ライフサイエンスコーパス: malfunction

1 dent CIED dose did not correlate with device malfunction.

2 ochondrial Ca2+ overload, dysmorphology, and malfunction.

3 clei and disrupted lamina and die of cardiac malfunction.

4 in vivo, which is associated with proteasome malfunction.

5 tion between the SMC loss and cardiovascular malfunction.

6 he occurrence of shocks, and possible device malfunction.

7 n ways that might affect biological function/malfunction.

8 dromes associated with WBSCR22 (human Bud23) malfunction.

9 ory stimuli associated with tissue damage or malfunction.

10 ecific genes, probably contributing to their malfunction.

11 time to first infection, bleeding, or device malfunction.

12 isease caused by Rab and vesicle trafficking malfunction.

13 isease secondary to intramolecular chaperone malfunction.

14 theter Angle had a greater risk for catheter malfunction.

15 y in a manner that is secondary to circadian malfunction.

16 Three patients (7%) had IP port malfunction.

17 own about the underlying mechanisms of their malfunction.

18 structures where clocks function-and perhaps malfunction.

19 in injury in development and later cognitive malfunction.

20 , and chronic exposure results in pancreatic malfunction.

21 compared with the advisory and potential for malfunction.

22 ty, leading to memory deficits and cognitive malfunction.

23 se of the lower rate of reoperation for pump malfunction.

24 slationally fold and function or misfold and malfunction.

25 genes that may avert harm from mitochondrial malfunction.

26 tal night blindness, are linked to rhodopsin malfunctions.

27 nd treating diseases caused by TLR signaling malfunctions.

28 tanding to devise methods for repair when it malfunctions.

29 ice (CF-LVAD) function and diagnosing device malfunctions.

30 tudy the pathophysiology associated with IAS malfunctions.

31 increase in the incidence of device and lead malfunctions.

32 rders associated with performance monitoring malfunctions.

33 day and night vision as well as some visual malfunctions.

34 self in an array of non-lethal physiological malfunctions.

35 even before denervation, contributing to NMJ malfunctions.

36 P=0.46); and 1 pacemaker in the study group malfunctioned.

37 s 0.39, respectively; P<0.01) and peripheral malfunctions (2.32 versus 1.78 for the HM II and HVAD, r

38 nfection (18%), pocket infection (32%), lead malfunction (30%), and other (device upgrade, venous occ

39 ed of difficult lead placement (18.4%), lead malfunction (9.8%), infection (1.4%), lead displacement

40 Malfunctioning adaptive reward coding may lead to overva

41 Genetic malfunctions affecting the hepcidin-ferroportin axis are

42 ed the independent risk factors for catheter malfunction among patients receiving intravenous port im

43 Strikingly, both telomere malfunction and activin A expression in epithelial cells

44 cases including breakage of a catheter, pump malfunction and arachnoid adhesions.

45 lted in lower risks of hemodialysis catheter malfunction and catheter-related bacteremia compared wit

46 ypic defects were accompanied by significant malfunction and damage of the photosynthetic machinery.

47 e fibrotic process eventually leads to organ malfunction and death.

48 he body and can progress to a state of organ malfunction and death.

49 ose dysfunction could contribute to neuronal malfunction and diseases of the nervous system including

50 Catheter malfunction and dislodgment occurred in one patient each

51 ith decreasing risks of infection and device malfunction and extremely high patient and partner satis

52 Despite the link between Drp1 malfunction and human disease, the molecular details of

53 Given the lack of correlation between CIED malfunction and incident dose observed up to 5.4 Gy, inv

54 This includes aspects of barrier malfunction and inflammation as well as the interaction

55 from astrocytes, contribute to motor neuron malfunction and loss.

56 lecular mechanisms of Abeta-induced synaptic malfunction and may offer new mechanism-based therapeuti

57 reeing with both hypotheses of mitochondrial malfunction and neuroinflammation.

