ライフサイエンスコーパス: macromolecule

1 tal stages and are ester-bound in the lignan macromolecule.

2 ld improve the percutaneous penetration of a macromolecule.

3 intermediates, energies, and kinetics of the macromolecule.

4 the structural integrity and function of the macromolecule.

5 ent with interactions between added ions and macromolecule.

6 thod for the study of interacting systems of macromolecules.

7 secondary or three dimensional structures of macromolecules.

8 membranes that are typically impermeable to macromolecules.

9 nance (NMR) spectroscopic data of biological macromolecules.

10 related a function of characteristic charged macromolecules.

11 g the nuclear positions of hydrogen atoms in macromolecules.

12 eal-time monitoring of cytosolic delivery of macromolecules.

13 signal, indicating intracellular delivery of macromolecules.

14 and drives cooperative binding of ligands to macromolecules.

15 etene forms a covalent bond with surrounding macromolecules.

16 phase separation behavior of the constituent macromolecules.

17 ls including polymers, dendrimers, and other macromolecules.

18 of the total force acting between atoms and macromolecules.

19 pillary convective flux of ultrafiltrate and macromolecules.

20 rs in most cellular events are assemblies of macromolecules.

21 epresent a valuable source of highly defined macromolecules.

22 al barrier that controls passage of ions and macromolecules.

23 ions in steady-state and capture blood-borne macromolecules.

24 rational contributions of the other cellular macromolecules.

25 melts and networks prepared from bottlebrush macromolecules.

26 fy key structural and functional features of macromolecules.

27 athological conditions can modify and damage macromolecules.

28 terogeneous behavior and actually manipulate macromolecules.

29 stance and endothelial cell permeability for macromolecules.

30 e backbones to become elaborate heterocylcic macromolecules.

31 cargo followed by recycling of the resulting macromolecules.

32 spatial and time scales accessed by dynamic macromolecules.

33 cers to measure metabolism and expression of macromolecules.

34 ovine serum albumin, taken as models of food macromolecules.

35 ee-dimensional (3D) structures of biological macromolecules.

36 tool for studying the folding of biological macromolecules.

37 ng vessel pumping and decreases transport of macromolecules.

38 of nuclear transport receptor (NTR)-bearing macromolecules.

39 venient way of phasing crystal structures of macromolecules.

40 ential new avenues to control the folding of macromolecules.

41 fficulty in creating structurally controlled macromolecules.

42 king sense of the intricate 3D structures of macromolecules.

43 a variety of thiol-containing molecules and macromolecules.

44 as they regulate the function of biological macromolecules.

45 al, and biochemical properties of biological macromolecules.

46 e (TEER) and decreasing permeability against macromolecules.

47 t roles when present at key locations within macromolecules.

48 These melanoidin macromolecules (1.7-5.6 kDa) were detected intact in bot

49 ponses elicited by commensal-derived surface macromolecules(3-5).

50 ults in substantially decreased synthesis of macromolecules; (4) ethanol can directly bind 213 protei

51 s shows that the GUI makes modeling of large macromolecules accessible to a wide audience.

52 atment does not affect the flux of uncharged macromolecules across cell monolayers but significantly

53 useful if they could enable the movement of macromolecules across membranes, a rare property in memb

54 cules and surfaces of crystalline materials, macromolecule adsorption on different types of crystal s

55 cial attention is paid to the selectivity of macromolecule adsorption on, and incorporation within, c

56 dulation of interactions between the charged macromolecules affects their resulting supramolecular st

57 can improve the percutaneous penetration of macromolecules after topical application to the skin.

58 pecimens helped confirm Evans blue (bound to macromolecule albumin) extravasation, and hematoxylin-eo

59 ion, associated with a sustained increase in macromolecule and lipid levels (ML9).

60 Autophagy, a catabolic mechanism for macromolecule and protein recycling, allows the maintena

61 both forms, mainly ester-bound in the lignan macromolecule and slightly in a free form.

62 if these molecules accumulate in the lignan macromolecule and/or in a free form.

