ライフサイエンスコーパス: male germ cell

1 but not the terminal differentiation, of the male germ cell.

2 exclusively expressed in the differentiating male germ cell.

3 rols the mitosis-meiosis transition in mouse male germ cells.

4 CKT2 plays a role in chromatin regulation of male germ cells.

5 ng events that lead to nuclear compaction of male germ cells.

6 as a decay-promoting factor for Pgk2 mRNA in male germ cells.

7 opment and function of neurons as well as of male germ cells.

8 -represented in somatic cells and in mitotic male germ cells.

9 survival and differentiation of the adjacent male germ cells.

10 e transition into meiosis in both female and male germ cells.

11 esin-13 is required for axoneme formation in male germ cells.

12 nuage and is required for differentiation of male germ cells.

13 ticity of adult somatic stem cells to become male germ cells.

14 tes required for terminal differentiation of male germ cells.

15 cle stoichiometry is tolerated in developing male germ cells.

16 ctivities and distribution during meiosis in male germ cells.

17 enescence, and apoptosis in both somatic and male germ cells.

18 me is dedicated to expression in postmeiotic male germ cells.

19 and transport of specific mRNAs in mammalian male germ cells.

20 their normal function, but is dispensable in male germ cells.

21 testis and increased apoptosis was noted in male germ cells.

22 mice, suggesting that Ovol2 is expressed in male germ cells.

23 ression is also developmentally regulated in male germ cells.

24 which are novel) that are expressed in only male germ cells.

25 ional regulation in lymphocytes, neurons and male germ cells.

26 ssibility that Camk4 has a novel function in male germ cells.

27 hange of basic nuclear proteins in mammalian male germ cells.

28 lpha gene and is transcriptionally active in male germ cells.

29 activity of Zfp127 in pre- and post-meiotic male germ cells.

30 nd all appear to be expressed exclusively in male germ cells.

31 a 108 kDa protein expressed specifically in male germ cells.

32 P colocalizes with actin in the cytoplasm of male germ cells.

33 mmals and is expressed only in the nuclei of male germ cells.

34 d Bmp8b are expressed in similar patterns in male germ cells.

35 (h-mtTFA) expression in somatic tissues and male germ cells.

36 esting that Esx1 expression is restricted to male germ cells.

37 n expressed in fetal, prepubertal, and adult male germ cells.

38 ls and low levels or an absence in different male germ cells.

39 volved in DNA recombination or DNA repair in male germ cells.

40 le mice, A-myb is expressed predominantly in male germ cells.

41 to activate mP2 transcription in postmeiotic male germ cells.

42 nded our analysis to meiotic and postmeiotic male germ cells.

43 H1 gain- or loss-of function specifically in male germ cells.

44 dinated proliferation and differentiation of male germ cells.

45 onal basal bodies, i.e., sensory neurons and male germ cells.

46 ation is essential epigenetic programming in male germ cells.

47 d spindle poles is severely reduced in Lis-1 male germ cells.

48 e sex chromosome-linked genes in postmeiotic male germ cells.

49 in turn control the developmental program of male germ cells.

50 ), in the normal terminal differentiation of male germ cells.

51 ngly, on a mixed genetic background, rescued male germ cells also generated fully developed teratomas

52 ressor is expressed transiently during mouse male germ cell and eye development.

53 nes are expressed exclusively in postmeiotic male germ cells and are crucial for the compaction of ch

54 lin-1 was indeed present in developing mouse male germ cells and both mouse and guinea pig spermatozo

55 e expression of specific mRNAs in developing male germ cells and brain cells, and is implicated in DN

56 trigger the female Sxl RNA splicing mode in male germ cells and can feminize triploid intersex (2X3A

57 e male germ line, we deleted this sirtuin in male germ cells and found that mutant mice had smaller t

58 hierarchy that drives mitotic transition in male germ cells and implicates gene repression pathways

59 eavage stimulation factor (CstF-64) in mouse male germ cells and in brain, a somatic M(r) 64,000 form

60 ates mRNA transport and translation in mouse male germ cells and is proposed to play a similar role i

61 ce of MAEL in these critical compartments of male germ cells and its interactions provide a link sugg

62 adients with high levels in undifferentiated male germ cells and low levels or an absence in differen

63 Despite its abundance in male germ cells and significant divergence in primary se

64 d process involving lineage determination of male germ cells and somatic cell types.

