ライフサイエンスコーパス: major

1 nt plants supplied by Pockwock Lake and Lake Major.

2 s, or both 5-5 and beta-O-4 linkages, showed major 1,2-eliminations of neutral compounds containing o

3 rlay assay, it was previously shown that the major AAV2 binding protein in membrane preparations of h

4 which lends support to idea that there was a major adaptive radiation of mammals in the mid-Jurassic

5 This progress has translated into major advances in the treatment of advanced breast cance

6 of AuNP-infused PPDO sutures indicates their major advantage as a radiopaque resorbable filter materi

7 Major adverse cardiac and cardiovascular event rate at 3

8 In-hospital major adverse cardiac and cerebral events occurred in 2.

9 This study recorded the occurrence of a major adverse cardiac event (MACE) assessed as the compo

10 Major adverse cardiac events occurred in 1.1% and 4.2% o

11 ndary end points included clinical outcomes (major adverse cardiac events), use of healthcare resourc

12 d followed for incident type 1 and T2MI, and major adverse cardiovascular events (MACE, a composite o

13 coronary heart disease by 27% (P=0.033) and major adverse cardiovascular events by 25% (P=0.037) dur

14 lerance, acarbose did not reduce the risk of major adverse cardiovascular events, but did reduce the

15 (0.87 to 2.97), and 3.09 (0.96 to 8.78) for major adverse cardiovascular events, hospitalizations, a

16 Secondary outcomes included major adverse cardiovascular events.

17 of cardiovascular risk factors at target and major adverse cardiovascular outcomes among patients wit

18 nificant interaction between travel time and major amputation as well as travel time and revasculariz

19 lonal antibodies (MAbs) that recognize known major antigenic sites in MeV-H, we identified a D4 genot

20 RNA-mediated interference has been one major approach for sequence-specific regulation of gene

21 ns of dissolved organic matter (DOM) in five major Arctic rivers (Kolyma, Lena, Yenisei, Ob, Mackenzi

22 88 individuals among 9978 participants of 3 major Asian ethnic populations, retinal emboli were most

23 In this review, eight major asthma-related comorbidities are discussed: rhinit

24 FAP gene, which is the gene that encodes the major astrocyte intermediate filament protein.

25 lycan of dividing cells from cleavage by the major autolysin LytA and occurs at the septal site.

26 ng those incorporating lipopolysaccharide, a major bacterial outer membrane component) and induce a c

27 dditionally, the eosinophil granule proteins major basic protein and eosinophil peroxidase were more

28 One of the major biological functions of the retinal pigmented epit

29 case study to investigate the influence of a major biomass burning event on the light absorption prop

30 atients; and apixaban, 12886 patients), 4770 major bleeding events occurred during 447037 person-quar

31 RR2HAGES improved their predictive value for major bleeding leading to improved clinical usefulness c

32 Major bleeding occurred in 36 patients (6.9%) in the edo

33 npatient admissions for ischemic strokes and major bleeding were compared across the 3 drugs (rivarox

34 A major bottleneck limiting understanding of mechanisms an

35 ibution in mice lacking lubricin (Prg4), the major boundary lubricant of articular cartilage.

36 rnmeal and grits), collected from one of the major Brazilian milling industries.

37 excellent tissue compatibility represents a major breakthrough in this field and a promising alterna

38 We discuss the two major candidate therapeutic targets to lower amyloid-bet

39 PRD1-adenovirus lineage, characterized by a major capsid protein bearing two beta-barrels.

40 However, the structure of the viral major capsid protein, elucidated at near-atomic resoluti

41 protrusions that are formed by loops of the major capsid protein.

42 inued the study medications) a lower risk of major cardiovascular events; however, they also had lowe

43 Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide

44 lcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldw

45 This condition, termed sarcopenia, is a major cause of falls and of the subsequent increase in m

46 kievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children

47 (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide.

