ライフサイエンスコーパス: maintenance

1 , is essential for mitochondrial DNA (mtDNA) maintenance.

2 ability and the easiness of construction and maintenance.

3 ctors normally involved in tissue repair and maintenance.

4 events related to cytoskeletal dynamics and maintenance.

5 lso affect its generation, amplification and maintenance.

6 ns including sterol uptake and cell envelope maintenance.

7 ntrol step produces defects in reading frame maintenance.

8 that has been implicated in striated muscle maintenance.

9 entify Lsd1 as a regulator of beige fat cell maintenance.

10 sion level on telomere elongation and length maintenance.

11 osphorylation, mitochondrial biogenesis, and maintenance.

12 to ssDNA intermediates formed during genome maintenance.

13 le for mTORC1 in controlling alpha cell-mass maintenance.

14 y and species-specific differences in genome maintenance.

15 ate prevention, and, therefore, proteostasis maintenance.

16 essential processes such as genome integrity maintenance.

17 eta-catenin and SNAIL in epidermal stem cell maintenance.

18 esis, metastasis, and cancer stem cell (CSC) maintenance.

19 myelination, but is not necessary for myelin maintenance.

20 eural development and neural progenitor pool maintenance.

21 ing reproduction, somatic growth, and tissue maintenance.

22 sion is unnecessary for synapse assembly and maintenance.

23 clear-cytoplasmic shuttling in a chromosomal maintenance 1-dependent manner.

24 able include streamline model monitoring and maintenance activities in a manufacturing setting.

25 d confirms the PFS benefit with lenalidomide maintenance after ASCT in patients with NDMM when compar

26 Given the low rates of successful weight maintenance after lifestyle-induced weight loss, it is c

27 specific function for CaMK2N1; enabling LTM maintenance after retrieval by inhibiting T286 autophosp

28 their extracellular environments for tissue maintenance and adaptation.

29 Genome maintenance and cancer suppression require homologous re

30 rs suggests a link between organellar genome maintenance and cell proliferation.

31 preliminary framework for characterizing the maintenance and cerebral representation of different typ

32 and required lipid raft localization for CSC maintenance and cisplatin resistance.

33 inge and Pds5p cooperate to promote cohesion maintenance and condensation.

34 NeuPCs, where it is indispensable for their maintenance and controls neuronal differentiation.

35 BACKGROUND & AIMS: Maintenance and differentiation of progenitor cells in t

36 -2 plays a critical role in endothelial cell maintenance and function by regulating eNOS activity.

37 system, on soluble molecules that guide the maintenance and function of the immune system and on lym

38 thrin-independent essential role in polarity maintenance and growth.

39 e; therefore, understanding mechanisms of SC maintenance and how aging affects SC function are of spe

40 major cellular processes of circadian rhythm maintenance and metabolism.

41 that Prdm16 is required for neural stem cell maintenance and neurogenesis in the adult lateral ventri

42 that JG cells are critically involved in the maintenance and protection of the renal microvascular en

43 c resources are directed more toward somatic maintenance and proteostasis, and away from cell growth

44 Mitochondrial division is critical for the maintenance and regulation of mitochondrial function, qu

45 osteoclasts that play a central role in the maintenance and repair of our bones are formed from bone

46 reducing conditions, which may contribute to maintenance and seasonal variability of U in groundwater

47 nstrate that the G1MDR holds the key to HSPC maintenance and suggest that release from this suppressi

48 ne ligands, thereby contributing to gradient maintenance and termination.

49 Disrupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential.

50 CTTNBP2 (synapse maintenance) and REEP3 (vesicle trafficking) are enriche

51 that is essential for tissue development and maintenance, and aberrant Notch signaling has been impli

52 ified several lncRNAs essential for leukemia maintenance, and found that a number act by promoting le

53 role of TNF on monocytes for their survival, maintenance, and function.

54 scriptional properties including activation, maintenance, and repression.

55 chanisms underlying urothelial formation and maintenance are largely unknown.

56 developmental origin and mode of homeostatic maintenance are unknown.

