ライフサイエンスコーパス: macromolecular complex

1 achine is either a single macromolecule or a macromolecular complex.

2 ompetition for PP1 molecules within the same macromolecular complex.

3 activity of multiple proteins, possibly as a macromolecular complex.

4 nnel proteins (Kir2.1 and Na(V)1.5) within a macromolecular complex.

5 domain protein SAP97 is a component of this macromolecular complex.

6 iple target sites in a pre-formed polymer or macromolecular complex.

7 g the integrity of the CFTR-PDE3A-containing macromolecular complex.

8 hat HCN4 associates with Cav3 to form a HCN4 macromolecular complex.

9 and AQP4 exist in astrocytic membranes as a macromolecular complex.

10 d that Cx43 and PKP2 can coexist in the same macromolecular complex.

11 in a three-dimensional reconstruction of the macromolecular complex.

12 ably coordinates the proper assembly of this macromolecular complex.

13 uced posttranslational modifications of RyR2 macromolecular complex.

14 ) with key functions in assembling the nodal macromolecular complex.

15 ity on the level of biological assemblies or macromolecular complexes.

16 ctural rearrangements during the assembly of macromolecular complexes.

17 0 to Hsp90 to facilitate their assembly into macromolecular complexes.

18 d by limited structural information on these macromolecular complexes.

19 mutant PrP(C) upon Kv4.2-based cell surface macromolecular complexes.

20 uning and versatile assembly of higher order macromolecular complexes.

21 rom their vicinity leads to self-assembly of macromolecular complexes.

22 unctionalities known today only from natural macromolecular complexes.

23 Mia40 for further folding and assembly into macromolecular complexes.

24 e used to locate other flexible molecules in macromolecular complexes.

25 ules for both the assembly and modulation of macromolecular complexes.

26 r the structural determination of biological macromolecular complexes.

27 tivities in a number of functional states or macromolecular complexes.

28 h for exploring the structure of pleomorphic macromolecular complexes.

29 Proteins perform most cellular functions in macromolecular complexes.

30 e of local cAMP production in the context of macromolecular complexes.

31 d here is applicable to other coarse-grained macromolecular complexes.

32 uctures of many important macromolecules and macromolecular complexes.

33 uding protein turnover and the remodeling of macromolecular complexes.

34 olenoid, implying a role as a facilitator of macromolecular complexes.

35 es on synthesis of two of the cell's largest macromolecular complexes.

36 n removing damaged or surplus organelles and macromolecular complexes.

37 should be broadly applicable to the study of macromolecular complexes.

38 ns depend on the assembly and disassembly of macromolecular complexes.

39 frozen-hydrated single-particle specimens of macromolecular complexes.

40 oles in function, assembly, or maturation of macromolecular complexes.

41 exes and in the exchange of subunits between macromolecular complexes.

42 cesses via their ATPase-driven remodeling of macromolecular complexes.

43 ATPase subunits found in other multisubunit macromolecular complexes.

44 s full capabilities in the analysis of large macromolecular complexes.

45 il aggregates to "cap" and stabilize soluble macromolecular complexes.

46 ulation of protein functions and assembly of macromolecular complexes.

47 ined with SDS-PAGE yielded NOX4 to reside in macromolecular complexes.

48 m contains structural information of all its macromolecular complexes.

49 res and associated conformational changes of macromolecular complexes.

50 is not required to form scribble-syntrophin macromolecular complexes.

51 rnary structure and in the assembly of large macromolecular complexes.

52 at most native ion channels are assembled in macromolecular complexes.

53 omic resolution structures of highly ordered macromolecular complexes.

54 rtant for the generation of atomic models of macromolecular complexes.

55 mechanical properties not seen with cellular macromolecular complexes.

56 ns (Q54IX5) and having homology to mammalian macromolecular complex adaptor proteins was identified.

57 oduce ChIMP as a versatile tool to probe the macromolecular complex and function of Ca(2+)-activated

58 identify new members of the cardiac Ca(v)1.2 macromolecular complex and identify a mechanism by which

59 ghout metazoans that associates with a large macromolecular complex and localizes with kinetochores a

60 in interactions involved in the formation of macromolecular complexes and biochemical pathways.