58 Telomere malfunction and other types of DNA damage induce an acti

59 is central to an understanding of function, malfunction and therapeutic modulation of biological sys

60 The malfunction and/or aberrant expression of ion channels m

61 implant of the potential for device and lead malfunction, and careful consideration must be employed

62 ological diseases in which there is also BBB malfunction, and highlighting current disease-modifying

63 k traffic and noise pollution, accidents and malfunctions, and psychosocial stress associated with co

64 ellular surface expression and physiological malfunction are believed to be pathologically implicated

65 PFC malfunctions are a common denominator in several neurops

66 s of cell homeostasis and development, whose malfunctions are associated with major pathologies such

67 Its malfunctions are implicated in many hereditary and degen

68 cause of CSD and implies primary basal NHE3 malfunction as a predisposition for IBD in a subset of p

69 glutamatergic deficiency leads to cognitive malfunction as observed in several neurodevelopmental ps

70 s with HVAD were 90% free of a pump-specific malfunction at 3 years compared with 56% for the HM II (

71 cardiovascular mortality, stroke, and device malfunction at 30 days was 86.6%.

72 substitute a sensory organ: they bypass the malfunctioning auditory periphery of profoundly-deaf peo

73 ne emissions may be attributed to proteasome malfunction based on three observations: leaves with TPS

74 n occur at many levels, with transcriptional malfunction being a major cause.

75 and control pathological states caused by a malfunctioning blood coagulation system.

76 makes it particularly catastrophic when they malfunction, both during development and for tissue home

77 rs might not just reflect underlying circuit malfunction, but could also play a direct role in the pr

78 investigate the molecular mechanisms of tau malfunction, but current models show little and inconsis

79 e multi-organ inflammation and immune system malfunction, but how SHARPIN regulates T cell responses

80 It follows, therefore, that PTP malfunction can actively contribute to a host of human d

81 Cardiomyocyte-restricted UPS malfunction can cause heart failure.

82 the pacemaker activity in the heart, and its malfunction can result in heart disorders.

83 Catheter malfunctions can be avoided by using proper surgical tec

84 Their malfunctions cause numerous diseases including neuronal

85 a establish that the locus of early synaptic malfunction caused by tau resides in dendritic spines.

86 rstitial tissue fluid balance, and lymphatic malfunction causes edema.

87 Integrin malfunction causes severe disease patterns characterized

88 Myosin-5B malfunction causes the congenital enteropathy microvillu

89 riminating between different RNAs, and whose malfunctioning causes serious autoimmune diseases.

90 ates a proapoptotic program to eliminate the malfunctioning cells from the organism.

91 transmembrane conductance regulator (CFTR), malfunctioning CFTR might impair sAC-mediated CBF regula

92 ocytes have abnormal cell cycle profiles and malfunctioning cilia.

93 re enumerated and responses of the different malfunctioning circuits to a 'test' input are used to gr

94 e have recently surged among patients with a malfunctioning cobalt-alloy hip prosthesis.

95 In settings with network malfunction, consumers of tap water versus POU-treated w

96 ad extraction: 152 with CDI and 10 with lead malfunction (control group).

97 s-induced maladaptive behaviors and synaptic malfunctions converge on the regulation of PV+ IN activi

98 d ADAR2 catalyze this modification and their malfunction correlates with disease.

99 on disease the relationship between synaptic malfunction, degeneration, and mitochondria has been neg

100 facilitate optimal speed changes and device malfunction detection and may be used to monitor the eff

101 nel cells that monitor for tissue stress and malfunction-deviations from optimal homeostasis-and that

102 ith a reference group of extraction for lead malfunction), diabetes mellitus (HR, 1.71; 95% CI, 1.25-

103 channel) contributes to nodose ganglia (NG) malfunction, disrupting gastrointestinal function in dia

104 water consumption is associated with GII in malfunctioning distribution networks.

