ライフサイエンスコーパス: main target

1 respiratory illness with pneumocytes as its main target.

2 vasodilatory EP2 and EP4 receptors as their main targets.

3 ident macrophage population being one of the main targets.

4 use it displayed balanced affinities for the main targets and clear selectivity over the two off-targ

5 ural features conducive to activities at the main targets and investigated activities at two off-targ

6 Megalin (gp330) is the main target antigen involved in the induction of Heymann

7 classes that differed with respect to their main target binding areas.

8 lassic IPC in which cardiac myocytes are the main target, cardiac mast cells are the critical site at

9 ng human primary lung endothelial cells, the main target cell infected in HPS patients.

10 hoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) i

11 indicates that neutrophils appear to be the main target cells for ACT, but not for PT.

12 Our studies identify IPCs as the main target cells for ZIKV.

13 intermediate progenitor cells (IPCs) are the main target cells for ZIKV.

14 Dendritic cells (DCs) are the main target cells of DENV, and we investigated their rol

15 The main target cells were macrophages, including Kupffer ce

16 gen, suggesting that the latter would be its main target during coagulation.

17 n yield and selecting large seeds has been a main target during plant domestication.

18 (HPA)-1a, located on integrin beta3, is the main target for alloantibodies responsible for fetal and

19 scular endothelial growth factor (VEGF), the main target for anti-angiogenic-based therapies, and int

20 The ribosome is the main target for antibiotics that inhibit protein biosynt

21 e IKKbeta, demonstrating that Cys-179 is the main target for attack by SNO.

22 e predominant betaAR in the heart and is the main target for beta-adrenergic antagonists, widely used

23 a duplex oligonucleotide substrate with one main target for bleomycin-induced damage.

24 beta1 integrin is the main target for Cdc42-mediating interaction of cancer ce

25 -1 virus, which explains why it has been the main target for design of drugs against acquired immunod

26 dentification of Galalpha1,3Gal (Gal) as the main target for human xenoreactive (anti-pig) antibodies

27 repeats, suggesting these repeats to be the main target for hypomethylation in MPNSTs.

28 Therefore, the main target for improving the outcome of pregnancy in wo

29 indicating that T cell proliferation is the main target for intervention.

30 fficking, with fully mature enzyme being the main target for lysosomal degradation.

31 The subthalamic nucleus (STN) is the main target for neurosurgical treatment of motor signs o

32 The D1 reaction center protein is the main target for photodamage(2), with repair involving th

33 the dogma that the DNA of the nucleus is the main target for radiation-induced genotoxicity and, as f

34 gen-associated molecular patterns and is the main target for recognition by host innate immune cells.

35 st visual center in most vertebrates and the main target for retinal ganglion cells (RGCs) conveying

36 Serotonin transporter (SERT) is the main target for widely used antidepressant agents.

37 ole in synaptic plasticity and is one of the main targets for alcohol (ethanol) in the brain.

38 lso performed tests that represent the three main targets for C difficile detection: bacterium (gluta

39 The NMDA receptor channel is one of the main targets for ethanol in the brain.

40 on in primary CD4+ T cells that serve as the main targets for HIV-1 replication in vivo.

41 chronic infections in the liver, one of the main targets for in vivo gene therapy, raise important c

42 's carboxyl-terminal serine residues are the main targets for phosphorylation by rhodopsin kinase.

43 One of the main targets for PKA modulation is the cardiac L-type Ca

44 we investigated whether neutrophils are the main targets for PT and/or ACT activity in promoting bac

45 uggest that these interneurons represent the main targets for supraspinal and sensory afferent signal

46 the importance of promoter sequences as the main targets for the activation mechanism of the human a

47 /proliferating CD4(+) T cells, which are the main targets for viral replication.

48 tl1-deficient mice indicate that Rtl1 is the main target gene of miR-127 in placental development.