48 are recalcitrant to antibiotic therapy and a major cause of persistent and recurrent infections.

49 Enterovirus A71 (EV-A71) is the major cause of severe hand, foot, and mouth disease and

50 ere, we examined the role of syndecan-1, the major cell-surface HSPG of hepatocytes, in AILI.

51 otein substrates in various forms, imposes a major challenge for these studies.

52 protect for opposite reasons, highlighting a major challenge in tuberculosis vaccine design.

53 A major challenge is the lack of a rapid and accurate poin

54 espite this astonishing rate of success, the major challenge still remains to not only confirm that t

55 , however, are still unclear and represent a major challenge to our understanding of glacial climates

56 of naked dsRNA sprayed on plants has been a major challenge towards its practical application.

57 cryo-electron microscopy (cryo-EM) maps is a major challenge, as the moderate resolution makes accura

58 ithout sequence-preference continues to be a major challenge.

59 Finally, we discuss major challenges and open questions related to the appli

60 his review, we begin with an overview of the major challenges GxE studies have faced (e.g., difficult

61 sustainability of marine ecosystems presents major challenges.

62 ts that evaluate the sense of smell face two major challenges.

63 Aging is accompanied by major changes in adipose tissue distribution and functio

64 We show that HSP22E and HSP22F are major chloroplast-targeted sHsps that have emerged from

65 nd heavy chain (Hc) heterodimers represent a major class of bispecific drug candidates.

66 Host cell proteins (HCP) are a major class of impurities derived from recombinant prote

67 rehensive description and expression of both major classes of drug transporters, SLC and ABC, in rest

68 groups containing X-X bonds are found in all major classes of natural products and often impart signi

69 In less than 2 decades, major clinical advances have been made in various areas

70 nditional targeting approach, we ablated the major CLP gene Irf6 only in the late embryonic oral epit

71 ing to sequential epitopes derived from five major CM proteins were measured with a peptide microarra

72 As the major coenzyme in fuel oxidation and oxidative phosphory

73 CMV reactivation is a major complication after allogeneic stem cell transplant

74 g the role of LOX-1 in atherogenesis and its major complication, myocardial ischemia; and summarizes

75 perioperative factors for associations with major complications and failure-to-rescue.

76 associated with a reduction in postoperative major complications, duration of mechanical ventilation,

77 paraplegia appeared similar, while those for major complications, in-hospital mortality, retrograde t

78 vidence that virus-induced inflammation is a major component of disease in the developing brain.

79 ynapses demonstrate that CP-AMPARs mediate a major component of glutamatergic transmission.

80 Contrary, topoisomerase II is not the major component of meiotic chromosomes, even though mito

81 Sphingolipids are a major component of plant plasma membranes and endomembra

82 Here the authors show that 3D collagen gels, major components of connective tissues and extracellular

83 It is important to identify the major components of these SMPs to understand what is in

84 erweight is epidemic in adolescents and is a major concern because it tracks into adulthood.

85 ruses at the animal-human interface remain a major concern for emergence of viruses with pandemic pot

86 Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genet

87 This multinational study shows major concerns in the delivery of critical care across L

88 rt cycle indicate that McjD does not undergo major conformational changes as previously proposed for

89 nding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface

90 Rosemary extract and its major constituent chemicals were tested for their cytoto

91 This phenomenon may be a major contributing factor in treatment failure in patien

92 surface states in few-monolayer MgB2 make a major contribution to the superconducting gap spectrum a

93 lly carbon nanotubes and nanowires, have had major contributions in the development of artificial mus

94 indicated that Group II motoneurons are the major contributor to actual eye movements over the teste

95 results imply that local circuitry is not a major contributor to gamma oscillations in the vStr LFP

96 we address Piezo1 in adult endothelium, the major control site in physical activity.

97 al bacteria and is believed to be one of the major costs of maintaining these defense systems.

