ライフサイエンスコーパス: male-specific

1 One recently evolved dimorphic trait is the male-specific abdominal pigmentation of Drosophila melan

2 In mice, we show that a male-specific activation of GnRH neurons occurs 0-2 h fo

3 at aromatase is also important in activating male-specific aggression and urine marking because these

4 ditional novel locus for BUA was seen in the male-specific analysis at DEFB103B (8p23.1) (P = 1.8 x 1

5 had P-values < 1 x 10(-6), of which two were male specific and four were female specific; all were an

6 We find that both the male-specific and embryo-specific exons exist in all Dro

7 In Diptera (Insecta), alternatively spliced male-specific and female-specific products of the double

8 Two male-specific and one female-specific isoforms of T. cas

9 Only four of these loci were male-specific and only one was polymorphic in our 97 mal

10 c synaptic inputs and conveying them to both male-specific and sex-shared circuitry.

11 The sex comb is a recently evolved, male-specific array of modified bristles derived from tr

12 Our results uncover a tiny population of male-specific aSP2 neurons that mediate a specific influ

13 It is intriguing that another significant male-specific association was also found between GCK CpG

14 psychiatric diagnoses, we found significant, male-specific associations between the Pro33 allele and

15 IRF1 locus is a strong candidate region for male-specific asthma susceptibility due to the associati

16 scarosides produced by hermaphrodites causes male-specific attraction.

17 We observe a male-specific axonal arbor in the lateral horn whose ela

18 In this issue, Lang et al. report use of the male-specific bacteriophage R17, a phage that binds conj

19 is circuitry is coordinated to generate this male-specific behavior, and sets the stage for a circuit

20 courtship circuitry capable of inducing this male-specific behavioral program.

21 itary bee species may reflect differences in male-specific behavioral traits and associated selection

22 on is sufficient for the performance of many male-specific behaviors [14], we have shown that without

23 function of neuronal circuits that underlie male-specific behaviors in Drosophila, including courtsh

24 that functional neuronal circuits underlying male-specific behaviours exist in the normal female mous

25 developing C. elegans larvae, including the male-specific blast cell, B, that divides asymmetrically

26 gain-of-function, allowing the production of male-specific call types without prohibiting the product

27 Here we show that the male-specific cell fusion and retraction that generate t

28 formation of the pigment cell precursors, a male-specific cell type in the embryonic gonad.

29 rons in both sexes; and later in a subset of male-specific cells that included an interneuron and eig

30 ed for the generation and differentiation of male-specific cells.

31 ther the underlying interactions require the male-specific cellular environment.

32 d for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons; the h

33 In male-specific CEM (cephalic sensilla, male) cilia, ccpp-

34 tations in ceh-30 cause the ectopic death of male-specific CEM neurons.

35 s: the AWA and AWC olfactory neurons and the male-specific CEM neurons.

36 courtship behavior was thought to arise from male-specific central neurons, our study shows that the

37 ciliated sensory neuron type K (ASK) and the male-specific cephalic companion neuron (CEM), are requi

38 rting on the association between female- and male-specific characteristics and stroke.

39 Male-specific characteristics increasing stroke risk inc

40 on occurs only in males and is mediated by a male-specific chromatin machinery that leads to global h

41 le for neuromodulators in the functioning of male-specific circuitry relating to behavioral choice.

42 rge from the collective dynamics of a single male-specific class of neurons, the cephalic sensory neu

43 that without Dsx(M), the determination of a male-specific CNS and thus a full complement of male beh

44 erve cord to cause activation of P1 neurons, male-specific command neurons that trigger courtship.

45 The male-specific connection between the TN1A neurons and th

46 ex-determinant candidate, OGI, that displays male-specific conservation among Diospyros species.

47 UITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calc

48 activate spermathecal secretion and repress male-specific courtship genes such as takeout.

49 technology to activate neurons that generate male-specific courtship song in flies.

50 control the command interneurons through the male-specific, decision-making interneuron PVY and its a

51 in males may have been accounted for by the male-specific decrease of inflammation in white adipose

52 PS-induced maternal immune activation caused male-specific deficits in certain social responses in th

53 Here we report male-specific deficits in striatal function important to

54 ell as in C. elegans body wall muscle and in male-specific diagonal muscles.