57 DDR activation and maintenance at telomeres depend on the biogenesis and fu

58 n, we compared the fMRI signal reflecting WM maintenance between hemispheric counterparts of various

59 in mammary ductal development and stem cell maintenance, but the ligands involved are ill-defined.

60 al cellular processes, like genome integrity maintenance, characterize HUWE1-promoted XLID.

61 AC cells, and correlated with minichromosome maintenance complex components (MCMs) and mediator of DN

62 ted that black and Hispanic adults receiving maintenance dialysis survive longer than non-Hispanic wh

63 ay an important and understudied role in the maintenance, diversification, and transmission of IAVs i

64 ave been identified as critical for telomere maintenance, DNA repair, transcription and other DNA met

65 g/kg; pertuzumab 840 mg loading dose, 420 mg maintenance doses) or docetaxel, carboplatin, and trastu

66 n; trastuzumab 8 mg/kg loading dose, 6 mg/kg maintenance doses) plus pertuzumab [same dosing as in th

67 ate ensuring adequate NSPCs self-renewal and maintenance during development.

68 re raised temperature is thought to increase maintenance energy demands and thereby decrease availabl

69 diverse functions in RNA metabolism and DNA maintenance, establishing Nol12 as a multifunctional RBP

70 These findings reveal a maintenance factor in the adult brain, and highlight a t

71 ith moderate-severe COPD, with 3 years of PR maintenance following an 8-week outpatient PR program.

72 a-analysis (605 patients in the lenalidomide maintenance group and 603 in the placebo or observation

73 to be a generalizable strategy for stemness maintenance in 3D.

74 rotubule polymerization contributes to their maintenance in axons.

75 IGF signaling is essential for mitochondrial maintenance in cancer cells and whether this contributes

76 o better understand the mechanisms of memory maintenance in CD8(+) T cells, we performed genome-wide

77 r investigation of immunomodulatory drugs as maintenance in high-risk patients with DLBCL.

78 tically significantly less MFR and better PH maintenance in IIP with thick biotype (MFR: MD -0.478, P

79 trols transcription, replication, and genome maintenance in infected cells.

80 transcriptase required for linear chromosome maintenance in most eukaryotes.

81 oposes that resources continue for long-term maintenance in resource-poor countries of AFP surveillan

82 hepatic FcRn to mediate albumin delivery and maintenance in the circulation, but they also enhance se

83 , collectively ensuring comprehensive genome maintenance in the nervous system.

84 al recombination/repair proteins to telomere maintenance in Ustilago maydis, a fungus that bears stro

85 d better symptom control, despite lower dose maintenance inhaled steroids.

86 ly the establishment of the IS, but also its maintenance is a highly regulated process.

87 The results indicate that ribosome maintenance is key for maintaining the ability of P. aer

88 LSC maintenance is related, at least in part, to signals fro

89 ssed in adult tissues but its role in tissue maintenance is unknown.

90 val recruitment, critical to reef-ecosystems maintenance, is altered by anthropogenic stressors.

91 The lack of C-strand maintenance leads to gradual shortening of the telomeric

92 FABP4 and FABP5 have a critical role in the maintenance, longevity and function of CD8(+) TRM cells,

93 duplication requires loading minichromosome maintenance (MCM) helicase complexes at many DNA replica

94 s (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers

95 s (ALT) is a telomerase independent telomere maintenance mechanism that occurs in approximately 15% o

96 een SacII digestion of both MB substrate and maintenance methylated MB corresponds to de novo methyla

97 disrupts Notch1 signaling and primary cilium maintenance necessary for radial progenitor functions.

98 We review recent findings in NMJ formation, maintenance, neuromuscular disorders, and aging of the N

99 ve breast cancer (TNBC), contributing to the maintenance of a chemoresistant breast cancer stem cell

100 cal vortex, we observed evolution toward and maintenance of a constant helicity state after the dissi

101 specific for METTL3 and is implicated in the maintenance of a leukaemic state.

