ライフサイエンスコーパス: macromolecular crowding

1 ither by a chaperone such as EF1A or through macromolecular crowding.

2 cessivity are not upregulated or hindered by macromolecular crowding.

3 three environmental variables: pH, salt, and macromolecular crowding.

4 tes are nearly equally adversely affected by macromolecular crowding.

5 h osmolality, presumably as a consequence of macromolecular crowding.

6 trates and protect them from the problems of macromolecular crowding.

7 our understanding of the functional role of macromolecular crowding.

8 arious macromolecules, a phenomenon known as macromolecular crowding.

9 f the brain that have limited solvent due to macromolecular crowding.

10 ing both theory and experiment to studies of macromolecular crowding.

11 vesting efficiency of photosystem (PS) II on macromolecular crowding.

12 rnatively as the "depletion interaction" or "macromolecular crowding."

13 Herein, we assessed the influence of macromolecular crowding, a biophysical phenomenon that r

14 However, it is known that macromolecular crowding, a key feature in natural cells,

15 Macromolecular crowding affects most chemical equilibria

16 Theory predicts that macromolecular crowding affects protein behavior, but ex

17 The results show that macromolecular crowding affects protein-folding dynamics

18 state of gp45 is, however, increased by the macromolecular crowding agent polyethylene glycol.

19 resence of 220 mg/mL dextran 70, a synthetic macromolecular crowding agent that occupies space but do

20 , we investigated the effects of a synthetic macromolecular crowding agent, dextran 20, on the folded

21 ClpB in the absence and presence of an inert macromolecular crowding agent.

22 presence of high concentrations of an inert macromolecular crowding agent.

23 We introduced macromolecular crowding agents into reconstituted fusion

24 solutions containing high concentrations of macromolecular crowding agents would give new insights i

25 lding speed for apoazurin in the presence of macromolecular crowding agents, a result that points to

26 g reaction is carried out in the presence of macromolecular crowding agents, such as Ficoll and dextr

27 ein, apoflavodoxin, in the presence of inert macromolecular crowding agents, using in silico and in v

28 glycosaminoglycans or high concentrations of macromolecular crowding agents.

29 nscript length and was greatly stimulated by macromolecular crowding agents.

30 in machinery is sensitive to the presence of macromolecular crowding agents.

31 nd on the nanoscale organization assumed for macromolecular crowding agents.

32 es fundamental differences between small and macromolecular crowding agents.

33 n with FIH in the presence of cell lysate or macromolecular crowding agents.

34 unfolded-state compaction in the presence of macromolecular crowding along with its energetic and kin

35 tro results obtained on isolated mRNAs, both macromolecular crowding and a high ionic strength favor

36 lytes via specific transporters both reduces macromolecular crowding and ionic strength, thus leading

37 The encapsulation results suggest that macromolecular crowding and molecular confinement are ac

38 perimental system for testing the effects of macromolecular crowding and molecular confinement on pro

39 Here, we discovered that macromolecular crowding and reducing agents increase ove

40 radict predictions from accepted theories of macromolecular crowding and show that cosolutes commonly

41 e of amyloidogenesis may be affected by both macromolecular crowding and spatial heterogeneity (e.g.

42 ents can critically influence the outcome of macromolecular crowding and that the structure of the am

43 ossibly enabling cellular cargos to overcome macromolecular crowding and to navigate obstacles along

44 y cooperative process, strongly dependent on macromolecular crowding, and involves back-to-back stack

45 Although the excluded-volume effects of macromolecular crowding are expected to cause compaction

46 mplicating the commonly overlooked aspect of macromolecular crowding as a possible factor in the etio

47 s on the available volume can be affected by macromolecular crowding, but the effects of crowding in

48 mimic intracellular compartmentalization and macromolecular crowding by partitioning RNA in an aqueou

49 scattering was used to study the effects of macromolecular crowding by two globular proteins, i.e.,

50 Macromolecular crowding can alter the structure and func

51 heir native intracellular environments where macromolecular crowding can drastically change reaction

52 te if combined application of ultrasound and macromolecular crowding can improve efficiency of MR.

53 Theoretical models predict that macromolecular crowding can increase protein folding sta

54 Here, we demonstrate that macromolecular crowding can increase the robustness of g

55 can be inferred from their observations that macromolecular crowding can lead to robustness in gene e

56 ligands of different sizes (actin and ATP), macromolecular crowding can modulate the kinetics of ind

57 , ligand affinity, switching free energy and macromolecular crowding collectively control riboswitch

58 Macromolecular crowding conditions accelerate reactions

59 Here we have investigated whether macromolecular crowding conditions are able to promote h

60 ciency, we varied the salt concentration and macromolecular crowding conditions.

61 protein domain, intracellular viscosity and macromolecular crowding dictate its in vivo behavior.

62 Increased macromolecular crowding does not activate OpuA but acts

63 periment and computer simulation to show how macromolecular crowding dramatically affects the structu

64 s at different fixed temperatures showed the macromolecular crowding effect to be temperature-indepen

65 ation of polyvalent binding and the enhanced macromolecular crowding effect using nanoparticles.