55 e to design genetic markers for studying the male-specific dispersal of this endangered species.

56 these neurons might be promoted in males by male-specific Dsx (Dsx(M)).

57 Activation of male-specific dsx/fru(+) P1 neurons in the brain initiat

58 Finally, we show that the male-specific early replication of the X chromosome is d

59 These results demonstrate a direct male-specific effect on the brain by a gene encoded only

60 tivation of a Y-located SRY gene could exert male-specific effects in development and physiology of m

61 Here we present male-specific effects of the mutant SOD1 transgene on pr

62 and a monogamous laboratory lineage revealed male-specific effects.

63 Dmrt1 exhibited early male-specific embryonic expression, preceding the onset

64 ignal of ancient balancing selection at the 'male-specific enhancer' of tan, with exceptionally high

65 conserved open reading frame starting in Sxl male-specific exon 3.

66 presented by between-family comparisons, the male-specific exon accumulated nonsynonymous substitutio

67 The homologous male-specific exon is also present in Scaptodrosophila l

68 lation of nonsynonymous substitutions in the male-specific exon occurred at a significantly greater t

69 The evolution of the male-specific exon of dsx thus shows a pattern reminisce

70 exes, the female-specific exons, and the and male-specific exon.

71 C. elegans mate searching is a male-specific exploratory behavior regulated by two comp

72 We determined gametogenesis stage- and male-specific expression and localization of Tdrd6, iden

73 The male-specific expression and splicing is part of a regul

74 Despite low homology between them, male-specific expression and X chromosome-specific bindi

75 tion of this protein, species difference and male-specific expression during the breeding season sugg

76 terility or in the frequencies of genes with male-specific expression in adults.

77 of the genes in Drosophila melanogaster show male-specific expression in adults.

78 PHF7 exhibits male-specific expression in early germ cells, germline s

79 PHF7 exhibits male-specific expression in early germ cells, germline s

80 d transmembrane protein, Sdmg1, owing to its male-specific expression in mouse embryonic gonads.

81 In addition, a homologue of dmd-1 exhibits male-specific expression in Schistosoma mansoni, a deriv

82 is review, recent work has demonstrated that male-specific expression of Fruitless transcription fact

83 Male-specific expression of Wnt2 within the somatic gona

84 We also show that Pde1c has a male-specific expression pattern in the CNS with an incr

85 ow that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sen

86 egments containing TRA-1-binding sites drive male-specific expression patterns, and RNAi depletion of

87 hronic regulatory genes, some of which drive male-specific expression, suggesting that TRA-1 imposes

88 96 +/- 0.04 day(-1)), but the decay rates of male-specific (F+) coliphages were not significantly dif

89 cating that both c-Kit signals and undefined male-specific factors are required for ILC2 function.

90 d Cox4, was also stimulated by caffeine in a male-specific fashion.

91 pre-Sertoli cells directs the gonad toward a male-specific fate.

92 tate (cis-vaccenyl acetate, cVA), a volatile male-specific fatty-acid-derived pheromone that regulate

93 me-to-needs: B, 27.741; P = .004), with some male-specific findings.

94 pathway is the recent acquisition in Mus of male-specific Fmo3 gene repression.

95 ease in the number of neurons that expressed male-specific forms of the fruitless protein in the late

96 ransgenic mice to convert naive T cells into male-specific Foxp3(+) regulatory T cells (Tregs) in WT

97 Male-specific Fru (Fru(M)) acts in foreleg GRNs to promo

98 sophila melanogaster males, when a subset of male-specific fruitless (fru)- and doublesex (dsx)-expre

99 Current models describe male-specific fruitless (fruM) as a genetic 'switch' reg

100 Male-specific fruitless (fruM) is a major component indu

101 The male-specific Fruitless proteins (FruM) act to establish

102 tes throughout prophase I, arguing against a male-specific function for this isoform.

103 sex chromosomes are enriched for genes with male-specific function such as testis genes.

104 moved onto the X chromosome while genes with male-specific functions moved off the X.