98 Lettuce (Lactuca sativa) is a major crop and a member of the large, highly successful

99 pCRP* constitutes the major CRP species in human-inflamed tissue and allows bi

100 Cool ambient temperatures are major cues determining flowering time in spring.

101 Drought can cause major damage to plant communities, but species damage th

102 Severe drought caused major declines in leaf water potential, elevated foliar

103 R2 or AMP-activated protein kinase (AMPK), a major decorin-activated energy sensor kinase, prevented

104 decreased functionality could be linked to a major defect in CD4 binding induced by the replacement o

105 itors of monoacylglycerol lipase (MAGL), the major degradative enzyme of the endocannabinoid 2-arachi

106 THOD: Adults aged 18-65 with treatment-naive major depression were randomly assigned with equal likel

107 Major depressive disorder (MDD) in the elderly is a risk

108 Major depressive disorder (MDD) is a debilitating mental

109 5 findings in stress disorders, particularly major depressive disorder (MDD), highlighting insights f

110 a (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric

111 Patients with major depressive disorder completed two rtfMRI-nf sessio

112 METHOD: Adult outpatients with major depressive disorder were randomly assigned to open

113 NRG3 class I was increased in bipolar and major depressive disorder, consistent with observations

114 armacologic Treatment of Adult Patients with Major Depressive Disorder." The evidence review done for

115 Our data identify Gag-protease as a major determinant of subtype differences in disease prog

116 The microbiome has emerged as a major determinant of the functioning of host organisms,

117 d demonstrate that accessory helicases are a major determinant of this balance.

118 Fin spines serve as a major deterrent to predators and enhance the locomotor f

119 Major dicarbonyl compounds such as methylglyoxal or glyo

120 study of the PrP(Sc) conformers has revealed major differences between the two diseases, which prefer

121 This analysis revealed major differences in the immune checkpoint expression pa

122 rvention and that led (or could have led) to major disability or death.

123 and ocean warming has the potential to cause major distributional shifts, particularly in polar regio

124 on the DNA base excision repair pathway, the major DNA repair system that deals with oxidative DNA da

125 Cell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emerg

126 ese regulators are thought to constitute the major driver of morphological evolution.

127 omprehensive understanding of symbiosis as a major driving force of ecological adaptation.

128 the less common E4 isoform differs from the major E3 isoform only by a C112R substitution.

129 on with fractional anisotropy of the forceps major (effect size [d] = 0.34) and the inferior longitud

130 Major efforts toward the identification of chemical modu

131 l cohort study of patients undergoing 1 of 6 major elective inpatient operation from 2002 to 2011 usi

132 h anaerobic microbial metabolism represent a major energy source for the host colonic epithelium and

133 IPMK deletion elicits a major enrichment of HIF-1alpha protein and thus VEGF.

134 contaminated subsurface systems represents a major environmental challenge.

135 DNA methylation, a major epigenetic mark, was investigated using targeted b

136 nd ubiquitin-proteasome systems regulate the major events of meiotic prophase in mouse.

137 Transposable elements are major evolutionary forces which can cause new genome str

138 l. contend that general intelligence poses a major evolutionary puzzle.

139 icating the role of female sex hormones as a major factor in determining migraine risk and characteri

140 A major factor in the variation of SUMO-target function is

141 The liver is a major factor VIII (FVIII) synthesis site, and mesenchyma

142 ond stabilization of helical structures is a major factor, which determines sequence-dependent behavi

143 cessing to siRNAs in the cells are among the major factors contributing to differential RNAi efficien

144 it difficult to generalize responses of this major feature of biodiversity to future environmental ch

145 In this Review, we summarise the major findings concerning the patients' perspective of t

146 Two other major findings were that the MFC reward signals persist

147 Our results support two major first, young eels distinguish among magnetic field

148 ce that hypoxia causes economic impacts on a major fishery.

149 ispersion are discussed, which highlight the major flaws in parametrization of existing models.

