ライフサイエンスコーパス: mammalian genome

1 ategic searches with small seeds (~14 nt for mammalian genomes).

2 well to many genomes of large size (such as mammalian genomes).

3 has evolved an essential function(s) in the mammalian genome.

4 been considered limiting for translating the mammalian genome.

5 higher coverage than has been reported in a mammalian genome.

6 ly suggests evolutionary conservation in the mammalian genome.

7 but also in distal regulatory regions in the mammalian genome.

8 ethylation process occurs extensively in the mammalian genome.

9 coding DNA occurs pervasively throughout the mammalian genome.

10 sex chromosomes impacts the evolution of the mammalian genome.

11 deoxyribonucleic acid (DNA) damage from the mammalian genome.

12 s), comprising a substantial fraction of the mammalian genome.

13 regulation of transcriptional networks in a mammalian genome.

14 ing the function of all genes encoded by the mammalian genome.

15 H3K4 trimethylation (H3K4me3) throughout the mammalian genome.

16 ranscriptionally silent genes throughout the mammalian genome.

17 lly to promoter and enhancer elements in the mammalian genome.

18 ranscription regulation of many genes in the mammalian genome.

19 ation is the most common modification in the mammalian genome.

20 e largest transcription factor family in the mammalian genome.

21 pes add to the transcriptional complexity in mammalian genome.

22 e of germline gene expression in shaping the mammalian genome.

23 s (ERVs), constitute a large fraction of the mammalian genome.

24 , including the largest miRNA cluster in the mammalian genome.

25 n and higher-order chromatin organization of mammalian genomes.

26 l fraction of endogenous Dicer substrates in mammalian genomes.

27 LINE retrotransposons actively shape mammalian genomes.

28 eramide synthase, both beta-transferases, in mammalian genomes.

29 ded to minimize off-target cleavage in large mammalian genomes.

30 grading enzymes, which are largely absent in mammalian genomes.

31 transposable elements (TEs) are abundant in mammalian genomes.

32 frequent CHR-based regulation is utilized in mammalian genomes.

33 tionships with multiple other SR proteins in mammalian genomes.

34 mostly unmethylated within highly methylated mammalian genomes.

35 e analysis of all CpG island sequences in 10 mammalian genomes.

36 in a PWM, based on a multiple alignment of 5 mammalian genomes.

37 gene expression and are abundant throughout mammalian genomes.

38 of TLS and HDR across defined DNA lesions in mammalian genomes.

39 egulation of the transcriptional products of mammalian genomes.

40 lexity from simple microbial species through mammalian genomes.

41 to correctly reconstruct the phylogeny of 10 mammalian genomes.

42 plified gene families in the mouse and other mammalian genomes.

43 the extent of structural divergence between mammalian genomes.

44 y distributed, autonomous retrotransposon in mammalian genomes.

45 to their suitability for analysis of hmC in mammalian genomes.

46 ological domains are an inherent property of mammalian genomes.

47 ion in the Csf1r locus in reptile, avian and mammalian genomes.

48 gene regulatory regions in large and complex mammalian genomes.

49 lomeric, promoter and transcribed regions of mammalian genomes.

50 c finger proteins (KRAB-ZFPs) are encoded in mammalian genomes.

51 s, each of which has a conserved ortholog in mammalian genomes.

52 e primary driver of non-random gene order in mammalian genomes.

53 ements, constitute a substantial fraction of mammalian genomes.

54 s of ten or more genes are extremely rare in mammalian genomes.

55 aspect of the evolution of functional DNA in mammalian genomes.

56 city for guanine, a highly prevalent base in mammalian genomes.

57 amplifies LINE-1 (L1) to high copy number in mammalian genomes.

58 es covering >80% of CpG dinucleotides within mammalian genomes.

59 were found in any of the other 44+ sequenced mammalian genomes.

60 sposons are the most common retroelements in mammalian genomes.

61 ewed as occupying a substantial niche within mammalian genomes.

62 viral vector for integrating transgenes into mammalian genomes.

63 eaving RNAs have recently been identified in mammalian genomes.

64 s, adding versatility to the manipulation of mammalian genomes.

65 lly increasing amounts of sequence data from mammalian genomes.

