ライフサイエンスコーパス: maleimide

1 t was inaccessible to tetramethylrhodamine-6-maleimide.

2 nadine E was described from tryptamine-based maleimide.

3 ble thiol reagent methoxypolyethylene glycol maleimide.

4 l crotonate, dimethyl fumarate, styrene, and maleimide.

5 with a lipophilic substrate mimic, Bodipy FL maleimide.

6 ero-bifunctional cross-linker benzophenone-4-maleimide.

7 of an enantiomerically pure anthracene with maleimide.

8 has to adopt a tilted approach angle toward maleimide.

9 ith a 9-ethynylanthracene optical tag, and a maleimide.

10 eic anhydride and a C18-alkyl chain-modified maleimide.

11 e-reactive, membrane-impermeable reagent PEG-maleimide.

12 zed on the AFM substrate functionalized with maleimide.

13 classical photochemistry has been found for maleimides.

14 eneration of singlet oxygen from the excited maleimides.

15 oaddition of benzodiazafulvenium methides to maleimides.

16 omputationally with a range of N-substituted maleimides.

17 eled the resulting proteins with fluorophore-maleimides.

18 tituted cyclohexenones to N-(2-t-butylphenyl)maleimides.

19 ol-yne ''click'' reactions involving N-allyl maleimide (1) and N-propargyl maleimide (2).

20 group N-[2-(4-(18)F-fluorobenzamido) ethyl] maleimide ((18)F-FBEM) was conjugated to Ac-Cys-Z(EGFR:1

21 fts with N-[2-(4-(18)F-fluorobenzamido)ethyl]maleimide ((18)F-FBEM)-HER(2:342) Affibody.

22 FDG- or (18)F-4-fluorobenzamido-N-ethylamino-maleimide ((18)F-FBEM)-labeled leukocytes was performed

23 -specific N-2-(4-(18)F-fluorobenzamido)ethyl]maleimide ((18)F-FBEM)-Z(HER2:342) Affibody molecule and

24 olving N-allyl maleimide (1) and N-propargyl maleimide (2).

25 obenzoate (1) and TIPS-protected N-propargyl maleimide (2).

26 eutral pHs, especially the surface using the maleimide acceptor.

27 ne, thiol, thioester, ketone, hydroxylamine, maleimide, acrylate, azide, alkene, alkyne, aryl halide,

28 eater efficacy than thioether conjugation to maleimide activated KLH (mKLH).

29 The system was primarily tested on maleimide activated microtitre plates as a proof-of-conc

30 Conjugation of the PI3P hapten to maleimide-activated keyhole limpet hemocyanin (KLH) prov

31 d probes were anchored with good efficacy on maleimide-activated microplates (MAM) and gold electrode

32 prepare METH-conjugated vaccines (MCV) from maleimide-activated proteins.

33 These methods made use of maleimide-activated silica (the SMCC method) or iodoacet

34 HSA columns prepared using maleimide-activated silica gave the best overall results

35 lerated retro-Diels-Alder reactions of furan/maleimide adducts.

36 ive intermediates reacted with N-substituted maleimides affording new 1H-indazoles characterized by a

37 vely and quantitatively to the electron poor maleimide alkene of 1 and 2 under base (Et3N) initiated

38 including nitrobenzofurazan-based scaffolds, maleimides, alkylating agents, and electrophilic aldehyd

39 h toxin binding to the channel pore precedes maleimide alkylation of a nucleophilic amino acid.

40 Biotinylated maleimide also reacted rapidly with Cys141, implying tha

41 dified at the chain ends with either biotin, maleimide, aminooxy, or nitrilotriacetic acid.

