ライフサイエンスコーパス: macropinocytosis

1 is dependent on CD47, and is facilitated by macropinocytosis.

2 bsequent cytoskeletal cross talk during KSHV macropinocytosis.

3 of HMPV by MDDC was found to be primarily by macropinocytosis.

4 r its efficient entry into HMVEC-d cells via macropinocytosis.

5 and catabolism of extracellular protein via macropinocytosis.

6 to stimulate host actin remodeling and toxin macropinocytosis.

7 the formation of ruffles, and the process of macropinocytosis.

8 lls by a process that most closely resembles macropinocytosis.

9 tially reduced by amiloride, an inhibitor of macropinocytosis.

10 ion in actin turnover occurring during toxin macropinocytosis.

11 (PI) 3-kinase activity, leading to receptor macropinocytosis.

12 ent tumor cells, and blocked KRAS-stimulated macropinocytosis.

13 signaling as a result of increased receptor macropinocytosis.

14 T protein and enters via c-Cbl-bleb-mediated macropinocytosis.

15 ruffles, where they are internalized through macropinocytosis.

16 ted endocytosis, but not for phagocytosis or macropinocytosis.

17 rocess associated with membrane ruffling and macropinocytosis.

18 of dextran was used to quantify the rate of macropinocytosis.

19 t endocytic pathway which is consistent with macropinocytosis.

20 ng with defects in protrusion, ruffling, and macropinocytosis.

21 TLR4-dependent fluid phase uptake typical of macropinocytosis.

22 with Rab34 GTPase that is known to regulate macropinocytosis.

23 ellipodial extensions that are essential for macropinocytosis.

24 ted cells, suggesting that RhoC is enhancing macropinocytosis.

25 tor amiloride, suggesting that PepB2 invokes macropinocytosis.

26 ared numerous features with phagocytosis and macropinocytosis.

27 ing that hCTR1 was internalized primarily by macropinocytosis.

28 fficking of Ad5 is enhanced by fiber-induced macropinocytosis.

29 coiling phagocytosis, and ruffling/triggered macropinocytosis.

30 oblast uptake of 10-kDa dextran, a marker of macropinocytosis.

31 by which a signaling kinase might influence macropinocytosis.

32 rapidly internalized by lipid raft-dependent macropinocytosis.

33 acrophages took up LDL in the fluid phase by macropinocytosis.

34 mbrane occurs through a kind of endocytosis, macropinocytosis.

35 ficiently blocked Ser-88 phosphorylation and macropinocytosis.

36 as Ser-88 substitution for alanine prevents macropinocytosis.

37 phosphorylation by Pak1 upon the process of macropinocytosis.

38 G regulate membrane dynamics in promotion of macropinocytosis.

39 ating that HIV-1 enters endothelial cells by macropinocytosis.

40 or triggering an uptake mechanism related to macropinocytosis.

41 th mannose receptor-mediated endocytosis and macropinocytosis.

42 t, RsDPLA was internalized predominantly via macropinocytosis.

43 ring followed by PS-stimulated, PSR-mediated macropinocytosis.

44 t) are important in regulating completion of macropinocytosis.

45 rethral epithelial cells (HUEC) can occur by macropinocytosis.

46 ance of DF into ECs occurs primarily through macropinocytosis.

47 ed whether THY-1 has a role in HCMV entry by macropinocytosis.

48 arity, lamellipodial assembly, ruffling, and macropinocytosis.

49 influx through transporters, receptors, and macropinocytosis.

50 membranous intracellular pH occurring during macropinocytosis.

51 ase substrate) in KSHV entry into HMVEC-d by macropinocytosis.

52 l proliferation that is supported by protein macropinocytosis.

53 in vivotarget cells, by lipid raft-dependent macropinocytosis.

54 in cell types, contributes to virus entry by macropinocytosis.

55 regates are internalized into AC16 cells via macropinocytosis.

56 er changes in cell morphology, and increased macropinocytosis.

57 C1 by amino acids, but not glucose, requires macropinocytosis.

58 hrin- and caveolar-dependent endocytosis and macropinocytosis.

59 ytic mechanism related to, but distinct from macropinocytosis.

