ライフサイエンスコーパス: major metabolite

1 g to give the biologically active 15-ol as a major metabolite.

2 -dependent manner, with (-)-OddCDP being the major metabolite.

3 taneously NTBPI, deferoxamine (DFO), and its major metabolite.

4 ive prodrug, and the O-aryl glucuronide is a major metabolite.

5 Ang III, and Ang IV, with Ang 1-7 being the major metabolite.

6 ma was analyzed for cyclophosphamide and its major metabolites.

7 cted by the transition temperatures of their major metabolites.

8 n (M1) and hydroxylation (M2) of GLB are the major metabolites.

9 ofloxacin (CIP) and desethylene-ENR were the major metabolites.

10 owed isogomphrenin III and gomphrenin III as major metabolites.

11 tant for removal of DFO (1.8 hour-1) and its major metabolite (0.6 hour-1).

12 662 residues+iron nonheme cofactor) and its major metabolite 12S-hydroxyeicosatetraenoic acid have b

13 The results suggest that the F(2)-IsoP major metabolite 15-F(2t)-IsoP-M may be a more sensitive

14 study examined the effects of 17-AAG and its major metabolite, 17-aminogeldanamycin (17-AG), on Chk1

15 s of an antidepressant, lamotrigine, and its major metabolite (2-N-glucuronide), in environmental wat

16 gonist 1, Ki = 2.7 nM, was studied and three major metabolites (2, 4, and 5) were found.

17 Of note, melatonin and its two major metabolites, 2-hydroxymelatonin and AFMK, were als

18 e-enkephalin (MENK) to PN and identified the major metabolite, 3-nitrotyrosine-methionine-sulfoxide (

19 ylglycolaldehyde, but not epinephrine or its major metabolite 4-hydroxy-3-methoxyphenylglycol, is a n

20 ed to serve as alternative precursors to the major metabolite, 4, of the cancer chemopreventive oltip

21 nd tobacco smoke, and glucuronidation of its major metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-

22 (1) the content of serotonin (5-HT) and its major metabolite 5-hydroxyindolacetic acid (5-HIAA), and

23 Compound 7-(R) and its major metabolites 5-(R) and 6-(R) were evaluated in seve

24 DG, 6-[18F]fluoro-L-m-tyrosine (FmT), or its major metabolite, 6-[18F]fluoro-3-hydroxyphenylacetic ac

25 tion in vivo resulting in the formation of a major metabolite, 6-oxo-M1dG.

26 The major metabolites, 6(OH)M and AFMK, were produced in all

27 of the model compound, testosterone, to its major metabolite, 6beta-hydroxy testosterone was noted.

28 inflammatory drug methotrexate (MTX) and its major metabolite, 7-hydroxymethotrexate (7OH-MTX) in hum

29 tiomerization was, however, observed for the major metabolite, a phenoxybutanoic acid.

30 ltiple-exposure temporal mass balance, three major metabolites accounted for >60% of BT.

31 However, with elaidoyl-CoA as a substrate, a major metabolite accumulated in the mitochondrial matrix

32 chiral PCBs to generate meta-OH-PCBs as the major metabolites after 60 min incubations.

33 carbonyl-4-phenylpiperidine is formed as the major metabolite and is an agonist at the mu-opioid rece

34 led that mixed-onium thiazolidine 29 was the major metabolite and that plasma cholinesterases do not

35 pha-thujone neurotoxicity and identifies its major metabolites and their role in the poisoning proces

36 t, CBB5 metabolized caffeine to theobromine (major metabolite) and paraxanthine (minor metabolite).

37 e size of microbial metabolomes (hundreds of major metabolites) and allow the nature, organisation an

38 extraction (SFE) behavior of cocaine and its major metabolite benzoylecgonine (BZE) was investigated

39 onsistent with production of 17alpha-hydroxy major metabolites, but functional and structural evidenc

40 and samples were assayed for monoamines and major metabolites by high-pressure liquid chromatography

41 ed for levels of NE, DA and 5-HT, as well as major metabolites, by high-pressure liquid chromatograph

42 Numerous molecules representing each of the major metabolite classes have been found that have a var

43 quantification of tryptophan and four of its major metabolites concurrently.

44 The major metabolites contributing to the discrimination wer

45 ynthetic building blocks associated with the major metabolite cyclomarin A, signifying that this mari

46 levels of maternal plasma sertraline and its major metabolite, desmethylsertraline, were 30.7 ng/ml a

47 Acteoside was the major metabolite detected from July to November while tr

48 iquid chromatography for doxorubicin and the major metabolite doxorubicinol.

49 ogenously provided DGLA was converted to one major metabolite during cell stimulation; this product m

50 simultaneous quantitation of cocaine and its major metabolites (ecgonine methyl ester, benzoylecgonin

51 -reactivity to TCC-related compounds and its major metabolites except for the closely related antimic

52 d 6-thioguanosine triphosphate ((S)GTP) is a major metabolite for these drugs.

53 ith an oxygen atom eliminated one of the two major metabolites for this lead molecule.