102 Elevated catecholamines also allow for maintenance of a normal fetal basal metabolic rate despi

103 ant challenge causes damage to biomolecules, maintenance of a physiological level of oxidant challeng

104 well-stratified epithelial constructs, with maintenance of a progenitor cell phenotype in their (sup

105 The maintenance of a proper nuclear architecture and three-d

106 loss of suppression when exposed to TAC and maintenance of a TSDR demethylated phenotype following i

107 Explaining the maintenance of adaptive diversity within populations is

108 Discovery, acquisition, installation, and maintenance of all these packages is a burdensome task.

109 es and whether macropinocytosis supports the maintenance of amino acid levels within pancreatic tumor

110 and will yield insights into the trigger and maintenance of atrial fibrillation.

111 ect could contribute to enhanced LTP and the maintenance of augmented excitatory synaptic strength in

112 This transport is essential for maintenance of axonal growth-cone dynamics and autophago

113 ons with increased mutation rate and observe maintenance of beneficial mutations in the sexual popula

114 n vivo functions of alphaB-crystallin in the maintenance of both lens transparency and muscle integri

115 ed super-enhancers (SEs), are central to the maintenance of cancer cell identity and promote oncogeni

116 ation is paramount for the establishment and maintenance of cell-specific programmes.

117 superfluous mitochondria are crucial for the maintenance of cellular and organismal homeostasis.

118 eplication, it also poses a challenge to the maintenance of cellular functions necessary for viral re

119 agy-lysosomal system plays a key role in the maintenance of cellular homeostasis in neurons.

120 envelopes the fungal cell, is pivotal to the maintenance of cellular integrity and for the protection

121 ucial modulators in the neurodevelopment and maintenance of central and peripheral nervous systems.

122 erican Board of Internal Medicine's (ABIM's) Maintenance of Certification program (MOC).

123 play a significant, nonredundant role in the maintenance of ChAT in intact adult motor neurons, the r

124 UND & AIMS: The role of the intestine in the maintenance of cholesterol homeostasis increasingly is r

125 er, our understanding of the development and maintenance of cholinergic circuits is limited, as the f

126 process is aided by condensin, a structural maintenance of chromosomes (SMC) family member.

127 matin scaffolding protein SMCHD1 (structural maintenance of chromosomes flexible hinge domain contain

128 ional constraints are more important for the maintenance of cis-regulatory variation than genome-scal

129 d likely contribute to population structure, maintenance of cooperation, and strain diversification.

130 We find that forced maintenance of CRISPR targets induces a fitness cost tha

131 underappreciated role in the development and maintenance of drug abuse by influencing neuronal and sy

132 e NAc may participate in the development and maintenance of drug-taking behaviors.

133 LPA1 plays a significant role in maintenance of epithelial barrier in the intestine via r

134 udy the contribution of cytoplasmic Esrp1 in maintenance of epithelial cell functions.

135 nd cultures with IDH1 CNA had decreased 2HG, maintenance of G-CIMP, and DNA methylation reprogramming

136 his novel mechanism might be specific to the maintenance of gaze direction across blinks or might dep

137 es transcriptional activation as well as the maintenance of gene silencing, while H2AX is important i

138 but pathways involved in microbial dormancy, maintenance of genome integrity and ATP homeostasis were

139 ungi, the protective function of RNAi in the maintenance of genome integrity is well known.

140 CA1 functions within chromatin to ensure the maintenance of genome integrity.

141 genetic element (transposons) silencing and maintenance of genome integrity.

142 olve replication blocks are critical for the maintenance of genome stability.

143 a near ubiquitous pathway, essential for the maintenance of genome stability.

144 so plays a fundamentally significant role in maintenance of genomic stability through a DDR-independe

145 Maintenance of glucose homeostasis is achieved via funct

146 of asexual clades may be correlated with the maintenance of heterozygosity by mechanisms that rearran

147 However, for the maintenance of high antioxidant activity, a storage time

148 cription of HIV genes and contributed to the maintenance of HIV-1 latency.

149 roles both in embryonic development and the maintenance of homeostasis in many adult tissues.

150 sociation of E2 and of the establishment and maintenance of HPV16 episomes.