105 ensing ion channel ppk29 and was mediated by male-specific GABAergic neurons acting on the GABAA rece

106 eo-Y haplotypes that differ in structure and male-specific gene content.

107 , suppression of RA signaling did not rescue male-specific gene expression in Smad2-mutant testes, in

108 lopment directly or indirectly by repressing male-specific gene expression.

109 gnal that represents an epigenetic memory of male-specific gene expression.

110 but not Smad3, from XY PGCs led to a loss of male-specific gene expression.

111 ontrolled transcripts comprising female- and male-specific gene modules, with greater p38alpha depend

112 or graft survival as assessed by PCR for the male-specific gene.

113 Based on these results, we propose that male-specific genes are repressed in C. elegans hermaphr

114 ractions in maintaining proper expression of male-specific genes, either directly or via indirect eff

115 isingly, in addition to small RNAs targeting male-specific genes, we show that males also harbor an e

116 ion-repressor complexes in the repression of male-specific genes.

117 id (RA)-dependent meiotic entry and inducing male-specific genes.

118 Y sex chromosomes, based on the discovery of male-specific genetic markers in both species.

119 A recent discovery of male-specific genetic markers reveals that these snakes

120 First, we found evidence for a male-specific genotypic association (P = 0.00017) TBX1/G

121 icient mice were previously found to display male-specific germ cell loss and infertility.

122 2 knockout pigs phenocopy knockout mice with male specific germline ablation but other aspects of tes

123 ons in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior.

124 ecific function on POP-1 by recruiting it to male-specific gonadal target genes.

125 The geometric mean of males' specific gravity-adjusted urinary phenol concentr

126 e an important trigger in the development of male-specific hepatosteatosis and secondary tumorigenesi

127 In the male-specific HOB neuron, DAF-19(M) acts downstream of t

128 ugh they mount a T-cell response against the male-specific HY antigen.

129 Moreover, we reveal surprising male-specific impact of RNAi factors on germ cell develo

130 The hermaphrodite signal is conveyed by male-specific interneurons that are postsynaptic to the

131 The rate of male-specific inviable or sterile mutations is 5 x 10(-4

132 In Drosophila, the action of the male-specific isoform of fruitless in about 2000 neurons

133 c behaviours that are regulated by Fru(M), a male-specific isoform of the fruitless gene.

134 diverting the splicing of Tcdsx pre-mRNA to male-specific isoform.

135 Drosophila dsx encodes female- and male-specific isoforms (DSX(F) and DSX(M)), but little i

136 using females constitutively expressing the male-specific isoforms of fru (Fru(M)), we show a critic

137 They use the Male Specific Lethal (MSL) complex composed of noncoding

138 chromosome are coordinately regulated by the male specific lethal (MSL) complex to achieve dosage com

139 This is achieved by the male- specific lethal (MSL) complex, which modifies chro

140 In Drosophila, the male-specific lethal (MSL) complex binds to hundreds of

141 The male-specific lethal (MSL) complex contains at least fiv

142 In Drosophila, a male-specific lethal (MSL) complex of proteins and nonco

143 In Drosophila melanogaster males, the male-specific lethal (MSL) complex of proteins and two n

144 of Sxl and a failure of localization of the male-specific lethal (MSL) complex to the X chromosome,

145 es, compensation involves recruitment of the male-specific lethal (MSL) complex to X-linked genes and

146 anogaster males is achieved via targeting of male-specific lethal (MSL) complex to X-linked genes.

147 finity sites (HAS), landing platforms of the male-specific lethal (MSL) complex, are enriched around

148 chromosome dosage compensation requires the male-specific lethal (MSL) complex, which associates wit

149 The male-specific lethal (MSL) complex, which includes two n

150 hesis to explain this phenomenon is that the male-specific lethal (MSL) complex, which is present at

151 sage compensation in Drosophila requires the male-specific lethal (MSL) complex, which up-regulates g

152 ) are 100- to 1,500-bp elements that recruit male-specific lethal (MSL) complexes to the X chromosome