63 utilize glucose and glutamine, which provide macromolecules and antioxidants that sustain rapid cell

64 stress establishes the relationship between macromolecules and cancer biomarkers in saliva.

65 vals for a long time due to no contacts with macromolecules and cells in the body.

66 phase during which seeds accumulate storage macromolecules and embryos acquire the ability to withst

67 question classic models for the drainage of macromolecules and immune cells from the CNS.

68 ia produces graded damage, including damaged macromolecules and inflammation.

69 with a new simulated basis set consisting of macromolecules and lipids apart from metabolites of inte

70 ients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import

71 ic process that eradicates damaged and aging macromolecules and organelles in eukaryotic cells.

72 stresses trigger autophagy to remove damaged macromolecules and organelles.

73 es support cellular homeostasis by degrading macromolecules and recycling nutrients.

74 ogenous damage accumulation in non-renewable macromolecules and spontaneously polymerized material is

75 viewed, with a focus on interactions between macromolecules and surfaces of crystalline materials, ma

76 ive role in both the endocytosis of filtered macromolecules and the maintenance of the filtration bar

77 The three-dimensional structures of macromolecules and their complexes are mainly elucidated

78 reasing interest in investigating individual macromolecules and their interactions, but current bioch

79 ty in biological systems as different as RNA macromolecules and transcriptional regulatory circuits.

80 The slincR transcript functions as an RNA macromolecule, and slincR expression is AHR2 dependent.

81 lected by the wealth of primary metabolites, macromolecules, and cofactors bearing this element.

82 ating the entry and exit of ions, nutrients, macromolecules, and energy metabolites.

83 Many new technologies utilize surfactants, macromolecules, and even nanoparticles, which are diffic

84 antibody analogues that recognize biological macromolecules, and hold great promise for medical and c

85 es and is thought to recycle proteins, other macromolecules, and organelles.

86 ortion of this device was designed to filter macromolecules, and the inner cotton portion was designe

87 Engulfed macromolecules are contained within vacuoles that are ta

88 Here, we examined how solutes and macromolecules are separated when they exit the phloem d

89 qRAS-labeled macromolecules are silent (off) inside the intact endocy

90 escence loses its PL when positively charged macromolecules are wrapped around its surface.

91 al role played by the size and complexity of macromolecules as compared to other crystallization addi

92 e the structure determination of challenging macromolecules as crystallization chaperones and as mole

93 coming increasingly used in the synthesis of macromolecules, as they can allow the rapid generation o

94 direct and irreversible oxidative damage to macromolecules, as well as disruption of redox-dependent

95 n offers a way to understand how mixtures of macromolecules assemble and organize into a complex syst

96 In this process, sets of macromolecules assemble themselves into liquid compartme

97 ith unique features, including the uptake of macromolecules at a single cell level.

98 er sources is a powerful method for studying macromolecules at biologically relevant temperatures.

99 by random shortening and lengthening of the macromolecules at resting active zones.

100 mportant nutrients used for the synthesis of macromolecules (ATP, nucleic acid, proteins, and lipids)

101 e the interplay between printing parameters, macromolecule backbone alignment and aggregation, and ch

102 arker involved in the degradation of various macromolecules) based on a polypeptide (JR2EC) functiona

103 eptidomimetics, these well-defined synthetic macromolecules become pharmacologically relevant when bi

104 terface as control points in the exchange of macromolecules between stele and cortex.

105 which suggest the potential passage of large macromolecules between the mother cell and forespore dur

106 pore complex (NPC) controls the transport of macromolecules between the nucleus and cytoplasm, but it

107 leocytoplasmic transport, the trafficking of macromolecules between the nucleus and cytoplasm, is tig

108 lex (NPC) selectively gates the transport of macromolecules between these compartments, but it is unk

109 ultimately restoring normal ATP production, macromolecule biosynthesis, and growth.

110 ancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathway

111 glucose and glutamine for bioenergetics and macromolecule biosynthesis.

