ライフサイエンスコーパス: major pathway

1 roduced in the biosphere is derived from two major pathways.

2 ese motifs involve cross-talk among multiple major pathways.

3 Among the major pathways activated by HER2/HER3 signaling, the PI3

4 Major pathways affected included those involved in metab

5 ut the key features in mutational landscape, major pathways, and tumor evolution and heterogeneity in

6 We found that 3 major pathways are abnormally activated by oncogenic H-r

7 For the benzylic radical ions, two major pathways are in competition, namely, depolymerizat

8 The major pathways are recursive: the dorsolateral pallium (

9 fied previously unrecognized AR functions in major pathways associated with clinical PCa progression.

10 with the promoters of genes involved in the major pathways associated with observed and well-studied

11 lated from measured concentrations for three major pathways: atmospheric processes, tributary runoff,

12 Whether there exist any major pathways beyond this canonical auditory neuraxis r

13 at EVI1 induces MDS in the mouse through two major pathways, both of which require the interaction of

14 ective transition-state stabilization of the major pathway by the thiourea catalyst in the rate- and

15 3rd issue of Molecular Cell indicates that a major pathway by which Akt suppresses cell death is by s

16 istant to restimulation-induced apoptosis, a major pathway by which autoimmune and chronically restim

17 nonhomologous DNA end-joining (NHEJ) is the major pathway by which DNA double-strand breaks are repa

18 e of T-cell extravasation into tissue is the major pathway by which efalizumab leads to improvement i

19 Vacuolar autophagy is a major pathway by which eukaryotic cells degrade macromol

20 Soil respiration (Rs) is a major pathway by which fixed carbon in the biosphere is

21 A major pathway by which hcrt/orx neurons are thought to p

22 al membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the

23 The major pathway by which the brain obtains essential omega

24 The MCU complex is the major pathway by which these signals are integrated in m

25 This reinforces the view that HR is the major pathway by which transforming DNA is integrated in

26 Previous work defined two major pathways by which normal transcripts are degraded

27 liary excretion of cholesterol represent two major pathways by which the body regulates cholesterol h

28 gdA mutant in X47, a strain deficient in the major pathway (cag pathogenicity island [PAI] encoded) f

29 se studies define the mechanism by which two major pathways can be simultaneously activated in metast

30 biosynthesis in plants proceeds through two major pathways compartmentalized in the chloroplast and

31 The model's three major pathways compute expected values of cues, timed pr

32 Two major pathways contribute to Ras-proximate-1-mediated in

33 This implicates reduced trophic support as a major pathway contributing to striatal degeneration in H

34 dentified 50 susceptibility regions, finding major pathways contributing to risk, with some loci shar

35 ation, and cell-cycle regulatory pathways as major pathways controlled by PEAK1.

36 sarum cells and that the che1 cluster is the major pathway controlling swimming bias and chemotaxis.

37 brane was generally thought to occur via two major pathways: cotranslational targeting by signal reco

38 ularly through the Notch effector HES5, is a major pathway critical for the onset and maintenance of

39 Therefore, the two major pathways delivering information to CA1 pyramidal n

40 Our findings identify EGFR signaling as a major pathway determining SG activity and suggest a func

41 Base excision repair (BER) is the major pathway employed to excise oxidized DNA lesions.

42 complement-and-coagulation cascades were the major pathways enhanced in DBD donors.

43 The major pathway for activation of copper/zinc SOD (CSD) in

44 ce and priming, and reveal that priming is a major pathway for adaptation during initial infection.

45 show that activation of the Pho regulon, the major pathway for adaptation to phosphate limitation, re

46 These data indicate that the major pathway for Ang-(1-7) generation in the intact hum

47 Thalamocortical (TC) projections provide the major pathway for ascending sensory information to the m

48 oltage-dependent anion channel (VDAC) is the major pathway for ATP, ADP, and other respiratory substr

49 A major pathway for B cell acquisition of lymph-borne part

50 suggesting endogenous photoinactivation is a major pathway for bacterial decay.