60 e peptide-conjugated QDs are internalized by macropinocytosis, a fluid-phase endocytosis process trig

61 l as a new role for nucleolin in stimulating macropinocytosis, a process with potential applications

62 rived cancer cells in a mechanism similar to macropinocytosis, albeit without the previously describe

63 Inhibitors of macropinocytosis also abolished the negative effects of

64 Macropinocytosis also allowed internalized soluble Ags a

65 s dominated by slow endocytic processing via macropinocytosis, although some caveolar endocytosis was

66 intestinal epithelial cells stimulates toxin macropinocytosis, an actin-dependent endocytic pathway.

67 nd occurred by a similar mechanism involving macropinocytosis and a low-pH endocytic pathway.

68 a combination of NaCl hypertonicity-induced macropinocytosis and a transduction compound (propanebet

69 Genes for macropinocytosis and actin/cytoskeleton rearrangement we

70 wth by downregulating nutrient transporters, macropinocytosis and autophagy still provide cancer cell

71 We also determined that macropinocytosis and caveolar endocytosis, both establis

72 ngly, however, TAT PTD-mediated induction of macropinocytosis and cellular transduction occurs in the

73 1-null cells exhibited pronounced defects in macropinocytosis and chemotactic aggregation that were r

74 Inhibitors and RNAi specific for macropinocytosis and clathrin-mediated endocytosis had n

75 urthermore, ssRNA-TNP uptake is dependent on macropinocytosis and clathrin-mediated endocytosis pathw

76 5 export from the Golgi, and PDGF-stimulated macropinocytosis and cytokinesis, but not for other endo

77 Both isoforms rescued macropinocytosis and cytokinesis, suggesting that dynami

78 soluble factors are sufficient to stimulate macropinocytosis and deliver toxin into enterocytes in v

79 ntly reduced capacity to phagocytose Ags via macropinocytosis and endocytosis as determined by flow c

80 the widely used axenic mutants, show little macropinocytosis and few large PIP(3) patches, but migra

81 in DU145 cells but was necessary for induced macropinocytosis and FL-AS1411 uptake at later times.

82 ar in size to parent DH1 cells, had enhanced macropinocytosis and grew faster to higher densities.

83 ls are unable to acquire these conjugates by macropinocytosis and instead depend on uptake through a

84 Thus PIP(3) promotes macropinocytosis and interferes with pseudopod orientati

85 ated internalization and fusion, and through macropinocytosis and lipid raft-dependent endocytosis.

86 Furthermore, macropinocytosis and lipid raft-mediated were shown here

87 vironments by recovering amino acids through macropinocytosis and lysosomal catabolism of extracellul

88 are dispensable for growth-factor-stimulated macropinocytosis and lysosomal catabolism of extracellul

89 ls in a low free-glutamine environment, when macropinocytosis and lysosomal degradation of extracellu

90 or pathways for antigen uptake: constitutive macropinocytosis and mannose receptor-mediated endocytos

91 t concentration (1 ng/mL), rapamycin impairs macropinocytosis and mannose receptor-mediated endocytos

92 ng severe hemorrhagic fever, enters cells by macropinocytosis and membrane fusion in a late endosomal

93 fle formation with a concomitant increase in macropinocytosis and motility.

94 but, unexpectedly, blebbistatin does inhibit macropinocytosis and phagocytosis by cells expressing my

95 Our results link NF1 with macropinocytosis and phagocytosis for the first time, an

96 Regulation of Ag uptake via macropinocytosis and phagocytosis has been extensively s

97 sin II in myosin II-null cells also inhibits macropinocytosis and phagocytosis.

98 ly, the data indicated that gp130 influenced macropinocytosis and played a role in adhesion during ve

99 c-Cbl knockdown blocked the macropinocytosis and receptor translocation and diverted

100 reased their capacity to take up antigens by macropinocytosis and receptor-mediated endocytosis.

101 ct the EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate AJ formation

102 vented JAM-A relocalization, suggesting that macropinocytosis and recycling to the membrane surface o

103 by aggregated Tau that enters cells through macropinocytosis and seeds the assembly of endogenous Ta

104 that immature DCs efficiently take up Ag by macropinocytosis and store the internalized material in

105 nvolves uptake of extracellular proteins via macropinocytosis and subsequent lysosomal degradation of

106 rane association of ESCRT protein Hrs during macropinocytosis and suggest that KSHV entry requires bo

107 activity, CD82 endocytosis is distinct from macropinocytosis and the documented dynamin-independent

108 cellular entry, the virus is internalized by macropinocytosis and trafficked through endosomes until

109 edge retraction involves ephrinB1-dependent macropinocytosis and trans-endocytosis.