66 portant factors influencing the evolution of mammalian genomes.

67 ansposons that comprise approximately 20% of mammalian genomes.

68 uencing of 5-hmC-containing DNA fragments in mammalian genomes.

69 of characterizing gene regulatory regions in mammalian genomes.

70 ng genomic architectures of yeast, plant and mammalian genomes.

71 ds of meiotic recombination hot spots across mammalian genomes.

72 approaches, with a focus on the analysis of mammalian genomes.

73 rt their workflows, which is intractable for mammalian genomes.

74 ion ( approximately 20%) of total lncRNAs in mammalian genomes.

75 inducible enhancers independently in diverse mammalian genomes.

76 osine is the only form of DNA methylation in mammalian genomes.

77 locations where DNA replication initiates in mammalian genomes.

78 s the ability to engineer precise changes in mammalian genomes.

79 gnancy and reproduction from 23 high-quality mammalian genomes.

80 revalent, collectively occupying up to 5% of mammalian genomes.

81 identifying functional noncoding elements in mammalian genomes.

82 re rare in yeasts but highly likely in large mammalian genomes.

83 of 9900 proteins conserved in all sequenced mammalian genomes.

84 t of the epigenetic regulation repertoire in mammalian genomes.

85 omous non-LTR retroelement that is active in mammalian genomes.

86 cating the application of such approaches to mammalian genomes.

87 l to maintain homeostatic gene expression in mammalian genomes.

88 or insert transgenes at precise locations in mammalian genomes.

89 gBGC) has a major impact on the evolution of mammalian genomes.

90 ransposable elements comprise roughly 40% of mammalian genomes.

91 ution of enhancers is a universal feature of mammalian genomes.

92 i-C to create kilobase-resolution 3D maps of mammalian genomes.

93 cles describing different approaches to edit mammalian genomes; 330 articles describing CRISPR-Cas9-m

94 In the mammalian genome, 5'-CpG-3' dinucleotides are frequently

95 The mammalian genome also contains 5-hydroxymethylcytosine (

96 constituting at least 10% of the orthologous mammalian genome and encompassing many hundreds of human

97 the annotation of functional elements in the mammalian genome and for the study of mechanisms regulat

98 e parental allele, represent a subset of the mammalian genome and often have key roles in embryonic d

99 veals a new example of the complexity of the mammalian genome and provides novel insights into the fu

100 s as one of the major states for 5hmC in the mammalian genome and suggest that they could function in

101 fault state of most CpG dinucleotides in the mammalian genome and that a combination of local dinucle

102 cRNAs) are derived from thousands of loci in mammalian genomes and are frequently enriched in transpo

103 -derived sequence dominates the landscape of mammalian genomes and can modulate gene function by dysr

104 dogenous retroviruses (ERVs) are abundant in mammalian genomes and contain sequences modulating trans

105 DSBs rapidly at defined endogenous sites in mammalian genomes and enables direct assessment of repai

106 the large amount of repetitive sequences in mammalian genomes and have been linked to species-specif

107 Structural variation is widespread in mammalian genomes and is an important cause of disease,

108 s) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gen

109 how the bacterial Cas9 protein interrogates mammalian genomes and navigates eukaryotic chromatin str

110 he two major DNA epigenetic modifications in mammalian genomes and play crucial roles in development

111 e define the group of CHR-regulated genes in mammalian genomes and provide evidence that the CHR is t

112 ed, hotspots occurs at thousands of genes in mammalian genomes and represents an important and dynami

113 transposons are still actively shaping some mammalian genomes and reveals an unprecedented opportuni

114 These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in divers

115 oding RNAs (ncRNAs) has expanded our view on mammalian genomes and transcriptomes, as well as their o

116 s dictating tissue-specific transcription in mammalian genomes and validate our enhancer classifier s

117 transposons compose approximately 20% of the mammalian genome, and ongoing L1 retrotransposition even

118 in viruses, are being identified within the mammalian genome, and that these may provide new insight

119 has not been rigorously measured across the mammalian genome, and until now little has been known ab

120 C17orf99 is only present in mammalian genomes, and it encodes a small ( approximatel

121 eage, a double loss seen in none of 56 other mammalian genomes, and suggests a hitherto unappreciated