105 ected data were reviewed for all LVAD device malfunctions (DMs) occurring in rotary LVADs implanted a

106 ad to aberrant mRNAs leading to synthesis of malfunctioning DNA repair proteins.

107 troke or reoperation to replace the pump for malfunction), driven by a reduced need for reoperations.

108 hysiological blood glucose levels, and their malfunction drives diabetes development.

109 pathology in parallel suggests that synaptic malfunction due to Abeta oligomers rather than plaque pa

110 Here, we analyze several distinct malfunctions during mitosis and cytokinesis that lead to

111 some types of monogenic diabetes linked with malfunctioning endoplasmic-reticulum (ER), the beta-cell

112 age concentration, likely from vehicles with malfunctioning engine coolant systems.

113 wise avoidable operating conditions, such as malfunctioning equipment.

114 rainstem irregularities rather than cortical malfunctions for early vocalizations/babbling.

115 The intervention-free periods of the malfunction group and nonmalfunction group were 317 and

116 Lysosomal malfunction has been implicated in several pathologies,

117 control mechanism is a priority because its malfunction has life-threatening consequences.

118 Consequently, their malfunctioning has been associated with numerous disease

119 rts of left ventricular assist device (LVAD) malfunction have focused on pump thrombosis.

120 abnormalities of head movements stem from a malfunctioning head neural integrator, either intrinsica

121 tailed understanding of protein function and malfunction hinges on the ability to characterize transi

122 tools have been optimized to interrogate the malfunctioning hippocampal circuit, and by applying thes

123 In contrast, transfection of malfunctioning human insulin receptor mutants, identifie

124 patients undergoing removal of an unused or malfunctioning ICD lead had slightly higher in-hospital

125 eficiency and mitochondrial metallochaperone malfunction, illustrating the importance of regulating c

126 of conditions that arise as a consequence of malfunctioning immune responses.

127 ght our understanding of the consequences of malfunctioning immunity on neurodevelopment and will dis

128 sm spectrum disorder, are the consequence of malfunctioning immunity.

129 Patients with an unused or malfunctioning implantable cardioverter-defibrillator (I

130 safety and the ability to respond to device malfunction in a timely fashion, improving outcomes.

131 re the importance of diet composition on CMA malfunction in aging.

132 ect common age-associated diseases when they malfunction in aging.

133 ts clarify new aspects of spinal motoneurons malfunction in ALS.

134 understanding CFTR's physiological role, its malfunction in disease and the mechanism of action of sm

135 the precise mechanism behind macroautophagy malfunction in HD is poorly understood.

136 ble the understanding of how those complexes malfunction in human diseases.

137 ed change thinking about the nature of brain malfunction in psychiatric disorders and during aging, a

138 be an underlying mechanism of NMDA receptor malfunction in redox-dependent disease states and presen

139 bility, reflect underlying dysregulation and malfunction in specific neural circuits.

140 tanding the mechanistic basis of ion channel malfunction in terms of trafficking, localization, bioph

141 ion can also be induced by tissue stress and malfunction in the absence of infection or overt tissue

142 Malfunction in the crosstalk between these components mi

143 f IL-17RA expression, which implies a severe malfunction in the IL-17 signaling pathway, conferring s

144 n LTP and provide insights into how retromer malfunction in the mature brain may contribute to sympto

145 A malfunction in this system can lead to an inadequate hos

146 Greater anxiety in two patients and hardware malfunction in three patients were noteworthy adverse ou

147 ncoding proteins that are often misfolded or malfunctioning in neuronal populations subserving overt

148 xhibit spatial memory impairment and synapse malfunctioning in the hippocampus, with abnormal enhance

149 sodium ions in cellular processes and their malfunctions in brain in vivo.