51 ctivated Ca(2+) (CRAC) channels constitute a major pathway for Ca(2+) influx and mediate many essenti

52 The major pathway for ceramide accumulation is via agonist-i

53 to MPO in vitro, suggesting that MPO is the major pathway for chlorination and nitration of HDL in h

54 y cytochrome P450 7A1 (CYP7A1) initiates the major pathway for cholesterol elimination in mammals.

55 cytochrome P450 46A1 (CYP46A1) initiates the major pathway for cholesterol removal from the brain.

56 Cotransporter Isoform-1 (NKCC1) provides the major pathway for Cl(-) accumulation in glioma cells.

57 Clathrin-mediated endocytosis (CME) is the major pathway for concentrative uptake of receptors and

58 Kinetically, Cr(III)-muscovite provides a major pathway for Cr(VI) formation and Cr(VI) production

59 Autophagy, a major pathway for degradation of macromolecules in the v

60 te-independent, 'direct entry' cleavage is a major pathway for degrading and processing RNA.

61 th a defect in non-homologous end joining, a major pathway for DNA double-strand break (DSB) repair,

62 homologous end-joining pathway, which is the major pathway for DNA double-strand break repair.

63 er, it is uncertain whether VRAC serves as a major pathway for EAA release from swollen cells.

64 The major pathway for elimination of cholesterol in mammals

65 te secretion of neutral sterols into bile, a major pathway for elimination of sterols.

66 Clathrin-mediated transport is a major pathway for endocytosis.

67 vers from PEPCK KO mice, indicating that the major pathway for entry of hyperpolarized [1-(13)C]pyruv

68 osine hydroxylase, identifying the TPOC as a major pathway for forebrain dopaminergic projections.

69 and how metabolite signals feed through to a major pathway for gut homeostasis.

70 A major pathway for HIV-1 resistance to nucleoside reverse

71 Food is a major pathway for human exposure to hazardous chemicals.

72 tofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in mur

73 get cell at the immunological synapse is the major pathway for inducing apoptosis of virus-infected c

74 and FcgammaRIV receptors on neutrophils is a major pathway for induction of anaphylaxis.

75 ults indicate that acyl editing of PC is the major pathway for initial incorporation of fatty acids i

76 crohomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologo

77 Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic

78 One major pathway for Listeria entry involves binding of the

79 der neutral conditions, protonolysis was the major pathway for metal-carbon cleavage, while under bas

80 CFTR provides a major pathway for mouse ocular surface Cl(-) secretion,

81 In yeast, the major pathway for mRNA decay is initiated by deadenylati

82 One major pathway for mRNA turnover occurs by deadenylation,

83 exchanger isoform 1) in dendrites presents a major pathway for Na(+) overload.

84 The major pathway for NTC recruitment occurs after U4 releas

85 The major pathway for O2 binding to mammalian myoglobins (Mb

86 Macroautophagy, a major pathway for organelle and protein turnover, has be

87 River discharge appeared to be the major pathway for PCBs into the Arctic Ocean with 115 +/

88 Base excision repair (BER) is the major pathway for processing of simple lesions in DNA, i

89 The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cell

90 A major pathway for protein degradation is initiated by th

91 The Sec machinery constitutes the major pathway for protein translocation in bacteria.

92 Clathrin-mediated endocytosis is the major pathway for recycling of granule membrane componen

93 er SGLT2 in the early proximal tubule is the major pathway for renal glucose reabsorption.

94 A major pathway for repair of DNA double-strand breaks is

95 Homologous recombination is a major pathway for repair of DNA double-strand breaks.

96 DNA nonhomologous end-joining (NHEJ) is the major pathway for repairing DNA double-strand breaks in

97 In higher organisms, a major pathway for repairing double stranded breaks in DN

98 Nucleotide excision repair is a major pathway for repairing UV light-induced DNA damage

99 show that polyamine oxidation is not only a major pathway for ROS production in prostate, but inhibi

100 e-sensitive Na-Cl cotransporter (NCC) is the major pathway for salt reabsorption in the mammalian dis

101 The ubiquitin-proteasome system is the major pathway for selective degradation of cellular prot

102 The ubiquitin-proteasome system is the major pathway for selective protein degradation in eukar

103 gs suggest that dormant origins constitute a major pathway for stalled fork recovery, contributing to

104 The results indicate that the major pathway for switch recombination occurs through ur

105 riven tension or actin dynamics regulate the major pathway for synaptic vesicle retrieval.

