ライフサイエンスコーパス: maladaptive

1 behaviors that would normally be considered maladaptive.

2 hemisphere engagement is ineffective or even maladaptive.

3 thway, but that this sustained activation is maladaptive.

4 abidopsis thaliana ERF-VII factor RAP2.12 is maladaptive.

5 y chronic adipose inflammation might lead to maladaptive adipose expansion and metabolically unhealth

6 Maladaptive aggression and violence are associated with

7 Maladaptive aggression and violence can lead to interper

8 Maladaptive aggressive behaviour is associated with a nu

9 type 1 receptor blockade may thus counteract maladaptive alterations in afferents to dopamine neurons

10 Repeated cocaine exposure causes persistent, maladaptive alterations in brain and behavior, and hope

11 n each behavior or phenotype is individually maladaptive, alternating between these losing strategies

12 tially evolved to benefit humans but are now maladaptive and increase the risk of disorders such as o

13 verride associative learning that has become maladaptive and offer a simple technique that could be s

14 sses is hypothesized to underlie many of the maladaptive and pathological behaviors observed in vario

15 dings, we suggest that tics are exaggerated, maladaptive, and persistent motor habits reinforced by a

16 role in the production of both adaptive and maladaptive anxiety.

17 Excess activation of this pathway can be maladaptive as in adulthood acute strong activation of M

18 However, avoidance responses can also be maladaptive, as in anxiety disorders such as phobias (e.

19 Evidence indicates that maladaptive autoimmune responses in the arterial wall pl

20 din-low tumor cells rely on SIK2 to restrain maladaptive autophagic activation.

21 , maintenance of high AcCoA levels inhibited maladaptive autophagy in a model of cardiac pressure ove

22 sponses, which can be targeted to ameliorate maladaptive avoidance in psychiatric disorders.

23 c stress disorder (PTSD) is characterized by maladaptive avoidance responses to stimuli or behaviors

24 s imbalanced activity (PFC < NAC) results in maladaptive behavior [1-6].

25 ion as a technique to prevent the relapse of maladaptive behavior and discuss novel approaches, infor

26 ical treatments, interventions to change the maladaptive behavior of addicted individuals mainly rely

27 he intimal layer, implicating T cells in the maladaptive behavior of vessel wall endogenous cells.

28 k cost effect, an interesting and well-known maladaptive behavior, is pervasive in real life, and thu

29 atial memory engram can alleviate associated maladaptive behavior.

30 with altered glutamatergic transmission and maladaptive behavior.

31 cial learning can also lead to mismatched or maladaptive behavior.

32 The neuronal mechanisms underlying such maladaptive behavioral changes, however, are poorly unde

33 interactions can lead to either adaptive or maladaptive behavioral outcomes.

34 tion that may contribute to the emergence of maladaptive behavioral responses in the face of adverse

35 evidence that mPFC dysfunction is linked to maladaptive behavioral responses to stress, and suggest

36 animal models of depression, in adaptive and maladaptive behavioral responses to stress.

37 echniques, which can be grouped according to maladaptive behaviors (pas-de-deux, "fighting," and with

38 viduals with anorexia nervosa (AN) engage in maladaptive behaviors (restrictive food choices and over

39 nmental approaches to prevent stress-induced maladaptive behaviors and synaptic malfunctions converge

40 ivity discovered to be causal in adaptive or maladaptive behaviors could become targets for treatment

41 lts explain how stressed individuals develop maladaptive behaviors through left cortical depression,

42 Maladaptive behaviors were more common in the surgical I

43 tary behavior in humans and is used to study maladaptive behaviors, such as overeating, drug taking,

44 ural networks and contribute to abnormal and maladaptive behaviors.

45 ntial therapeutic nodes for intervening with maladaptive behavioural states.

46 the neural circuitry underlying adaptive and maladaptive behaviours.

47 e estimation of independent contributions of maladaptive bias (mean departure from optimum) and impre

48 ) channel mediates pressure overload-induced maladaptive cardiac fibrosis by forming stably functiona

49 Loss of the K8/K18 network resulted in a maladaptive cardiac phenotype following transverse aorti

50 n of multiple pathogenic systems involved in maladaptive cardiac remodeling and contractile dysfuncti

51 disparate causes for dilated cardiomyopathy, maladaptive cardiac remodeling and decreased systolic fu

52 ifically regulates pressure overload-induced maladaptive cardiac remodeling in mice.