42 rther demonstrated by preparation of a novel maleimide analog of 1B4M-DTPA from a key synthetic inter

43 Topology analysis of TM1 with biotin maleimide and 2-((5(6)-tetramethylrhodamine)carboxylamin

44 y distinct inhibitors of MGL [N-arachidonoyl maleimide and 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-y

45 alkylation with an impermeable conjugate of maleimide and a 5000 MW polyethylene glycol (MPEG), and

46 ell labeling with a membrane-permeant biotin maleimide and a membrane-impermeant 2-((5(6)-tetramethyl

47 comparison of the Diels-Alder reaction of a maleimide and an anthracene in water and the active site

48 oscopy, as well as labeling of the liberated maleimide and furan moieties with appropriate chromophor

49 rived microvesicles were labeled with BODIPY-maleimide and incubated with THP-1-derived macrophages.

50 pecifically labeled by tetramethyl-rhodamine-maleimide and showed significant changes in the emission

51 edia with Met(858) accessible to both biotin maleimide and TAMRA and Thr(926)-Ala(929) only to TAMRA

52 ing of cysteine residues by a lipophilic dye-maleimide and the blocking of Nile red efflux by covalen

53 and delivery of the model probe fluorescein-maleimide and the medicinal agent paclitaxel (PTX) into

54 Orthogonal maleimide and thiol deprotections were combined with thi

55 The activity is insensitive to both N-ethyl-maleimide and ubiquitin aldehyde, indicating that it lac

56 cts of blocking the thiol group with N-ethyl-maleimide and using carboxypeptidase-A to stabilize the

57 d unsymmetrical azobenzene derivatives, with maleimides and maleate esters.

58 The reaction between maleimides and resin-linked diene-polyamides allows the

59 lement a system with this topology using two maleimides and two nitrones of different sizes-either sh

60 n engineered Cys was reacted with undecagold-maleimide, and the labeled ELC was exchanged into myosin

61 nes were labeled with tetramethylrhodamine-6-maleimide, and voltage-dependent conformational changes

62 (methyl acrylate) (PMA) chains anchored by a maleimide-anthracene cycloadduct were synthesized to dem

63 These data demonstrate that N-aryl maleimides are a convenient and flexible platform to imp

64 Maleimides are often used to covalently attach drugs to

65 In case protected maleimides are used, maleimide deprotection and Diels-Al

66 using the thiol-ene addition of cysteine and maleimide as a stoppering protocol.

67 when alkenes are used is avoided by choosing maleimide as an alkene, which cannot undergo beta-hydrid

68 characterized the reactivity of an arsenical-maleimide (As-Mal) that can be efficiently conjugated to

69 e site-specific incorporation of N-(1-pyrene)maleimide at either T34C (PyN-CaM) or T110C (PyC-CaM) in

70 Following derivatization with N-(1-pyrene)maleimide at engineered sites (T34C and T110C) within th

71 at were covalently labeled with N-(1-pyrene) maleimide at introduced cysteines in the C- and N-domain

72 a second-generation photoswitch for LiGluR, maleimide-azobenzene-glutamate 0 with peak efficiency at

73 R6 using a family of photoiosomerizable MAG (maleimide-azobenzene-glutamate) PTLs that covalently att

74 treatment of mood disorders, SAR studies on maleimide-based compounds were undertaken.

75 sed efficacy, whereas the heterobifunctional maleimide-based conjugation yielded potent vaccine produ

76 development of second-generation cobalt- and maleimide-based liposomes that have improved in vitro st

77 veloped an analogue of compound 1 that lacks maleimide-based reactivity but retains RAD51 inhibitory

78 A 4-methylbenzothiazole linked maleimide-based single molecular bifunctional probe 1 ha

79 Maleimide-based, alkylating, and aldehydic thiol labelin

80 e dose of trastuzumab-Lx-AF outperformed its maleimide benchmark trastuzumab-Mal-AF and FDA-approved

81 of PKC or MAPK/ERK kinase (MEK) (bisindolyl maleimide (BIM) or U0126, respectively) blocked both PMA

82 s in DAT as probed by a membrane-impermeable maleimide-biotin conjugate.

83 labeled with both membrane permeant (biotin maleimide (BM)) and impermeant (2-((5(6)-tetramethylrhod

84 permeable, cysteine-specific chemical biotin maleimide (BM).

85 und to the MspA mutant MspAA96C via cysteine-maleimide bonds.