65 was localized in freshly isolated, purified male germ cells and somatic cells of mouse and rat teste

66 mine DNA methylation patterns differ between male germ cells and somatic cells, and elements of these

67 tricted its activity to nuclei of developing male germ cells and sperm.

68 piRNA-directed retrotransposon silencing in male germ cells and suggest that MOV10L1 functions as a

69 he Sertoli cell to support the maturation of male germ cells and the production of spermatozoa (sperm

70 Ovol1 in regulating pachytene progression of male germ cells, and identify Id2 as a Ovol1 target.

71 E) is a unique form of ACE, only produced by male germ cells, and results from a testis-specific prom

72 c segmentation, imaginal discs, blood cells, male germ cells, and sex determination.

73 show that L1 elements can retrotranspose in male germ cells, and that expression of a human L1 eleme

74 this, targeted disruption of Rhox5 increased male germ cell apoptosis and reduced sperm production, s

75 ollicles in vitro and in vivo and suppresses male germ cell apoptosis in vivo, thus demonstrating the

76 growth factor binding protein-3 (IGFBP-3) in male germ cell apoptosis.

77 lar, expression of several of these genes in male germ cells appears to be insensitive to sterols, co

78 all microtubule functions in the postmitotic male germ cells are carried out by a single tubulin hete

79 Developing male germ cells are exquisitely sensitive to environment

80 subcellular locations of TB-RBP and TRAX in male germ cells are modulated by the relative ratios of

81 ase (sAC), the predominant source of cAMP in male germ cells, are infertile, as the sperm are immotil

82 Male germ cells arrest mitotically, while female germ ce

83 ineage, identifying epigenetic signatures in male germ cells as possible substrates of transgeneratio

84 e presence of Nek2 protein was not unique to male germ cells, as it was found in meiotic pachytene st

85 drogen receptor activity using PSA and human male germ cell-associated kinase (hMAK), as read-outs in

86 , we have identified a protein kinase, human male germ cell-associated kinase (hMAK), which is transc

87 Male germ cell-associated kinase (MAK) and intestinal ce

88 tify a homozygous Alu insertion in exon 9 of male germ cell-associated kinase (MAK) as the cause of d

89 rtion (c.1297_8ins353, p.K433Rins31*) in the male germ cell-associated kinase (MAK) gene (39% of fami

90 Male germ cell-associated kinase (MAK), a direct transcr

91 MAK (male germ cell-associated protein kinase) and MRK/ICK (M

92 iotic genome scanning process that occurs in male germ cells at about the time of birth.

93 equired cell autonomously in differentiating male germ cells at or after the spermatocyte stage.

94 anner, and activates the JAK/STAT pathway in male germ cells at the time of gonad formation.

95 To determine if male germ cell base excision repair activity changes wit

96 nt, and is sufficient to activate aspects of male germ cell behaviour in female germ cells.

97 y equal intensity, but the innate feature of male germ cells being self-renewing while those of the f

98 uting approximately 0.7% of total protein in male germ cells, binds to a consensus promoter element,

99 genes, which are normally expressed only in male germ cells but are activated by ill-defined epigene

100 nscripts accumulate faster in female than in male germ cells but disappear later in embryogenesis (E1

101 sequence, a strong CGI, is hypomethylated in male germ cells but hypermethylated in somatic tissues,

102 tigens, which are normally expressed only in male germ cells but may be aberrantly expressed in melan

103 ion channel (CatSper2) that is expressed in male germ cells but not in other cells.