66 Macromolecular crowding effects may be a tool for the ma

67 To quantify macromolecular crowding effects on protein folding mecha

68 Recent results support the notion that macromolecular 'crowding' enhances protein aggregation,

69 ing condition, the excluded volume effect of macromolecular crowding favors aggregation, whereas incr

70 Most theories about macromolecular crowding focus on two ideas: the macromol

71 a qualitatively different dependence on the macromolecular crowding for high and low values of the r

72 We studied how macromolecular crowding guides protein between different

73 Macromolecular crowding has a profound effect upon bioch

74 Macromolecular crowding has long been known to significa

75 This study demonstrates that macromolecular crowding has structural effects on the fo

76 al implications, few experimental studies of macromolecular crowding have been reported.

77 Studies of macromolecular crowding have shown its important effects

78 mbles a fractal structure with its origin in macromolecular crowding in the cell membrane.

79 n important factor in limiting the degree of macromolecular crowding in the cell.

80 e roles of cytoplasmic osmolytes, water, and macromolecular crowding in the growth of osmotically str

81 n be regulated jointly by the local level of macromolecular crowding in the nucleus, together with th

82 We seek to elucidate the role of macromolecular crowding in transcription and translation

83 Our results demonstrate that macromolecular crowding in two dimensions can play a sig

84 structures because milder water deficit and macromolecular crowding induce high alpha-helix levels i

85 hese findings have profound implications for macromolecular crowding inside cells.

86 Macromolecular crowding intensifies oxidative modificati

87 Macromolecular crowding is a critical parameter affectin

88 Macromolecular crowding is commonly understood in terms

89 Macromolecular crowding is expected to have a significan

90 Macromolecular crowding is known to profoundly influence

91 Macromolecular crowding is one of the key characteristic

92 This volume exclusion because of macromolecular crowding is predicted to affect both equi

93 ere, we present an unexpected discovery that macromolecular crowding is required for reconstituting t

94 With increasing macromolecular crowding levels, the precision of particl

95 To explore how macromolecular crowding may influence cellular protein f

96 Our results demonstrate how macromolecular crowding may influence protein folding by

97 asound, biophysical properties of tissue and macromolecular crowding of insonated zone of tissue are

98 s generally assumed to be anomalous due high macromolecular crowding of the milieu.

99 the importance of approaching the effects of macromolecular crowding on a case-by-case basis.

100 Thus, the effect of macromolecular crowding on activity and structure need t

101 We addressed the effects of macromolecular crowding on alpha-synuclein by combining

102 mental question we investigate the effect of macromolecular crowding on cell metabolism.

103 s attention has been given to the effects of macromolecular crowding on cell physiology.

104 the present study we analyzed the effect of macromolecular crowding on fibrillation of four proteins

105 To study the effects of macromolecular crowding on folding thermodynamics and ki

106 We have studied the effects of macromolecular crowding on protein folding kinetics by s

107 We investigate the effect of macromolecular crowding on protein folding, using purely

108 esidue-level interrogation of the effects of macromolecular crowding on protein stability.

109 s for the effects of spatial confinement and macromolecular crowding on protein stability.

110 However, the effect of macromolecular crowding on protein structure is poorly u

111 udy the effects of cellular architecture and macromolecular crowding on signal transduction in Escher

112 Here we analyze the effect of macromolecular crowding on structure and function of the

113 To investigate the consequences of macromolecular crowding on the behavior of a globular pr

114 The effect of macromolecular crowding on the binding of ligands to a r

115 rom effects of preferential interactions and macromolecular crowding on the membrane or on ProP.

116 The observed effects of macromolecular crowding on the myosin-ligand interaction

117 The effect of macromolecular crowding on the rates of association reac

118 ive transition-state ensemble, the effect of macromolecular crowding on the relative stability betwee

119 l-angle scattering to measure the effects of macromolecular crowding on the size of a protein complex

120 he effect of intermolecular excluded volume (macromolecular crowding) on protein stability and confor

121 Macromolecular crowding opens new avenues for a more rat

122 pic, excluded-volume effect variously called macromolecular crowding or depletion attraction.

123 Macromolecular crowding ought to stabilize folded forms

124 Although it is still underappreciated, macromolecular crowding plays a critical role in life as

125 Consequently, macromolecular crowding plays a major role in determinin

126 In vitro studies show that macromolecular crowding, rather than changes in monolaye

127 Our results show that macromolecular crowding reduces noise (as measured by th

128 Accordingly, macromolecular crowding should constitute an integral el

129 lisecond time resolution under conditions of macromolecular crowding similar to those within cells.

130 Our data reinforce the assertion that macromolecular crowding stabilizes the protein by destab

131 d HIV-1 CA-NC complexes is not due solely to macromolecular crowding, suggesting the presence of spec

132 Models for macromolecular crowding tend to focus on the steric effe

133 robes provides more detailed readouts on the macromolecular crowding than a single sensor.

134 o-collective hydration transition induced by macromolecular crowding that slows the hydration dynamic

135 However, the contribution of macromolecular crowding to receptor retention remains po

136 Here we examine macromolecular crowding using the replication system of

137 Specifically, we demonstrate that, during macromolecular crowding, viscosity dominates over the ex

138 At high osmolarity, the increase in macromolecular crowding which accompanies the reduction

139 an might be anticipated considering the high macromolecular crowding within the cell.