86 In all instances, the introduction of a maleimide bridge across positions 9 and 10 of the anthra

87 can insert into a disulfide bond, forming a maleimide bridge, and this is illustrated on the peptide

88 llows for subsequent substitution of the two maleimide bromides by the generated thiols.

89 ives that differ by the substituent on their maleimide C horizontal lineC bond.

90 ags or reporter enzymes as well as efficient maleimide chemistry for fluorophore coupling.

91 Ag-carrier protein conjugation system using maleimide chemistry was used to enhance the efficacy of

92 ached covalently to phospholipid anchors via maleimide chemistry, and served as receptors for the rec

93 (Herceptin) was achieved by efficient thiol-maleimide chemistry, thereby yielding immunoconjugate 2.

94 cessible N-terminal Cys residue to 20kDa PEG-maleimide (Co-hArgI-C(PEG-20K)); (ii) engineering of the

95 fication of cysteines by polyethylene glycol maleimide confirms the cytoplasmic location of the conse

96 were derivatized under a more stable N-ethyl maleimide conjugate.

97 an plasma and in mice than the corresponding maleimide conjugates.

98 ide group, consistent with the commonly-used maleimide conjugation chemistry, and the acceptor probe

99 ier protein linkage was cleavable only after maleimide conjugation.

100 odified phosphorothioate DNA and biotin- and maleimide-containing bifunctional linkers.

101 nstable in vivo because they are formed from maleimide-containing components conjugated to reactive t

102 thiol of cysteine is often used for coupling maleimide-containing linker-payloads to antibodies resul

103 rge and DNA loading capacity with increasing maleimide content.

104 Thiol-maleimide coupling and ADC stabilization via thiosuccini

105 ldehyde-containing cross-linkers using thiol-maleimide coupling at cysteine residues introduced into

106 Labeling was accomplished by maleimide coupling of NOTA to a unique cysteine residue

107 thiol deprotections were combined with thiol-maleimide coupling to synthesize discrete oligomers/macr

108 upling, copper-free click coupling and thiol-maleimide coupling were quantitatively controlled during

109 Derivatization of Cys78 with maleimide creates a solution mimic of the Lys-ligated cy

110 Fifteen substituted maleimide cycloadducts of anthracene derivatives were sy

111 In the case of maleimide-cysteine-based dimerization of proteins, we sh

112 acceptor 4-(dimethylamino)phenylazophenyl-4'-maleimide (DABM) attached to cysteine 374 of actin.

113 In case protected maleimides are used, maleimide deprotection and Diels-Alder cycloaddition can

114 from the cyclohexadiene intermediate to the maleimide derivative (therefore producing succinimides).

115 The same applies to a maleimide derivative carrying a BODIPY dye which was cho

116 -VS-NT were compared with the thiol-specific maleimide derivative N-[2-(4-(18)F-fluorobenzamido)ethyl

117 We prepared a series of fluorogenic coumarin maleimide derivatives that differ by the substituent on

118 ycloaddition reaction between anthracene and maleimide derivatives with high turnover.

119 es are commercially available in the form of maleimide-derivatives of fluorescent dyes and bioaffinit

120 bsRICs were constructed by reacting the maleimide-derivatized trastuzumab Fab fragments that bin

121 he cDbs were site-specifically conjugated to maleimide-desferrioxamine for (89)Zr radiolabeling and s

122 t Ruthenium(II) aminophenanthroline-viologen maleimide Diads (Ru-Diads) have been successfully bound

123 largely dependent on the substituent on the maleimide double bond but minimally affected by the subs

124 sines, whereas JVZ-007-cys was conjugated to maleimide-DTPA via the C-terminal cysteine.

125 We labeled filaments first with a green maleimide dye and then, following an additional period o

126 g an additional period of growth, with a red maleimide dye.