112 r activated T lymphocytes to support ATP and macromolecule biosynthesis.

113 cancer depends on glucose metabolism to fuel macromolecule biosynthesis.

114 nrichment was for cell wall organization and macromolecule biosynthesis.

115 Elongated-shaped macromolecules, both in the presence and absence of NTRs

116 f Trolox, vitamin E analogue, in presence of macromolecule-bound antioxidants in aqueous radical medi

117 Trolox and macromolecule-bound antioxidants were added to radical s

118 Three main groups of macromolecule-bound antioxidants were assayed: dietary f

119 The interactions between free and macromolecule-bound antioxidants were investigated in or

120 ntagonistic interactions for Trolox with all macromolecule-bound antioxidants.

121 The macromolecule building blocks released by lysosomal hydr

122 tic cell structures that concentrate diverse macromolecules but lack a bounding membrane.

123 atural prototypes to bind to specific target macromolecules but resist degradation by proteases.

124 disrupted upon interacting with NTR-bearing macromolecules, but immediately reconstructs itself betw

125 le to synthesize monomer sequence-controlled macromolecules by means of complex, time-consuming and i

126 he permeability of endothelial monolayers to macromolecules by promoting EC proliferation and migrati

127 SVs are associated with dense aggregates of macromolecules called active zone material (AZM) that ha

128 icroED and suggests that structures of novel macromolecules can also be determined by direct methods.

129 macromolecule uptake; instead, extracellular macromolecules can be taken up and accumulate in the per

130 ng disease, but immune surveillance of these macromolecules can drive an antidrug immune response tha

131 ular biology, RNA has emerged as a versatile macromolecule capable of mediating an astonishing number

132 Collagen is a biological macromolecule capable of second harmonic generation, all

133 dynamics is fundamental to understanding how macromolecules carry out their functions in the cell.

134 rophilic molecules, due to their amphiphilic macromolecule composition.

135 posite resonance of GABA, homocarnosine, and macromolecules) concentrations in healthy subjects recei

136 al that [Yfh1]24.[Isu1]24 is a roughly cubic macromolecule consisting of one symmetric Isu1 trimer bi

137 Stretching a macromolecule containing colorless STP converts it into

138 isolariciresinol diglucoside, is stored in a macromolecule containing other ester-bound phenolic comp

139 its intensity is majorly influenced by other macromolecules containing diverse phosphate groups, such

140 hrenia and the first to examine GABA without macromolecule contamination, a potentially significant i

141 ne of the two phases is vesicles rather than macromolecules, could underlie the formation of synaptic

142 through >4,400 small-molecule transport and macromolecule degradation events.

143 e intraerythrocytic parasites, necessitating macromolecule degradation.

144 cytokinesis plasmodesmata allow diffusion of macromolecules despite the apparent lack of an open cyto

145 ear programming (NLP) problem, mainly due to macromolecule dilution constraints.

146 cro- and nanoparticles, cells, proteins, and macromolecules down to small molecules and ions.

147 High concentrations of macromolecules dramatically reduce the amount of free sp

148 KEY POINTS: It is unclear precisely how macromolecules (e.g. endogenous proteins and exogenous i

149 Gylated protein (PegIntron) and multiarm PEG macromolecules (eight-arm PEG20K-NH2 and eight-arm PEG40

150 ivery route that has been proposed to target macromolecules either to the brain via direct extracellu

151 pulation of inorganic materials with organic macromolecules enables organisms to create biominerals s

152 se structures are implicated in facilitating macromolecule entry into the FP and nucleating the flage

153 nt protein include folding, binding to other macromolecules, enzymatic modification, and secretion th

154 The LP cells demonstrated an adhesion macromolecule expression pattern distinct from Hodgkin a

155 d chemical biology approaches are applied to macromolecules extrapolated from their native context.

156 heir metabolism to increase the synthesis of macromolecules for rapid proliferation.

157 trols fluid homeostasis and the clearance of macromolecules from interstitial compartments.

