ライフサイエンスコーパス: mammalian

1 al roles, the anucleate platelet is uniquely mammalian.

2 We show that mammalian aerodigestion develops in two phases: (1) from

3 lycogen metabolism might also have a role in mammalian aging.

4 aits with pallial genesis in mammals and non-mammalian amniotes such as birds or reptiles, suggesting

5 ient diets from the predicted microbiomes of mammalian ancestors.

6 itive-sense RNA viruses that infect numerous mammalian and avian species and are capable of causing s

7 mOmpA; AM854) contributes to the invasion of mammalian and tick host cells.

8 ored proteins (GET) pathway was described in mammalian and yeast cells that serve as a blueprint of T

9 has remained controversial, however, whether mammalian and yeast IRE1 use a common mechanism for ER s

10 Autophagy plays a paramount role in mammalian antiviral immunity including direct targeting

11 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA

12 basis for the similarities between avian and mammalian arcopallial and amygdala subregions is poorly

13 tricular hypothalamus (the equivalent of the mammalian arcuate nucleus), projecting throughout the hy

14 l nucleus (NLT), the putative homolog of the mammalian arcuate nucleus.

15 oxytoca, but it has recently been shown that mammalian ARD enzymes (mouse and human) are also capable

16 kably, human IKKgamma does not interact with mammalian Atg8-family proteins.

17 genes for each subfamily as well as all six mammalian ATG8s.

18 l a number of novel heterogeneity markers in mammalian beta cells.

19 Here we present new magnetostratigraphy and mammalian biostratigraphy that refine the onset of basin

20 topoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell renewal.

21 ction, its overall expression pattern in the mammalian brain at the resolution of individual neuronal

22 s with high temporal precision within intact mammalian brain circuitry would enable powerful explorat

23 The mammalian brain contains diverse neuronal types, yet we

24 The mammalian brain is supplied with blood by specialized va

25 The major endocannabinoid in the mammalian brain is the bioactive lipid 2-arachidonoylgly

26 In the mammalian brain, auditory information is known to be pro

27 gnaling pathway regulates development of the mammalian brain, including neuron migrations in various

28 ce the discovery of neural stem cells in the mammalian brain, the possibility of brain tissue regener

29 n the development of sensory circuits in the mammalian brain.

30 diverse cortical and subcortical regions of mammalian brain.

31 Adult mammalian cardiomyocyte regeneration after injury is tho

32 Mammalian cardiomyocytes lose the ability to proliferate

33 The relative roles of hominids, mammalian carnivores, and crocodiles in the formation of

34 ssue culture room by personnel with standard mammalian cell culture expertise.

35 purified at industrial scale with a standard mammalian cell culture platform and a routine purificati

36 avage of concatemeric DNA is not required in mammalian cell DNA replication, indicating that drugs ta

37 ignificance of external glutamine supply for mammalian cell growth and proliferation.

38 bodies (mAbs) manufactured from immortalized mammalian cell lines are becoming increasingly important

39 enotyping variant libraries in transfectable mammalian cell lines in two steps.

40 r 30% of the effectors localize to yeast and mammalian cell membranes, including a subset of previous

41 d compositions that mimic both bacterial and mammalian cell membranes.

42 independent information across a variety of mammalian cell state transitions.

43 n the mitochondrial matrices of a variety of mammalian cell types.

44 thaliana HAP2/GCS1 is sufficient to promote mammalian cell-cell fusion.

45 Consistent with the above, Crb3 knockdown in mammalian cells affects the dynamics of IFT particle mov

46 regulator of ribosomal protein production in mammalian cells and suggest that this activity can be co

47 a as a flexible platform for studying RNA in mammalian cells and therapeutic development.