110 producing strains, can stimulate Shiga toxin macropinocytosis and transcellular transcytosis alters c

111 alization mechanisms with characteristics of macropinocytosis and, assisted by Golgi fragmentation, i

112 the comparative mechanisms of CPP uptake and macropinocytosis, and accentuate the significant methodo

113 erturbations, such as blebs, observed during macropinocytosis, and activation of the signal molecules

114 elective uptake of Plekho1 siRNA, mainly via macropinocytosis, and boosted in vivo osteoblast-specifi

115 ese associations, membrane ruffle formation, macropinocytosis, and cell migration were all impaired i

116 ypes of endocytosis, including phagocytosis, macropinocytosis, and clathrin-independent endocytosis.

117 , lamellipodial assembly, membrane ruffling, macropinocytosis, and collective cell migration.

118 es released from dying cells and taken up by macropinocytosis, and exosomes secreted from living cell

119 cellular responses such as actin remodeling, macropinocytosis, and nuclear responses.

120 d influx of extracellular fluid, a marker of macropinocytosis, and this increased fluid uptake was in

121 c cells, Dictyostelium amoebae are active in macropinocytosis, and various proteins have been identif

122 facilitates assembly of signaling molecules, macropinocytosis, and virus entry.

123 Phagocytosis and macropinocytosis are Ras-regulated and actin-driven proc

124 These results identify macropinocytosis as a mechanism by which cancer cells su

125 nd suggest the involvement of actin-mediated macropinocytosis as a mechanism of uptake of EBOV GP and

126 esults showing that influenza virus utilizes macropinocytosis as an alternate entry pathway.

127 The current investigation has identified macropinocytosis as the pathway for fluid-phase LDL endo

128 find that filamentous influenza viruses use macropinocytosis as the primary entry mechanism.

129 ellular roles, notably in growth control and macropinocytosis as well as cell motility.

130 EphA2 shRNA ablated macropinocytosis-associated signaling events, virus inte

131 However, inhibitors of macropinocytosis blocked internalization of TJ proteins

132 ultured neonatal rat ventricular myocytes by macropinocytosis but did not replicate.

133 3-kinase inhibitor, LY294002, which inhibits macropinocytosis but does not inhibit micropinocytosis,

134 atment resulted in decreased ZEBOV entry via macropinocytosis but had no effect on the clathrin-depen

135 n of the Rac1 and cdc42 GTPases that control macropinocytosis but not activation of the phosphoinosit

136 ic Ras proteins have been shown to stimulate macropinocytosis but the functional contribution of this

137 trastructurally, CendR endocytosis resembles macropinocytosis, but is mechanistically different.

138 s via both dynamin-dependent endocytosis and macropinocytosis, but likely not relying on taurine tran

139 T cell activation by DCs, selectively limits macropinocytosis, but not receptor-mediated phagocytosis

140 Blocking macropinocytosis by inhibition of PI 3-kinase prevented

141 Stimulation of macropinocytosis by platelet-derived growth factor coord

142 Conversely, increasing macropinocytosis by Rabankyrin-5 overexpression was suff

143 e plasma membrane enhances cell motility and macropinocytosis, by which junction-associated E-cadheri

144 Here, we demonstrate that protein macropinocytosis can also serve as an essential amino ac

145 In particular, macropinocytosis can be a nutrient source for pancreatic

146 Macropinocytosis can be induced ex vivo by high Shh, cor

147 acking CARMIL1 have defects in lamellipodia, macropinocytosis, cell migration, and Rac1 activation.

148 ndocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, phagocytosis,

149 Because the endocytic process of macropinocytosis concentrates extracellular solutes into

150 ti-inflammatory macrophages perform vigorous macropinocytosis constitutively, while proinflammatory c

151 iding a possible mechanism for GILZ-mediated macropinocytosis control.

152 ion, we find that intratumoral inhibition of macropinocytosis decreases amino acid levels.