53 ly after MI impaired healing and exacerbated maladaptive cardiac remodeling.

54 tion is critical for determining why sterile maladaptive cardiovascular inflammation perpetuates.

55 h proteotoxic gain-of-function activation of maladaptive cell signaling pathways including cell death

56 Telomere attrition can lead to potentially maladaptive cellular changes, block cell division, and i

57 initiated by molecular defects that pattern maladaptive cellular mechanisms of pathological cardiac

58 zation of astrocytes represents an important maladaptive cellular response to cocaine and the mechani

59 Pathological mechanical stress can lead to maladaptive cellular responses and subsequent cartilage

60 adverse left ventricular (LV) remodeling, a maladaptive change associated with progressive heart fai

61 pt, and BNST PACAP signaling may mediate the maladaptive changes associated with chronic stress.

62 nized role for ghrelin and growth hormone in maladaptive changes following prolonged stress.

63 Weight gain in IS humans causes maladaptive changes in adipose cells, regional fat distr

64 chronic dysregulation of CRF systems induces maladaptive changes in amygdalar eCB signaling.

65 Maladaptive changes in chloride homeostasis due to a dec

66 ng these critical periods can yield enduring maladaptive changes in neural circuits that impair brain

67 Injury to the trigeminal nerves may cause maladaptive changes in synaptic connectivity that plays

68 e emerging picture is that diabetes leads to maladaptive changes in the cerebrovascular system that u

69 -dependent cognition have been attributed to maladaptive changes in the functional properties of pyra

70 data support the hypothesis that age-related maladaptive changes involving nAChRs within thalamocorti

71 the brain, chronic stress leads to long-term maladaptive changes that increase vulnerability to psych

72 setting of AF and appears to counteract the maladaptive changes that lead to intracellular Ca(2+) si

73 ivation in vivo prevented the stress-induced maladaptive changes to amydalo-cortical physiology and m

74 mechanisms whereby mitochondria may promote maladaptive changes within motor neurons, the neuromuscu

75 hat these salient cues may have in promoting maladaptive choice.

76 hol-dependent individuals make riskier, more maladaptive choices than nondependent individuals, even

77 These maladaptive choices were further shown to be unaffected

78 itories of the striatum and thereby underpin maladaptive cocaine-seeking habits.

79 Child maladaptive cognitions and parental anxiety did not medi

80 ncing chronic kidney disease, seems to reach maladaptive concentrations, and then induces left ventri

81 g the relationships between the adaptive and maladaptive consequences of the epigenetic modifications

82 e to stressful stimuli can result in several maladaptive consequences, including increased anxiety-li

83 n the VmPFC also predicted a higher level of maladaptive coping behaviors in real life, including bin

84 eover, they suggest that TMSR may counteract maladaptive cortical plasticity typically found after li

85 est that this aberrant learning results from maladaptive corticostriatal plasticity and learned motor

86 ining whether this fuel shift is adaptive or maladaptive could unveil new therapeutic strategies for

87 These findings raise the possibility that maladaptive decision making in psychopathic individuals

88 Yet, the circuit-level mechanisms underlying maladaptive decision making in psychopathy remain unclea

89 s linking valuation, affective deficits, and maladaptive decision making in psychopathy remain unclea

90 ortico-striatal circuit dysregulation drives maladaptive decision making in psychopathy, supporting t

91 Maladaptive decision making is associated with several n

92 models to provide insight into drug-induced maladaptive decision making that may ultimately identify

93 chanism by which salient cues can invigorate maladaptive decision making, an important and understudi

94 dependence and other disorders that involve maladaptive decision making.

95 gic- and stress-dependent sex differences to maladaptive decision making.