54 6,6'-Hexachlorobiphenyl-5-ol (5-136) was the major metabolite formed by microsomes from all other spe

55 Doxorubicinol (dxol) is the major metabolite formed in the hearts of cancer patients

56 5-oxo-eicosatrienoic acid (5-oxoETE), is the major metabolite formed within the murine peritoneal mac

57 analysis showed the presence of propranolol major metabolites formed by hydroxylation, correlating w

58 The major metabolites formed by P450 2B1 from the furanocoum

59 The diphosphate derivatives were the major metabolites formed in cells on both these agents,

60 a mucolytic agent, and the S-oxides are the major metabolites found in urine.

61 The three major metabolites generated by CYP3A4 were 1,23R,25(OH)(

62 For 135 strains, OP-1118, a major metabolite, had an MIC for inhibition of 50% of or

63 s of DHEA such as pregnenolone or six of its major metabolites, had no significant effect on prolifer

64 While AR pharmacokinetics and two major metabolites have been reported, the metabolic path

65 As a major metabolite in anaerobic bacterial growth, hydrogen

66 sponding carboxylic acid was identified as a major metabolite in blood.

67 may explain why 3beta-hydroxytibolone is the major metabolite in human target tissues and why 3alpha-

68 6,6'-Hexachlorobiphenyl-4-ol (4-136) was the major metabolite in incubations with HLMs and monkey and

69 Formate is a major metabolite in the anaerobic fermentation of glucos

70 chniques identified N-dealkylated FECNT as a major metabolite in the rat brain, and reverse-phase HPL

71 A major metabolite in these sensitive cell lines has been

72 ally reside in the aquatic environment and a major metabolite in this habitat is the chitinous exoske

73 We then quantitate catecholamines and their major metabolites in human brain, plasma, and urine.

74 ll glucuronidation rates of nicotine and its major metabolites in smokers.

75 study to report variability of all PCBs and major metabolites in two generations of people and sugge

76 onsistent study to evaluate all 209 PCBs and major metabolites in two generations of people living in

77 on legal and illegal psychoactive drugs, and major metabolites, in breast milk.

78 Major metabolites influenced by cropping period were alp

79 tructures of parent compound GLB and its two major metabolites M1 and M2 were identified in plasma us

80 The two major metabolites M7 and M9 were unambiguously verified

81 Our discovery that MDMA and a major metabolite, MDA, induce prolonged mitogenic respon

82 oids lutein and zeaxanthin, along with their major metabolites, meso-zeaxanthin, and 3'-oxolutein, ar

83 both cell lines, conversion of 4-HPR to its major metabolite, N-[4-methoxyphenyl]retinamide, as well

84 In contrast, its major metabolite, N-desmethylclozapine (NDMC), is though

85 This was confirmed by its major metabolite norfluoxetine whose load did not increa

86 mine's psychoactive effects, ketamine or its major metabolite norketamine could act intracellularly t

87 The major metabolite O-des-methylibogaine was 75-fold less a

88 omitant increase in the concentration of the major metabolite o-desmethylvenlafaxine during the same

89 sappeared from plasma and was converted to a major metabolite, O6-Benzyl-8-oxoguanine.

90 Desethylamiodarone, a major metabolite of amiodarone, also exerts voltage-inde

91 ethacin-sensitive fashion, and (c) PGE2, the major metabolite of arachidonic acid, stimulated cAMP fo

92 e-diagnosis levels of plasma salicylurate, a major metabolite of aspirin, in 396 pancreatic cancer ca

93 A major metabolite of BHA, tert-butylhydroquinone (tBHQ),

94 Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute

95 Prostaglandin E2 is a major metabolite of COX activation.

96 concentrations of thiocyanate (SCN(-) ), the major metabolite of cyanide, in the bodily fluids of kon

97 The major metabolite of dietary gammaT, 2,7,8-trimethyl-2-(b

98 4-Hydroxyequilenin (4-OHEN), a major metabolite of equilin and equilenin, promotes 4-OH

99 Acetaldehyde, a major metabolite of ethanol, reacts with dG residues in

100 ine F(2)-isoprostanes, and urine levels of a major metabolite of F(2)-isoprostanes were unchanged by

101 Alpha-methyldopamine (alpha-MeDA) is a major metabolite of MDA.

102 nd, could be observed for BE, cocaine, and a major metabolite of MDMA (i.e., 4-hydroxy-3-methoxymetha

103 yl-N2-formyl-5-methoxykynuramine (AMFK) is a major metabolite of melatonin in mammals.

104 n levels of 6-sulphatoxymelatonin (aMTS6), a major metabolite of melatonin.

105 The related compound cotinine, the major metabolite of nicotine in humans, also slows down

106 Cotinine is the major metabolite of nicotine, and measuring serum cotini

107 dy to apply the measurement of cotinine, the major metabolite of nicotine, as a quantitative method t

108 A major metabolite of norepinephrine (NE) in brain is 4-hy

109 reflects lipid peroxidation in vivo) and the major metabolite of PGE(2) (PGE-M).