104 support some functional microtubules in the male germ cells, but alpha 85E causes dominant male ster

105 egulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has

106 fragment recognized a 1020-bp transcript in male germ cells by northern blot analysis and was used t

107 d to control CREM-dependent transcription in male germ cells by regulating the intracellular location

108 es the transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation.

109 A subset of male germ cell cancers presenting with advanced stage ab

110 To explore these FGF4 signals in male germ cell cancers, the multipotent human EC NTERA-2

111 anslational repression of Prm-1, we screened male germ cell cDNA expression libraries with the 3' unt

112 milarly, both our XY and our sex-reversed XX male germ cells clearly showed a male rather than a fema

113 These results suggest that in normal meiotic male germ cells, cyclin A1 participates in the regulatio

114 nes are normally expressed in BORIS-positive male germ cells deficient in CTCF and meCpG contents, bu

115 unofluorescence analysis of developing mouse male germ cells demonstrated partial co-localization wit

116 ex with Ack, and the localization of Dock in male germ cells depends on its SH2 domain.

117 mbination checkpoint is in fact activated in male germ cells despite the lack of apoptosis.

118 , piRNA populations are dynamic, shifting as male germ cells develop.

119 ntinue to corroborate that genes influencing male germ cell development and differentiation have emer

120 In this review, two major aspects of male germ cell development are discussed: underlying mec

121 nd has homologs required for both female and male germ cell development in other organisms; and BOULE

122 and somatic differentiation, but its role in male germ cell development is unknown.

123 s a number of genes specifically involved in male germ cell development, and deletion of the AZFc reg

124 usible genes encoding proteins important for male germ cell development, chromosomal segregation and

125 the core PRC2 subunits EED and SUZ12 during male germ cell development, we identified a requirement

126 es evade methylation more effectively during male germ cell development, whereas other subfamilies sh

127 on (SAGE) representing major stages in mouse male germ cell development, with 150,000 sequence tags i

128 ormone receptor-mediated gene activation and male germ cell development.

129 ired for embryonic development and regulates male germ cell development.

130 he gene product in the postmeiotic stages of male germ cell development.

131 a mutually exclusive manner with CTCF during male germ cell development.

132 in parental identity at the H19 locus during male germ cell development.

133 n patterns at the H19 locus during postnatal male germ cell development.

134 le for Gli and Gli3 during mitotic stages of male germ cell development.

135 me-regulated fetal-maternal interactions and male germ cell development.

136 kbp6, which has a critical function in mouse male germ cell development.

137 taining genes encoding proteins important in male germ cell development.

138 ation imposed by small noncoding RNAs during male germ cell development.

139 is predominantly expressed during embryonic male germ cell development; however, it is also expresse

140 X chromosome acquired this prominent role in male germ-cell development as it evolved from an ordinar

141 The beta-TrCP-deficient male germ cells did not enter meiosis, but instead under

142 nslation patterns of populations of genes as male germ cells differentiate and identifies groups of m

143 rmiogenesis, a process through which haploid male germ cells differentiate into spermatozoa, represen

144 lian spermiogenesis, a process where haploid male germ cells differentiate to become mature spermatoz

145 tion are synthesized early in the process of male germ cell differentiation and are stored in a repre

146 , and function of the Golgi apparatus during male germ cell differentiation is unknown.

147 During male germ cell differentiation, elevated expression of D

148 f NPAP60 protein changes dramatically during male germ cell differentiation, from nuclear pore comple

149 tion of key developmental transitions during male germ cell differentiation, including the switch fro

150 tions in the gene-selective transcription in male germ cell differentiation.

151 for regulation and execution of key steps in male germ cell differentiation.

152 t the transcriptional mechanisms that direct male germ cell differentiation.

153 rement for androgen receptor activity during male germ cell differentiation.

154 nction in the control of both blood cell and male germ cell differentiation.

155 lly related to nuclear reorganization during male germ cell differentiation.

156 lationally repressed for several days during male germ cell differentiation.

157 1) mRNA is repressed for several days during male germ cell differentiation.

158 thylation pathways play an essential role in male germ cell differentiation.

159 s-meiotic arrest complex, to transcripts for male germ cell differentiation.

