ライフサイエンスコーパス: malformed

1 latter 11 valves also had been congenitally malformed.

2 mation is not complete and the male gonad is malformed.

3 erface, and the extra-embryonic tissues were malformed.

4 the cytoplasm, and focal adhesions appeared malformed.

5 and somatic gonadal structures are severely malformed.

6 However, the resulting structures are often malformed.

7 and the cardiac outflow tracts are short and malformed.

8 e Gle1-FinMajor protein, these particles are malformed.

9 ificantly enlarged, and the meibomian glands malformed.

10 ricles of Tg737orpk mutant mice are severely malformed.

11 Widespread observations of malformed amphibians across North America have generated

12 heir widespread appearance in the mid-1990s, malformed amphibians have evoked fear, as well as fascin

13 Ribeiroia ondatrae were more likely to have malformed amphibians, but these effects were strongest w

14 cted later this century had shells that were malformed and eroded.

15 hen this balance is lost, the vessels can be malformed and fragile, and they can lose arteriovenous d

16 tional TAS1R3 and GNAT3 is compromised, with malformed and immotile sperm.

17 rs was often noted at the border between the malformed and normal cortex.

18 that the sensory cilia of these neurons are malformed and the neurons are nonfunctional in d-plp mut

19 bryos and rapidly induced several additional malformed and uncoordinated blood vessel structures that

20 s of valve replacement surgery, congenitally malformed aortic valves continue to be more common than

21 -2004) had a lower frequency of congenitally malformed aortic valves, a higher frequency of tricuspid

22 neme cargo is either highly efficient at the malformed apical prominence or secretion may also occur

23 fish require lower levels of Tbx5 to produce malformed appendages and display whole-heart rather than

24 Teratological (malformed) assemblages of fossil plankton that correlate

25 esented with bilateral cleft lip and palate, malformed auricles, and bilateral ectrodactyly of his ha

26 171 pregnancies (43% of prenatally diagnosed malformed babies) were terminated because of suspected a

27 Depletion of TbPLK leads to malformed bilobed structures, which is consistent with a

28 Electron microscopy confirmed malformed blood vessels and wide pericapillary ECM space

29 l, and other intramembranous bones caused by malformed blood vessels that lack a mature vascular smoo

30 en studied extensively, synaptic function in malformed brain regions remains poorly understood.

31 examine inhibitory synaptic function in the malformed brain.

32 that inhibitory systems are enhanced in the malformed brain.

33 tricular septum, and atrial septum) that are malformed by CHD.

34 s each increase the fraction of virions with malformed capsids (from approximately 12% to approximate

35 eduction of granule cell proliferation and a malformed cerebellum.

36 Mutations in the GPR56 gene cause a malformed cerebral cortex in both humans and mice that r

37 brain disorder characterized by an enlarged, malformed cerebral hemisphere, typically causing epileps

38 die perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during br

39 lly, electrical stimulation of the CC led to malformed chirping movements by crickets, and pharmacolo

40 d also results in the increased formation of malformed coccoliths in C. braarudii.

41 We performed a population-based case-malformed control study testing signals identified in a

42 ng both nonmalformed controls (OR = 0.3) and malformed controls (OR = 0.2) and for urinary tract defe

43 ng both nonmalformed controls (OR = 0.6) and malformed controls (OR = 0.5).

44 with defects other than those of the cases (malformed controls).

45 ias, we performed logistic regression, using malformed controls.

46 Fourth, malformed cores, typical of integrase-deleted virus, are

47 ated decreased maximum firing frequencies in malformed cortex compared to control FS cells.

48 Cells in malformed cortex identified as having an apical dendrite

49 Most intrinsic properties measured in malformed cortex were unchanged, suggesting that subtype

50 were clearly identified in both control and malformed cortex.

51 induced zebrafish crusher variant results in malformed craniofacial skeleton, kinked pectoral fins an

52 osition of adult-born granule cells within a malformed dentate gyrus critically influences their func

53 ar anomaly comprised of aberrant clusters of malformed dermal venule-like channels underlying hyperke

54 us in fetu (FIF) is a rare entity in which a malformed diamniotic monochorionic parasitic fetal twin

55 to wildtype mice: They die at birth due to a malformed diaphragm and they lack metanephric kidneys.