153 The Drosophila male-specific lethal (MSL) dosage compensation complex i

154 MOF is the catalytic subunit of the male-specific lethal (MSL) HAT complex, which plays a ke

155 Each RNA finger binds chromatin and the male-specific lethal (MSL) protein complex and can indiv

156 A complex composed of the male-specific lethal (MSL) proteins and RNA is recruited

157 The male-specific lethal (MSL) ribonucleoprotein complex is

158 In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex med

159 Depletion of MOF or male-specific lethal 1 (MSL1) in mouse ES cells causes a

160 siognomy, but also translationally represses male-specific lethal 2 (msl-2) to prevent dosage compens

161 s, including components of Wnt signaling and male-specific lethal 3 (msl3), regulate the development

162 ion, the CLAMP (chromatin-linked adaptor for male-specific lethal [MSL] proteins) zinc finger protein

163 The male-specific lethal complex mediates this process, but

164 with the binding sites of proteins from the male-specific lethal complex that affects dosage compens

165 MSL (Male-specific lethal) complex increases transcription on

166 nations of hypomorphic ocm alleles display a male specific lethality similar to mutations in the clas

167 n the abdominal ganglion through female- and male-specific Lgr3 enhancers.

168 ific lincRNAs in male liver, but not that of male-specific lincRNAs in female liver, was associated w

169 rosophila is 11-cis-vaccenyl acetate (VA), a male-specific lipid that mediates aggregation behavior.

170 Previously, we identified a panel of male-specific loci misexpressed in sterile male hybrids

171 significant linkage to total IgE on a novel male-specific locus on chromosome 20p12 (LOD=3.63 at 36

172 nce was assembled, revealing two clusters of male-specific low copy number genes, separated by an amp

173 , isolated from 16 of 17 UCB samples, showed male-specific lysis in vitro.

174 antennal lobe organization, although several male-specific macroglomeruli are present.

175 00 vs. approximately 130), of which four are male-specific macroglomeruli.

176 ion is regulated in both sex-nonspecific and male-specific manners.

177 for the Z chromosome of the Gouldian finch (male-specific map distance=131 cM), using 618 captive-br

178 identify the transcription factor MYBL1 as a male-specific master regulator of several crucial meioti

179 ductive maturity, which functions to promote male-specific mate-searching behavior.

180 ection in three mouse models: 1) mismatch of male-specific minor Ags, 2) mismatch of minor Ags distin

181 Ags, 2) mismatch of minor Ags distinct from male-specific minor Ags, and 3) skin transplant.

182 The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens th

183 are missense mutations in genes that produce male-specific minor histocompatibility (H-Y) antigens.

184 murine CD4(+) and CD8(+) T cell responses to male-specific minor histocompatibility (HY) Ags followin

185 stent with this, F(1) females do not express male-specific molecular germline markers.

186 e sex determination pathway is necessary for male-specific morphogenesis of sex comb bristles.

187 fic patterning of bristle precursor cells or male-specific morphogenesis of sexually monomorphic prec

188 the Drosophila sex comb, a recently evolved, male-specific morphological structure composed of modifi

189 ts counter to fruM in the development of the male-specific muscle of Lawrence.

190 We report the first estimates of male-specific mutational effects in an androdioecious or

191 First, when males are rare, selection on male-specific mutations is less efficient than in hermap

192 served role of fru in the specification of a male-specific nervous system.

193 soform diversity plays in the formation of a male-specific nervous system.

194 Here we identify a male-specific neural pathway that coordinates the timing

195 courtship behaviors and the establishment of male-specific neuronal architecture.

196 study describes a pair of newly discovered, male-specific neurons in C. elegans that control a sex-s

197 w that the drive to explore is stimulated by male-specific neurons in the tail, the ray neurons.

198 that dsx was required for the development of male-specific neurons that coexpressed fruitless (fru),

199 In sensory cilia of Caenorhabditis elegans male-specific neurons, the TRPPs LOV-1 and PKD-2 are req

200 cystic kidney disease genes are expressed in male-specific neurons.

201 enes, PKD1 and PKD2), which are expressed in male-specific neurons.