48 KEY POINTS: Mammalian cells are frequently exposed to stressors caus

49 We demonstrate that conditioning of mammalian cells by electroporation with nanosecond pulse

50 Cbl enters mammalian cells by receptor-mediated endocytosis of prot

51 f proteins entering the secretory pathway in mammalian cells frequently requires the insertion of dis

52 We found that mammalian cells have a strong tendency to maintain physi

53 el expression of the human ClC-Kb channel in mammalian cells impedes the functional study of CLCNKB m

54 ombinant expression of antibody molecules in mammalian cells offers important advantages over traditi

55 relied on the self-organizing properties of mammalian cells or used bioengineered constructs to arra

56 Cellular metabolism in mammalian cells represents a challenge for analytical ch

57 we show that damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and

58 ke extensions of the plasma membrane of most mammalian cells that serve specialized signaling functio

59 y engineering the surfaces of live yeast and mammalian cells through cell surface-initiated controlle

60 avenues for the exploration of adaptation of mammalian cells to gravitational changes.

61 In mammalian cells under one-photon (1P) illumination, RVF5

62 The plasma membrane of mammalian cells undergoes constitutive endocytosis, endo

63 Because betaine can be synthesized in mammalian cells via choline dehydrogenase (CHDH; EC 1.1.

64 Treatment of mammalian cells with histone deacetylase inhibitors to i

65 In mammalian cells, active or primed enhancers are commonly

66 reported to be the brightest in non-neuronal mammalian cells, in primary neuronal culture, in brain s

67 s and extends the bivalency model posited in mammalian cells, in which the coexistence of H3K4me3 and

68 -activated chloride channel expressed widely mammalian cells, including epithelia, vascular smooth mu

69 r data suggest that ZIKV, when produced from mammalian cells, infects fetal endothelial cells much mo

70 Ubiquitously expressed in mammalian cells, its loss-of-function mutations are the

71 In mammalian cells, M1 coimmunoprecipitated with Apaf-1-pro

72 of U6 and Y RNA 3' ends, suggesting that in mammalian cells, the formation of a 3' end for noncoding

73 In mammalian cells, this process is dependent on the recogn

74 As carmaphycin B is toxic to mammalian cells, we synthesized a series of chemical ana

75 Unlike the other 14 known galectins in mammalian cells, which have dimeric or tandem-repeated C

76 In this study, we demonstrate that akin to mammalian cells, wild-type yeast possess only two TRAPP

77 subset of primary microRNAs (pri-miRNAs) in mammalian cells.

78 d inducer or repressor of gene expression in mammalian cells.

79 the formation of ER-mitochondria contacts in mammalian cells.

80 ks and elevates sister chromatid exchange in mammalian cells.

81 . paralogs) are critical for efficient HR in mammalian cells.

82 when exposed to the reducing environment in mammalian cells.

83 adhesion-based biomarkers for characterizing mammalian cells.

84 n factor regulates the response to stress in mammalian cells.

85 of cholesterol, and peroxisome biogenesis in mammalian cells.

86 nergy homeostasis, and glucose metabolism in mammalian cells.

87 ization of miRNP components in Mfn2-depleted mammalian cells.

88 mplexes were nontoxic to either bacterial or mammalian cells.

89 he AMPs exhibited inhibited toxicity against mammalian cells.

90 y to profile their ubiquitination targets in mammalian cells.

91 hyladenine (6mA), has recently been found in mammalian cells.

92 double strand break (DSB) repair pathway in mammalian cells.

93 the largest and most complicated enzymes in mammalian cells.

94 maging of endogenous RNA molecules in living mammalian cells.

95 l sorting for perfusion culture of suspended mammalian cells.

96 titute approximately 30% of the cells in the mammalian central nervous system (CNS).

97 In the mammalian central nervous system, Lpd contributes to neu

98 , the microtubule-organizing centers (MTOCs; mammalian centrosome and yeast spindle pole body [SPB])

99 mical synapses, about 1 per microm(3) in the mammalian cerebral cortex.

100 ns implicated in the formation of the active mammalian channel.

101 Arnt-like protein 1) sits at the core of the mammalian circadian transcription/translation feedback l

102 .1 regulation of neurotransmitter release in mammalian CNS synapses.