153 Macropinocytosis delivered small, fluorescent fluid-phas

154 results reveal that oncogenic activation of macropinocytosis determines BCG uptake by bladder cancer

155 However, inhibition of macropinocytosis did not reduce Ad5 uptake.

156 ernal routes and identify a new function for macropinocytosis during growth factor-induced cell migra

157 tion was associated with internalization via macropinocytosis during paracellular route opening.

158 d growth factor beta-receptor (PDGFRbeta) by macropinocytosis, enhancing its signaling activity and i

159 ntracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis.

160 In addition, we showed that phagocytosis or macropinocytosis, flotillin-1, and GRAF1 are not require

161 internalization from the plasma membrane by macropinocytosis followed by proteasomal degradation.

162 Cells take up Ebola virus by macropinocytosis, followed by trafficking through endoso

163 cted, both are ts for FITC-dextran uptake by macropinocytosis, for internalising their surface membra

164 pits, and DN PAK-1, an obligate mediator of macropinocytosis, had no significant impact on RVFV infe

165 Assessing macropinocytosis has been challenging in the past becaus

166 We tested whether inhibition of macropinocytosis impacted rAAV transduction of HeLa cell

167 I3K, and Pak1 kinase, which are critical for macropinocytosis, impaired HCMV infection.

168 n is further shown to involve the process of macropinocytosis, implicated as a primitive and relative

169 r, and knob, but not penton base, stimulated macropinocytosis in acini and that inhibition of macropi

170 can induce structural changes reminiscent of macropinocytosis in actin-encapsulated giant vesicles wi

171 hanism of uptake was different, occurring by macropinocytosis in cancer cells, but by a nonmacropinoc

172 or visualizing and quantifying the extent of macropinocytosis in cells both in culture and growing in

173 identify GILZ as an endogenous inhibitor of macropinocytosis in DCs, the action of which contributes

174 LPS did not induce membrane ruffling or macropinocytosis in enterocytes, excluding their role in

175 ntly, we have revealed a functional role for macropinocytosis in fueling cancer cell growth through t

176 isolated mitochondria being internalised by macropinocytosis in HOS cells.

177 Macropinocytosis in macrophages and possibly other vascu

178 w report that Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK

179 hat Akt3 is a specific negative regulator of macropinocytosis in macrophages.

180 ding cytokines, chemokines, and LPS, induced macropinocytosis in proinflammatory cells.

181 xtracellular proteins being degraded through macropinocytosis in quantities necessary to meet glutami

182 Accordingly, blockage of EGFR signaling or macropinocytosis in reggie-deficient cells restores norm

183 , we directly observe protein catabolism and macropinocytosis in situ by pancreatic cancer cells, but

184 sin II or treatment of phorbol ester induces macropinocytosis in the axons and elicits growth cone co

185 rt that Sonic hedgehog (Shh) protein induces macropinocytosis in the axons through activation of a no

186 These results suggest a role for macropinocytosis in the process by which EV1 enters pola

187 on requires factors commonly associated with macropinocytosis, including amiloride-sensitive Na(+)/H(

188 tivation of signaling molecules critical for macropinocytosis, including phosphatidylinositol 3-kinas

189 d for initial cellular entry of LNPs through macropinocytosis, including proton pumps, mTOR and cathe

190 Macropinocytosis induced by Shh is independent of clathr

191 ells, and inhibitors that are known to block macropinocytosis inhibited both dextran uptake and ZEBOV

192 Microscopy revealed that macropinocytosis inhibition correlated with expedited nu

193 We found that macropinocytosis inhibitor cytochalasin D blocked rAAV t

194 Similar results were obtained with another macropinocytosis inhibitor, 5-(N-ethyl-N-isopropyl) amil

195 Treatment with a macropinocytosis inhibitor, 5-(N-ethyl-N-isopropyl)amilo

196 othelial cells were significantly blocked by macropinocytosis inhibitors (EIPA [5-N-ethyl-N-isoproami

197 y reduced SHFV entry efficiency, whereas the macropinocytosis inhibitors EIPA, blebbistatin, and wort

198 ce the ability of HMPV to be internalized by macropinocytosis into human dendritic cells (DC).