158 capable of carrying fluid, immune cells, and macromolecules from the central nervous system (CNS) to

159 anisms governing the central distribution of macromolecules from the cerebrospinal fluid (CSF) to the

160 The endocytic delivery of macromolecules from the mammalian cell surface for degra

161 rgents are usually used to extract these bio-macromolecules from the membranes and maintain them in a

162 hy offers researchers the ability to observe macromolecules frozen in action in situ, but a primary c

163 ntracellular delivery of biologically active macromolecules has been a challenging but important proc

164 r self-adhesion due to the interdiffusion of macromolecules has been an active area of research for s

165 r, only limited characterization of relevant macromolecules has been reported to date.

166 Traditionally, crystallographic analysis of macromolecules has depended on large, well-ordered cryst

167 o sieve elements may explain the plethora of macromolecules identified in phloem sap.

168 and chain-length dependent solvation of the macromolecules, identified from viscometric studies.

169 tle as a few tens of copies of redox-labeled macromolecules immobilized on individual nanodots can be

170 r a complete structural understanding of any macromolecule in solution.

171 BLECs endocytose macromolecules in a selective manner, which can be block

172 Translational diffusion of macromolecules in cell is generally assumed to be anomal

173 Proteins interact with other macromolecules in complex cellular networks for signal t

174 roposed for exploring the structure space of macromolecules in isolation and in assemblies for the pu

175 c insight into the pathologic aggregation of macromolecules in neurons and suggests exocytosis as cel

176 et this as due to enhanced interactions with macromolecules in the nanoconfined environment.

177 ients, and sedimentation coefficients of the macromolecules in the solution-based analysis clearly sh

178 t to which the micropollutants interact with macromolecules in water.

179 rough their interactions with other cellular macromolecules including DNA, protein, and RNA.

180 f these species in the cell causes damage to macromolecules including several proteins and induces ch

181 crystal growth processes in the presence of macromolecules, including peptides and proteins, is revi

182 ds a script of commands to represent complex macromolecules, including proteins and nucleic acids, in

183 ena and their underlying mechanisms by which macromolecules, including RNA, protein, and even DNA, ar

184 r efficient delivery of large and/or charged macromolecules, including therapeutic DNA and RNA oligon

185 f the membrane and chelation of lead with AG macromolecules incorporated in the membrane matrix contr

186 in the presence of macromolecular additives, macromolecule incorporation, and defect generation.

187 tions suggest that the stability of a folded macromolecule increases in a confined space due to entro

188 These macromolecules interact with the intracellular calcifyin

189 he nuclear pore and inhibits the movement of macromolecules into and out of the nucleus.

190 al organisms (5-7) , which act to break down macromolecules into constitutive monomers that can be tr

191 To facilitate modeling of macromolecules into cryo-EM density maps, fast and easy

192 oalbuminemia caused by leakage of fluids and macromolecules into tissues.

193 ing high-resolution structures of biological macromolecules invites the questions, how much better ca

194 ization approach in which a vinyl-terminated macromolecule is used as an efficient chain-transfer age

195 Entanglement in macromolecules is an important phenomenon and a subject

196 omising nano-sized biotherapeutics including macromolecules is that owing to their size they are subj

197 commercial use of p-block element-containing macromolecules is the synthetic challenge associated wit

198 In plants, a complex mixture of solutes and macromolecules is transported by the phloem.

199 Lipid and macromolecule levels may represent a biomarker of activa

200 also shows the 'best structures' for a given macromolecule, ligand complex or sequence family using d

201 membrane surface is mediated by cell-surface macromolecules (likely to be outer membrane proteins and

202 M and with shortness of active zone material macromolecules linking vesicles to PM components, some t

203 he determination of the size-distribution of macromolecules, macromolecular complexes, and nanopartic

204 tems, up to molecules as large as biological macromolecules (N > 1000 atoms).