61 icellular eukaryotes-pinpointing subunits of macromolecular complexes and components functioning in c

62 large/zona occludens) protein that assembles macromolecular complexes and determines the localization

63 our understanding of the formation of large macromolecular complexes and how their components intera

64 tively stable linkages between components of macromolecular complexes and in some cases to bridge to

65 exemplified in studies of the biogenesis of macromolecular complexes and in the exchange of subunits

66 Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, co

67 of a protein's mobility, its exchange within macromolecular complexes and its interactions with other

68 free energy required to assemble these large macromolecular complexes and maintain them under physiol

69 ion for in situ three-dimensional imaging of macromolecular complexes and organelles.

70 an important source of experimental data on macromolecular complexes and protein-protein interaction

71 can provide better estimates of the size of macromolecular complexes and report on sample homogeneit

72 nges within biomolecules to the formation of macromolecular complexes and the associations between th

73 eptor 2, cardiac (RyR2)/Ca2+ release channel macromolecular complexes and the sarcoplasmic/endoplasmi

74 a powerful tool for analyzing structures of macromolecular complexes and their spatial organizations

75 ble structural features in 14-3-3 containing macromolecular complexes and to illuminate important str

76 e the shape and size of the macromolecule or macromolecular complex, and are therefore complementary

77 Co-immunoprecipitation showed formation of a macromolecular complex, and live immunolabeling demonstr

78 ften these enzymes function as components of macromolecular complexes, and DNA translocation by the m

79 of the size-distribution of macromolecules, macromolecular complexes, and nanoparticles.

80 urprising degree of functional plasticity of macromolecular complexes, and the existence of numerous

81 s of amyloid and membrane proteins and large macromolecular complexes are an important new approach t

82 ility in the way that homologous prokaryotic macromolecular complexes are assembled than has generall

83 These two macromolecular complexes are connected by a direct inter

84 ast Saccharomyces cerevisiae, organelles and macromolecular complexes are delivered from the mother t

85 Spatially organized macromolecular complexes are essential for cell and tiss

86 Macromolecular complexes are essential to conserved biol

87 Domains in macromolecular complexes are often considered structural

88 Macromolecular complexes are responsible for many key bi

89 Molecular machines or macromolecular complexes are supramolecular assemblies o

90 cognize that numerous proteins assemble into macromolecular complexes as part of normal physiology, s

91 Furthermore, recruitment of SMN into large macromolecular complexes as well as increased associatio

92 ervation, as well as the precise timeline of macromolecular complex assembly during key cell cycle ev

93 death, translation and protein folding, and macromolecular complex assembly.

94 he PDZ scaffolding protein, PDZK1, forming a macromolecular complex at apical surfaces of gut epithel

95 y and that the corresponding proteins form a macromolecular complex at the cytoplasmic membrane, whic

96 Formation of multiple-protein macromolecular complexes at specialized subcellular micr

97 ner through the formation of CFTR-containing macromolecular complexes at the plasma membrane.

98 We discover a macromolecular complex between the scaffolding protein G

99 interactome have identified several hundred macromolecular complexes, but direct binary protein-prot

100 polyubiquitinated proteins from membranes or macromolecular complexes, but how they perform these fun

101 Cb proteins are cotransported as one or more macromolecular complexes, but the basis for this cotrans

102 m the functionality of the Sall1-associating macromolecular complex by showing that the complex posse

103 Visualizing macromolecular complexes by single-particle electron mic

104 the stability, homogeneity and solubility of macromolecular complexes by sparse-matrix screening of t

105 of EM structural data of macromolecules and macromolecular complexes by the wider scientific communi

106 red by formation of a stable, tRNA-dependent macromolecular complex called the Asn-transamidosome.

107 precise structural ensembles of proteins and macromolecular complexes can be obtained with metainfere

108 Many new macromolecular complexes can benefit significantly from

109 ate signal-dependent RNA processing and that macromolecular complexes can compartmentalize c-di-GMP s

110 one H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes

111 ochondrion, by increasing interaction with a macromolecular complex composed of the VDAC1 (voltage-de

112 Ribosomes exist as a heterogenous pool of macromolecular complexes composed of ribosomal RNA molec

113 o new databases of protein-protein and other macromolecular complexes, ComPPI and the Complex Portal.

