ライフサイエンスコーパス: mammaglobin

1 for breast cancer based on the detection of mammaglobin.

2 terized as the biologically relevant form of mammaglobin.

3 eviously characterized breast-specific gene, mammaglobin-1 (n = 54; Spearman r = 0.34, P = 0.011).

4 Interestingly, a higher SBEM:mammaglobin-1 ratio was observed in primary tumors with

5 Mammaglobin A (MGA) is an organ specific molecular bioma

6 Mammaglobin, a promising diagnostic marker for breast ca

7 Using DNA and tissue microarray, mammaglobin-A was validated as a cell-surface target tha

8 few as 1,000 cells that endogenously express mammaglobin-A were detected in ALN, indicating high sens

9 y i.v. injection of MamAb-680 into mice with mammaglobin-A-positive and -negative mammary fat pad (MF

10 MamAb-680) was developed by conjugation of a mammaglobin-A-specific monoclonal antibody to a near-inf

11 Two markers yielded exceptional results; mammaglobin and carcinoembryonic antigen transcripts wer

12 = 304) to determine the threshold levels of mammaglobin and cytokeratin 19 correlating with metastas

13 ycosylation sites in the primary sequence of mammaglobin and each site having an attached sugar of ap

14 ge expression was highly significant between mammaglobin and lipophilin B (p < 0.0001).

15 LC-ESI-MS shows that mammaglobin and lipophilin B are bonded in a head to tai

16 N-Terminal sequencing revealed that mammaglobin and lipophilin B are processed as predicted

17 Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on huma

18 ose chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both n

19 upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members

20 Reducing agents release lipophilin B from mammaglobin, and the free peptides are seen at their pre

21 to investigate the full clinical utility of mammaglobin as a tool for breast cancer patient manageme

22 Mammaglobin B (MGB2) is highly homologous to mammaglobin

23 er with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q

24 proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and

25 sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mam

26 Hemopexin, transferrin, mammaglobin B, and secretoglobin 1D were found significa

27 he expression pattern of a novel human gene, mammaglobin B.

28 We identified several known genes, including mammaglobin, cytokeratin 19, fibronectin, and hair-speci

29 , we have evaluated the frequency with which mammaglobin expression can be detected in primary and me

30 ntained detectable mammaglobin mRNA, whereas mammaglobin expression in uninvolved lymph nodes was und

31 ns of expression, we have isolated the human mammaglobin gene and performed an initial assessment of

32 Mammaglobin gene architecture is very similar to that of

33 The mammaglobin gene encodes a novel secreted protein whose

34 The mammaglobin gene encodes a novel, breast cancer-associat

35 The mammaglobin gene has been shown to be preferentially exp

36 The human mammaglobin gene is localized by fluorescent in situ hyb

37 Expression of the mammaglobin gene is restricted to the adult mammary glan

38 However, the mammaglobin gene itself is not well conserved phylogenet

39 Mammaglobin has generated much interest, and studies are

40 We report here that mammaglobin, in breast tissue, is found as a complex wit

41 ssion and tumor-associated overexpression of mammaglobin is mediated by complex transcriptional contr

42 in encoded by this cDNA, which we have named mammaglobin, is homologous to a family of secreted prote

43 This work describes the biochemistry of the mammaglobin/lipophilin B complex and lays the framework

44 in primary human breast tumors suggest that mammaglobin may be a novel marker for the management of

45 Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gen

46 in an analysis of 35 breast tumor biopsies, mammaglobin mRNA levels were increased at least 10-fold

47 ng a nested reverse transcription-PCR assay, mammaglobin mRNA was also detected in 9 of 15 products (

48 etastatic breast cancer contained detectable mammaglobin mRNA, whereas mammaglobin expression in unin

49 The sequence of proximal 1 kb of mammaglobin promoter contains several potential transcri

50 xamined, 81 were strongly immunopositive for mammaglobin protein.

51 Mammaglobin was the most informative marker in the panel