103 fast-releasing inhibitory connections in the mammalian CNS: the medial nucleus of the trapezoid body

104 The correct development and function of the mammalian cochlea relies not only on the sensory hair ce

105 e most crucial functional refinements in the mammalian cochlea, the disruption of which contributes t

106 mutase (iPGM) structurally distinct from the mammalian cofactor-dependent (dPGM) isozyme.

107 velopment can occur in the context of Trr or mammalian COMPASS-like proteins deficient in H3K4 monome

108 RNA-seq data, and found that, except for few mammalian conserved editing sites, editing is significan

109 ightened transcriptional coordination during mammalian cortical neurogenesis.

110 ression of the Drosophila orthologues of all mammalian CPA factors and note that their expression dec

111 on may have been crucial in the evolution of mammalian CS systems that improved fine motor control in

112 Although mammalian Ctr1 functions as a Cu(+) transporter for Cu a

113 sults clarify the functional role of Phf8 in mammalian development and behaviour and establish a dire

114 ve defects and cleft lip/palate, its role in mammalian development and physiology remains unexplored.

115 (all-trans retinol) plays critical roles in mammalian development and vision.

116 and dynamics of translational control during mammalian development remain poorly understood.

117 miswired during the onset and progression of mammalian disease states.

118 Collectively, our findings shed light on how mammalian dynein complexes associate with dynamic microt

119 Establishment of cell polarity in the mammalian embryo is fundamental for the first cell fate

120 Mammalian embryogenesis requires intricate interactions

121 During mammalian embryogenesis, cardiac progenitor cells consti

122 , we review the crucial functions of KLFs in mammalian embryogenesis, stem cell biology and regenerat

123 Mammalian embryos transiently exhibit aerobic glycolysis

124 al bacteria can promote infection of several mammalian enteric RNA viruses, but the mechanisms and co

125 tated form of Kv2.1 mimicking apoptosis in a mammalian expression system, and protected cortical neur

126 y expressed at pressure-bearing sites of the mammalian footpad.

127 lion symbiotic microorganisms inhabiting the mammalian gastrointestinal tract (i.e., the microbiota)

128 chanisms by which ExPEC strains colonize the mammalian gastrointestinal tract.

129 mutated in epilepsy, recruits a fraction of mammalian GATOR1 and GATOR2 to form a SZT2-orchestrated

130 systematic literature review identifying 13 mammalian genes for which there is evidence for polycist

131 Here we monitored translation of the mammalian genome as cells become specified and organize

132 The mammalian genome contains hundreds of p53-binding sites.

133 undamental insights into the rules governing mammalian genome organization.

134 illion rNMPs transiently incorporated in the mammalian genome per cell cycle.

135 een limited to fungal systems due to lack of mammalian genome-wide deletion collections.

136 oding RNAs (ncRNAs) has expanded our view on mammalian genomes and transcriptomes, as well as their o

137 Mammalian genomes are replete with interspersed repeats

138 Intriguingly, mammalian genomes encode many poorly characterized SR-li

139 Mammalian genomes exhibit complex patterns of gene expre

140 hat GeoCas9 is an effective tool for editing mammalian genomes when delivered as a ribonucleoprotein

141 C17orf99 is only present in mammalian genomes, and it encodes a small ( approximatel

142 omous non-LTR retroelement that is active in mammalian genomes.

143 Recent studies suggest that the mammalian globin cytoglobin (CYGB) regulates nitric oxid

144 Cellular prion protein (PrP(C)) is a mammalian glycoprotein which is usually found anchored t

145 stitium) are two major somatic cell types in mammalian gonads, but the mechanisms that control their

146 aving a significant role in the evolution of mammalian gut microbiome compositions.

147 n viruses also interact with bacteria in the mammalian gut.

148 We show that the mammalian HC proteome comprises hundreds of uniquely or

149 gether, our results uncover a new inducer of mammalian heart regeneration and highlight fundamental r

150 The inability of the adult mammalian heart to regenerate following injury represent

151 During normal lifespan, the mammalian heart undergoes limited renewal of cardiomyocy

152 modulates protein synthetic capacity of the mammalian heart.