106 d by the Orai family of proteins represent a major pathway for the agonist-induced entry of calcium a

107 Autophagy is a major pathway for the clearance of harmful material from

108 drial fatty acid beta-oxidation (FAO) is the major pathway for the degradation of fatty acids and is

109 pendent anion channel (VDAC) constitutes the major pathway for the entry and exit of metabolites acro

110 Base excision repair is a major pathway for the removal of simple lesions in DNA i

111 Homologous recombination provides a major pathway for the repair of DNA double-strand breaks

112 n occur throughout the cell cycle and is the major pathway for the repair of double-strand breaks in

113 Homologous recombination (HR) is a major pathway for the repair of double-strand DNA breaks

114 NHEJ is the major pathway for the repair of double-strand DNA breaks

115 rly identical sequence composition, and is a major pathway for the repair of double-stranded DNA brea

116 Base excision repair is the major pathway for the repair of oxidative DNA damage in

117 Base excision repair (BER) is the major pathway for the repair of simple, non-bulky lesion

118 CT) catalyzes the rate-controlling step in a major pathway for the synthesis of phosphatidylethanolam

119 d store-operated calcium entry (SOCE) as the major pathway for this Ca(2+) influx.

120 The major pathway for this transformation is shown to be a L

121 cerol 3-phosphate dehydrogenase (mGPDH) is a major pathway for transfer of cytosolic reducing equival

122 Radical addition-elimination reactions are a major pathway for transformation of unsaturated hydrocar

123 othalamic (ST) system has been viewed as the major pathway for transmitting nociceptive and thermocep

124 Clathrin-mediated endocytosis is a major pathway for uptake of lipid and protein cargo at t

125 n-mediated endocytosis (CME) constitutes the major pathway for uptake of signaling receptors into euk

126 The major pathway for visual information reaching cerebral c

127 oascorbate degradation into erythrulose as a major pathway for vitamin C degradation in vivo.

128 Several major pathways for Abeta clearance include receptor-medi

129 Two major pathways for apoptosis have been identified, invol

130 trumental in disclosing the contributions of major pathways for central carbon and amino acid metabol

131 usal link between the UPS and autophagy, the major pathways for degradation of intracellular substrat

132 Cells use two major pathways for DSB repair: nonhomologous end joining

133 ubsequent degradation of Abeta is one of the major pathways for its clearance in the brain.

134 microvesicle shedding models constitute the major pathways for nonclassical IL-1 beta secretion from

135 teins and demonstrate cross-talk between two major pathways for nutrient control of gene expression i

136 ific recombination and transposition are the major pathways for rearranging genomes on both long- and

137 The two major pathways for repairing double-strand breaks (DSBs)

138 vents in eukaryotic cells, and there are two major pathways for repairing them: homologous recombinat

139 ommon in all living cells, and there are two major pathways for their repair.

140 h factor 1 receptor signaling cascade as two major pathways for therapeutic development.

141 There are two major pathways for this synthesis, the non-mevalonate pa

142 Arabidopsis by regulating the expression of major pathway genes in response to developmental and env

143 g strong evidence that the E7 channel is the major pathway (>/=90%) for ligand entry in human hemoglo

144 is at the transcriptional level, and several major pathways have been elucidated in recent years.

145 Two major pathways have been identified, One direct, in whic

146 trand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) an

147 ology (GO) and pathway analyses revealed the major pathways impacted in endophthalmitis includes: met

148 phate dehydrogenase (GAPDH), which activates major pathways implicated in diabetic complications, inc

149 In this review, we explore some of the major pathways implicated in HCC.

150 A major pathway in Arabidopsis thaliana generates IAA in t

151 The major pathway in mammalian cells dedicated to the repair

152 Base excision repair is the major pathway in mammalian cells responsible for correct

153 Nonhomologous end joining (NHEJ) is a major pathway in multicellular eukaryotes for repairing

154 f P. gingivalis on beta-catenin signaling, a major pathway in the control of cell proliferation and t

155 The kynurenine pathway is the major pathway in the metabolism of tryptophan.

156 ha-cleaved APP ectodomain (sAPPalpha) is the major pathway in the most cells.