151 arunavir/ritonavir plus 2 nucleos(t)ides for maintenance of human immunodeficiency virus type 1 (HIV-

152 In this study, we report that maintenance of human memory CD8 T cell effector potentia

153 in the regulation of peanut sensitivity and maintenance of immune homeostasis.

154 by T reg cells is continuously required for maintenance of immune tolerance and for a major part of

155 al anatomical connections play a role in the maintenance of interhemispheric functional connectivity.

156 lt tissues they aid in wound healing and the maintenance of intestinal cell populations in particular

157 oxp2 may function downstream of Tshz1 in the maintenance of ITCs.

158 roducing pathway, and we further showed that maintenance of its function is important for vaccinia vi

159 synthesis and secretion is important for the maintenance of juxtaglomerular apparatus architecture.

160 trates of K-Rta may provide insight into the maintenance of KSHV latent infection and the switch to l

161 onally interchangeable for establishment and maintenance of latency and suggest that repression of ly

162 nd R-spondin1, and are sufficient to promote maintenance of Lgr5(+) IESCs in intestinal organoids, an

163 This latter group included the maintenance of lipid asymmetry genetic pathway as a key

164 bly, CSCs are critical for the formation and maintenance of liver metastasis derived from colorectal

165 Shisa7 KO mice showed reduced initiation and maintenance of long-term potentiation of glutamatergic s

166 We sought to understand whether maintenance of lung TH17 inflammation requires environme

167 on lymphoid organs that coordinate both the maintenance of lymphocytes and the initiation of immune

168 c areas and are thought to contribute to the maintenance of malaria immunity.

169 ells is associated with PDAC development and maintenance of malignancy in human cells and mice.

170 renewal and de novo influx contribute to the maintenance of memory compartments.

171 lyses, we show that She1 is required for the maintenance of metaphase spindle stability.

172 ARL2-TBCD interaction is critical for proper maintenance of microtubule densities in cells.

173 s than smaller animals with implications for maintenance of migration and body size in the face of en

174 nges of matrix contents are essential to the maintenance of mitochondria.

175 Maintenance of mitochondrial function during stress cond

176 ined effects of Parkin and PGC-1alpha in the maintenance of mitochondrial homeostasis in dopaminergic

177 s, we dissect the role of condensin I in the maintenance of mitotic chromosome structure with unprece

178 eting bacterial populations critical for the maintenance of mucosal homeostasis.

179 at elevated Ctnnd1 expression contributes to maintenance of murine B-ALL cells with compromised Ikaro

180 iring represents an essential factor for the maintenance of muscle homeostasis during adaptation to h

181 lator of the actin cytoskeleton, implicating maintenance of muscular function.

182 D repeat containing protein coronin 1 in the maintenance of naive T cells in peripheral lymphoid orga

183 ents is essential for the normal cycling and maintenance of neural stem cells (NSCs) in the brain sub

184 and wild type mice in either development or maintenance of neuropathic nociception in either neuropa

185 importance of aberrant afferent input in the maintenance of neuropathic pain and the potential for ta

186 icotine addiction, including acquisition and maintenance of nicotine taking, nicotine withdrawal, and

187 usly shown that the mechanism permitting the maintenance of non-vertical GSAs is highly auxin-depende

188 he regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interes

189 Dmrta2 modulation of Hes1 expression and the maintenance of NPCs during cortical development.

190 roid hormone 20-hydroxyecdysone (20E) in the maintenance of numerous patterning systems in vivo and i

191 cription opioid dependence, and is long-term maintenance of opioid agonist treatment associated with

192 In aggregate, maintenance of Orai activation required not only the con

193 tood to play a key role in establishment and maintenance of oral health.

194 The role of keratinized tissue (KT) for maintenance of periodontal health has been debated for m

195 ls is essential for both the development and maintenance of peripheral nerve function.