153 In healthy mammalian hearts the action potential (AP) waveform init

154 model that demonstrates conservation of the mammalian hemostatic and vascular systems.

155 s in specialized eukaryotic cells such as in mammalian hepatocytes and B-cells.

156 In other cell types, Munc13 (mammalian homolog of Caenorhabditis elegans uncoordinate

157 their molecular functions, including how the mammalian homologs Cripto-1 and Cryptic recognize and re

158 tream-form type proteome upon entry into the mammalian host and resumption of cell division.

159 urvival of B. burgdorferi spirochetes in the mammalian host is achieved though VlsE-mediated antigeni

160 k between a soil-associated ancestor and the mammalian host-adapted pathogenic Brucella species.

161 We observed a significant focus on mammalian hosts, a few well-studied or purely theoretica

162 virus has been only moderately pathogenic to mammalian hosts, virulence can still increase.

163 f enterobacteria to the environment of their mammalian hosts.

164 hanisms to evade detection by its insect and mammalian hosts.

165 endows bacilli with invasive attributes for mammalian hosts.

166 ) is expressed in the arcuate nucleus of the mammalian hypothalamus and plays a key role in regulatin

167 cytokine families, suggesting a function in mammalian immune responses.

168 The mammalian immune system has evolved over many millennia

169 To detect potential infections, the mammalian immune system utilizes several families of pat

170 IL17 cytokines are central mediators of mammalian immunity.

171 lex (G4)-containing substrates mimicking the mammalian immunoglobulin switch regions are particularly

172 However, the in vivo roles of TFEB in the mammalian intestinal epithelium were not known.

173 The mammalian intestine is colonized by trillions of bacteri

174 zinc-binding site and regions unique to the mammalian IP5 2-K, as an unexpected basic patch on the p

175 Key players in mammalian iron trafficking include several types of cell

176 entally reduced, the absence of KLP-7 or the mammalian kinesin-13 protein MCAK (KIF2C) also resulted

177 Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that ca

178 ndergone adaptive pseudogenization in select mammalian lineages.

179 The fat body, a counterpart of mammalian liver and adipose tissues, is the metabolic ce

180 Our studies identified a highly up-regulated mammalian lncRNA, FOXD3-AS1, known as linc1623 in mice,

181 In Drosophila and mammalian macrophages, lysosomal dysfunction due to loss

182 The mammalian Major Histocompatibility Complex (MHC) region

183 The calyx of Held synapse in the mammalian medial nucleus of the trapezoid body (MNTB) pl

184 In mammalian melanocytes, it is well known that the Rab27a/

185 a combination of high-content imaging and a mammalian membrane two-hybrid protein-protein interactio

186 Although Ascl1 is not expressed in mammalian MG after injury, forced expression of Ascl1 in

187 nsional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive im

188 ones and Shugoshins is a fundamental step in mammalian mitotic progression.

189 In this study, we used an emerging mammalian model of epimorphic regeneration, the African

190 me- and active site-specific GST activity in mammalian model systems.

191 using the regenerating mouse digit tip as a mammalian model, we demonstrate that macrophages are ess

192 TRUB1 and PUS7 as the two key PUSs acting on mammalian mRNA and to computationally model the sequence

193 Psi presence, regulation, and biogenesis in mammalian mRNA.

194 The mammalian Msi genes, Msi1 and Msi2, have been most thoro

195 e proposal is based on research on yeast and mammalian muscle and brain that demonstrates that the gl

196 SIRT1, the most conserved mammalian NAD(+)-dependent protein deacetylase, plays a

197 estigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD(+)-dependent protein deacetylase, senses e

198 lability of probes for functional studies of mammalian Nav is limited.

199 The mammalian need for social proximity, attachment and belo

200 Notch signaling plays important roles during mammalian nephrogenesis.

201 eported spread of pathogenic proteins in the mammalian nervous system, but whether nonpathogenic ones

202 In the mammalian nervous system, myelin provides electrical ins

203 ate synaptic composition and function in the mammalian nervous system.