114 In eukaryotes, this process requires a macromolecular complex comprising over 200 proteins and

115 The cardiac I(Ks) potassium channel is a macromolecular complex consisting of alpha-(KCNQ1) and b

116 Ribosomes are large and highly charged macromolecular complexes consisting of RNA and proteins.

117 identified novel layers of interplay within macromolecular complexes containing diverse channel type

118 high levels, bound to detergent-solubilized macromolecular complexes containing neuronal voltage-gat

119 h eukaryotic cellulose synthases function in macromolecular complexes containing several different en

120 The kinetic stability of non-covalent macromolecular complexes controls many biological phenom

121 s between CFTR and other transporters within macromolecular complexes coordinated at the apical membr

122 mple of such protein assemblies, the BRCA1-A macromolecular complex, couples ubiquitin recognition an

123 o proteins that form, with CASQ2 and RyR2, a macromolecular complex devoted to control of calcium rel

124 microscopy and allows the probing of single macromolecular complexes directly from cell or tissue ex

125 We report the first description of a macromolecular complex display system using bacteriophag

126 lter protein-protein interactions modulating macromolecular complexes enriched in disease risk candid

127 roach for analyzing assembly and function of macromolecular complexes, especially those too large for

128 a framework to generate crowded mixtures of macromolecular complexes for realistically simulating cr

129 produce specimens of His-tagged proteins or macromolecular complexes for single-particle electron mi

130 previously described to isolate proteins and macromolecular complexes for single-particle EM, we were

131 companying protocol entitled 'Preparation of macromolecular complexes for visualization using cryo-el

132 ying the dynamic regulation of submembranous macromolecular complex formation between group I mGluRs

133 ing kinetic coupling, collision coupling, or macromolecular complex formation has remained unknown.

134 ilencing by unpaired DNA (MSUD) and observed macromolecular complex formation involving only SAD-1 pr

135 Macromolecular complex formation is governed by two oppo

136 Our findings illustrate that the asymmetric macromolecular complex formation of chemoattractant rece

137 activation, IL-1beta production, cell death, macromolecular complex formation, self-association, and

138 In vitro, a macromolecular complex formed by TRPC1/TRPC3/TRPC6 exist

139 IT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin

140 e multifunctional protein nephrin within the macromolecular complex forming the glomerular slit diaph

141 Averaging of macromolecular complexes found within tomograms is known

142 e or multi-modular protein, and assembling a macromolecular complex from its subunits.

143 We have implemented this screen on several macromolecular complexes from a variety of organisms, re

144 rating one solution to construction of large macromolecular complexes from small repeating units.

145 This macromolecular complex functioned to amplify inside-out

146 athies, demonstrating the importance of this macromolecular complex in muscle structure and function.

147 ma-aminobutyric acid(A)-chloride ion channel macromolecular complex in the pathophysiologic mechanism

148 est that alpha-actinins may link ASIC1a to a macromolecular complex in the postsynaptic membrane wher

149 and lymphoid enhancer-binding factor-1 form macromolecular complexes in cells, (b) ERRalpha transcri

150 is an important tool to study structures of macromolecular complexes in close to native states.

151 to investigate complete and fully functional macromolecular complexes in different functional states,

152 esults, H1 existed in large (400 to >650kDa) macromolecular complexes in human T cell nucleolar extra

153 yo-electron tomography allows the imaging of macromolecular complexes in near living conditions.

154 st reliably map the interactomes of cellular macromolecular complexes in order to fully explore and u

155 and to evaluate the local involvement of the macromolecular complexes in regulation of functional act

156 technique allows structure determination of macromolecular complexes in situ.

157 luable tool for the structural dissection of macromolecular complexes in situ.

158 e structural characterizations of biological macromolecular complexes in solution.

159 This system is applicable to studying macromolecular complexes in the context of cell signalin

160 D) is the dominant method for probing intact macromolecular complexes in the gas phase by means of ma

161 To improve the stability of macromolecular complexes in vitro, we present a generic

162 bly factors facilitate the formation of many macromolecular complexes in vivo.