157 Our results indicate that a major pathway in the target association process for the

158 thways revealed that ERK1/2 functions as the major pathway in TIMP-3 expression, whereas Akt plays a

159 These findings delineate major pathways in a large segment of the flavone metabol

160 The major pathways in melanoma signaling mediated through BR

161 There are two major pathways in oncogenic Ras-driven proliferation: MA

162 Major pathways in primary metabolism were identified, in

163 licate canonical Wnt signaling as one of the major pathways in the organization of the mammalian urog

164 The human genetic studies implicate some major pathways in the pathogenesis of IBD, including epi

165 Although the major pathways in turnover have been identified, account

166 d metabolism by signaling via at least three major pathways, including STATs, ERK1/2, and phosphatidy

167 The major pathways inhibited include formation of myeloperox

168 Transcription-coupled repair (TCR) is the major pathway involved in the removal of UV-induced phot

169 We hypothesized that PI3K and MAPK, the major pathways involved in insulin receptor signaling, m

170 endent endocytosis and macropinocytosis were major pathways involved in lipo-Tat uptake, and actin-fi

171 Additionally, apoptosis was one of the major pathways involved in splenic cell death, which coi

172 roxide production causes the activation of 5 major pathways involved in the pathogenesis of complicat

173 In animals this major pathway is located within the cytoplasm of cells,

174 3))(OAc)(2)(OH(2)) has been studied, and the major pathway is proposed to involve pre-equilibrium ace

175 The major pathway is the canonical ethylene signal transduct

176 nor anti-host cytotoxicity by way of the two major pathways is not a prerequisite for induction of Gv

177 programmed death ligand-1 (PD-L1) pathway, a major pathway known to control diabetes occurrence, coul

178 urs is, however, not understood, because the major pathway known to upregulate FT, the photoperiod pa

179 1 does not appear to act in any of the three major pathways known to mend DNA DSBs, namely homologous

180 Both of the major pathways lead directly to the formation of the met

181 t 5-endo-dig cyclization was found to be the major pathway leading to good yields of dehydropyrrolidi

182 llagen-induced GPVI-mediated pathway, is the major pathway leading to platelet activation after laser

183 s and gain in fat mass, in older adults is a major pathway leading to the onset of functional decline

184 We also found four major pathways leading to these docking poses after the

185 he canonical arm of the NF-kappaB pathway, a major pathway linked to the NSCLC tumorigenesis.

186 oltage-dependent anion channel (VDAC) is the major pathway mediating the transfer of metabolites and

187 tion is not the only and most likely not the major pathway mediating translational shutoff during SIN

188 Consistent with the literature, one of the major pathways mediating the antidepressant action of ke

189 module was observed, integrating all of the major pathways needed for lipid storage.

190 classical pathway had been assumed to be the major pathway of activation leading to injury, the manno

191 glycosylation, but not glycoxidation, as the major pathway of AGE formation.

192 e cellular response to replication stress, a major pathway of apoptosis induction by many chemotherap

193 i are the most abundant plant symbiont and a major pathway of carbon sequestration in soils.

194 Cytochrome P450 46A1 (CYP46A1) initiates the major pathway of cholesterol elimination from the brain

195 tion rather than oxidative metabolism as the major pathway of citrate formation.

196 tions with birnessite has been shown to be a major pathway of Cr(VI) production in serpentine soils.

197 cyclization of the heptadienone moiety as a major pathway of degradation.

198 enzyme, a protein machine essential for the major pathway of DNA break-repair and recombination.

199 Nonhomologous DNA end-joining (NHEJ) is a major pathway of DNA double-strand break (DSB) repair in

200 Nonhomologous end joining (NHEJ), a major pathway of DNA double-strand break (DSB) repair, i

201 A study has found that the major pathway of DNA repair is altered with age in the t

202 Non-homologous DNA end-joining (NHEJ) is a major pathway of double strand break (DSB) repair in hum

203 tions in Escherichia coli and constitute the major pathway of error-free DSB repair.