49 IL-27 as well as its main target genes are up-regulated in colonic tissue and

50 Two main target genes of Haa1 are the multidrug resistance g

51 , and of heme oxygenase-1 (HO-1), one of its main target genes, in OA cartilage from T2DM and non-T2D

52 mitogen-activated protein (MAP) kinase is a main target in drug research concerning inflammatory dis

53 Human porphobilinogen synthase (PBGS) is a main target in lead poisoning.

54 Pattern-recognition receptors are the main target in the study of innate immunity in the intes

55 One of the main targets in current clinical oncology is the develop

56 fic innervation, i.e., interneurons were the main targets in the alveus, both interneurons and pyrami

57 to screen for autoantibodies, identify their main targets, investigate the mechanism behind their ind

58 ure of the native form of this enzyme, whose main target is ADP-ribose 1",2"-cyclic phosphate, a prod

59 The main targeted metabolites were flavonoids and cuticular

60 Accordingly, Rac1 is the main target of 6-TP in activated T-cells.

61 Synaptic function is a main target of A-to-I editing, which can selectively rec

62 12S rRNA carrying the A1555G mutation is the main target of aminoglycosides.

63 Thrombin is the main target of anticoagulant therapy, and major efforts

64 terial function of white blood cells, is the main target of arsenic-induced ROS production.

65 The main target of cAMP is PKA, the main regulatory subunit

66 ulosis (TB), and CD4+ T cell immunity is the main target of current TB vaccine candidates.

67 xO transcription factor DAF-16, which is the main target of DAF-2 ILS.

68 The CB1 cannabinoid receptor, the main target of Delta(9)-tetrahydrocannabinol (THC), the

69 ple other processes, but angiogenesis is the main target of drugs such as the tyrosine kinase inhibit

70 The cerebral cortical area that is the main target of each output channel is a major source of

71 Furthermore, cysteine was the main target of effective reactive species in the CAPs me

72 he G protein-coupled receptor family and the main target of endogenous opioid neuropeptides and morph

73 lacements involving Lys14 of histone H3 (the main target of Gcn5), but not other H3 or H4 lysine resi

74 The main target of HIV-1 infection is the CD4(+) helper T ly

75 unterintuitive result that knocking down the main target of ICI (ERalpha) increased the effectiveness

76 ts and show CD14(+)CD16(+) monocytes are the main target of infection, with ZIKV replication detected

77 s or 'podocytes', the cell type which is the main target of injury in MCN.

78 ced the splicing of mRNA encoding XBP1s, the main target of IRE1 activity.

79 As the main target of LA and with its strong projection to CeM,

80 me that regulates the inositol cycle and the main target of lithium in neurons.

81 an striatal medium spiny neurons (MSNs), the main target of neurodegeneration in ChAc.

82 ly conserved surface glycoprotein and is the main target of neutralizing antibodies induced by natura

83 nd E2 mediate viral entry, with E2 being the main target of neutralizing antibody responses.

84 In other words, the main target of our critique is the model of change that

85 Lsdp1 is the main target of PKA, suggesting that this protein is a ma

86 s virus hemagglutinin (MeV-H) protein is the main target of protective neutralizing antibodies.

87 y and motor areas and mostly in layer 4, the main target of relay thalamic inputs, and layer 3.

88 though human airway epithelial cells are the main target of respiratory syncytial virus (RSV), it als

89 defense in the respiratory tract and are the main target of respiratory viruses.

90 holipid cardiolipin molecules are likely the main target of ROS because they are particularly rich in

91 SIRT1 has been described as the main target of RSV.

92 sual regions which apparently constitute the main target of stabilizing extra-retinal oculomotor infl

93 he substantia nigra pars reticulata (SNr), a main target of striatal efferents and the primary output

94 hese results support the hypothesis that the main target of the antibiotics is the mitochondrial 12S

95 The main target of the antilipolytic action of insulin is be

96 hepatic mitochondria were identified as the main target of the beneficial effect of both butyrate-ba

97 DAF-16 is thought to be the main target of the DAF-2 pathway.

98 We show here that the main target of the elevated p27/Kip1 in this system is c

99 ctivity of Yes-associated protein (YAP), the main target of the Hippo pathway, which results in decre

100 ts sexually active before the trial were the main target of the intervention.