204 Like mammalian neural stem cells, Drosophila type II neurobla

205 e findings link the O-GlcNAc modification to mammalian neurogenesis and highlight the role of this nu

206 enzymatic activity had slower replication in mammalian neuronal cells and reduced virulence in 2-day-

207 osphorylated and -phosphorylated recombinant mammalian NM2A, NM2B, and NM2C polymerized in the presen

208 le for RNH1 in global DNA replication in the mammalian nucleus.

209 between microtubules assembled in vitro from mammalian or budding yeast tubulin.

210 strategy generalizable to the study of other mammalian organelles.

211 sive splicing programs and are essential for mammalian organogenesis.

212 ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression.

213 role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (G

214 ors, including Syp1 in budding yeast and its mammalian orthologue, FCHo1.

215 human breast cancer, elevated levels of the mammalian paralogs MMP2, MMP9, and MMP13 are associated

216 nd secreted heme peroxidase with homology to mammalian peroxidases.

217 technology as a way to locally eliminate the mammalian pests that threaten its unique flora and fauna

218 he genetic/molecular model Dictyostelium and mammalian phagocytes share mechanistic pathways for chem

219 on of cross-species mapping efforts with the Mammalian Phenotype Ontology, an improved quality contro

220 Seasonal changes in mammalian physiology, such as those affecting reproducti

221 gene in nephrocytes, fly cells homologous to mammalian podocytes, induced increased endocytic activit

222 physiology, yet few cases are documented in mammalian postnatal life.

223 Mammalian PRC2 binds RNA promiscuously, with thousands o

224 Misofolding of mammalian prion proteins (PrP) is believed to be the cau

225 screening for potential interactions between mammalian proteins possessing one or more WW domains and

226 A complex of two related mammalian proteins, SFPQ and NONO, promotes DNA double-s

227 importance of S-nitrosation sites across the mammalian proteome, remain largely uncharacterized.

228 nctional interactions between the endogenous mammalian prototoxin, lynx1, and alpha3- and beta4-subun

229 The mammalian pupillary light reflex (PLR) involves a bilate

230 We highlight some of the mammalian regulatory innovations driven by specific KRAB

231 Here, using mammalian reovirus, we highlight the molecular mechanism

232 Mammalian reproductive function depends upon a neuroendo

233 basic scheme of neuronal organization in the mammalian retina is the segregation of ON and OFF pathwa

234 (+) (BKCa ) channels play important roles in mammalian retinal neurons, including photoreceptors, bip

235 Foamy viruses have the largest genomes among mammalian retroviruses and their vectors have shown pote

236 odifying enzymes that functionally diversify mammalian ribosomes.

237 Collectively, these data reveal that mammalian RNAs can harbor a 5' end modification distinct

238 Here, we report that mammalian RNase H1 enriches in nucleoli and co-localizes

239 Mammalian shelterin proteins POT1 and TPP1 form a stable

240 tion of Sin3B, an essential component of the mammalian Sin3-histone deacetylase corepressor complex,

241 ble novel biological analyses of hundreds of mammalian-sized genomes.

242 peptides derived from milk proteins from any mammalian source.

243 key role for Osx for bone formation in a non-mammalian species, and reveals conserved and non-conserv

244 Using a global dataset of mammalian species, Mazel and colleagues find that both c

245 visual cortex increases over a wide range of mammalian species.

246 g retrocopies of the same parental gene in a mammalian species.

247 have a poor sense of smell compared to other mammalian species.

248 hing expanded potential stem cells for other mammalian species.

249 ecies are quite distinct from those in other mammalian species.

250 ts requires formation of unusual, long-range mammalian-specific RNA duplexes.

251 veal substantial global epigenomic change in mammalian sperm methylomes and point to a divergence in

252 The mammalian spiral ganglion neurons (SGNs) are specialzed

253 Here, we analyzed gene expression in mammalian stem cells and cells at various stages of diff

254 tal role in directing asymmetric division of mammalian stem cells to sustain the stem cell pool.