163 spatial distributions of previously unknown macromolecular complexes in whole cell tomograms.

164 lcitrant insoluble substrate by an intricate macromolecular complex, in which the essential synergy b

165 ence of cellular lysis, of other cytoplasmic macromolecular complexes, including infectious agents an

166 hy (ECT) provides three-dimensional views of macromolecular complexes inside cells in a native frozen

167 The human SMN protein is part of a large macromolecular complex involved in the biogenesis of sma

168 its to specific subcellular locations and/or macromolecular complexes involved in signaling pathways.

169 ng the nuclear transport channel to multiple macromolecular complexes involved in the regulation of g

170 -encoded protein tat triggers formation of a macromolecular complex involving the low-density lipopro

171 ivation induces internalization of a cardiac macromolecular complex involving VDCC and beta-arrestin

172 e further observed that the CXCR2-containing macromolecular complex is critical for the CXCR2-mediate

173 f the structure and mechanism of these large macromolecular complexes is an active and ongoing resear

174 ow phosphorylation affects NHERF to assemble macromolecular complexes is unknown.

175 The cardiac RyR2 macromolecular complexes isolated from murine and human

176 ber of experimentally resolved structures of macromolecular complexes, it becomes clear that the inte

177 In light of the complexity of macromolecular complexes, it is essential to use compute

178 ds another dimension by which this essential macromolecular complex may be regulated in health and di

179 f-organization and that introduction of such macromolecular complexes may advance nanoengineering of

180 Macromolecular complexes may disassociate or adopt nonra

181 ing E2-BSA-FITC (fluorescein isothiocyanate) macromolecular complex, membrane E2 binding sites were o

182 cretory molecules, enzymes, receptors, large macromolecular complexes, membrane vesicles, and exosome

183 y for small-angle scattering data of various macromolecular complexes; MoonProt, a database of 'moonl

184 l-cell contact sites and assemble into large macromolecular complexes named adherens junctions (AJs).

185 tion, perhaps through disruption of the I Ks macromolecular complex necessary for beta-AR-mediated I

186 unctional node and that perturbation of this macromolecular complex not only is responsible for the w

187 this membrane, PTEX is arranged in a stable macromolecular complex of >1230 kDa that includes an app

188 hologue to DYF-13, PIFTC3, participates in a macromolecular complex of approximately 660 kDa.

189 data to produce a systems-level view of the macromolecular complex of chromatin.

190 We assembled a macromolecular complex of CXCR2.NHERF1.PLC-beta2 in vitr

191 on of the PDZ motif-mediated assembly of the macromolecular complex of LPA2 disorganizes the gradient

192 n together, we suggest that 4.1R organizes a macromolecular complex of skeletal and transmembrane pro

193 II delta(C) (CaMKIIdelta(C)) is found in the macromolecular complex of type 2 ryanodine receptor (RyR

194 of RyR2s in the middle of the sarcomere are macromolecular complexes of approximately 20 RyR2s with

195 h Galpha and Gbeta are associated with large macromolecular complexes of approximately 700 kDa in the

196 it is possible to obtain reconstructions of macromolecular complexes of different sizes to better th

197 are critically dependent on the formation of macromolecular complexes of Kv4 channels with a family o

198 These localized PDZ motif-mediated macromolecular complexes of LPA2 trigger a Ca(2+) puff g

199 ssential and participates in the assembly of macromolecular complexes of RNA and protein in all cells

200 y regulating cAMP in microdomains containing macromolecular complexes of SR calcium ATPase type 2a-ph

201 SK channels are stable macromolecular complexes of the ion pore-forming subunit

202 and pi-basicity of metal-organic trimetallic macromolecular complexes of the type [M(mu-L)]3, where M

203 insight into the mechanisms, structures, and macromolecular complexes of these enzymes has grown expo

204 These results indicate that Myc populates macromolecular complexes of widely heterogenous size and

205 High-resolution structures of macromolecular complexes offer unparalleled insight into

206 eral of the Coq proteins are associated in a macromolecular complex on the matrix face of the inner m

207 inase (PKA) holoenzyme typically nucleates a macromolecular complex or a "PKA signalosome." Using the

208 method to study the detailed architecture of macromolecular complexes or cellular structures.