122 s (ERVs) constitute a substantial portion of mammalian genomes, and their retrotransposition activity

123 Recently, it was shown that enhancers in the mammalian genome are associated with characteristic hist

124 Our capacities to understand and manipulate mammalian genomes are accelerating at an astounding pace

125 Browsers for several mammalian genomes are available at http://www.biodallian

126 ites and show that several mammalian and non-mammalian genomes are enriched for strong microRNA tripl

127 Mammalian genomes are extensively transcribed outside th

128 Mammalian genomes are folded into unique topological str

129 est scoring and the largest neighborhoods in mammalian genomes are formed by tandem gene duplication.

130 ate catalogs of structural variants (SVs) in mammalian genomes are necessary to elucidate the potenti

131 Mammalian genomes are organized into megabase-scale topo

132 Mammalian genomes are partitioned into domains that repl

133 omosome conformation capture have shown that mammalian genomes are partitioned into topologically ass

134 Mammalian genomes are pervasively transcribed to produce

135 Mammalian genomes are pervasively transcribed, yielding

136 Mammalian genomes are populated with thousands of transc

137 it is less clear how unmethylated regions in mammalian genomes are protected from de novo methylation

138 Most oxidized bases in mammalian genomes are repaired via the base excision rep

139 Mammalian genomes are replete with interspersed repeats

140 Mammalian genomes are replete with retrotransposable ele

141 Mammalian genomes are spatially organized into compartme

142 Large parts of mammalian genomes are transcriptionally inactive and enr

143 re theory." Instead, our findings depict the mammalian genome as a tapestry of mostly short homogeneo

144 Here we monitored translation of the mammalian genome as cells become specified and organize

145 s a path forward for the routine assembly of mammalian genomes at a level approaching that of the cur

146 ation is not encountered when reconstructing mammalian genomes at the synteny-block level, although t

147 firms widespread distribution of 5hmC in the mammalian genome but also reveals sequence bias and stra

148 ci of genetic and epigenetic lability in the mammalian genome but argue against a direct role for spe

149 (TFs) bind to thousands of DNA sequences in mammalian genomes, but most of these binding events appe

150 Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) h

151 oding RNAs (lincRNAs) are generated from the mammalian genome by RNA polymerase II (Pol II) transcrip

152 bly the most abundant base lesion induced in mammalian genomes by reactive oxygen species, is repaire

153 Adjacent CpG sites in mammalian genomes can be co-methylated owing to the proc

154 Remodeling DNA methylation in mammalian genomes can be global, as seen in preimplantat

155 In the mammalian genome, certain genomic loci/regions pose grea

156 All hitherto analyzed mammalian genomes code for two mARC genes (also referred

157 Only a small fraction of the mammalian genome codes for messenger RNAs destined to be

158 th iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gat

159 protein (HMGCLL1) has been annotated in the Mammalian Genome Collection as a previously unidentified

160 Approximately half of the mammalian genome consists of repetitive elements, includ

161 However, because of their complexity mammalian genomes contain millions of randomly occurring

162 Although mammalian genomes contain only one Aqp0 gene, the zebraf

163 Mammalian genomes contain thousands of loci that transcr

164 Most mammalian genomes contain two copies of miR-1, and in mi

165 Mammalian genomes contain two Sec23 paralogs, Sec23A and

166 The mammalian genome contains hundreds of p53-binding sites.

167 dependence on AIP provides evidence that the mammalian genome contains more than one class of AHR-res

168 The mammalian genome contains on the order of a million enha

169 Finally, while the mammalian genome contains two orthologous Gcm genes, the

170 al mutagens that substantially contribute to mammalian genome content.

171 In the mammalian genome, cytosines (C) were long known to exist

172 r the former enzyme, GTK/KAT I, is listed in mammalian genome data banks as CCBL1 (cysteine conjugate

173 ltaneous editing of several sites within the mammalian genome, demonstrating easy programmability and

174 suggest that, though relatively rare in the mammalian genome, divergence in higher order chromatin s

175 In the mammalian genome, DNA methylation is an epigenetic mecha

176 Within the vertebrates, the mammalian genomes do not contain the second dCK, while b

177 Retrotransposons are highly prevalent in mammalian genomes due to their ability to amplify in plu

178 marize CRISPR-based technologies that enable mammalian genome editing and their various applications.