150 and delayed development stages to infer the major forces shaping range edges and to predict their dy

151 regulatory elements are currently considered major forces that drive cell differentiation and genome

152 ghlights this part of the fossil record as a major frontier in understanding the evolutionary assembl

153 the 17 patients (88%) were alive and free of major functional disability, with minimal clinical sympt

154 A major gap in our understanding of biodiversity-ecosystem

155 h cluster, and generated a model GRN for the major gene batteries in heart morphogenesis.

156 Rhg4 is a major genetic locus that contributes to soybean cyst nem

157 We defined two major genomic subtypes of primary stage Ta tumors.

158 natal mortality and morbidity continue to be major global health challenges strongly associated with

159 evolution of increased resistance has been a major goal of researchers of plant-herbivore interaction

160 l residue is entirely solvent-exposed in the major groove of the DNA.

161 between the other uridines, thus filling the major groove.

162 of plant feeding in the Crustacea, the other major group of arthropods that commonly consume plants,

163 Analyses described the incidence of major (>1000 copies/mL) and minor (50-1000 copies/mL) vi

164 out heart defects to that of 15 fetuses with major heart defects: transposition of the great arteries

165 India faced a major heat wave during the summer of 2015.

166 The Major Histocompatibility Complex (MHC) is a key componen

167 The mammalian Major Histocompatibility Complex (MHC) region contains s

168 stinct from interactions between the TCR and major histocompatibility complex (MHC).

169 iated immunity is the recognition of peptide-major histocompatibility complex class I (p-MHC I) prote

170 Major histocompatibility complex class I molecules (MHC

171 Ablation of endothelial cell class II major histocompatibility complex molecules by small inte

172 selected, including the parent forms and the major human metabolites of mephedrone, methadone, cocain

173 Streptococcus pneumoniae (pneumococcus) is a major human pathogen.

174 tion of ICP0 expression by miR-H2 has been a major hypothesis to help explain the repression of lytic

175 analysis of (68)Ga-PSMA-11 PET/CT implied a major impact on SRT planning in 52 of 270 patients (19%)

176 crossroad for APP and these secretases, with major implications for APP processing and amyloidogenesi

177 arbapenem resistance in Escherichia coli has major implications for the management of common infectio

178 omes, stratifying households by proximity to major industrial plants.

179 Location of pelvic tumor was the major inferior disease-specific prognostic factor in phy

180 As expected, groundwater upwelling had a major influence on nutrient spatial patterns.

181 -jarosite can increase Sb mobility and exert major influences on As partitioning and speciation.

182 in mammals that fully regenerates even after major injury.

183 Our results show that the major insect opsin class (SW) that typically confers sen

184 Aging is a major international concern that brings formidable socio

185 Since K(+), NO3(-), and NH4(+) are major ions taken up by plants, CIPK23 appears to occupy

186 tic lakes and show that the concentration of major ions, especially SO4(2-), has rapidly increased up

187 genomes (mitogenomes) are available from all major land plant lineages except ferns.

188 ent broad scale representations of change in major land use classes impact modelled future distributi

189 use photoreceptors and that RIM2alpha is the major large RIM isoform present at photoreceptor ribbon

190 reef environments (recruitment) represents a major life-history transition.

191 ating functional primary cholangiocytes is a major limitation in the study of biliary disorders and t

192 h due to soil compaction or soil drying is a major limitation to root growth and crop productivity.

193 Despite a major loss of H3K27me3, PRC2 activity is still detected

194 ide of human origin that binds hyaluronan, a major macromolecular component of the eye's vitreous, wi

195 These polysaccharides contained two major macromolecular populations; the high molecular wei

196 A major mechanism underlying the genetic diversification o

197 There are several major mechanisms that cause AF in patients, including a

198 This was tested using a major mitochondrial DNA (mtDNA) survey and sequencing of

199 d around the narrative of oil palm and other major monocrops as drivers of prosperity and development

200 Since glutamate is the major monovalent anion in E. coli, these results suggest

201 iological mechanism of a novel risk gene for major mood disorders involved in synaptic function and r

202 least 1 complication, and 26.9% experienced major morbidity (>/=grade III), mostly related to pulmon

203 In multivariable analyses, the odds of major morbidity/mortality were similar for early-career

204 e that Myo2p, not Myp2p, is likely to be the major motor driving actomyosin ring contractility.