127 ious findings, and those of others, that the maleimide dyes are not affected by the presence of 2 M t

128 zed, the drug-linker is no longer subject to maleimide elimination reactions, preventing nonspecific

129 a self-assembled monolayer (SAM) containing maleimide end groups and oligo(ethylene glycol) spacer s

130 rand DNA (HS-ssDNA) covalently attached to a maleimide-ethylene glycol disulfide (MEG) monolayer on g

131 ed thiol-reactive linkers in plasma owing to maleimide exchange with reactive thiols in albumin, free

132 uccinimide ring hydrolysis and negatively by maleimide exchange with thiol-reactive constituents in p

133 Cysteine-linked ADCs prepared with N-aryl maleimides exhibited less than 20% deconjugation in both

134 the P2X7R using as readouts (i) the covalent maleimide fluorescence accessibility of the surface-boun

135 d fluorescence changes from the Alexa 546 C5 maleimide fluorophore attached to residues in the extrac

136 Using DyLight-maleimide fluors and a modified biotin switch method, we

137 Specifically, we conjugated fluorescein maleimide (FM) to two separate single cysteine-substitut

138 tion of surface loop residues by fluorescein maleimide (FM) was strongly temperature-dependent in viv

139 lic thiol-reactive fluorophore fluorescein-5-maleimide (FM) was studied in vivo in the presence of va

140 vable trigger in the linker and consist of a maleimide for cysteine antibody conjugation, a hydrophil

141 a fluorescent probe, tetramethylrhodamine-5-maleimide, for biophysical studies.

142 Here, we report that N-aryl maleimides form stable antibody conjugates under very mi

143 for tethering to peptides and proteins via a maleimide function have been prepared.

144 ntermediate enone required protection of the maleimide function through their Diels-Alder adducts wit

145 ee cysteine residues relative to established maleimide functional reagents.

146 work, the CNT-mer entails a N-hydroxyphenyl maleimide functionality to be utilized in the chain prop

147 rough either MaHA concentration (1-5wt.%) or maleimide functionalization (10-40%f).

148 uorous-phase immobilization and capture by a maleimide-functionalized affinity tag to selectively enr

149 d at 50- to 100-fold excess of the uncharged maleimide-functionalized BODIPY dyes over Cys.

150 ted by conjugating bovine serum albumin to a maleimide-functionalized derivative.

151 cis-(PEt(3))(2)Pt(II)(OTf)(2), and amine- or maleimide-functionalized isophthalate forms discrete hex

152 Here, using maleimide-functionalized lipid vesicles, we successfully

153 d alkyl substituents ("legs") was coupled to maleimide-functionalized molecular switches or motors un

154 bstrate and subsequently derivatized using a maleimide-functionalized oligomer of ethylene glycol.

155 pt for the quantification of PEG ligands for maleimide-functionalized PEG molecules and the determina

156 molecular weight (M(n)) or liberation of the maleimide, furan, or anthracene moieties was observed (i

157 equimolar amounts of thiol and N-substituted maleimides give complex mixtures of products.

158 glycol spacer for aqueous solubility, and a maleimide group for conjugation.

159 ar cycloaddition reactions with a stoppering maleimide group, forming rotaxane and thread, respective

160 orms of this toxin bearing cysteine-reactive maleimide groups are available through total synthesis a

161 Maleimide groups are used extensively in bioconjugation

162 es covalently immobilized to pendant surface maleimide groups are used to bind and successfully discr

163 The amino or maleimide groups decorating the isophthalate pillars of

164 n photochemistry that dictates reactivity of maleimide groups in two-photon mode.

165 5 kDa), thiolated and covalently attached to maleimide groups on lipid-coated microbubbles.

166 inase and a synthetic reagent containing two maleimide groups, for selective attachment to cysteines

167 m salts bearing terminal carboxylic acid and maleimide groups.

168 Maleimide has been used as a selective coupling partner

169 irected 1,4-addition of an ortho C-H bond to maleimides has been developed using Co(III) catalyst.