199 EAEC) O104:H4 robustly stimulate Shiga toxin macropinocytosis into intestinal epithelial cells.

200 Since macropinocytosis involves integrin signaling, is PI3K/Ak

201 mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to a

202 Macropinocytosis is a fundamental mechanism that allows

203 Macropinocytosis is a highly conserved endocytic process

204 Our results suggest that macropinocytosis is a potential mechanism of intracellul

205 Macropinocytosis is a type of poorly characterized fluid

206 Furthermore, macropinocytosis is also induced by ephrin-A2, and inhib

207 Scavenging of extracellular protein via macropinocytosis is an alternative to monomeric amino ac

208 Macropinocytosis is an ancient mechanism that allows cel

209 partments deeper within mature DCs (in which macropinocytosis is down-regulated).

210 l products such as lipopolysaccharide (LPS), macropinocytosis is dramatically downregulated as part o

211 In pancreatic cancer, macropinocytosis is driven by oncogenic Ras signaling an

212 Toxin macropinocytosis is independent of EHEC type 3 secretion

213 (HMVEC-d), natural in vivo target cells, via macropinocytosis is initiated through a multistep proces

214 ted proteins into lysosomes, its function in macropinocytosis is not known.

215 Consistent with this hypothesis, active macropinocytosis is observed in primary human PDAC speci

216 Although macropinocytosis is reduced in cells expressing dominant

217 Macropinocytosis is the major entry pathway of KSHV in h

218 Macropinocytosis is upregulated in oncogene-expressing c

219 Although macropinocytosis is used by both epithelial and endothel

220 TLR ligands first acutely stimulate antigen macropinocytosis, leading to enhanced presentation on cl

221 Thus, the observation that inhibiting macropinocytosis leads to cell-specific enhancement or i

222 d on actin remodeling and Pak1, suggesting a macropinocytosis-like cell entry pathway.

223 al changes as well as fluid uptake through a macropinocytosis-like pathway as chemical inhibition of

224 rin-dependent endocytic pathway to a slower, macropinocytosis-like pathway.

225 iated chemokine endocytosis occurs through a macropinocytosis-like process in endothelial cells and c

226 , we found that HCMV enters these cells by a macropinocytosis-like process.

227 efficient entry into certain cell types by a macropinocytosis-like process.

228 HMVEC-d and HUVEC cells colocalized with the macropinocytosis marker dextran and not with the clathri

229 and TJ proteins did not colocalize with the macropinocytosis marker dextran.

230 ins and junctional proteins colocalized with macropinocytosis markers, dextran and phosphatidylinosit

231 T PTD enters cells by a lipid raft-dependent macropinocytosis mechanism that all cells perform.

232 loride or wortmannin blocked the increase in macropinocytosis mediated by CTR2 knockdown.

233 These results demonstrate that macropinocytosis-mediated membrane trafficking is an imp

234 Macropinocytosis mediates the uptake of antigens and of

235 key cellular processes such as phagocytosis, macropinocytosis, membrane trafficking, motility, autoph

236 P27 prevents virus accumulation by inducing macropinocytosis (MPC).

237 As expected, macropinocytosis (myosin I-dependent), contractile vacuo

238 PAK1 nor vector controls exhibited enhanced macropinocytosis, nor did PAK1 (H83,86L) affect clathrin

239 PDGF-BB and epidermal growth factor promoted macropinocytosis of both receptors and increased their a

240 uffled border also need to be recycled after macropinocytosis of digested bone materials.

241 Recently, Ras-induced macropinocytosis of extracellular proteins was shown to

242 the immunosuppressive macrolide rapamycin on macropinocytosis of fluorescein isothiocyanate (FITC)-al

243 ignals in LRs, leading to bleb formation and macropinocytosis of KSHV.

244 ics to the cytosolic signaling events during macropinocytosis of KSHV.

245 hange is an essential event required for the macropinocytosis of KSHV.

246 Thus, macropinocytosis of LDL by macrophages differentiated fr

247 e was mediated by continuous actin-dependent macropinocytosis of LDL by these M-CSF-differentiated ma

248 Macropinocytosis of LDL depended on Rho GTPase signaling

249 Macropinocytosis of LDL taken up in the fluid phase with

250 f Rac/RhoG was responsible for the deficient macropinocytosis of proinflammatory macrophages, as sugg

251 In this study, we demonstrate that although macropinocytosis of soluble Ag is diminished following D

252 cgamma receptors and CR3, it does not affect macropinocytosis or receptor-mediated endocytosis.