255 ocytes is dispensable for HCC formation when mammalian sterile 20-like kinase 1 and 2 (Mst1 and Mst2)

256 ative algal structure resembles the in vitro mammalian structure, but additionally reveals cargo boun

257 target-binding cystine-dense peptides using mammalian surface display, capable of interrogating high

258 most prominent example, which is critical to mammalian survival, is that of pancreatic alpha and beta

259 ed gene 1 (Brg1), a catalytic subunit of the mammalian SWI/SNF chromatin-remodeling enzymes, is requi

260 ss and reveal functional similarities to the mammalian system.

261 isassembly and testing in both bacterial and mammalian systems as a strategy for the creation of puta

262 Mammalian systems inactivate endobiotic and xenobiotic c

263 l nonrepressed 2 serine/threonine kinase and mammalian target of rapamycin (both molecules involved i

264 f mTORC2, or pharmacologic inhibition of the mammalian target of rapamycin (mTOR) kinase, promotes gl

265 lity of inflammatory cells by activating the mammalian target of rapamycin (mTOR) pathway.

266 factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway a

267 d with uric acid priming, with NF-kappaB and mammalian target of rapamycin (mTOR) signaling strongly

268 Further, the mammalian target of rapamycin (mTOR) signaling was impli

269 -isoxazolepropionic acid (AMPA) receptor and mammalian target of rapamycin (mTOR) signaling, respecti

270 er docetaxel chemoresistance mediated by the mammalian target of rapamycin (mTOR)/sphingosine-kinase-

271 -AMPK and lower levels of phosphorylation of mammalian target of rapamycin (phospho-mTOR).

272 unds targeting phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling are

273 usly that Trex1-deficient cells have reduced mammalian target of rapamycin complex 1 (mTORC1) activit

274 The mammalian target of rapamycin complex 1 (mTORC1) kinase

275 family GTPase, which binds to and activates mammalian target of rapamycin complex 1 (mTORC1) when GT

276 This event requires the mammalian target of rapamycin complex 1 (mTORC1), a sign

277 keletal muscle myostatin expression, reduced mammalian target of rapamycin complex 1 function, and hy

278 atenin, whereas hypertrophy was dependent on mammalian target of rapamycin complex 1.

279 that loss of Pdcd4 increases the activity of mammalian target of rapamycin complex 2 (mTORC2) and the

280 Mammalian target of rapamycin inhibitors may confer card

281 phatase activity in the nucleus can regulate mammalian target of rapamycin signaling and neuronal gro

282 alterations in the proteins associated with mammalian target of rapamycin signalling were detected i

283 sphorylated protein kinase B, phosphorylated mammalian target of rapamycin, phosphorylated eukaryotic

284 threonine kinase and increased expression of mammalian target of rapamycin, suggesting reduced amino

285 state, synchrony, and rhythmogenesis in the mammalian thalamocortical system, similar to chemical sy

286 e action potential evoked calcium signals in mammalian tibial nerve axons using an in vitro mouse mod

287 Mammalian tissues rely on a variety of nutrients to supp

288 ge, this vascular plasticity is unique among mammalian tissues, and we expect this insight will decis

289 iverdin tetrapyrrole, which is ubiquitous in mammalian tissues, as a chromophore.

290 he structural basis for Na(+) selectivity in mammalian TPCs.

291 to determine the role of BTA121 in the tick-mammalian transmission cycle of B. turicatae.

292 allows us to model their evolution along the mammalian tree and to infer ancient diets from the predi

293 Crystals of the CRD in complex with a mammalian-type high-mannose Man9GlcNAc2 oligosaccharide

294 n assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1

295 The constructs are then expressed from mammalian vectors, secreted into culture media, purified

296 atson and Puelles now newly propose that the mammalian ventral pallium gives rise not only to all of

297 The mammalian ventricular-subventricular zone (V-SVZ) presen

298 eplacement (turnover) throughout life in non-mammalian vertebrates.

299 natural product biosynthesis through to the mammalian visual cycle.

300 The 19 mammalian Wnt proteins are cross-reactive with the 10 FZ