160 Polyadenylation in male germ cells differs from that in somatic cells.

161 hich has been implicated in regulating human male germ cell division by prohibiting the degradation o

162 eckpoints that induce apoptosis; conversely, male germ cells do not undergo apoptosis.

163 rast, engagement of the Sxl feedback loop in male germ cells does not invariably disrupt spermatogene

164 Messenger RNA polyadenylation in male germ cells does not seem to require the AAUAAA poly

165 sgenic mice, ectopically expressing Figla in male germ cells, downregulated a subset of these genes a

166 Egr4 is expressed at low levels within male germ cells during meiosis and is critical for germ

167 new regulator of the epigenetic landscape of male germ cells during the period of global de novo meth

168 as hypothalamic-pituitary axis disorders and male germ cell dysfunction, 62.0% [95% CI, 59.5%-64.6%])

169 These male germ cell endo-siRNAs can potentially target hundre

170 nemal complex antigens demonstrated that -/- male germ cells enter meiosis but fail to progress beyon

171 YTHDC2-deficient male germ cells enter meiosis but have a mixed identity,

172 which female germ cells initiate meiosis and male germ cells enter mitotic arrest.

173 entified INSL6 as a novel CUL4B substrate in male germ cells, evidenced by its direct polyubiquinatio

174 elopment, Arf-null mice are blind, and their male germ cells exhibit defects in meiotic maturation an

175 In piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic

176 Differentiating male germ cells express a testis-specific form of cytoch

177 ponsive element)-like motifs directs correct male germ cell expression of the beta-galactosidase repo

178 In male germ cells, expression of Gm114 begins at 12.5-13.5

179 armi mutant male germ cells fail to silence Stellate, a gene regulat

180 ssociated RHAMM as an intrinsic regulator of male germ cell fate and as a gatekeeper preventing initi

181 rmathecal lineage also appear to promote the male germ cell fate since ablation of one sheath/spermat

182 hytene, oocyte meiotic maturation/ovulation, male germ cell fate specification, and a nonessential fu

183 sis, providing a lead compound targeting the male germ cell for contraception.

184 serves a critical function of preparing the male germ cells for fertilization.

185 importance of NOTCH signaling regulation in male germ cells for their survival and differentiation.

186 K4me3/H3K27me3 bivalent) epigenetic state in male germ cells from five mammalian and one avian specie

187 vation techniques were used, suggesting that male germ cells from other species can also be stored fo

188 pecifically, in both human somatic and mouse male germ cell genomes, histone Kcr marks either active

189 was only detected in meiotic and postmeiotic male germ cells, giving us the opportunity to examine Cs

190 ion factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the pla

191 Terminal differentiation of male germ cells in Drosophila and mammals requires exten

192 Male germ cells in mammals contain large amounts of a ge

193 a model of 2-step oligoclonal development of male germ cells in mice, the second step distinguishing

194 LH also promotes the survival of meiotic male germ cells in the testis.

195 Pathways enriched in male germ cells included ubiquitin-mediated pathways, pa

196 ed in pre-meiotic embryonic female and adult male germ cells, including cyclin D1 (Ccnd1) and stimula

197 Owing to their accessibility, however, male germ cells, including mature sperm, have material a

198 Using a biochemical enrichment of male germ cell intercellular bridges, we identified addi

199 rosophila TZ assembly in sensory neurons and male germ cells involves cooperative actions of Cby and

200 er of asun and that localization of LIS-1 in male germ cells is ASUN dependent.

201 t autoregulation of TRA-2(226) expression in male germ cells is necessary for normal spermatogenesis.

202 Da protein, which accumulates in postmeiotic male germ cells, is abundant in the nucleus.

203 wed that GFP is expressed in differentiating male germ cells, is enriched among BM-derived hematopoie

204 expressed in both Sertoli cells and diploid male germ cells, it has been unclear which of these cell

205 n revealed that cyclin A1 is present only in male germ cells just prior to or during the first, but n

206 Many mRNAs in male germ cells lack the canonical AAUAAA but are normal

207 ng number of genes expressed specifically by male germ cells late in development.