170 owever, ADCs formed with traditional N-alkyl maleimides have variable stability in the bloodstream le

171 1,2-a]indol-3-yl]-3-(1-methyl-1H-indo l-3-yl)maleimide, HCl, bisindolylmaleimide X, HCl), GRK2 [C-ter

172 DOTA or (125)I-iodo-((4-hydroxyphenyl)ethyl) maleimide (HPEM).

173 Maleimide Id-KLH conjugates eradicated A20 lymphoma from

174 Maleimide Id-KLH elicited tumor-specific IgG Abs and T c

175 Maleimide Id-KLH vaccines also demonstrated superior eff

176 heir sulfhydryl side chains with fluorescein maleimide in live cells.

177 9-hydroxymethylanthracene with N-substituted maleimide in the aqueous medium.

178 1,2-Addition of Grignard reagent to maleimide, internal activation of formed lactamol for in

179 ng the course of the catalyzed reaction, the maleimide is held in the hydrophobic pocket while the an

180 The approach angle of anthracene toward maleimide is twisted by 18 degrees in the TS structure o

181 eaction of polycyclic 1,2-dithiolethiones to maleimides is described.

182 Maleimide KLH conjugation was easily performed with huma

183 The biotin-N-maleimide-labeled oxidized and/or S-nitrosylated mitocho

184 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)-maleimide-labeled platelet microparticles.

185 teine-scanning mutagenesis and fluorescein-5-maleimide labeling we found that positions throughout th

186 Using western blots and fluorescein-5-maleimide labeling, we conclude that EtOH exposure modif

187 olicin B caused increased exposure to biotin maleimide labelling of all Cys substitutions, but to dif

188 de was conjugated to the MB by using a thiol-maleimide linkage.

189 the C-terminal sequence of minigastrin, the maleimide-linked compound DOTA-GSC(succinimidopropionyl-

190 In addition, Au102 was functionalized with a maleimide linker (Au102_C6MI) for maleimide-thiol conjug

191 ctive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugat

192 n this study to understand the impact of the maleimide linkers on ADC stability.

193 obenzoic acid)44 clusters, functionalized by maleimide linkers to target cysteines of viral capsid pr

194 of the Affibody molecule for the coupling of maleimide linkers, and 3 radiolabeling strategies were a

195 In particular, the maleimide liposomes captured HIV-1 Env trimers via a mor

196 te addition reactions used both acrylate and maleimide Michael acceptors.

197 polymerization of styrene with N-substituted maleimides (MIs), namely pentafluorophenyl 4-maleimidobe

198 g-term exposure to serum whereas the N-alkyl maleimide MMAE ADC lost potency over time.

199 oss and the heme loss of Hb are increased by maleimide modification at Cys-93(beta) and further decre

200 heme environment of Hb is attributed to the maleimide modification at Cys-93(beta) and not due to co

201 mine-sensitivity of thioesters and selective maleimide-modification of cysteines, termed acyl-PEG exc

202 te antigens, Globo-H, GM2, STn, TF and Tn-to maleimide-modified carrier protein KLH.

203 n tetrazole-oligonucleotide conjugates and a maleimide-modified dye worked quantitatively.

204 acilitates the site-specific attachment of a maleimide-modified gold nanoparticle to the enzyme, whic

205 Specifically, maleimide-modified HA (MaHA) macromers were crosslinked

206 repared by total synthesis and conjugated to maleimide-modified keyhole limpet hemocyanin (KLH) carri

207 pathway in [2+2] cycloaddition reactions of maleimide moieties.

208 The probe 1.Tb, possessing a maleimide moiety, as its sulfhydryl acceptor, was poorly

209 ls-Alder reaction between dithienylfuran and maleimide monomers to generate a photoresponsive diaryle

210 s prepared with the anticancer drug N-phenyl maleimide monomethyl-auristatin-E (MMAE) maintained high

211 The maleimide motif is widely used for the selective chemica

212 ed trypsin digestion and reactivity with PEG-maleimides (MPEG) to study Ca(2+)-induced conformational

213 rivative N-[2-(4-(18)F-fluorobenzamido)ethyl]maleimide-neurotensin ((18)F-FBEM-NT).