202 neurons are overtly dimorphic and identify a male-specific neuropil that integrates inputs from multi

203 Our data show that male-specific npf (ms-npf) expression is controlled by t

204 c viruses generally give better results than male-specific ones, and suggests that virus choice shoul

205 If a single decision is used, a male-specific or female-specific meiotic entry would lea

206 transcribed and that most are expressed in a male-specific or male-biased manner.

207 sex comb - a novel and rapidly diversifying male-specific organ.

208 cleus they are enriched in the dense body, a male-specific organelle associated with synapsis and the

209 l behavior by decreasing the activity of the male-specific P1 neurons that coexpress the sex determin

210 ion of target genes such as UTY (KDM6c), the male-specific paralog of UTX (KDM6a) We propose that an

211 and H2O2 stress adaptation and produces the male-specific paraquat (superoxide) stress adaptation.

212 In this study, we identified a male-specific pathway for courtship hearing via third-or

213 sponse to the opposite sex is conferred by a male-specific pathway that renders subordinate, sex-shar

214 Androgen receptor (AR) controls the male-specific pattern of Shh in pelvic fins by regulatio

215 this study, we implicate HP-I, an Aedes- and male-specific peptide transferred to females [7], and it

216 known about the mechanism that generates the male-specific perinatal testosterone surge.

217 n mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the so

218 The male-specific pheromone 11-cis-vaccenyl acetate (cVA) mo

219 d pC1 neurons physiologically respond to the male-specific pheromone cis-vaccenyl acetate (cVA), whil

220 e odorant receptor Or67d and responds to the male-specific pheromone cis-vaccenyl acetate (cVA).

221 We have expressed a male-specific, pheromone-sensitive odorant receptor (OR)

222 However, the influence of male-specific PHF7 on female reproductive biology via ma

223 Within the melanogaster species group, male-specific pigmentation has subsequently been lost by

224 daf-19m is expressed in male-specific PKD and core IL2 neurons via internal prom

225 portion of the neural circuitry in which the male-specific product of fruitless (fru) is produced, in

226 The male-specific product of the doublesex gene (dsx(M)) is

227 ential for this behavior is specified by the male-specific products of the fruitless (fru(M)) gene; m

228 Male-specific products of the fruitless (fru) gene contr

229 ereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributi

230 Furthermore, eliminating a large number of male-specific ray neuron targets only partially attenuat

231 evidence of historical exchange between the male-specific region of the human Y and the X in patchy

232 or inverted orientation--are abundant in the male-specific region of the human Y chromosome (MSY) and

233 The male-specific region of the mammalian Y chromosome (MSY)

234 We now report the sequence of the entire male-specific region of the Y (MSY).

235 The male-specific region of the Y chromosome (MSY) has been

236 A), but large-scale sequence analysis of the male-specific region of the Y Chromosome (MSY) has not y

237 of modern horses by screening 1.46 Mb of the male-specific region of the Y chromosome (MSY) in 52 hor

238 Here we finished sequencing of the male-specific region of the Y chromosome (MSY) in our cl

239 ently, the contributions of the genes on the male-specific region of the Y chromosome (MSY) in these

240 Knowledge of the nucleotide sequence of the male-specific region of the Y chromosome (MSY) makes it

241 ates the suppression of recombination at the male-specific region of the Y chromosome (MSY) mapped on

242 Here, we report that the male-specific region of the Y chromosome (MSY) spans app

243 omosomal rearrangements were detected in the male-specific region of the Y chromosome (MSY), includin

244 We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6

245 Here, we present the first MSY (male-specific region of the Y chromosome) sequences from

246 The human MSY (male-specific region of Y chromosome) retains only three

247 A Quick guide to Love Spots: striking male-specific regions of the eye found in some insects t

248 interneurons (LUA) to potentiate downstream male-specific reproduction circuits, allowing copulatory

249 As a male-specific risk factor, LOY might explain why males o

250 atic review and meta-analysis of female- and male-specific risk factors for stroke.