150 asmic reticulum (ER) stress response detects malfunctions in cellular physiology, and microbial patte

151 Malfunctions in regulatory pathways that control cell si

152 zed by insulin resistance, which arises from malfunctions in the intracellular insulin signaling netw

153 All possible single malfunctions in the resulting circuit are enumerated and

154 In-depth understanding of how SAC silencing malfunctions in these cases is yet missing, but is belie

155 Malfunctions in transcriptional regulation are associate

156 uits to a 'test' input are used to group the malfunctions into classes.

157 Retinal pigment epithelial cell malfunction is a causative feature of age-related macula

158 Its malfunction is associated with severe liver disease.

159 siological well-being, whereas mitochondrial malfunction is associated with various pathologies and r

160 plasmic reticulum is a complex process whose malfunction is implicated in disease and aging.

161 The cardinal manifestation of lymphatic malfunction is lymphedema.

162 Device malfunction is much broader than pump failure alone and

163 involved in key metabolic processes and its malfunction is related to several diseases.

164 xample of a cascade of failures ('concurrent malfunction') is the electrical blackout that affected m

165 rebrain structures may contribute to network malfunction leading to progressive neuropsychiatric symp

166 abilization could easily result in hair cell malfunction leading to the late-onset hearing loss obser

167 peptide (Abeta) is responsible for synaptic malfunctions leading to cognitive deficits ranging from

168 BBSome malfunction leads to Bardet-Biedl syndrome, a ciliopathy

169 sible for many cellular functions, and their malfunction manifests itself in several human diseases.

170 Many of these malfunctions may result in inadequate neuronal decision

171 found at an over 50-fold higher level in the malfunctioning media lot with a proposed molecular formu

172 d a riboflavin degradant, lumichrome, in the malfunctioning media lot, relative to working media lots

173 ecognizing and correcting the early signs of malfunctioning mitochondria is of critical importance fo

174 To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed by mitoph

175 were identified as likely mechanisms of the malfunctioning mutants.

176 Malfunctioning neurotransmitter systems, such as glutama

177 Many varieties of autoregulatory malfunction occur within the cardiovascular system; thus

178 Malfunctions occur in different ways and at different lo

179 orary CIEDs, all cases of single-event upset malfunction occurred in the setting of notable neutron p

180 , particularly inappropriate shocks and lead malfunction, occurred in 91 patients (41%) at 17 +/- 5 y

181 vide a molecular basis for understanding how malfunction occurs whereby mutations shift the ADP-bound

182 The malfunction of a mutated GABA(A) receptor (alpha1beta2ga

183 maintaining glucose homeostasis; the loss or malfunction of beta cells results in diabetes mellitus.

184 n of the LAMTOR complex which results in the malfunction of both ERK and mTOR signal pathways.

185 of CD4(+) T cells is often accompanied by a malfunction of CD8(+) T cells that are persistently acti

186 A plethora of evidence indicates that malfunction of cell death can lead to inflammation, auto

187 de the first structural insight into how the malfunction of centriole proteins results in human disea

188 Absence or malfunction of CFTR leads to Cystic Fibrosis, a disease

189 Malfunction of CIED attributable to RT occurred during 1

190 Malfunction of CIED, characterized as single-event upset

191 ggest that individual symptoms may represent malfunction of different segregated networks running in

192 om water-electrolyte imbalance partly due to malfunction of ENaC regulation.

193 Malfunction of GABA(B) receptor has been implicated in s

194 wer levels of protein carbonyls (PC) causing malfunction of hepatic and renal tissues, when compared

195 Malfunction of intravenous ports may lead to discontinua

196 atory network and consider examples in which malfunction of its components leads to system failure an

197 vide new insights into both the function and malfunction of key embryonic and postembryonic events.

198 n to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c

199 Malfunction of mutant AIPL1 proteins triggers a severe f

200 Therefore, these data suggest that malfunction of NEP in infected macrophages may contribut

201 Malfunction of NMDARs has been implicated in a variety o

202 Drug-induced malfunction of nucleus accumbens (NAc) neurons underlies

203 pressant effects that can compensate for the malfunction of other brain circuits that results in depr

204 ifferent stages of lung involvement (L), and malfunction of peripheral organs such as the kidney, liv

205 ing to localized cell responses and systemic malfunction of phloem.