96 n dopamine network dynamics that may promote maladaptive decision-making after chronic adolescent alc

97 rlying circuitry involved in alcohol-induced maladaptive decision-making and identify a novel therape

98 Maladaptive decision-making is a common problem across m

99 Maladaptive decision-making is increasingly recognized t

100 ting from chronic alcohol use is persistent, maladaptive decision-making that is associated with ongo

101 show that adolescent alcohol use may produce maladaptive decision-making through a disruption in dopa

102 nd cognitive limitations which may result in maladaptive decisions.

103 Identification and management of maladaptive dietary strategies are important for long-te

104 In summary, tinnitus can be regarded as a maladaptive 'disconnection' syndrome, which tries to bot

105 Development of maladaptive drug-seeking habits occurs in conjunction wi

106 It is characterized by maladaptive drug-seeking habits that are maintained desp

107 Because of this, it is theorized that maladaptive eCB signaling may contribute to the developm

108 ore the potential physiological relevance of maladaptive eCB signaling to addiction vulnerability.

109 ultrasociality in humans may be mediated by maladaptive effects of modern civilization on family gro

110 ual speech does not exert previously assumed maladaptive effects on CI success, but instead provides

111 MPH serves to reduce maladaptive electrophysiological precursors of lapsing a

112 , we propose that - in addition to replacing maladaptive emotions - new emotions experienced in the t

113 ramatically decreased ERAD, while increasing maladaptive ER stress proteins and cell death.

114 functions to blunt excessive CHOP to prevent maladaptive ER stress-induced cell death and adverse car

115 The maladaptive expression and function of several stress-as

116 on against novel trajectories that result in maladaptive facial clefts.

117 mune modulation should be possible to temper maladaptive factors, enabling beneficial immune response

118 is system could contribute to disorders with maladaptive fear circuitry.

119 ison between normal/adaptive versus abnormal/maladaptive fear memory to identify biomarkers of PTSD w

120 is not proportional to the level of threat, maladaptive fear-related behaviors characteristic of anx

121 a seemingly self-propelling spiral that the maladaptive features of a disorder emerge.

122 these changes may be reversed or persist as maladaptive features, leading to axon degeneration.

123 ciprocal cross talk permits amplification of maladaptive feedforward inflammatory loops that contribu

124 merging hypothesis is that the transition to maladaptive feeding behavior seen in eating disorders or

125 ctivity exhibited resistance to Rho-mediated maladaptive fibrosis in pressure-overloaded mouse hearts

126 ment of chronic reward desensitization and a maladaptive focus on negative cognitions, as prevalent i

127 individuals with anorexia nervosa, who make maladaptive food choices to the point of starvation, eng

128 ortical changes in a way that may facilitate maladaptive food-seeking behaviors.

129 t has been suggested that visual language is maladaptive for hearing restoration with a cochlear impl

130 Addiction is thought to be a maladaptive form of learning and memory caused by drug-e

131 tection and neurodegeneration may convert to maladaptive functions as the disease progresses.

132 ann cell c-Jun is implicated in adaptive and maladaptive functions in peripheral nerves.

133 It has been challenging to target maladaptive generalized memories without affecting adapt

134 licated Grief-Revised for Children to assess maladaptive grief symptoms in the past 4 weeks.

135 thm differentiated functionally adaptive and maladaptive groups.

136 evel, groups were separated by problem type (maladaptive groups; internalizing vs. externalizing prob

137 These stimuli might otherwise promote maladaptive habit-based behavioral response strategies t

138 Environmental degradation can cause maladaptive habitat selection, inducing ecological traps

139 ive drug-seeking habits and relapse to these maladaptive habits.

140 ng the path between adaptive hypertrophy and maladaptive heart failure.

141 ng ANP propeptides (pro-ANP), a signature of maladaptive hypertrophy having counteractive functions.

142 including induction of cardiac fibrosis and maladaptive hypertrophy.

143 ial response to low cellular PO2, may become maladaptive if excessively elevated under chronic hypoxi

144 Allergic reactions can be considered as maladaptive IgE immune responses towards environmental a

145 If this association is causal, maladaptive immune activation due to an absence of stres

146 Maladaptive immunity and inflammation provoke changes in

147 ltiple roles in regulation of protective and maladaptive immunity.

148 tifies the AI as a novel neural substrate of maladaptive impulse control mechanisms that may facilita

149 not appropriately regulated they can also be maladaptive in a context-dependent manner.