204 monium oxidation with nitrite (anammox) is a major pathway of fixed nitrogen removal in the anoxic zo

205 The major pathway of genetic recombination and DNA break rep

206 lex helicase and nuclease, essential for the major pathway of homologous recombination and DNA repair

207 7.5 microm GroEL to 100-250 microm HOCl, the major pathway of inactivation was through the oxidation

208 ated calcium (CRAC) channels constitutes the major pathway of intracellular Ca(2+) increase.

209 Autophagy is a major pathway of intracellular degradation mediated by f

210 elective lipid uptake (SLU) is known to be a major pathway of lipoprotein cholesterol metabolism in e

211 ein kinase B/Akt (PKB/Akt), a component of a major pathway of mammalian antiapoptotic signaling syste

212 x), an inner membrane Ca(2+) transporter and major pathway of mitochondrial Ca(2+) entry.

213 In yeast, a major pathway of mRNA decay begins with deadenylation fo

214 The major pathway of mRNA decay in yeast initiates with dead

215 phosphorylation of p150(Glued) might be one major pathway of NEBD regulation.

216 The ubiquitin-proteasome system is the major pathway of non-lysosomal intracellular protein deg

217 Atmospheric deposition is a major pathway of PCDD/Fs to the Baltic Sea.

218 eal a previously unrecognized TH-independent major pathway of peripheral dopamine synthesis in young,

219 ns-cinnamic acid, the committed step for the major pathway of Phe metabolism.

220 One major pathway of platelet activation is triggered by 2 r

221 ential protein SecA1, a key component of the major pathway of protein secretion across the cytoplasmi

222 '-to-3' translocase) that is involved in the major pathway of recombinational repair.

223 e ubiquitin-proteasome system represents the major pathway of selective intracellular protein degrada

224 2)(+)](SR) ( >600 mum) where sparks become a major pathway of SR Ca(2)(+) leak.

225 TNF blockade with infliximab can suppress a major pathway of the adaptive immune response and this o

226 One major pathway of this anthropogenic N input into ecosyst

227 We evaluated the major pathways of cholesterol regulation in the peroxiso

228 he cholesterol 24-hydroxylase initiating the major pathways of cholesterol removal from the brain, an

229 on of pathogens and altered self through two major pathways of complement activation.

230 ologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair i

231 ent developments in the understanding of the major pathways of extracellular vesicle biogenesis and h

232 We recently reported that one of the major pathways of neuronal apoptosis in PPT1-knockout (P

233 Both major pathways of protein degradation, the proteasome an

234 t shock factor 1 (HSF1) regulates one of the major pathways of protein quality control and is essenti

235 Three major pathways of proteolysis have been identified as be

236 operative involvement of each of these three major pathways of proteolysis within the cardiac sarcome

237 erstand the caveats of regeneration, so that major pathways of repair and regrowth can be exploited i

238 nzannulation, and oxy-Cope rearrangement are major pathways of transforming the putative sigma-alkylp

239 amplicons, as well as their cooperation with major pathways of tumorigenesis.

240 The cross-talk between the two major pathways-one mediated by cAMP and the other by EFA

241 ed by IL-4 is classically divisible into two major pathways: one mediated by STAT6, and the other by

242 hing pathways, either precedes P(i) release (major pathway) or occurs simultaneously with it (minor p

243 2,3-dihalopropanoates, debromination is the major pathway providing 3-phenylacrylate derivatives in

244 In the major pathway, Rec10 is loaded, together with Rec25 and

245 Wnt signaling is a major pathway regulating cell fate determination, cell p

246 of TGF-beta and that ShcA/ERK signaling is a major pathway regulating the tumor-promoting activity of

247 , we investigated the role of one of the two major pathways regulating innate immunity in invertebrat

248 dy shows that simultaneous inhibition of two major pathways regulating redox homeostasis using l-buth

249 at remineralization of organic matter is the major pathway releasing DFe throughout the water column

250 Isc pathway, but not the Suf pathway, is the major pathway required for conversion of O(2)-inactivate

251 al oxidative phosphorylation (OXPHOS) as the major pathway required for optimal proliferation in low

252 We propose this mechanism of activation as a major pathway responsible for the rapid activation of NK

253 ly(ADP-ribose) polymerase (PARP), two of the major pathways responsible for cellular responses to str

254 ATR-dependent cell cycle checkpoint are the major pathways responsible for repair of UV-induced DNA

255 BMP signaling is one of the major pathways responsible for the patterning of the Dro

256 There are the two major pathways responsible for the repair of DNA double-

257 ative 5' splice site selection is one of the major pathways resulting in mRNA diversification.