206 This reaction is mainly caused by malfunction of photosystem I and oxidative damage induce

207 Emerging evidence has shown that loss or malfunction of primary cilia or ciliary proteins in bone

208 Malfunction of protein arginine methyltransferases (PRMT

209 Malfunction of such a repression mechanism at the molecu

210 Malfunction of such different parameters produces simila

211 provide the first direct demonstration of a malfunction of the astrocytic thalamic GAT-1 transporter

212 Malfunction of the cystic fibrosis transmembrane conduct

213 central role in homocysteine metabolism, and malfunction of the enzyme leads to homocystinuria, a dev

214 ants, therefore, appears to be the result of malfunction of the influx/efflux systems due to modifica

215 t 2, leading to about 50% alleviation of the malfunction of the inheritable mutated (alpha1beta2gamma

216 ibutes to metabolic disease and suggest that malfunction of the innate immune system may promote the

217 ficit in alcoholism causally associated with malfunction of the medial prefrontal cortex (mPFC), but

218 regnan-20-one (5alpha-THDOC) alleviates this malfunction of the mutated receptor transiently expresse

219 neration can provide understanding regarding malfunction of the regenerative process in liver disease

220 the testis, irrespective of cause, leads to malfunction of the somatic (Leydig, Sertoli) cells and c

221 necessary for cellular resistance to chronic malfunction of the UPR(MT) Given the increasingly recogn

222 ress urinary incontinence mainly suffer from malfunction of the urethra closure mechanism.

223 not identified, and it is not known whether malfunction of these cells may contribute to bone loss i

224 cation, however, comes greater potential for malfunction of these intricate processes.

225 these genes are expressed in podocytes, and malfunction of these proteins leads to a universal end p

226 cancers could exert their properties through malfunction of these Trr/MLL3/MLL4-specific (Trrific) en

227 on-contraction coupling and establishes that malfunction of this mechanism may contribute to neuromus

228 We hypothesize that malfunction of this quorum-sensing mechanism may lead to

229 cell differentiation and maturation and that malfunction of this switch during sepsis promotes MDSC e

230 and MLL4 exert their properties through the malfunction of Trr/MLL3/MLL4-dependent enhancers.

231 mages may be affected by the wearing down or malfunctioning of equipment.

232 Malfunctioning of one of these hydrolases can lead to a

233 and most diseases are somehow related to the malfunctioning of one or more of these proteins.

234 epilepsies and is generally associated with malfunctioning of the hippocampal formation.

235 Malfunctioning of the system caused all other adverse ev

236 Rather, they induce a toxic malfunctioning of their target biosynthetic machinery in

237 These findings suggest that the malfunctioning of these cellular processes in both midgu

238 Malfunctioning of these channels has been implicated in

239 Malfunctioning of these complexes in humans is associate

240 Malfunctioning of these signaling molecules may result i

241 Malfunctioning of this machinery renders virions incapab

242 referentially because it causes the death or malfunctioning of those that do not carry it.

243 Malfunctions of quality control systems are linked to ag

244 Malfunctions of selenoproteins lead to various human dis

245 Possible malfunctions of the ICD were found in 3% of all patients

246 tral nervous system (CNS) are underpinned by malfunctions of the immune system, including disorders i

247 Malfunctions of these inhibitor proteins have been linke

248 Malfunctions of this channel are known to cause heredita

249 easily seen themselves, the effects of their malfunction on the brain can be tracked with detailed br

250 sorders are being discovered to be linked to malfunction or deficits of INs, this review will cover h

251 rol group than in the study group had device malfunction or device failure requiring replacement (16.

252 from disabling stroke or device removal for malfunction or failure.

253 from disabling stroke or device removal for malfunction or failure.