205 rom nine sites at varying distances from two major municipal wastewater treatment plants (MWWTPs) (Wa

206 Strawberry is a major natural source of bioactive compounds.

207 ing the assembly process to be punctuated by major network reorganisations.

208 g months of inactivity, thereby supporting a major neuroscience hypothesis in a normal context for an

209 10 h in hypoxia, decreased blood flow to the major nodes of the default mode network became more pron

210 microbiota utilizes complex carbohydrates as major nutrients.

211 The major obstacle to studying this phenomenon in plants is

212 ins and are required for construction of all major organ systems during embryogenesis.

213 The major outcome of interest was CR-POPF occurrence, which

214 is gaining momentum; however, its impact on major outcomes, including pancreatic fistula, has yet to

215 The major outer sheath protein (MOSP) is a prominent constit

216 Microsamples collected on 27 major paintings by Old European Masters dating from the

217 veals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage.

218 Hyperglycemia is a major pathogenic factor that promotes diabetic nephropat

219 1 does not appear to act in any of the three major pathways known to mend DNA DSBs, namely homologous

220 A major peptide fragment was detected at m/z 1088 by a MAL

221 The major perturbed metabolic pathways included purine and p

222 The second major phase involves ecological shifts associated with e

223 The biochemical characterization of the L. major phosphatase revealed that the enzyme is redox sens

224 Phosphatidylethanolamine (PE) is a major phospholipid species with important roles in membr

225 six monophyletic clades corresponding to the major plant lineages.

226 These critics made six major points.

227 y, in addition to the cerebral motor cortex, major portions of CPC streamlines leave the prefrontal a

228 of pancreatic fistula development and other major postoperative outcomes.

229 ease-associated DNA methylation patterns has major potential to advance molecular diagnostics and und

230 We found that SRS is the major predictor of transcriptomic variation; a small num

231 cellular proapoptotic Bcl-2 and engages all major proapoptotic Bcl-2 proteins.

232 Easi-CRISPR solves the major problem of animal genome engineering, namely the i

233 se strategies may help to remedy some of the major problems in cancer targeting: heterogeneity, chang

234 we determined the kinetics and pathways for major products (ethylene and methane) and minor products

235 Polysialic acid (PSA) and its major protein carrier, the neural cell adhesion molecule

236 of the HIF-alpha network, we identified the major protein kinase C substrate MARCKS (myristoylated a

237 t Drosophila centrosomin (cnn) expresses two major protein variants: the centrosomal form (CnnC) and

238 We found that sensory neurons express major proteins necessary for GABA synthesis and release

239 genomic orientation, and common features of major proteins with human anelloviruses, and PCV2 DNA ma

240 (9)-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive component of cannabis, produced dose-

241 ith excess cardiovascular risk, represents a major public health burden.

242 ous cause of disability worldwide, remains a major public health challenge in the most severely affec

243 The emergence of Zika virus (ZIKV) as a major public health threat has focused research on under

244 The two major QTLs identified in undomesticated B. distachyon co

245 DC-SIGN is a major receptor for infection of both monocyte-derived de

246 These changes have driven major reductions in reef growth potential, which have de

247 gene editing technology to silence VEGFR2, a major regulator of angiogenesis, in retinal endothelium

248 rrelated positively with levels of miR156, a major regulator of VPC in plants, and corresponding chan

249 helix to engage in DNA binding, triggering a major reprogramming of gene expression that includes com

250 as a radiosensitizer were associated with a major response.