209 can now be obtained, not only for megadalton macromolecular complexes or highly symmetrical assemblie

210 -1, and demonstrate that disruption of these macromolecular complexes or knockdown of TRIP6 or NHERF2

211 Proteins within most macromolecular complexes or organelles continuously turn

212 Macromolecular complexes play crucial roles in transcrip

213 Conformational changes of macromolecular complexes play key mechanistic roles in m

214 These results suggest that the INAD macromolecular complex plays an essential role in termin

215 The fact that ions of macromolecular complexes produced by electrospray ioniza

216 and demonstrate that detailed dissection of macromolecular complexes provides fuller understanding o

217 4 as a critical component of the Nav channel macromolecular complex, providing evidence for a novel G

218 on the state of cytoplasmic and intraluminal macromolecular complexes regulating cardiac RyR2 functio

219 Additional antigenic components of VGKC macromolecular complexes remain to be defined.

220 gh the proposed requirement for a TRPV4-AQP4 macromolecular complex remains to be resolved.

221 mediate protein folding, translocation, and macromolecular complex remodeling reactions.

222 RyR2 macromolecular complex remodeling, characterized by depl

223 ors of phagocytosis such as the 'exocyst', a macromolecular complex required for exocytosis but not p

224 T6SS components are proposed to be part of a macromolecular complex resembling the bacteriophage tail

225 The macromolecular complex responsible for processing both c

226 spectrometry (IM-MS), we find that all four macromolecular complexes retain their native-like topolo

227 plications are illustrated for several large macromolecular complexes: ribosome, virus capsids, chemo

228 the nanostructure formation of a biological macromolecular complex: RNA interference microsponges.

229 In yeast, the macromolecular complex Set1/COMPASS is capable of methyl

230 ein containing a CARD (ASC) formed cytosolic macromolecular complexes (so-called pyroptosomes) that w

231 as well as a substantial boost in successful macromolecular complex structure determination by both X

232 -network tend to include components of large macromolecular complexes such as ribosomes and photosynt

233 Low copy number proteins within macromolecular complexes, such as viruses, can be critic

234 proteins are synthesized by the ribosome, a macromolecular complex that accomplishes the life-sustai

235 The kinetochore is a macromolecular complex that controls chromosome segregat

236 The cytomatrix at the active zone (CAZ) is a macromolecular complex that facilitates the supply of re

237 The RNA degradosome is a multiprotein macromolecular complex that is involved in the degradati

238 In these mutants, the macromolecular complex that links metabotropic glutamate

239 stem (MAPS), which enables the creation of a macromolecular complex that mimics the properties of WCV

240 Radial spokes are conserved macromolecular complexes that are essential for ciliary

241 ss out interesting patterns present in large macromolecular complexes that are typically solved by lo

242 On bi-oriented chromosomes, kinetochores (macromolecular complexes that attach the chromosome to t

243 i that promote the assembly of kinetochores, macromolecular complexes that bind spindle microtubules

244 e dynamics of assembly and turnover of other macromolecular complexes that can be isolated from cells

245 s operate in intact tissues as part of large macromolecular complexes that can include cytoskeletal p

246 Chemoreceptor arrays are macromolecular complexes that form extended assemblies p

247 including proteins, nucleic acids and large macromolecular complexes that have been determined using

248 including proteins, nucleic acids and large macromolecular complexes that have been determined using

249 Kinetochores are the macromolecular complexes that interact with microtubules

250 gments the formation of MRP4-CFTR-containing macromolecular complexes that is mediated via scaffoldin

251 Inflammasomes are macromolecular complexes that mediate inflammatory and c

252 in controlling the assembly and activity of macromolecular complexes that monitor chromosome duplica

253 ement of such breathing in the mechanisms of macromolecular complexes that operate at these loci is n

254 -linked ubiquitin chains as part of distinct macromolecular complexes that participate in either inte

255 ges iNOS with CFTR, forming CFTR-NHERF2-iNOS macromolecular complexes that potentiate CFTR channel fu

256 ation and function, we know little about the macromolecular complexes that regulate electrical synaps

257 cterial ribosome is an extremely complicated macromolecular complex the in vivo biogenesis of which i

258 The NPC is a large macromolecular complex, the size and complexity of which

259 stoichiometric differences among members of macromolecular complexes, the interactome, and signaling

260 ector phospholipase C (PLC)-beta2, forming a macromolecular complex, through a PDZ-based interaction.