214 hey differ in the nature of the group on the maleimide nitrogen atom and of the substituents on the a

215 with a 4-(dimethylamino)phenyl group on the maleimide nitrogen atom undergo retro-cycloaddition upon

216 an orthogonally protected thiol, a protected maleimide, or an alkyne.

217 or the coupling of 77-81% of this protein to maleimide- or iodoacetyl-activated silica.

218 mbrane impermeant reagent polyethyleneglycol maleimide (PEG-mal) in the presence and absence of the p

219 nctionalization of monomethoxy-PEG (mPEG) as maleimide-PEG has been now investigated as the potential

220 athione, dithiothreitol, and hemoglobin with maleimide-PEG have been developed.

221 Commercial maleimide-PEG reagents synthesized using multiple steps

222 P with hemoglobin varied with the batches of maleimide-PEG.

223 In contrast, maleimide-PEG2-biotin reactivity of Cys148 is unaffected

224 mately 29 A), impermeant hydrophilic reagent maleimide-PEG2-biotin.

225 In reactions with maleic anhydride or maleimides, phenoxyacetic acid produced chromenedione de

226 ore was achieved by application of a [5 + 2] maleimide photocycloaddition.

227 ), thiol-acetamide (SA), penicillamine-thiol-maleimide (PM) or penicillamine-thiol-thiol (PS).

228 y of these mutants with progressively larger maleimide-polyethylene glycol derivatives (MPEG) was mea

229 ery of lysine dendrons and poly(ethylene-alt-maleimide) polymer backbone interact with CNCs.

230 porating a basic amino group adjacent to the maleimide, positioned to provide intramolecular catalysi

231 al evaluation of benzofuran-3-yl-(indol-3-yl)maleimides, potent GSK-3beta inhibitors.

232 lternative to the routinely used p-phenylene maleimide (pPDM) for APD detection, allowing for fast an

233 strategy, which combines the CuAAC and thiol-maleimide processes, could become more widely adopted in

234 The resultant protein-maleimide products can be cleaved to regenerate the unmo

235 d-group modification with fluorescent BODIPY-maleimide provided a dye-labeled pOEG-BODIPY conjugate w

236 MPyP pretreatment were labeled with biotin-N-maleimide, purified with streptavidin-agarose, and resol

237 ective and quantitative aspects of the thiol-maleimide reaction.

238 alkyne-azide cycloaddition (CuAAC) and thiol-maleimide reactions is reported.

239 recognition sequences by amidation or thiol-maleimide reactions.

240 00], are conjugated to sulfhydryl lipids via maleimide reactive groups on the QD surface.

241 ction with a water-soluble biotin-conjugated maleimide reagent and fluorescein isothiocyanate-conjuga

242 ed cysteine to a series of novel hydrophilic maleimide reagents increases with increasing volume of t

243 red efflux by covalent labelling with bulky maleimide reagents.

244 Maleimides remain the reagents of choice for the prepara

245 K cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A

246 The reactions of aryloxyacetic acids with maleimides resulted in a cascade process in which a pyrr

247 res and modifications, such as oxidation and maleimide ring opening of PEGylated peptides or proteins

248 ulation of functional groups attached to the maleimide ring-head nitrogen.

249 r para (M(p)) or meta (M(m)) relative to the maleimide ring.

250 The resulting maleimide scaffold was optimized to subnanomolar potency

251 junction by cleaving SNAREs (soluble N-ethyl maleimide sensitive factor attachment protein receptors)

252 r that can directly regulate soluble N-ethyl-maleimide sensitive fusion protein attachment protein re

253 hospholipase D implicated in soluble N-ethyl-maleimide sensitive fusion protein attachment protein re

254 Soluble N-ethyl-maleimide sensitive fusion protein attachment protein re

255 es fusion by both ATL and ER-soluble N-ethyl-maleimide-sensitive factor adaptor protein receptors.

256 +) exchange regulatory factor-1) and N-ethyl-maleimide-sensitive factor-regulated exocytosis.