253 the formation of micropinocytotic vesicles, macropinocytosis (or phagocytosis), formation of clathri

254 tosis (RhoA, dynamin-2, Rac1, and Arp2), and macropinocytosis (Pak1, Rac1, and Arp2).

255 sts, and endothelial cells, likely through a macropinocytosis pathway.

256 ay that shares features with canonical viral macropinocytosis, phagocytosis, and mechanotransduction.

257 unctions including cell migration, invasion, macropinocytosis, plasma membrane recycling, and others.

258 Macropinocytosis plays an important role in the internal

259 cells with AS1411 caused hyperstimulation of macropinocytosis, provoking an increase in its own uptak

260 es, engulfment is rare and may occur through macropinocytosis rather than directed engulfment.

261 ake of BCG by bladder cancer cells occurs by macropinocytosis rather than phagocytosis.

262 ons associated with CDR formation, including macropinocytosis, receptor internalization, and cell mig

263 DCs use constitutive macropinocytosis, receptor-mediated endocytosis, and pha

264 only inhibited in A431 cells depleted of the macropinocytosis regulator Pak-1, but experimental varia

265 (GP-wt), GP-F88A-mediated entry occurs via a macropinocytosis-related pathway and requires endosomal

266 Consistent with macropinocytosis representing an important route of nutr

267 Inhibition of macropinocytosis resulted in the distribution of viral c

268 Macropinocytosis seems to be the main route used by poly

269 Macropinocytosis serves as an internalization pathway fo

270 opinocytosis in acini and that inhibition of macropinocytosis significantly reduced Ad5 transduction

271 Uptake occurred by macropinocytosis, similar to the uptake of bacteria pass

272 influences metabolic phenotypes and whether macropinocytosis supports the maintenance of amino acid

273 and abolishing the constitutive ruffling and macropinocytosis that characterize macrophages and immat

274 -dependent and -independent pathways such as macropinocytosis that mediate high-molecular-weight dext

275 Macropinocytosis, the internalization of extracellular f

276 nstrate for the first time that Axl enhances macropinocytosis, thereby increasing productive ZEBOV en

277 Cs markedly down-regulate their capacity for macropinocytosis, they continue to capture, process, and

278 As) associated with serum albumin stimulated macropinocytosis through a pathway that involves FFA rec

279 We demonstrate macropinocytosis through the uptake of FITC-dextran and

280 M selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal

281 Cells use phagocytosis and macropinocytosis to internalise bulk material, which in

282 sly unveils a requirement for Rac1-dependent macropinocytosis to provide non-essential amino acids, i

283 Here we show that Ras-transformed cells use macropinocytosis to transport extracellular protein into

284 cDDP in part through control of the rate of macropinocytosis via activation of Rac1 and cdc42.

285 dent, platelet-derived growth factor-induced macropinocytosis was abolished by Dyn2(K44A) expression.

286 PDGFRbeta macropinocytosis was both necessary and sufficient for e

287 nd that lipid raft-dependent endocytosis and macropinocytosis were major pathways involved in lipo-Ta

288 eola-mediated endocytosis, phagocytosis, and macropinocytosis were not.

289 ntegrate signal pathways and productive KSHV macropinocytosis were unknown, we immunoprecipitated KSH

290 an occur by nonreceptor mediated fluid-phase macropinocytosis when macrophages are differentiated fro

291 sm involves actin-driven lipid raft-mediated macropinocytosis, where particles primarily accumulate i

292 tivation by C5a was inhibited by UDP, as was macropinocytosis, which depends on PI 3-kinase.

293 Each plays roles in mediating macropinocytosis, which has been shown to be important f

294 ncreasing the uptake of endocytic markers of macropinocytosis while decreasing those for clathrin- an

295 Inhibition of macropinocytosis with either amiloride or wortmannin blo

296 tivation of signaling pathways that activate macropinocytosis, with phosphoinositide 3-kinase inhibit

297 ular replication prevented dot/icm-dependent macropinocytosis, with the result that phagosomes bearin

298 nexpectedly at sites of clathrin-independent macropinocytosis within cell surface ruffles.

299 within vesicles (<0.1 microm diameter) or by macropinocytosis within vacuoles ( approximately 0.5-5.0

300 important pathway enabling cells to sustain macropinocytosis without bulk degradation of plasma memb