251 Antibiotic therapy is a major risk factor for the development of diarrhea and co

252 Inflammation is one of the major risk factors for cancer.

253 centile) for air toxics after adjustment for major risk factors.

254 We found xylem conduit dimensions play a major role in determining the susceptibility of the leaf

255 Genetic factors play a major role in the etiology of epilepsy disorders.

256 ricans, private insurance will likely play a major role.

257 indicated that secreted proteins may play a major role.

258 1 Sox genes as Sox2 and Sox19 appear to play major roles in neural development.

259 ate of 86% (95% CI, 83.0% to 88.7%), with no major safety signals.

260 lopment of exocrine glands, specifically the major salivary glands.

261 Identification of major salt tolerance genes and marker assisted selection

262 entia-free adults >/=70 years old undergoing major scheduled noncardiac surgery (N = 566; 24% deliriu

263 ic carbohydrate sequencing methods is both a major scientific challenge and a strategic priority.

264 rmination (TSD) in vertebrates has attracted major scientific interest.

265 e MRV nonstructural protein sigmaNS with the major SG effector protein G3BP1 and subsequent localizat

266 The intestinal epithelium is a major site for the conversion of dietary beta-carotene t

267 body, in particular the gut mucosa, are the major sites where immune cells traffic and reside.

268 oughout the brain and spinal cord and is the major source of central noradrenaline.

269 Impingement is a major source of dislocation and aseptic loosening in tot

270 Comorbidity patterns have become a major source of information to explore shared mechanisms

271 spino-parabrachial neurons, which serve as a major source of nociceptive transmission to the brain.

272 processes such as denitrification represent major sources of the potent greenhouse gas nitrous oxide

273 Overall, our findings have proved a major step forward to accurately modeling multisolute ad

274 examine the origin and adaptation of the two major strains of weedy rice found in the United States.

275 we investigated the causal influence of two major stress neuromodulators, cortisol and noradrenaline

276 In the modified houses, major structural problems such as leaking roofs were rep

277 This glycoprotein undergoes a major structural shift from the prefusion (pre-F) to the

278 The monophyly of the major subgroups of Copepoda, including Progymnoplea Lang

279 alize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs).

280 The guaianolides, a major subset of this group, have been intensely investig

281 d the expression of distinct variants of the major surface antigen of the blood stages known as Pf EM

282 , restricted-volume fluid administration for major surgery, there remains little consensus on optimal

283 ively induces mechanical hypersensitivity, a major symptom of neuropathic pain.

284 , we associated neuropathy with one of three major syndromic categories: (1) ataxia, (2) spasticity a

285 icotinic acetylcholine receptor (nAChR) is a major target of autoantibodies in myasthenia gravis (MG)

286 by luciferase reporter assays, spanning all major TE classes, and showed that 95.6% of tested TEs ca

287 te containing two 21-bp direct repeats and a major terminase cleavage site in the phage genome.

288 nthesis routes are categorized into the four major themes for colloidal capsule formation, i.e. the P

289 -of-flight, we were able to identify several major time-dependent phenotypic changes in blood immune

290 Additionally, radiation absorbed doses for major tissues of human were calculated based on the mous

291 Our data suggest that Top3beta is the major topoisomerase for mRNAs, and requires both RNA bin

292 ration and load in NT and CT systems via two major transport pathways: runoff and leaching.

293 It is not known if the other major types of pyramidal neurons in this layer also expr

294 In view of the major unmet need in this population and the importance o

295 There is a major unmet need to identify high-risk patients in myoca

296 c episodes (VEs) and factors associated with major VEs.

297 uitment of diverse host proteins that became major virion components.

298 SPD patients showed decreased FA in multiple major white matter fiber bundles, which connect the fron

299 tion of fractional anisotropy in the forceps major with number of fights (P = .03, d = 0.38) and year

300 ught can severely damage crops, resulting in major yield losses.