257 Unlike soluble N-ethyl-maleimide-sensitive fusion attachment protein receptors

258 inetics of binding of SNARE (soluble N-ethyl maleimide-sensitive fusion protein attachment protein re

259 n, a component of the SNARE (soluble N-ethyl-maleimide-sensitive fusion protein attachment receptor)

260 25C channels labeled with Alexa Fluor 488 C5-maleimide showed a change in the emission of the fluores

261 Thiol modification with polyethylene glycol-maleimide showed disulfide bond formation at the active

262 of Phe615Cys mutant AcrB with fluorescein-5-maleimide showed that presumed groove-binders competed a

263 eas the analogous ADCs prepared with N-alkyl maleimides showed 35-67% deconjugation under the same co

264 ne peptide through a thiol-thiol (SS), thiol-maleimide (SM), thiol-vinylsulfone (SV), thiol-acetamide

265 NHS ester-labeling of lysines, the cysteine-maleimide strategy resulted in far less background in fl

266 m active chromogenic Alexa Fluor 350 (AF350) maleimide tag.

267 ct (L126C) was expressed and modified with 4-maleimide TEMPO for electron paramagnetic resonance (EPR

268 ered with a Cys site for bioconjugation with maleimide-terminated chromophores, which include synthet

269 ands underwent successful cycloaddition with maleimide-terminated fluorescence dyes and a polymeric r

270 ing agents, and blocked by pretreatment with maleimide that alkylates cysteines.

271 1,3-dipolar cycloaddition reactions with two maleimides that differ in the relative position of their

272 eadily functionalizable 5-alkoxyoxazoles and maleimides that readily react together under mild and ea

273 nance energy transfer signal between CPT and maleimide thioether bond is monitored to visualize the d

274 olecules are connected by a reduction-labile maleimide thioether bond.

275 the subsequent (bio-) functionalization via maleimide-thiol chemistry.

276 zed with a maleimide linker (Au102_C6MI) for maleimide-thiol conjugation to nanocapsid cysteines.

277 80 Ab (Fab'-bearing) onto the NP surface via maleimide/thiol group-mediated covalent bonding improves

278 ting reactions in plasma: elimination of the maleimide through a retro-Michael reaction, which result

279 ocket while the anthracene approaches to the maleimide through the back passage of the active site.

280 P of Synechocystis with tetramethylrhodamine-maleimide (TMR) and obtained a photoactive OCP-TMR compl

281 ive fluorescent probe tetramethylrhodamine-6-maleimide (TMRM).

282 e-specific fluorescence labeling with pyrene maleimide to gain insight into the structure and conform

283 an be simply addressed using 3,4-substituted maleimides to bridge and thus functionalize disulfide bo

284 f various 2H-pyran-2-ones with N-substituted maleimides toward isoindole derivatives through the reac

285 Second-generation maleimide-toxin conjugates, which include bioorthogonal

286 thyl mercaptan) with N-allyl and N-propargyl maleimide under both base-initiated and radical-mediated

287 Using structure-guided design, pyrene maleimide was attached to pairs of Cys residues separate

288 mbrane-impermeant reagent polyethyleneglycol maleimide was determined.

289 Set designated NSC 19630 [1-(propoxymethyl)-maleimide] was identified that inhibited WRN helicase ac

290 hysical studies, the triplet energies of the maleimides were estimated.

291 Atropisomeric maleimides were synthesized and employed for stereospeci

292 tigate the defect in the mutant, fluorescent maleimides were used to examine the accessibility/reacti

293 We conceived of a new class of maleimide which would address some of these limitations

294 MdtC were covalently modified by fluorescein maleimide, which acted as a substrate and presumably pro

295 little affected by pretreatment with biotin maleimide, which cannot reach the cytoplasmic surface.

296 Benzophenone-4-maleimide, which normally forms intramolecular cross-lin

297 ermally robust [4+2] cycloaddition adduct of maleimide with anthracene.

298 e grown from a [4+2] cycloaddition adduct of maleimide with furan containing two polymerization initi

299 ies, exploiting the quantitative reaction of maleimide with l-cysteine, and the subsequent determinat

300 This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as V