56 fied histologically in Eisenmenger syndrome: malformed, dilated, muscular arteries within alveolar se

57 CXCR4 null mice exhibited small and malformed DRGs.

58 Loss of either gene results in malformed eyes and head capsules due to defects in eye p

59 eages in which these cells reside results in malformed eyes.

60 396 (55%) malformed fetuses and infants had been correctly identif

61 More than half of all malformed fetuses can be identified prenatally in routin

62 13 is not established, resulting in severely malformed forelimbs lacking all posterior, Shh-regulated

63 The affected mice exhibited malformed glial borders, larger lesions, and impaired re

64 ed by neurodegeneration and accumulations of malformed glycogen (Lafora bodies).

65 homozygous for sys-1(q544) possess a grossly malformed gonad and are sterile; in contrast, sys-1(q544

66 In germ unit malformed (gum) mutants, the vegetative nucleus is posit

67 also result in short, fat, and occasionally malformed hairs and bristles.

68 ow a decrease in motility and an increase in malformed heads.

69 ll heart, develops a diminutive and severely malformed heart and multiple developmental defects of th

70 x40(-/-) or Cx43(-/-) mice, and they exhibit malformed hearts with ventricles that are abnormally rot

71 of treatments for patients with congenitally malformed hearts, efforts that span traditional geograph

72 no significant variations between normal and malformed hearts.

73 re its absence leads to the development of a malformed, immotile, non-infectious ookinete with an ext

74 ngly, middle ear structures are enlarged and malformed in a majority of Ednra(fl/fl);Wnt1-Cre embryos

75 In the node, primary cilia were absent or malformed in homozygous mutant and heterozygous embryos,

76 Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw (

77 t to maintain homeostasis, was also severely malformed in mutants.

78 ontaining hippocampal nerve terminals appear malformed in the absence of collagen XIX.

79 The urethra was malformed in the colliculus region and was significantly

80 al complexity; oligodendrocytes are severely malformed in vitro (a relatively simple environment), bu

81 and controls were 429 randomly selected non-malformed infants.

82 However, the small and malformed inner ear at E17.5 exhibits residual and grade

83 all middle ear cavity, short nasal bone, and malformed interface between the nasal bone process and c

84 w that cells deficient in Shk1 function have malformed interphase microtubules and mitotic microtubul

85 certain individuals with NTDs are born with malformed kidneys, and recent studies have discovered VA

86 enetic screens for dominant enhancers of the malformed leg phenotype associated with a mutation in th

87 -lethality, with adult 'escapers' possessing malformed legs.

88 mb skeletal defects, including shortened and malformed limb bones, oligodactyly, and fusion of joints

89 MP inhibitor GM6001 produces either dwarfed, malformed limb regenerates or limb stumps with distal sc

90 Msx2-noggin mutant mice have severely malformed limbs characterized by syndactyly, postaxial p

91 s in the formation of shortened and severely malformed limbs that lack one or more skeletal elements.

92 -/-) neonates have mandibular hypoplasia and malformed mandibular incisors.

93 xilla-maxilla suture, smaller premaxilla and malformed maxilla during midface development.

94 Grem2(-/-) mice have small, malformed maxillary and mandibular incisors, indicating

95 s a quality-control center for mutant and/or malformed membrane proteins.

96 However, the otoliths are malformed, misplaced, lack an organic matrix, and often

97 to aberrant microtubule structure, including malformed mitotic spindles and impaired interphase micro

98 a drastic reduction in astral microtubules, malformed mitotic spindles, defocused spindle poles, and

99 Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessel

100 This was associated with the presence of malformed nodes of Ranvier characterized by an accumulat

101 en surveillance or clearance is compromised, malformed NPCs accumulate in a storage of improperly ass

102 less cardiomyocyte invasion and resulted in malformed OFT valves.

103 canals, endolymphatic duct and utricle, are malformed or absent.

104 morphology, lumbar and sacral vertebrae were malformed or completely absent, and no tail vertebrae we

105 frustrated by kinetic traps corresponding to malformed or incompletely formed capsids.

106 Kinetic trapping in malformed or intermediate structures often impedes a dir

107 to treat proteinopathies (diseases caused by malformed or misfolded proteins) is to restore protein f

108 neurons, one MB pathway, the medial lobe, is malformed or missing.