110 hydroxyphenyl)-5-phenylhydantoin (HPPH), the major metabolite of phenytoin in man, and the prevalence

111 The major metabolite of progesterone, 3alpha-hydroxy-dihydro

112 assay using 3-phenoxybenzoic acid (3-PBA), a major metabolite of pyrethroid insecticides as a model s

113 This indicates monohydroxy-TBECH as the major metabolite of TBECH by in vitro HLM-based assay.

114 Terfenadine carboxylate, the major metabolite of terfenadine, does not block either H

115 ple who use tobacco products are cotinine, a major metabolite of the addictive constituent nicotine,

116 2,7-Diaminomitosene (2,7-DAM), the major metabolite of the antitumor antibiotic mitomycin C

117 An asymmetric synthesis of the major metabolite of the calcitonin gene-related peptide

118 r condors from exposure to DDE (p,p'-DDE), a major metabolite of the chlorinated pesticide DDT.

119 19-Norandrosterone (19-NA) is the major metabolite of the steroid nandrolone, one of the m

120 The major metabolites of 11C-choline were phosphocholine in

121 One of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3

122 Among the major metabolites of 4-HPR, 4-oxo-N-(4-hydroxyphenyl)ret

123 Major metabolites of 5-MeC were its proximate carcinogen

124 Major metabolites of 6-MeC were 6-MeC-1,2-diol, bay regi

125 im of the current study is to synthesize the major metabolites of [6]-shogaol and evaluate their inhi

126 The major metabolites of AA made by PMN, leukotriene B(4) an

127 These data indicate that all the major metabolites of APAP and multiple low-abundance met

128 indomethacin depressed urinary excretion of major metabolites of both TxA2, 2,3-dinor TxB2 (Tx-M), a

129 he NADPH and time-dependent formation of two major metabolites of D3 (i.e., 20-hydroxyvitamin D3 and

130 with human liver microsomes resulted in two major metabolites of each drug, which had HPLC retention

131 Herein we demonstrate that the major metabolites of ethanol in neural tissues, fatty ac

132 te and the urinary excretion of oxalate, the major metabolites of ethylene glycol, uniformly fell aft

133 r simulations of the population dynamics and major metabolites of microbial communities from the huma

134 ured cerebrospinal fluid (CSF) levels of the major metabolites of serotonin (5-hydroxyindoleacetic ac

135 Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediat

136 The major metabolites of tamoxifen (tam) formed by animal an

137 providing low cross-reactivity (<5%) to the major metabolites of TCS and to brominated diphenyl ethe

138 the zebra finch song system holds that both major metabolites of testosterone, dihydrotestosterone (

139 l (THC), cannabidiol and cannabinol, and two major metabolites of THC, 11-nor-9-carboxy-THC and 11-hy

140 yl or diaryl phosphates (DAPs), the expected major metabolites of the most prominent PFRs, and qualit

141 Two major metabolites of the tobacco-specific lung carcinoge

142 By doing so, we demonstrate that several major metabolites of these SCs retain their activity at

143 By doing so, we demonstrate that several major metabolites of these SCs retain their activity at

144 cts and associated mechanisms of iAs and its major metabolites on adipogenesis were determined in 3T3

145 The effect of FDX and its major metabolite, OP-1118, on C. difficile growth and sp

146 These findings indicate that gammaT and its major metabolite possess anti-inflammatory activity and

147 this work, sclerotiorin was obtained as the major metabolite produced in liquid fermentation by P. s

148 ,3,3',6,6'-hexachlorobiphenyl-5-ol being the major metabolite recovered from feces.

149 e (SFN-GSH) had little or no effect, the two major metabolites SFN-cysteine and SFN-N-acetylcysteine

150 e access to the absolute concentration of 14 major metabolites, showing significant differences betwe

151 Aspirin and its major metabolite sodium salicylate induced apoptosis and

152 of substantial plasma concentrations of the major metabolite, SU0020, for the entire treatment perio

153 ere measured as well as protein, starch, and major metabolites, such as hexoses, sucrose, organic aci

154 onolide AF is 231 times more potent than the major metabolite taccalonolide A and differs only by the

155 n polymorphonuclear leukocytes (PMNs) to two major metabolites that comigrated with synthetic 12(S)-

156 Two major metabolites, TLM K-1 and TLM K-2, together with th

157 in vivo evaluation of compound 1a showed its major metabolite to be a mu-opioid agonist, 4-methoxycar

158 -radiolabel associated with tamoxifen or its major metabolites was detected.

159 wed that urine levels of F(2)-IsoPs or their major metabolite were not significantly different betwee

160 The PK of the parent compound and major metabolites were apparently linear, with a half-li

161 trations of oblimersen (parent drug) and its major metabolites were variable.

162 ing the procarcinogenic 3,4-dihydrodiol as a major metabolite, whereas CYP1B1-null EF showed no signi

163 re conditions, spirohexenolide A (1) was the major metabolite with traces of spirohexenolide B (2) ar

164 een groups were detected in any of the other major metabolites within this region (P > 0.05 for all c

165 r simultaneous quantification of TRP and its major metabolites would be highly desirable, and may be