251 dmd-1 has a male-specific role in the maintenance and regeneration o

252 Thus, male-specific selection appears as a dominant force shap

253 Mate contact is sensed by male-specific sensilla of the tail, the rays, which subs

254 fically controls TRPP complex trafficking in male-specific sensory neurons and does so in a cell-auto

255 localizes to ciliated endings of C. elegans male-specific sensory neurons and mediates several aspec

256 kinesin-3 KLP-6 and the polycystin PKD-2 in male-specific sensory neurons in C. elegans.

257 We have studied how a set of male-specific sensory neurons in Caenorhabditis elegans

258 e control of genes involved in life span and male-specific sex determination in the fly.

259 In addition, signals corresponding to two male-specific sex pheromones were detected in the ejacul

260 s that bacteria can target components of the male-specific sex-determination pathway.

261 uppressed recombination, which surrounds the male-specific sex-determining gene, remains very small,

262 We demonstrate that in C. elegans, male-specific sexual attraction behavior is programmed i

263 l maturation if necessary to generate robust male-specific sexual attraction behavior.

264 ra dsRNA injected final instar larvae showed male-specific sexually dimorphic structures.

265 Male-specific short nucleotide sequences were used to de

266 Male-specific single-stranded RNA (FRNA) coliphages belo

267 GH infusion suppressed the vast majority of male-specific sites and induced a subset of female-speci

268 the pigment cell precursors, as well as the male-specific somatic gonadal precursors, is non-cell au

269 Isoform b represents the first report of male-specific splicing in C. elegans.

270 expressed throughout a male's life, controls male-specific splicing of the doublesex gene.

271 tive polymerase chain reaction (PCR) for the male-specific SRY gene was performed to validate the PET

272 primers for the SOD1(G93A) transgene or the male-specific Sry gene, and cultured as neurospheres.

273 d the gustducin alpha-subunit GNAT3 leads to male-specific sterility.

274 rimental evidence for vocal elaboration as a male-specific strategy to maintain social bonds with fem

275 o map out the early development of Area X, a male-specific striatal structure.

276 lopment, in the sex comb, a recently evolved male-specific structure found in some Drosophila species

277 wing birth and that this correlates with the male-specific surge of testosterone occurring up to 5 h

278 n/interneuron, integrating a large number of male-specific synaptic inputs and conveying them to both

279 emale (Tcdsxf1, Tcdsxf2 and Tcdsxf3) and one male-specific (Tcdsxm) isoforms.

280 We report the discovery of male-specific thoracic interneurons-the TN1A neurons-tha

281 ale tissues, neo-X genes highly expressed in male-specific tissues undergo increased rates of protein

282 i, particularly for genes with expression in male-specific tissues, but autosomal and X-linked genes

283 neo-Y genes evolve biased expression toward male-specific tissues--the shrinking gene content of the

284 We then performed genetic linkage mapping of male-specific traits important for reproductive isolatio

285 of evolutionary innovations are provided by male-specific traits involved in mating and sexual selec

286 hromosome promotes both the up-regulation of male-specific transcription and origin activation.

287 ophila melanogaster, fruitless (fru) encodes male-specific transcription factors (FRU(M); encoded by

288 We show that male-specific transcriptional regulator DSX(M) and the c

289 ion EXO70C2 allele resulted in a significant male-specific transmission defect (segregation 40%:51%:9

290 In vivo, disruption of RABA4D resulted in a male-specific transmission defect with mutant raba4d pol

291 Male-specific Treg clones against H-Y antigens DBY, UTY,

292 iprocal parental crosses reveal asymmetry in male-specific viability, female fertility, and backcross

293 antle of Mytilus edulis found transcripts of male-specific vitelline coat lysin (VCL) and female-spec

294 e show that 11-cis-vaccenyl acetate (cVA), a male-specific volatile pheromone, robustly promotes male

295 lopmental disorders, including mechanisms of male-specific vulnerability and female-specific resilien

296 s in a reduction of the male life span and a male-specific wing extension/twitching phenotype that oc

297 D. elegans possesses a male-specific wing melanin spot and a stereotypical wing

298 We identified a gene that induces male-specific wing size and shape differences between Na

299 We found that male-specific Wnt4 expression in mouse Mullerian duct me

300 icting our analysis to 8.97 Mb of the unique male-specific Y sequence, we identified 6662 high-confid