208 nstitution had a significant effect, with XX male germ cells less methylated than the XY controls.

209 HF1, in NIH 3T3 cells and cells of the mouse male germ cell line GC1spg results in global alteration

210 ication and transplantation techniques, this male germ cell line may be used to generate transgenic m

211 loid XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be

212 re allele was appropriately expressed in the male germ cell lineage.

213 in concert to direct differentiation of the male germ cell lineage.

214 In this study, metabolic changes in male germ cell lines (GC-2 and TM-4) were analyzed after

215 ne, we have defined culture conditions where male germ cells lose (on STO cells) or maintain (on MSC-

216 In male germ cells many mRNAs are sequestered by proteins i

217 Gene expression and processing during mouse male germ cell maturation (spermatogenesis) is highly sp

218 ogs required for terminal differentiation of male germ cells may activate target gene expression in p

219 , which is specifically expressed in haploid male germ cells, MBD3L2 expression is more widespread.

220 ealed an indispensable role for Cul4a during male germ cell meiosis.

221 ctivation of the heterologous XY bivalent in male germ cells (meiotic sex chromosome inactivation [MS

222 In response to telomere shortening, male germ cells mostly undergo apoptosis, whereas female

223 reductions in the mRNA levels of postmeiotic male germ cell mRNAs and smaller reductions of meiotic g

224 Polyadenylation of male germ cell mRNAs is unusual, exhibiting increased al

225 gh incidence of alternative 3'-processing in male germ cell mRNAs, including reduced usage of the can

226 ion changes in the vinclozolin-exposed fetal male germ cells (n = 3) to control samples (n = 3), thei

227 In the absence of Sxl, or in male germ cells, Nanos protein is continuously expressed

228 In developing male germ cells, newly synthesized protamine mRNAs are s

229 Conditional inactivation of beta-TrCP2 in male germ cells of beta-TrCP1 knockout mice resulted in

230 ard mechanism for the genetic information in male germ cells of mammals.

231 However, nuages in postnatal male germ cells of mice are poorly studied.

232 on of bivalent H3K4me3/H3K27me3 chromatin in male germ cells of six vertebrate species.

233 anslational delay in meiotic and postmeiotic male germ cells of the mouse.

234 In the mouse, Bmp8b is expressed in male germ cells of the testis and trophoblast cells of t

235 truct directed tissue-specific expression in male germ cells of transgenic mice.

236 scripts of type 1 hexokinase exist in murine male germ cells, only one form, HK1-sc, is found at the

237 ton-insoluble preparation, whereas in either male germ cells or when exogenously expressed in transfe

238 These observations demonstrated that male germ cells, particularly those with high thiamin tr

239 e is no contribution of somatic cells to the male germ cell pool during development or in adulthood.

240 spermatogonial stem cell divisions unique to male germ cell production are thought to contribute to a

241 or, BMP8B, is required for the resumption of male germ-cell proliferation in early puberty, and for g

242 he germ cell-specific start site and binds a male germ cell protein that we have termed TASS-1 (trans

243 We have therefore included some relevant male germ cell publications.

244 , mitotic kinesin-like protein 1 (MKLP1) and male germ cell Rac GTPase-activating protein (MgcRacGAP)

245 in new CENP-A loading caused by depletion of male germ cell Rac GTPase-activating protein (MgcRacGAP)

246 ic exit, and recruitment of Aurora B kinase, male germ cell Rac GTPase-activating protein, and RhoA t

247 vivo expression of beta4GalT-I in developing male germ cells requires an essential and previously und

248 The differentiation of mature sperm from male germ cells requires both chromatin remodeling and c

249 Inactivation of PRC1 in male germ cells results in the gradual loss of a stem ce

250 ule1 is necessary for meiotic progression of male germ cells, similar to the known function of boule

251 le2 is required for the maintenance of early male germ cells, similar to vertebrate Dazl To examine i

252 ductive defects of aux males were rescued by male germ cell-specific expression of aux, indicating th

253 The male germ cell-specific fatty acid-binding protein 9 (FA

254 function for an SREBP as a transactivator of male germ cell-specific gene expression.