254 Improper setup can result in equipment malfunction or may cause serious damage to instruments d

255 Equipment malfunction or operation error was reported in all study

256 5-1.692), reimplantation for device upgrade, malfunction, or manufacturer advisory (OR, 1.354; 95% CI

257 ortant in detecting disease or physiological malfunction, or tracking disease progression.

258 Angle was the only risk factor for catheter malfunction (P < 0.001).

259 Angle was the only risk factor for catheter malfunction (P = 0.001).

260 Our data show that SCN malfunctioning plays an important role in the disturbanc

261 Cells with a malfunctioning PLC and silenced for PC7 have substantial

262 of modulatory capacity, possibly reflecting malfunctioning precision in GABAAergic neurotransmission

263 ere not advantageous with regard to catheter malfunction prevention as compared to open tip catheters

264 phenotype that begins with left ventricular malfunction progressing to a dilated cardiomyopathy and

265 There were no pump exchanges, pump malfunctions, pump thrombosis, or hemolysis events.

266 d be the result of a chromosomal segregation malfunction resulting in the development of nodules.

267 ntrol of inflammation and healing, and their malfunction results in cardiometabolic disorders.

268 aining glucose homeostasis; their absence or malfunction results in diabetes mellitus.

269 sts that small nucleolar RNAs (snoRNAs) have malfunctioning roles in tumorigenesis.

270 Cancer is usually caused by malfunction(s) in the cellular signaling pathways.

271 ata suggest that the inhibitory effects of a malfunctioning SCN on cognition require preservation of

272 y to precisely intervene with the underlying malfunctioning signalling pathway using endogenous subst

273 g therapeutic target for age-dependent brain malfunction.SIGNIFICANCE STATEMENT We found that local r

274 y included analysis of infection rates, line malfunctions, temporary hospitalization, neurological ev

275 lationship between the two systems and their malfunction that may underlie some neurological diseases

276 In many retinal diseases, the malfunction that results in photoreceptor loss occurs on

277 s a diagnostic feature of WD linked to liver malfunction; the mechanism behind urinary copper elevati

278 ir adjacent stages, suggesting spread of tau malfunction through neuroanatomical pathways in hippocam

279 Recent studies suggest that enhancer malfunction through point mutations in either regulatory

280 tinosin deficiency, is characterized by cell malfunction, tissue failure, and progressive renal injur

281 deciding drug efficacy, thereby mapping each malfunction to an appropriate set of drugs.

282 ould first identify the location and type of malfunction to arrive at a suitable drug combination.

283 about the molecular mechanism linking Kv11.1 malfunction to cardiac death.

284 ling metabolism, growth, and aging and whose malfunctioning underlies diabetes, some cancers, and neu

285 of abnormal process conditions (for example, malfunctions upstream of the point of emissions; equipme

286 ead until extraction is indicated because of malfunction versus an aggressive management strategy of

287 Freedom from lead malfunction was 97% at 5 years (from implantation) and 9

288 r disabling stroke, but reoperation for pump malfunction was less frequent in the centrifugal-flow pu

289 arge for speed optimization and/or if device malfunction was suspected.

290 A higher rate of pump-specific malfunctions was discovered in those implanted with an H

291 d the pathologies that arise during response malfunction we must reveal the environmental variables t

292 Cumulative rates of malfunction were examined for the main components of eac

293 T grafts immersed in the milieu of circadian malfunction were normal and absent of lesions, comparabl

294 The risk factors for catheter malfunction were then evaluated.

295 No delayed malfunctions were directly attributed to RT.

296 ysfunction, muscle degeneration, and cardiac malfunction, which were prevented by pharmacological act

297 findings suggest that RBC in trauma patients malfunctions, which may explain organ damage and constit

298 s studies of severe diseases caused by miRNA malfunction, will benefit from the proposed computationa

299 time to first infection, bleeding, or device malfunction with either pulsatile- or continuous-flow LV

300 gy and acquired or innate immunity and their malfunctioning with age.