205 Structural information about biological macromolecules near the atomic scale provides important

206 But, synthesis of long-chain macromolecules needed to support higher-order functions

207 ngths, while the presence of natural organic macromolecules (NOM) stabilized the oxidation state and

208 aminocyclopropenium (TAC) ion-functionalized macromolecules of various architectures, which are the f

209 harmaceutically relevant PEGs by alternative macromolecules offering a suite of similar or tractably

210 structures of proteins and other biological macromolecules often aids understanding of how they perf

211 de coupling to synthesize discrete oligomers/macromolecules on a gram scale with molecular weights up

212 position of each connection site of the AZM macromolecules on their SV, directly linking the SV with

213 n of purely diamagnetic objects, such as bio-macromolecules or heavy metals.

214 a ubiquitous pathway that degrades cytosolic macromolecules or organelles, as well as intracellular p

215 walls are composed of the large cross-linked macromolecule peptidoglycan, which maintains cell shape

216 to three prominent surface immunomodulatory macromolecules-peptidoglycan, lipopolysaccharide and cap

217 from molecular characteristics of synthetic macromolecules plays a pivotal role in many areas, in pa

218 s (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs

219 to bind to reactive groups at the surface of macromolecules primarily through hydrogen bonds, where t

220 have been attributed to tholin-like organic macromolecules produced by energetic radiation processin

221 tricarboxylic acid (TCA) cycle anaplerosis, macromolecule production, and redox homeostasis.

222 parent cell make-up, is composed of soluble macromolecules (proteins, glycans, lipids, DNAs, RNAs, e

223 rce of structural information for biological macromolecules, providing fundamental insights into biol

224 to differences in the total concentration of macromolecules rather than compositional differences.

225 saturable tubular capture, determines which macromolecules reach the urine without the need to invok

226 including signal from unrelated proteins or macromolecules) referenced to creatine or water were stu

227 -mineral single crystals containing embedded macromolecules-remain poorly understood.

228 he rational design of synthetic molecules or macromolecules remains a challenge.

229 itional geometry, using data on elements and macromolecules, respectively, have independently made ma

230 use multiple autophagy pathways to sequester macromolecules, senescent organelles, and pathogens.

231 Imaging the spread of macromolecules shows them increasingly hindered as a fun

232 -Gill (CPMG) presat as a T2 filter to remove macromolecule signals.

233 The lysosome degrades and recycles macromolecules, signals to the cytosol and nucleus, and

234 oncentration and (ii) efficient formation of macromolecule-sized defects in synthetic lipid membranes

235 l for all researchers working on modeling of macromolecules, structure prediction, properties of poly

236 (pi-pi) interactions, within user-submitted macromolecule structures.

237 modulating the functions of various anionic macromolecules such as DNA, RNA and proteins.

238 d, from macroscopic twine down to long-chain macromolecules such as DNA.

239 can be used for the detection of biological macromolecules such as mismatch repair proteins through

240 use of racemic mixtures of naturally chiral macromolecules such as protein and DNA can significantly

241 ransporters, biosynthesis of cells walls and macromolecules such as starch and lipids, epigenetics an

242 anostructures comprising multiple classes of macromolecules, such as ribosomes (proteins and RNA) or

243 al frontal/anterior cingulate cortex using a macromolecule-suppressed MEGA-PRESS sequence.

244 ficant advance in the development of complex macromolecule synthesis, where a high level of molecular

245 derived from high-spin carbon-based polymers/macromolecules tailored through appropriate synthetic ro

246 d thus should be regarded as a dual-function macromolecule that exhibits both structural and enzymati

247 c applications, it is not only the size of a macromolecule that must be considered, but also its shap

248 In living organisms, the most common macromolecules that affect bioavailability of a drug (or

249 Unlike most macromolecules that are homogeneously distributed in the

250 ructural studies of a variety of challenging macromolecules that bind to microtubules and other filam

251 We show how this can be used for morphing of macromolecules that can be heterogeneous in biopolymer t

252 stylectomy experiments have identified many macromolecules that move in the phloem, the functional s

253 Creating functional macromolecules that possess the diversity and functional

254 oinciding with interaction sites for partner macromolecules: the methyl-CpG binding domain and the NC