196 endogenous IL-4 and IL-13 contribute to the maintenance of peripheral tolerance and whether their fu

197 The mechanisms that regulate maintenance of persistent TH2 cells and potentiate aller

198 l for the function of the primary cilium and maintenance of phosphoinositide balance in nondividing c

199 lated proteins, Photosystem II Subunit S and Maintenance of Photosystem II under High Light1, which w

200 e) (PLGA) was developed that shows sustained maintenance of plasma drug concentrations and drug effic

201 Maintenance of proficiency was evaluated by video assess

202 rimental in atherosclerosis by promoting the maintenance of proinflammatory CD11c(+) macrophages with

203 o all target nuclei investigated here is the maintenance of projection topology from different barrel

204 (SSDHN) are essential in the development and maintenance of prolonged pain.

205 The role of AP-2 in the maintenance of proper apical membrane lipid and cell wal

206 Maintenance of proper levels of the methyl donor S-adeno

207 ance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our underst

208 that increasing reward funds facilitates the maintenance of prosocial rewarding but prevents its inva

209 plexes with Rad51 in vivo, and the stability maintenance of Rad51 requires TCTP in MCF-7 cells under

210 f Spt6 to sites of transcription and for the maintenance of repressive chromatin.

211 the metabolic and hepatic outcomes of 1-year maintenance of serum ferritin levels <50 mug/L by bloodl

212 ss-related traits, (3) are necessary for the maintenance of sexual dimorphism, (4) influence reproduc

213 er ablation over pharmacological therapy for maintenance of sinus rhythm in patients with both paroxy

214 ABSTRACT: The maintenance of skeletal muscle mass is essential for hea

215 al symmetry.Retinoic acid (RA) regulates the maintenance of somitogenesis symmetry.

216 le of marginal populations for the long-term maintenance of species' genetic diversity and evolutiona

217 , as well as patterning, differentiation and maintenance of specific retinal cell types.

218 nimals displayed a defect in the homeostatic maintenance of splenic CD8alpha(+) DCs and in the capaci

219 enewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epit

220 ' shows increased HSF1 and chaperone levels, maintenance of striatal excitatory synapses, clearance o

221 ivation is common and possibly necessary for maintenance of survival.

222 view will focus on the role of cell death in maintenance of T-cell homeostasis and outline novel ther

223 is critically influences the development and maintenance of TCL and represents a potential therapeuti

224 elopment, JunB is required for induction and maintenance of Th17 effector responses in the inflammato

225 Here we show that the assembly and maintenance of the adipose vascular niche is controlled

226 s demonstrate that Klf4 is essential for the maintenance of the AdvSca1 progenitor phenotype.

227 lterations and abnormal growth; as a result, maintenance of the antioxidant glutathione (GSH) is esse

228 lase activity, important for development and maintenance of the barrier function of the epidermis.

229 Maintenance of the Bully phenotype is temperature depend

230 ed to the concept that glia are required for maintenance of the gastrointestinal epithelium.

231 nsitions during cellular differentiation and maintenance of the germ line.

232 EBV-specific CD4 + T cells may contribute to maintenance of the HIV DNA reservoir following chemother

233 l functions, including receptor turnover and maintenance of the immunological synapse.

234 nscription in ES cells, also plays a role in maintenance of the inactive state through regulation of

235 hromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enz

236 nd exhaustion and is necessary for long-term maintenance of the mammary gland.

237 2 (FGF2) is crucial for the development and maintenance of the mesostriatal dopaminergic system.

238 eview here sentinel functions of IELs in the maintenance of the mucosal barrier integrity, as well as

239 loading is necessary for the development and maintenance of the musculoskeletal system.

240 t that DNA methylation may contribute to the maintenance of the TDF phenotype.

241 ons were similarly crucial at late times for maintenance of the Tfh and GC B cells.

242 pendence of podocyte mechanotransduction and maintenance of their physiological function.

243 re assessments of inflammation's role in the maintenance of these disorders (ie, sex, co-morbid condi

244 The establishment and maintenance of these distinct cell fates are driven by m

245 The evolution and maintenance of this variation depends on genetic archite

246 cognition across the adult lifespan, and the maintenance of this, along with maintained DM deactivati

247 al subcellular mechanisms, the formation and maintenance of tissue boundaries involves long-lived, lo

248 Maintenance of tissue homeostasis upon reduction of Pink

249 hat orchestrates epithelial regeneration and maintenance of tissue integrity.

