor necrosis factor

95 ed by prescription fills for a penicillin or macrolide antibiotic, or for trimethoprim-sulfamethoxazo

96 ycin was associated with previous use of any macrolide antibiotic (P < 0.001), and resistance to metr

97 Emergence of bacterial resistance to macrolide antibiotics, particularly in Gram-positive bac

98 Macrolide antibiotics penetrate cells, but the mechanism

99 MtrE multidrug-resistance efflux pump expels macrolide antibiotics, penicillin, and antimicrobial eff

100 Telithromycin (2) is a third-generation macrolide antibiotic prepared from erythromycin (1) and

101 The proportion of macrolide antibiotics prescribed increased from 36.8% to

102 However, long-term treatment with macrolide antibiotics presents a considerable risk for p

103 ch as the prostanoids, indole alkaloids, and macrolide antibiotics, provide ample evidence for the en

104 The macrolide antibiotic rapamycin effectively blocks oncoge

105 The macrolide antibiotic rapamycin inhibits the mammalian ta

106 The potent antiproliferative activity of the macrolide antibiotic rapamycin is known to involve bindi

107 t has been suggested that the ability of the macrolide antibiotic rapamycin to inhibit 4BP-1 phosphor

108 Previously, we reported that the macrolide antibiotic rapamycin, but not the related comp

109 Macrolide antibiotic rapamycin, in complex with a cytoso

110 have demonstrated that chronic therapy with macrolide antibiotics reduces the morbidity of patients

111 erties of the ribosomal exit tunnel and that macrolide antibiotics reshape the cellular proteome rath

112 onas vaginalis Sequencing was used to assess macrolide antibiotic resistance among M. genitalium-posi

113 lly transmitted organisms, and high rates of macrolide antibiotic resistance in a diverse sample of s

114 transmitted organisms and the frequency of a macrolide antibiotic resistance phenotype were determine

115 ositions has previously been associated with macrolide antibiotic resistance.

116 The total synthesis of the antifungal macrolide antibiotic roxaticin has been accomplished.

117 The asymmetric synthesis of the macrolide antibiotics (+)-rutamycin B (1) and (+)-oligom

118 new class of macrocyclic HDACi based on the macrolide antibiotics skeletons.

119 reactionary sites which are complementary to macrolide antibiotic spiramycin (SPI) were synthetized b

120 Macrolide antibiotics such as erythromycin may improve c

121 r aromatic compounds such as mithramycin and macrolide antibiotics such as erythromycin.

122 The antibacterial properties of macrolide antibiotics (such as erythromycin, tylosin, an

123 ling in the presence of clinically important macrolide antibiotics, such as erythromycin, leading to

124 desosamine are aminohexoses found in several macrolide antibiotics, such as tylosin and methymycin, r

125 of which were predicted to be susceptible to macrolide antibiotics, suggesting that different strains

126 Management includes macrolide antibiotics, supplemental oxygen, modest hydra

127 Rapamycin is a macrolide antibiotic that inhibits vascular smooth muscl

128 Azithromycin is a macrolide antibiotic that is active against several peri

129 Rapamycin, a lipophilic macrolide antibiotic that regulates mitochondrial transm

130 lav, and third-generation cephalosporins, or macrolide antibiotics that exceeded hospital-specific th

131 means to control the biological activity of macrolide antibiotics, the availability of macrolide gly

132 rate specificity of oxidative enzymes toward macrolide antibiotics, the x-ray structure of CYP154C1 f

133 Treatment depends on macrolide antibiotic therapy and intubation, with assist

134 Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in lif

135 ne (1), the parent aglycone precursor of the macrolide antibiotic tylosin.

136 The macrolide antibiotic, tylosin (Ty), is produced by Strep

137 proved latrine (0.89; 0.82-0.97), and recent macrolide antibiotic use (0.68; 0.63-0.74).

138 BOTTOM LINE Continuous macrolide antibiotic use for prophylaxis was associated

139 not, which makes comparisons between these 2 macrolide antibiotics useful in assessing clinically imp

140 ide synthase (PKS) biosynthetic tailoring of macrolide antibiotics usually involves one or more oxida

141 uvenimicin, M-4365, and rosamicin classes of macrolide antibiotics via late-stage diversification.

142 and actively extrudes substrates, including macrolide antibiotics, virulence factors, peptides and c

143 The completion of the synthesis of the two macrolide antibiotics was accomplished by the union of t

144 Macrolide antibiotics were discovered over 50 years ago

145 xposure has ceased.High or multiple doses of macrolide antibiotics, when given early in life, can per

146 Macrolide antibiotics, which have anti-inflammatory and

147 e observed after exposure to clindamycin and macrolide antibiotics, which have been proposed to targe

148 ion experiment over 25 days except for three macrolide antibiotics, which reached saturation at 300 n

149 Solithromycin, a novel macrolide antibiotic with both intravenous and oral form

150 , led to the discovery of gladiolin, a novel macrolide antibiotic with potent activity against Mycoba

151 Interactions of macrolide antibiotics with biological membranes contribu

152 the interaction strength and localization of macrolide antibiotics with membrane-mimetics.

153 and potency by bafilomycin and concanamycin, macrolide antibiotics with similar structures.

154 our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of

155 eceptor (e.g., some anticancer compounds and macrolide antibiotics), with subsequent effects on trans

156 Macrolide antibiotics yield high concentrations in infla