255 ic dynein in many tissues, could result in a male germ cell-specific phenotype.

256 e-I (beta4GalT-I) gene is transcribed from a male germ cell-specific start site.

257 t how the switch to meiosis is controlled in male germ cells (spermatogonia) remains poorly understoo

258 lates on the heterochromatic Y chromosome in male germ cells, strongly suggesting that it controls th

259 urse cells in direct contact with developing male germ cells, suggesting that they regulate the expre

260 nterstitial cell population is important for male germ cell survival and testis cord formation.

261 n CTCF- and 5-methylcytosine-deficient adult male germ cells, switching DNA occupancy from CTCF to BO

262 During spermatogenesis, male germ cells temporally synthesize many proteins as t

263 ne gene; these are genes normally present in male germ cells (testis) that are also expressed in canc

264 ested prior to abscission in differentiating male germ cells that are interconnected by TEX14-positiv

265 as been recognized that somatic mutations in male germ cells that modify proliferation through dysreg

266 hat RNF17 is a component of a novel nuage in male germ cells--the RNF17 granule, which is an electron

267 t functions in the initiation and passage of male germ cells through meiosis.

268 uirement for cyclin A1 in the progression of male germ cells through the meiotic cell cycle.

269 esting that DND1 regulates mitotic arrest in male germ cells through translational regulation of cell

270 Bag of Marbles (Bam) protein is required for male germ cells to cease spermatogonial TA divisions and

271 tigate the loss of Dicer1 in mouse postnatal male germ cells to determine how disruptions in the miRN

272 nesis, and it functions cell autonomously in male germ cells to ensure spermatozoa motility, whereas

273 at the recombination checkpoint functions in male germ cells to promote repair of meiotic recombinati

274 ophila, eIF4G2, is required specifically for male germ cells to undergo meiotic division and proper s

275 tools for browsing, comparing and searching male germ cell transcriptome data at different stages wi

276 easures were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumu

277 Male germ cell tumors (GCTs) are uniquely sensitive to c

278 Adult male germ cell tumors (GCTs) arise by transformation of

279 Adult male germ cell tumors (GCTs) comprise distinct groups: s

280 29 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes.

281 Adult human male germ cell tumors (GCTs) provide a unique opportunit

282 t the 12q22 region is recurrently deleted in male germ cell tumors (GCTs), suggesting that this site

283 letion has previously been reported in human male germ cell tumors (GCTs).

284 open reading frame and is expressed in human male germ cell tumors.

285 om adopting practices developed for managing male germ cell tumours (GCTs).

286 While most Egr4 null male germ cells undergo apoptosis during early-mid pachy

287 Therefore, DMRT1 determines whether male germ cells undergo mitosis and spermatogonial diffe

288 Because the male germ cell undergoes many more cell divisions across

289 e of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.

290 ription factor that promotes the survival of male germ cells via its effects on cellular metabolism.

291 e stimulation factor (CstF-64) is altered in male germ cells, we examined its expression in mouse tes

292 In male germ cells, we observed a de novo methylation event

293 2 and TM-4, which are two different types of male germ cells were exposed to Silica NP for 24h, and t

294 s that in both mouse hippocampal neurons and male germ cells where the expression of FMRP and NXF2 is

295 ass of small RNAs that bind to MILI in mouse male germ cells, where they accumulate at the onset of m

296 d epigenetic features of closed chromatin in male germ cells, which suggests that CNVs may repress re

297 had seminiferous tubules and advanced stage male germ cells, while in females stage 1 oocytes were p

298 disruption of gene expression can result in male germ cells with a bias for gamete fusion.

299 genes and proteins were determined in mouse male germ cells, with a particular emphasis on prophase

300 tic Auger electron-emitting radionuclides by male germ cells within the testis is possible after intr