150 is the mitochondria become dysfunctional and maladaptive in conjunction with reactive oxygen species

151 nfluence is normally adaptive, it can become maladaptive in disordered states, such as addiction.

152 lammatory effects, chronic expression may be maladaptive in mice.

153 elp cope with chronic stress but have become maladaptive in modern societies, worsening health.

154 ntages for infectious diseases, but that are maladaptive in modern-day environments.

155 free areas suggests that toxin resistance is maladaptive in the absence of selection.

156 l and reactivity which could be related to a maladaptive increase in the automated sensory change det

157 the pathway in triggering both adaptive and maladaptive inflammation in various clinically important

158 This reduction in maladaptive inflammation translated to increased insulin

159 aggravates tubular injury and exacerbates a maladaptive inflammatory response.

160 on after myocardial infarction are offset by maladaptive innate immune cell function, and therapeutic

161 (HF) is a complex syndrome associated with a maladaptive innate immune system response that leads to

162 In conclusion, obesity promotes a maladaptive ISR during asparaginase exposure.

163 and profibrotic signaling in the setting of maladaptive kidney repair.

164 These data indicate that maladaptive LA remodeling occurs early during HFpEF deve

165 ditions, the remodeling processes can become maladaptive, leading to altered physiological function a

166 Alcohol addiction is considered maladaptive learning and memory processes.

167 on can be conceptualized at a basic level as maladaptive learning and memory.

168 ped by learning models that frame anxiety as maladaptive learning.

169 ardiomyocyte p65 NF-kappaB deletion promoted maladaptive left ventricular hypertrophy and accelerated

170 oduce more but smaller offspring, which is a maladaptive life-history strategy.

171 iences when animals are awakened may produce maladaptive long-term memory, or may interrupt consolida

172 shold for emotional activation, leading to a maladaptive loss of emotional neutrality.

173 shold for emotional activation, leading to a maladaptive loss of emotional neutrality.

174 to which patients use their medications in a maladaptive manner will determine their susceptibility t

175 Smoking is a maladaptive mechanism for coping with pain that carries

176 hts for developing strategies in alleviating maladaptive memories accompanying anxiety disorders.

177 tential treatment approaches for attenuating maladaptive memories associated with emotional disorders

178 to prevent relapse through the disruption of maladaptive memories.

179 tion methods to target and potentially alter maladaptive memories.

180 apeutic strategies for selectively reversing maladaptive memories.

181 pture the consolidation, perhaps producing a maladaptive memory, or may interrupt the consolidation.

182 onse may initially be beneficial; however, a maladaptive microglial response eventually develops, fue

183 cord injury (SCI) involves poorly understood maladaptive modulation of neuronal excitability.

184 is intrinsically buffered against producing maladaptive morphologies, such as clefts of the primary

185 ng acute sickness but might also account for maladaptive, motivational changes that underpin the asso

186 sarcomeric proteins and is characterized by maladaptive myocardial hypertrophy, diastolic heart fail

187 Organ injury is the consequence of maladaptive neurohormonal activation, oxidative stress,

188 n fraction with the use of agents that block maladaptive neurohormonal pathways.

189 limiting food conditions thereby leading to maladaptive offspring production.

190 a functional state that could be considered maladaptive or "dysfunctional." This laryngeal dysfuncti

191 Youths with irritability also show maladaptive orienting to, interpreting, and labeling of

192 o regulate these behaviors increase risk for maladaptive outcomes including substance abuse.

193 lation impulsively and an increased risk for maladaptive outcomes, including substance abuse.

194 feeding in the absence of hunger and lead to maladaptive overeating behavior.

195 undervalued contribution of K(+) channels in maladaptive pain signaling.

196 adventitial cells, both of which resulted in maladaptive paracrine interactions between the vessel wa

197 sical, emotional, or sexual abuse, or severe maladaptive parenting (or both) between ages 8 weeks and

198 iance and is also important when coping with maladaptive patient attitudes.