101 Transcriptionally active genes, the main target of the NER pathways in mice, contain HMGN1 p

102 ecially in the piriform cortex, which is the main target of the olfactory bulb.

103 riments using GR chimeras indicated that the main target of the p38-mediated (but not JNK-mediated) i

104 After this, the main target of the Plains Paleoindian hunters consisted

105 The main target of the study was to evaluate the diagnostic

106 A main target of this sensory information is the superior

107 The main targets of 5-HT+ terminals were spines and distal d

108 These data suggest that mitochondria are the main targets of alpha-synuclein and their defective auto

109 suggests that genes distal to Erbb2 are the main targets of amplification.

110 The main targets of anterograde transport were the deep laye

111 d neurofascin-186 and neurofascin-140 as the main targets of autoantibodies in five patients presenti

112 a and androgen receptor, which are two known main targets of bisphenols.

113 amily of transcription factors is one of the main targets of cytokines and other agents that induce H

114 ion and serological conversion have been the main targets of diagnostic assessment for many years, ho

115 These dual-phenotype neurons are the main targets of E2 in the region and are more than twice

116 and EIL1, we show that EIN3 and EIL1 are the main targets of EBF1/2.

117 One of the main targets of estrogens in the immune system is the th

118 inor histocompatibility (H) antigens are the main targets of graft-versus-host and graft-versus-leuke

119 The main targets of hepatitis C virus (HCV) are hepatocytes,

120 ydryl groups of protein-cysteines constitute main targets of HNE.

121 mononuclear phagocytes, and hepatocytes are main targets of infection, and IHC showed an association

122 The main targets of M1R+ terminals forming asymmetrical syna

123 The main targets of M1R+ terminals forming symmetrical synap

124 The main targets of M2R(+) terminals forming asymmetrical (p

125 The main targets of M2R(+) terminals forming symmetrical (pu

126 duced IFN-beta in the brains and livers, two main targets of MHV replication, of infected wild-type m

127 on in the central nervous system and are the main targets of neurodegenerative disease.

128 One of the main targets of orexinergic neurons is the arcuate nucle

129 reactive oxygen species, but also one of the main targets of oxidative damage.

130 ur amino acids in them, were found to be the main targets of positive selection.

131 bulbocavernosus and levator ani muscles, the main targets of SNB motoneurons, was not affected in eit

132 ing that conventional CD4(+) T cells are the main targets of TGF-beta to suppress T1D.

133 This CPS is known to be one of the main targets of the adaptive immune response in humans a

134 The BLC is also one of the main targets of the mesolimbic dopamine (DA) system.

135 lamina monopolar cells, L1 and L2, were the main targets of the R cell pathway, L1 and L2 each fed a

136 ind that locally translated proteins are the main targets of the ubiquitin-proteasome system in growt

137 fic subsets of CD4(+) T cells, which are the main targets of virus infection and differ substantially

138 t macrophages accumulated in the kidney, the main target organ of infection, and formed direct contac

139 The gill was the main target organ where immature and mature poxvirus par

140 d on clinical symptoms in one or more of the main target organs (skin, liver, gastrointestinal tract)

141 The cAMP-dependent phosphorylation of PKA's main target, originally described as p29 in Paramecium,

142 Because pregnant women are the main target population for ZIKV treatment, therapeutic c

143 ermeable to calcium, has been considered the main target responsible for calcium overload in ischemic

144 Knowledge of the main target sequences for Sau1 will facilitate the synth

145 MEF8-E549A failed to restore editing at the main target sites but was able to restore editing at the

146 The PVN or CeA are probably not the main target sites of immediate BT action.

147 A common denominator of the main target sites of the Foxb1-positive axons of the par

148 monstrated that otoferlin interacts with two main target-SNARE proteins of the hair-cell synaptic com

149 One of the main target structures of 5-HT(4) receptors on 'cognitiv

150 admission and significant improvement in the main target symptoms.

151 concomitant increased activity in one of its main targets, the posterior nucleus of the thalamus (PO)

152 ation between the granule cell layer and its main targets, the Purkinje cells, Golgi cells and molecu