261 We hypothesized that XB130 and Tks5 form a macromolecular complex to mediate signal transduction ca

262 esting that they work in tandem as part of a macromolecular complex to regulate KOR/MOR formation.

263 that p97 extracts proteins from membranes or macromolecular complexes to enable their proteasomal deg

264 tin structure confines the movement of large macromolecular complexes to interchromatin corrals.

265 d serve as a scaffold for the recruitment of macromolecular complexes to modify chromatin accessibili

266 ell shapes and the targeting of proteins and macromolecular complexes to specific subcellular sites s

267 structure neighboring results and shows, for macromolecular complexes tracked in MMDB, lists of simil

268 and modulatory proteins are organized into a macromolecular complex ("transducisome").

269 gh-throughput structural characterization of macromolecular complexes under physiological conditions.

270 Nanostructures formed from biological macromolecular complexes utilizing the self-assembly pro

271 ystal structure of this large membrane-bound macromolecular complex via in silico modeling.

272 2-R2474S+/- mice were oxidized, and the RyR2 macromolecular complex was depleted of calstabin2.

273 The RyR1 macromolecular complex was oxidized, S-nitrosylated, Ser

274 bunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, which is an intracellular calciu

275 ent of the cardiac ryanodine receptor (RyR2) macromolecular complex, which modulates Ca(2+) release f

276 Proteins of the secretin family form large macromolecular complexes, which assemble in the outer me

277 rinciples underlying the formation of stable macromolecular complexes, which in many cases are likely

278 res organization of signaling molecules into macromolecular complexes, whose components are in intima

279 ests that targeting CFTR and CFTR-containing macromolecular complexes will ameliorate diarrheal sympt

280 f Salmonella-infected macrophages revealed a macromolecular complex with an outer ring of apoptosis-a

281 is novel method of pERK1/2 accumulation to a macromolecular complex with dual specific phosphatase ac

282 , the NuRD components HDAC1/2 associate in a macromolecular complex with Foxp proteins, and loss of e

283 to accurately predict how to capture a given macromolecular complex with its physiological binding pa

284 Prx exists in a macromolecular complex with proteins involved in membran

285 ic approach, we found that DOCK8 exists in a macromolecular complex with the Wiskott-Aldrich syndrome

286 lized at apical cell membranes and exists in macromolecular complexes with a variety of signaling and

287 as source for purifying thermostable native macromolecular complexes with an emphasis on the nuclear

288 r results suggest that endogenous NOX4 forms macromolecular complexes with calnexin, which are needed

289 ne the stoichiometry, affinity, and shape of macromolecular complexes with dissociation equilibrium c

290 rocesses can be driven by Brownian motion of macromolecular complexes with one-sided binding biasing

291 ral under physiological conditions reside in macromolecular complexes with other sticky proteins due

292 o the R7 subfamily of RGS proteins that form macromolecular complexes with R7-binding protein (R7BP).

293 y involved as a consequence of forming large macromolecular complexes with the DNA-binding subunits o

294 established that R7 RGS proteins function as macromolecular complexes with two subunits: type 5 G pro

295 physically and functionally associated in a macromolecular complex within lipid rafts at the apical

296 vious version enabling the analysis of large macromolecular complexes within a user-friendly interfac

297 ed clarity, the organizational principles of macromolecular complexes within cells, thus leading to d

298 Se7942 Rubisco and CcmM35 formed macromolecular complexes within the chloroplast stroma,

299 d to determine the structure of proteins and macromolecular complexes without the need for crystals.

300 ein interactions (PPIs) regulate assembly of macromolecular complexes, yet remain challenging to stud