250 c mechanism leading to the establishment and maintenance of tissue-specific, epigenetic pattern is st

251 tion of the two other isoforms, which allows maintenance of total actin levels and preserves F-actin

252 es a conceptual framework for explaining the maintenance of tree diversity in tropical forests.

253 ndancy to facilitate angiogenesis and ensure maintenance of uterine blood flow during pregnancy.

254 with rapid efflux capacity contribute to the maintenance of viral-specific memory T cells.

255 le for microglia in the development, but not maintenance, of morphine tolerance in male rats.

256 Erf is necessary for hematopoietic stem cell maintenance or differentiation.

257 At quarterly maintenance or prophylaxis visits during the subsequent

258 o varied by plan type (range, 31% for health maintenance organizations to 49% for preferred provider

259 es such as inflammation, as well as cellular maintenance pathways, including RNA splicing and nuclear

260 )] every 3 weeks for four cycles followed by maintenance pemetrexed); randomisation was stratified by

261 and remained seizure-free entered a 6-month maintenance period on the same dose.

262 d at least one dose of study drug during the maintenance period were included in the primary efficacy

263 patients with severe hypoglycemia during the maintenance period.

264 ith a 16-week titration period and a 16-week maintenance period.

265 %] of 231 patients in the R-CVP group in the maintenance phase).

266 noninferiority trial and subsequent 40-week maintenance phase.

267 ding operations were preserved, while memory maintenance processes were abnormal.

268 To determine whether a long-term (3-yr) maintenance program after PR preserves the short-term ef

269 early conversion to an mTOR inhibitor-based maintenance regime.

270 ndomized multicenter trials of induction and maintenance regimens in first-line FL therapy published

271 optimization of appropriate conditioning or maintenance regimens.

272 t the mechanisms underlying their origin and maintenance remain disputed.

273 le of these mutations in MDS development and maintenance remain.

274 into other essential functions (eg, growth, maintenance, reproduction).

275 Sey1p is inhibited, indicating that network maintenance requires continuous membrane fusion and that

276 Toxicant effects on feeding and maintenance resulted in initially small adverse effects

277 Routine rituximab maintenance should be avoided.

278 eir flux organization is crucial for guiding maintenance strategies of these highly stressed systems

279 onments can encourage efficient planting and maintenance strategies to maximize pollination and estab

280 costs, which suggests an emphasis on ongoing maintenance subsidies rather than upfront capital cost s

281 ppocampus impairs LTM formation, but not LTM maintenance, suggesting that CaMKII activity is not requ

282 dy, we focused on the role of T cells in the maintenance/survival of the mature naive peripheral B ce

283 nd second primary malignancies, lenalidomide maintenance therapy after ASCT significantly improved ti

284 evaluated and resampled and received regular maintenance therapy at 3, 6, and 12 months after treatme

285 We investigated whether rituximab maintenance therapy at a dose of 375 mg per square meter

286 high-dose cytarabine and anthracycline, and maintenance therapy comprising ATRA, oral methotrexate,

287 (AML) have a poor prognosis, and innovative maintenance therapy could improve their outcomes.

288 Results under loading dose and maintenance therapy regimens were nearly identical.

289 s given, the total dose received, or whether maintenance therapy was used.

290 days; thereafter, all the patients received maintenance therapy with itraconazole.

291 zed phase III trial compared lenalidomide as maintenance therapy with placebo in elderly patients wit

292 phine (BUP) are widely prescribed for opiate maintenance therapy.

293 s at relapse reduce the potential benefit of maintenance therapy; this should only be advocated in th

294 ability of a group of SDIs during methadone maintenance treatment (n = 23) with a control group (n =

295 rated, suggesting that SCIg can be used as a maintenance treatment for CIDP.

296 Maintenance treatment with bevacizumab monotherapy was c

297 s, as measured by FACT-Leu and EQ-5D, during maintenance treatment.

298 hese primary cancer cells focus on long-term maintenance under growth factor supplements into cell li

299 lls in nonlymphoid organs to assist in their maintenance upon injury or stress.

300 ons, the receptors become essential for ChAT maintenance when the motor neurons are challenged by ner