199 Addiction is a maladaptive pattern of behavior following repeated use o

200 e impact of nature exposure on rumination, a maladaptive pattern of self-referential thought that is

201 ontextual factors in shaping adaptive versus maladaptive patterns of thought and behavior.SIGNIFICANC

202 sed on disrupting the reconsolidation of the maladaptive Pavlovian memories that can precipitate rela

203 at isolates the specific contribution of one maladaptive Pavlovian memory to relapse, the acquisition

204 itions require flexibility, helps to explain maladaptive performance that is not readily explained by

205 elevance, the neural circuitry governing the maladaptive persistence of anxiety remains unclear.

206 at compensation for CO2 leads to a seemingly maladaptive persistent base (HCO3(-)) loss that incurs a

207 Contemporary research has shown that maladaptive personality (when personality traits are ext

208 Tinnitus-related maladaptive plastic changes of MGB-related neuronal netw

209 , single-target-drugs can be circumvented by maladaptive plasticity in any one of several ion channel

210 of addiction, is hypothesized to arise from maladaptive plasticity in the mesolimbic dopamine pathwa

211 wing popularity, the evidence to support the maladaptive plasticity theory is largely based on correl

212 aps the most striking example of this is the maladaptive plasticity theory, according to which phanto

213 applications of microstimulation to correct maladaptive plasticity underlying dysfunctional decision

214 ral sensitization associated to nociception (maladaptive plasticity) and plasticity related to the se

215 t nervous system contributes to adaptive and maladaptive plasticity, and dysfunction of this process

216 Alternatively, climate change could induce maladaptive plasticity, reducing fitness, and potentiall

217 hypothesize tinnitus to be a consequence of maladaptive plasticity-induced disturbance of excitation

218 brain function and prevent trauma-associated maladaptive plasticity.

219 k but also diminished the frequency of these maladaptive pretarget increases through a reduction of a

220 f HPA activation, play roles in adaptive and maladaptive processes by targeting cognate receptors thr

221 n atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI).

222 iew, we discuss both the neural adaptive and maladaptive processes in response to hypoxaemia.

223 ptors on which opioids act to initiate these maladaptive processes remain disputed, which has prevent

224 Maladaptive processing of the DNA damage by DNA repair e

225 onstrated to be locally adapted, but locally maladaptive quantitative trait loci were also found, sug

226 ifferences in the underlying neurobiology of maladaptive reactive aggression in youths with DBD who h

227 defiant disorder) have an elevated risk for maladaptive reactive aggression.

228 ncrease of decision bound in anticipation of maladaptive reductions in sensitivity to incoming eviden

229 Importantly, Ser571 is required for maladaptive remodeling and arrhythmias in response to pr

230 a mechanistic role in the development of the maladaptive remodeling and myocardial fibrotic response

231 cally encodes signals to induce ROS-mediated maladaptive remodeling and offers new therapeutic possib

232 ng the processes that initiate transition to maladaptive remodeling are of major clinical interest.

233 Maladaptive remodeling of ECM networks has been reported

234 siological adaptation to mechanical load and maladaptive remodeling of the heart.

235 controversial theory is that it results from maladaptive reorganization of the sensorimotor cortex, s

236 Maladaptive repair after AKI may lead to progressive fib

237 ponse can restore homeostasis, a consecutive maladaptive repair and persistent inflammation represent

238 romised cells persist, then they may lead to maladaptive repair and proinflammatory changes, thereby

239 ial fibrosis provides strong support for the maladaptive repair hypothesis in the AKI to CKD transiti

240 Maladaptive repair mechanisms that persist following the

241 nt 1A during kidney injury promotes fibrotic maladaptive repair.

242 The maladaptive reproduction suppression seen in HL group su

243 Maladaptive response control is a feature of many neurop

244 associated with T cell aging culminates in a maladaptive response that directly contributes to chroni

245 tivation or the reflection of a long-lasting maladaptive response to an in utero immune-related insul

246 This maladaptive response to climate change was more prevalen

247 cells to propose the development of ORG as a maladaptive response to hyperfiltration and albuminuria.

248 ggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration

249 s and thus, in this context, is considered a maladaptive response.

250 1 upregulation in the failing heart may be a maladaptive response.

251 ge to maintain contractile function from the maladaptive responses associated with disease.

