ライフサイエンスコーパス: major basic protein

1 to blockade of inhibitory M2Rs by eosinophil major basic protein.

2 antagonism of the M2 receptor by eosinophil major basic protein.

3 ed in these secondary granules (by mass) are major basic protein 1 (MBP-1) and eosinophil peroxidase

4 deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophi

5 not dependent upon eosinophil peroxidase or major basic protein 1 and did not correlate with activit

6 r RNase 2), eosinophil peroxidase (EPO), and major basic protein-1 (MBP1) intradermally into guinea p

7 ficient for the secondary granule component, major basic protein-1 (mMBP-1).

8 Major basic protein-1 activation of CBMC primed with fib

9 Major basic protein-1-induced CBMC activation is mediate

10 rived granule protein double knock-out mice (major basic protein-1/eosinophil peroxidase dual gene de

11 dditionally, the eosinophil granule proteins major basic protein and eosinophil peroxidase were more

12 ophilia was determined by immunostaining for major basic protein and flow cytometry for cell-surface

13 There was deposition of major basic protein and nitrotyrosine at the base of the

14 of peribronchial cells staining positive for major basic protein and TGF-beta.

15 ain cytoplasmic granules with immunoreactive major basic protein and they express surface Siglec F an

16 inic receptors from antagonism by eosinophil major basic protein, and this protective mechanism appea

17 ion of Epx (eosinophil peroxidase) and Prg2 (major basic protein) as well as lower interleukin 1beta

18 s, such as the eosinophil peroxidase and the major basic protein, but did not express basophil/mast c

19 ss surface Siglec F and transcripts encoding major basic protein, eosinophil peroxidase, and GATA-1,

20 robial host defense peptides, neuropeptides, major basic protein, eosinophil peroxidase, and many US

21 ing a marker for eosinophil precursor cells (major basic protein gene expression) suggest that the pe

22 of a cDNA with 64% identity to human prepro-major basic protein (hprepro-MBP).

23 We assessed eosinophil numbers by using anti-major basic protein immunostaining, goblet cell hyperpla

24 2 muscarinic receptor function by eosinophil major basic protein in antigen-challenged guinea pigs.

25 ntrations of cytokines and compounds such as major basic protein in BAL fluids, only the cellular ele

26 rized by impingement of eosinophilic rods of major basic protein into the muscle cell membrane.

27 s, such as eosinophil-derived neurotoxin and major basic protein, into the extracellular milieu and o

28 RNA silencing of EGO results in decreased major basic protein (MBP) and eosinophil derived neuroto

29 deficient in the eosinophil granule products major basic protein (MBP) and eosinophil peroxidase (EPO

30 s investigation, we find that the release of major basic protein (MBP) by eosinophils is a prominent

31 The cDNA for eosinophil granule major basic protein (MBP) encodes a prepromolecule with

32 Eosinophil major basic protein (MBP) is an effective stimulus for n

33 To test the hypothesis that eosinophil major basic protein (MBP) is an important regulator of f

34 Human eosinophil major basic protein (MBP) is strongly implicated as a me

35 re immunostained with either anti-eosinophil major basic protein (MBP) or with anti-neutrophil Ab.

36 s of eosinophil-derived neurotoxin (EDN) and major basic protein (MBP) were elevated in patients with

37 Among soluble mediators, eosinophil major basic protein (MBP), a hallmark of allergy, is par

38 the expression of eosinophil granule genes, major basic protein (MBP), and eosinophil peroxidase (EP

39 ted the in vitro effects of human eosinophil major basic protein (MBP), eosinophil cationic protein (

40 using antibodies directed against eosinophil major basic protein (MBP), however, revealed massive ext

41 Release of eosinophilic major basic protein (MBP), IL-4, and IL-5 to the periton

42 of a model eosinophil granulocyte gene, the major basic protein (MBP).

43 tors by the endogenous antagonist eosinophil major basic protein (MBP).

44 pendent stimulus, eosinophil-derived granule major basic protein (MBP).

45 cytotoxic proteins, including the eosinophil major basic protein (MBP-1).

46 ncentrations of eosinophil granule proteins (major basic protein [MBP] and eosinophil-derived neuroto

47 Human eosinophil granule major basic protein (MBP1) is an exceedingly basic (isoe

48 Additionally, IL-13, IL-10 and eosinophil major basic protein mRNA levels were greater in patients

49 Specific staining of the major basic protein of eosinophils showed peribronchiola

50 and their degranulation/activation products (major basic protein [p < 0.001, r = 0.7353] and eosinoph

51 ith rabbit antibody to guinea pig eosinophil major basic protein prevented hyperresponsiveness, and p

52 ogenous inhibitor, the proform of eosinophil major basic protein (proMBP), may also play a role in th

53 Major basic protein released from eosinophils to airway

54 tochemical staining for the granule protein, major basic protein, revealed that eosinophils accumulat

55 Major basic protein secretion from eosinophils parallele

56 d eosinophils (bmEos) express immunoreactive major basic protein, Siglec F, IL-5R alpha-chain, and tr

57 Major basic protein staining demonstrated eosinophil deg

58 ficantly reduced the number of peribronchial major basic protein(+)/TGF-beta(+) cells, suggesting tha

59 hil granule proteins (eosinophil peroxidase, major basic protein, the ribonucleases) together with ar

60 Extracellular major basic protein was present on the surface of airway

61 A rabbit antibody to guinea pig eosinophil major basic protein was used to determine whether M2 mus

62 Eosinophils and the eosinophil product major basic protein were absent from the skin of sham an

63 Immunohistochemistry analyses of CCL26 and major basic protein were done on bronchial biopsy specim

64 d nasal levels of IL-6, IL-5, and eosinophil major basic protein were observed in CRSwNP patients.

65 y nerves where, when activated, they release major basic protein, which binds to and blocks the M2Rs.

66 Activated eosinophils release major basic protein, which binds to M2 receptors and pre

67 Activated eosinophils release major basic protein, which blocks inhibitory M2 muscarin

68 receptor dysfunction is caused by eosinophil major basic protein, which is an allosteric antagonist a

69 of peribronchial cells staining positive for major basic protein, which was paralleled by a similar r