ライフサイエンスコーパス: macula densa

1 so expressed in thick ascending limb and the macula densa.

2 marily adjusting transport downstream of the macula densa.

3 ortant in its highly specialized role in the macula densa.

4 helial cells of the thick ascending limb and macula densa.

5 ck ascending limb of Henle's loop and of the macula densa.

6 , with the most pronounced expression in the macula densa.

7 old in the cortical thick ascending limb and macula densa.

8 immunoreactive COX-2 expression inthe cTALH/macula densa.

9 r upregulation of NOS1beta expression in the macula densa affects sodium excretion and salt-sensitive

10 onship between (a) NaCl concentration at the macula densa and (b) glomerular filtration rate or glome

11 at tubular epithelial cells located near the macula densa and associated with the renal arterioles ex

12 rtical pp38 expression, predominantly in the macula densa and cTALH.

13 a is a primary NOS1 isoform expressed in the macula densa and regulates the tubuloglomerular feedback

14 nal cortex, COX-2 expression is localized to macula densa and surrounding cortical thick ascending li

15 ocalized to cTALH cells in the region of the macula densa, and that dietary salt restriction increase

16 Evidence for the regulation of macula densa apical Na/H exchange by AngII was recently

17 lar elements involves ATP release across the macula densa basolateral membrane through a maxi-anion c

18 These results indicate that AngII stimulates macula densa basolateral Na/H exchange via AT1 receptors

19 p38 stimulates COX-2 expression in cTALH and macula densa by transcriptional regulation predominantly

20 erences in glomerular tuft contractility and macula densa cell calcium handling were observed.

21 activity or expression we clonally derived a macula densa cell line (MMDD1 cells) from SV-40 transgen

22 nd AT(2) receptor expression in the cultured macula densa cell line MMDD1.

23 Because macula densa cells also express a basolateral Na/H excha

24 Macula densa cells are renal sensor elements that detect

25 Macula densa cells detect changes in luminal sodium chlo

26 Macula densa cells in the distal nephron, according to t

27 Communication from macula densa cells to the glomerular vascular elements i

28 rabbit kidney, the intracellular pH (pHi) of macula densa cells was measured with fluorescence micros

29 neuronal isoform of nitric oxide synthase in macula densa cells, reduces the constrictor effect of ad

30 The Ca2+ oscillations were absent in the macula densa cells.

31 trated marked accumulation of elastin in the macula densa, collecting ducts, and pelvicalyceal epithe

32 r and outer medullary collecting ducts), and macula densa-containing segments.

33 In summary, these results demonstrate that macula densa COX-2 expression is oppositely regulated by

34 Macula densa cyclooxygenase 2 (COX-2)-derived prostaglan

35 ice had decreased hyperfiltration, decreased macula densa cyclooxygenase-2 expression, decreased albu

36 al delivery of fluid yet does not activate a macula densa-dependent fall in SNGFR because it blunts t

37 Macula densa epithelial cells displayed bright AE2 immun

38 lar epithelial cells at the perimeter of the macula densa exhibit spontaneous oscillations in intrace

39 We recently found that macula densa expresses alpha-, beta-, and gamma-splice v

40 ty NKCC2B contributes to salt absorption and macula densa function in the low NaCl concentration rang

41 on microscopy is providing new insights into macula densa-glomerular signaling.

42 ase 1 (NOS1), and NOS1beta expression in the macula densa increases on a high-salt diet.

43 luminal chloride [Cl(-)] at the level of the macula densa increases renin production and secretion, w

44 sed by a change in NaCl concentration at the macula densa, is likely initiated by the generation of a

45 that ATP consumed in active transport by the macula densa leads to formation of adenosine, which caus

46 Because of the presence of NKCC2A in the macula densa, maximum tubuloglomerular feedback response

47 Macula densa (MD) cells detect changes in distal tubular

48 Macula densa (MD) cells express COX-2 and COX-2-derived

49 Macula densa (MD) cells of the juxtaglomerular apparatus

50 nd G(olf) colocalize in renal tubules and in macula densa (MD) cells which modulate glomerular filtra

51 of neuronal nitric oxide synthase (nNOS) in macula densa (MD) cells, experiments were performed in a

52 d NKCC2A were shown to be coexpressed in the macula densa (MD) segment of the mouse TAL.

53 TGF) depends on Na-K-2Cl co-transport in the macula densa (MD), but it is less clear whether Na,K-ATP

54 merular cell granules and exhibit an altered macula densa morphology.

55 and/or cellular uptake of L-arginine limits macula densa nitric oxide generation and actions on tubu

56 tion, which was prevented with inhibitors of macula densa nitric oxide synthase (NOS).

57 Furthermore, macula densa NO production was similar in the isolated p

58 S (NOS-I) blockers correlated with increased macula densa NOS-I immunoreactivity.

59 flow and SNGFR through a mechanism involving macula densa NOS.

60 sting that it had blunted the effects of the macula densa on SNGFR.

61 ine and autocrine factors of endothelial and macula densa origins.

62 It also suggests that the altered macula densa phenotype is related to the activity of the

63 lar cells that were within 100 microm of the macula densa plaque using four-dimensional multiphoton m

64 the thick ascending loop of Henle (TALH) and macula densa, providing the error signal for tubuloglome

65 Reducing luminal NaCl concentration in the macula densa region of the nephron stimulates renin secr

66 ited by changes in NaCl concentration in the macula densa region of the nephron, thereby serving as a

67 tion elicited by elevations in [NaCl] in the macula densa region of the nephron.

68 we discuss recent advances in understanding macula densa sensing and suggest these cells, in additio

69 tubuloglomerular feedback through increased macula densa sodium and chloride delivery, leading to af

70 Compared with control mice, mice with macula densa-specific knockout of all nitric oxide synth

71 was unable to rescue the abnormality seen in macula densa structure.

72 tracellular calcium dynamics in cells of the macula densa, the observation was made that tubular epit

73 interrupt distal tubular fluid flow past the macula densa, thus minimizing tubuloglomerular feedback-

74 at least in part, through direct effects on macula densa transport processes.