252 pathways are also apparently involved in the maladaptive responses observed after repeated injury.

253 es associated with striatal paths, including maladaptive responses such as drug seeking, social withd

254 serve as critical mediators of adaptive and maladaptive responses through their effects on gene expr

255 d to set goals, plan for the future, inhibit maladaptive responses, and change behavior flexibly.

256 ct on CeA stress- and nociception-associated maladaptive responses, which can be ameliorated upon rec

257 f-harm are particularly at risk of providing maladaptive responses, which we have termed dysregulatio

258 e speculate that these mechanisms may play a maladaptive role in human pathological conditions such a

259 may become upregulated, with an adaptive or maladaptive role, only at a later stage in case of occur

260 Consistent with this maladaptive role, the effects of DPP4 inhibition seem to

261 e across development or the clinical course; maladaptive rumination and poor executive control from d

262 At the molecular level, maladaptive RVH displays greater impairment of angiogene

263 Clinically, maladaptive RVH is characterized by increased N-terminal

264 The differentiation of adaptive versus maladaptive RVH is imprecise, but adaptive RVH is associ

265 In maladaptive RVH there is reduced inotrope responsiveness

266 retained RV function), while others develop maladaptive RVH, characterized by dilatation, fibrosis,

267 an provide neuroprotection or participate in maladaptive secondary injury reactions.

268 This is indicative of maladaptive sex behavior following Meth and sex experien

269 ata suggest that loss of dopamine triggers a maladaptive shift in the balance of synaptic excitation

270 e long-term goals and suppresses conflicting maladaptive short-lived urges to balance impulsivity, ex

271 ggers cardiac injury, and this initiation of maladaptive signaling can be blocked by pharmacological

272 ilated cardiomyopathy by not only preventing maladaptive signaling, but also improving cardiac functi

273 Maladaptive social behaviour accordingly was a major for

274 Maladaptive social behaviour accordingly was a major for

275 y prove useful in future clinical studies of maladaptive social cognition.

276 llnesses and may be caused and reinforced by maladaptive social cognition.

277 The factors that drive adaptive vs maladaptive social responses to stress are not yet clear

278 iety related circuit across its adaptive and maladaptive stages.

279 We show that down-regulation of this maladaptive stress response (MSR), through silencing of

280 er weaker selective pressure accumulate more maladaptive substitutions and are more prone to splicing

281 erative pathway and prevented FGFR1-mediated maladaptive subversion of angiocrine factors.

282 gments cardiac efficiency via attenuation of maladaptive sympathetic signaling in the setting of obes

283 These findings identify a maladaptive sympathetic-neuroendocrine adrenal reflex me

284 ubjected to stress, some individuals develop maladaptive symptoms whereas others retain normal behavi

285 nd abundant research describing drug-induced maladaptive synaptic plasticity, there are few effective

286 hermore, the original population exhibited a maladaptive syndrome including excessive ear and plant h

287 egies to reduce the microbial stimulation of maladaptive TH2 inflammation or to suppress the local el

288 horylation (oxphos), thereby contributing to maladaptive tissue remodeling that is associated with, a

289 It would be maladaptive to learn about catastrophes by trial and err

290 It is likely that stress-induced maladaptive transcriptional regulation in limbic neural

291 th in type 2 diabetes may not be caused by a maladaptive UPR but by the inhibition of the adaptive UP

292 on: Is beta-cell dysfunction the result of a maladaptive UPR or a failure of the UPR to adequately ad

293 cts of the entire secretory pathway, whereas maladaptive UPR outputs trigger apoptosis.

294 role of endothelial cell MR (ECMR) in these maladaptive vascular effects has not been explored.

295 berrantly high, contribute to lung fibrosis, maladaptive vascular remodeling, and allergic asthma.

296 t only in cardiac morphology but also in the maladaptive ventricular responses and extracellular chan

297 d in the proximal tubule after injury and is maladaptive when chronically expressed.

298 ges when elicited by tall trees, but are now maladaptive when elicited by wind turbines.

299 keeps away harmful events and can be highly maladaptive when individuals elude harmless situations i

300 Maladaptive wound healing responses to chronic tissue in