109 UG1 with RNA interference (RNAi) resulted in malformed or nonexistent outer segments of transfected p

110 hat the deletion of NCKX1 in mice results in malformed outer segment disks, suppressed expression and

111 heterozygous rds/+ retinas which have short malformed outer segments.

112 Jagged1-deficient mice displayed malformed pancreatic ducts with resulting acinar cell de

113 severe fin fold defect, which also displays malformed pectoral fins.

114 1 have been conditionally ablated, including malformed periodontal ligament (PDL) (recently shown to

115 second-site noncomplementation assay for the malformed phenotype.

116 own-regulation was required to induce a wing-malformed phenotype.

117 anomalies, characteristic facial appearance (malformed pinnae, oral clefts), and, less commonly, rena

118 of alpha-factor, but instead formed a single malformed projection, which frequently gave rise to a bu

119 eart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Dis

120 patterning of the brain, including absent or malformed regions.

121 n addition, the placenta of ABCA1-/- mice is malformed, resulting in severe embryo growth retardation

122 illar projections, and subsequently leads to malformed rhabdomeres.

123 ior and posterior semicircular canals, and a malformed saccule and cochlear duct.

124 se in the dentin formation rate; (3) a small malformed second molar and an absent third molar; (4) an

125 mice are shorter and wider with delayed and malformed secondary ossification centers and an irregula

126 HB-EGF(-/-) newborns had enlarged and malformed semilunar and atrioventricular heart valves, a

127 dig cell aggregation, ectopic Sertoli cells, malformed seminiferous cords) is not evident until after

128 ent shape, whereas leukemia samples map into malformed shapes that are distinct from healthy bone mar

129 ozygotes thus lack hands and feet except for malformed single digits, whereas heterozygotes lack phal

130 al sinusoids, and macrophage accumulation in malformed sinuses.

131 oggin null mice die at birth with a severely malformed skeleton that is postulated to reflect the act

132 ibit cranial neural tube closure defects and malformed somites and are caudally truncated.

133 organized apical ectoplasmic specialization, malformed spermatids, and marked hyperspermia.

134 spine plasticity, decreased the presence of malformed spines in diabetes, attenuated neuronal hyperr

135 c neuropathic pain, then (1) the presence of malformed spines should coincide with the development of

136 ed outer whorl organs and reduced numbers of malformed stamens in the double mutant.

137 ls (NCCs) of the pharyngeal arches display a malformed stapes.

138 nd postsynaptic specializations, albeit with malformed synaptic ribbons.

139 The KO mice exhibited small malformed teeth, severe enamel defects, very thin dentin

140 llicle induction, lack sweat glands and have malformed teeth.

141 equent pulmonary infections, and missing and malformed teeth.

142 Cre;Erk2(fl/fl) mice exhibited cleft palate, malformed tongue, micrognathia and mandibular asymmetry.

143 orming ameloblasts, resulting in eruption of malformed tooth enamel that phenocopies human amelogenes

144 ssection), the aortic valve was congenitally malformed (unicuspid or bicuspid) in 58 (98%) of the 59

145 ed to turbulent hemodynamic flow through the malformed valve leading to focal defects in the vessel w

146 ngly suggest that an underlying congenitally malformed valve, at least in men, is more common than a

147 nosis: A total of 504 (54%) had congenitally malformed valves (unicuspid in 46 [unicommissural in 42;

148 e effort is given to repairing even severely malformed valves in pediatric patients.

149 hat, among the 96 patients with congenitally malformed valves, the 38 AR patients had a significantly

150 Knockdown lines of TpSAP1 and 3 displayed malformed valves; which confirmed their roles in frustul

151 Injection of soluble VEGFR-1 results in malformed vascular networks and the absence of large ves

152 ability in tumours is thought to result from malformed vascular walls with leaky cell-to-cell junctio

153 wounds were characterized by an early leaky, malformed vasculature followed by abundant granulation t

154 Curvatures caused by malformed vertebrae (congenital scoliosis (CS)) are appa

155 Cystic cholangiocyte cilia were short and malformed, whereas in renal cysts they appeared normal.

156 The dap160 mutant synapse is grossly malformed with abundant, highly ramified, small synaptic

157 ss anatomy of the inner ear is distorted and malformed, with cochlear duct outgrowth and coiling most

158 mals were infected 113 days before producing malformed young, the commonest symptom of reported infec

159 t kernels have an opaque, starchy phenotype, malformed zein protein bodies, and highly increased leve