258 K activation has been shown to be one of the major pathways resulting in the activation of Nrf2 and i

259 Thus, while apoptosis is a major pathway that causes muscle weakness in OPMD, other

260 Thus, the need for a major pathway that controls integrin adhesion turnover d

261 BER is a major pathway that copes with DNA damage induced by seve

262 RNA-directed DNA methylation (RdDM) is the major pathway that initiates de novo DNA methylation in

263 idylcholine-dependent phospholipase C is the major pathway that leads to prolonged PKCalpha recruitme

264 A major pathway that mediates brain Abeta clearance is the

265 n pathway of homologous recombination is the major pathway that repairs topoisomerase II-induced DNA

266 Calmodulin (CaM) is the major pathway that transduces intracellular Ca2+ increas

267 A major pathway that was compromised, when TCR signaling w

268 l biological function and a critical role in major pathways that are closely linked to cancer.

269 In summary, we have identified two major pathways that control perineural and cortex glioge

270 We summarize the major pathways that govern the first cell fate decisions

271 3 posttranscriptionally regulates one of the major pathways that promotes chondrogenesis, the transfo

272 ulated kinases 1/2 (ERK1/2) pathways are two major pathways that regulate autophagy induced by nutrie

273 PK via two distinct mechanisms as follows: a major pathway (the APPL1/LKB1-dependent pathway) that pr

274 Cells undergo apoptosis through two major pathways, the extrinsic pathway (death receptor pa

275 s and the IkappaB kinase complex through two major pathways: the canonical and non-canonical NF-kappa

276 tabolite induces apoptosis by converging two major pathways: the death receptor-mediated extrinsic an

277 Although NPC1/NPC2 constitutes the major pathway, therapies that amplify minor egress route

278 es available or under development target the major pathways thought essential in the pathogenesis of

279 o mediate cellular Abeta uptake and define a major pathway through which Abeta gains entry to neurona

280 rendered dysfunctional, and that A-NHEJ is a major pathway to process dysfunctional telomeres.

281 Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs),

282 e significance of afferent vagal fibers as a major pathway to the brain, serving the purpose of maint

283 en chromosome homologs in somatic cells is a major pathway to the loss of heterozygosity (LOH), which

284 Recent studies suggest that one of the major pathways to the pathogenesis of autism is reduced

285 However, the impact of the other major pathway triggered by intracellular DNA, the absent

286 Lytic granule exocytosis is the major pathway used by CD8+ CTL to kill virally infected

287 tein kinase C, though activated, was not the major pathway used for bacterium-induced viral reactivat

288 Autophagy is a major pathway used to degrade long-lived proteins and or

289 The frequency of mutations within the 4 major pathways varied markedly across genetic subtypes.

290 adduct processing, equal involvement of two major pathways was established: one that requires functi

291 Three major pathways were identified among these proteins: the

292 Changes in three major pathways were involved in this transition to a mul

293 ongitudinal and medio-lateral axes, in which major pathways were local condensations.

294 ironmental or oncogenic stress constitutes a major pathway whereby p53 exerts its tumor suppressor fu

295 The first and major pathway, which involves 4-hydroxy-4-phosphoacyl-Co

296 at the top of a hierarchy that directs three major pathways, which are specified by CENP-C, -I, and A

297 We find three major pathways, which provide new insights into (un)bind

298 atively described by a mechanism involving a major pathway with a series of intermediate states and a

299 with hydrogen abstraction from C13 being the major pathway with unlabeled AA but abstraction from C10

300 ation of adult stem cells homeostasis by two major pathways with opposing functions to coordinate bet