255 from inorganic nanostructures to biological macromolecules.Three-dimensional ptychographic imaging w

256 Transport of macromolecules through the nuclear pore by importins and

257 esources.Bacteria can exchange nutrients and macromolecules through tubular membranous structures cal

258 we use a synthetic polypeptide-grafted comb macromolecule to demonstrate how the in situ modulation

259 of biomolecular NMR spectroscopy that allows macromolecules to be analyzed in living cells, at the at

260 d was developed for the sustained release of macromolecules to enhance the differentiation of stem ce

261 (EPR) effect, which refers to the ability of macromolecules to extravasate leaky tumor vessels and ac

262 llenge, as this requires large, preorganized macromolecules to facilitate interactions.

263 ed basement membrane, facilitate delivery of macromolecules to highly metabolic hepatocytes.

264 rstanding and improving the drug delivery of macromolecules to the central nervous system via the int

265 Targeting drugs and macromolecules to the mitochondria may provide an effect

266 In environmental samples, relevant macromolecules to which micropollutants bind are referre

267 plex that traffics organelles, vesicles, and macromolecules toward microtubule minus ends.

268 lative capillary permeability to hydrophilic macromolecule tracers is significantly greater in nasal

269 liable method of HMM for kinetics studies of macromolecules under thermodynamic equilibrium.

270 ructural features and dynamics of biological macromolecules underlie the molecular biology and correc

271 le dynamics and seconds to minutes for local macromolecule uptake and cell membrane reorganization).

272 ic compartmentalization and endocytosis-like macromolecule uptake.

273 e that is inconsistent with endocytosis-like macromolecule uptake; instead, extracellular macromolecu

274 These results indicate that both types of macromolecules use the same import channel across the ou

275 providing facile access to semi-fluorinated macromolecules using a single methodology with unprecede

276 recognized as potential platforms for remote macromolecule visualization.

277 city of 293T/SL-alphaPEG cells for PEGylated macromolecules was higher than that of 293T/S-alphaPEG o

278 easurements on single nucleotides within DNA macromolecules, we demonstrate that the distance over wh

279 ound to stabilize the collapsed state of the macromolecule when paired with well-hydrated anions such

280 ctural and mechanistic studies of biological macromolecules where large conformational changes are in

281 ation that defines the pathway through these macromolecules which actin-cytoskeleton-generated tensil

282 at albumin, as a model for biocorona-forming macromolecules which nanoparticles may encounter in wast

283 aracterized, the cell interior is crowded by macromolecules, which affects both the thermodynamics an

284 organization of protoplasm by concentrating macromolecules, which allows efficient cellular processe

285 ily conjugated to both synthetic and natural macromolecules, which can be used for RTP microscopy.

286 tructure determination of complex biological macromolecules, which cannot be coaxed to form crystals

287 ortant structural and functional features of macromolecules, which depend on their native network of

288 hemical exchange phenomena are ubiquitous in macromolecules, which undergo conformational change or l

289 ives in mitochondrial targeting of drugs and macromolecules will be discussed.

290 mplexes to the surface results in a globular macromolecule with a diameter of approximately 15 nm and

291 Here, we report a polypeptide-based macromolecule with spatially organized alpha-helices tha

292 l require some deformation of those flexible macromolecules with a higher molecular weight (>250 kDa)

293 lic delivery rely on fluorescent labeling of macromolecules with an "always on" reporter and subcellu

294 Interactions of macromolecules with growing crystalline surfaces play an

295 asement membrane and internal elastic lamina macromolecules with minimal deformation of the sensitive

296 TMV VLPs are high surface area macromolecules with nanorod structures constructed from

297 Unmodified oligonucleotides are polyanionic macromolecules with poor drug-like properties.

298 the alpha-helical bundle yields monodisperse macromolecules with programmable folding and self-assemb

299 The chemical labelling of three specific macromolecules within a live organism offers the potenti

300 density of the FG-polypeptides and embedded macromolecules within intact NPCs.