179 Sequence capture technologies, pioneered in mammalian genomes, enable the resequencing of targeted g

180 (Pyl)CUA pair (and its derivatives) into the mammalian genome enables efficient, homogeneous incorpor

181 Mammalian genomes encode 2 DUOX isoenzymes (DUOX1/DUOXA1

182 Mammalian genomes encode 4 PCBPs, including the minimall

183 Mammalian genomes encode a family of structurally relate

184 Mammalian genomes encode at least 15 distinct DNA polyme

185 Vast parts of mammalian genomes encode for transcripts that are not fu

186 Mammalian genomes encode four complexins that are compos

187 Mammalian genomes encode genetic information in their li

188 Intriguingly, mammalian genomes encode many poorly characterized SR-li

189 Mammalian genomes encode multiple homologs of the Polyco

190 Mammalian genomes encode numerous cis-natural antisense

191 Mammalian genomes encode roughly 70 F-box proteins, but

192 Mammalian genomes encode seven catalytic proteasome subu

193 relatively recently has it become clear that mammalian genomes encode tens of thousands of long non-c

194 Mammalian genomes encode two provitamin A-converting enz

195 Between 0.5% to 1% of the mammalian genome encodes for proteins that are tethered

196 The mammalian genome encodes multiple Wnt proteins and recep

197 The mammalian genome encodes two A-type cyclins, which are c

198 To facilitate mammalian genome engineering applications, we provide a

199 and its subsequent adaptation as a tool for mammalian genome engineering has opened up new avenues f

200 93 cells and represents a promising tool for mammalian genome engineering.

201 genomic locations is a significant driver of mammalian genome evolution, but these mutagenic events c

202 Mammalian genomes exhibit complex patterns of gene expre

203 ifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an integr

204 d data from the Functional Annotation of the Mammalian Genome (FANTOM5) project.

205 chanism and function of DNA demethylation in mammalian genomes, focusing particularly on how developm

206 nsidered to be functionally important in the mammalian genome for transcriptional regulation, DNA rep

207 resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells a

208 are enabling the systematic interrogation of mammalian genome function.

209 The mammalian genome harbors up to one million regulatory el

210 eletions, insertions and replacements in the mammalian genome has revolutionized the field of genome

211 The vast majority of the mammalian genome has the potential to express noncoding

212 Sequencing of the human and other mammalian genomes has facilitated identification of the

213 associated with transcriptional silencing in mammalian genomes, has been shown to be an important mec

214 Although more than thirty mammalian genomes have been sequenced to draft quality,

215 However, plant and mammalian genomes have evolved to contain repetitive ele

216 e chromosome damage at specific sites of the mammalian genome in living cells.

217 Mammalian genomes include a considerable number of endog

218 3 ligase is essential for the maintenance of mammalian genome integrity and the proper development an

219 Folding of mammalian genomes into spatial domains is critical for g

220 DSB repair in complex mammalian genomes involves a fast phase (2-6 h) in which

221 n at the 5 position of cytosine (5mC) in the mammalian genome is a key epigenetic event critical for

222 he development of new approaches to edit the mammalian genome is a prerequisite to delivering the cli

223 Because a large portion of the mammalian genome is associated with the nuclear lamina (

224 It has been suggested that the mammalian genome is composed mainly of long compositiona

225 Almost half of the mammalian genome is composed of endogenous retroviruses

226 The typical mammalian genome is dominated by two types of transposab

227 The mammalian genome is extensively transcribed, a large fra

228 The mammalian genome is extensively transcribed, giving rise

229 t, suggesting that a large proportion of the mammalian genome is functional.

230 More than 98% of the mammalian genome is noncoding, and interspersed transpos

231 ecent studies show that transcription of the mammalian genome is not only pervasive but also enormous

232 A large fraction of the mammalian genome is organized into inactive chromosomal

233 Transcription of the mammalian genome is pervasive, but productive transcript

234 replisome) at telomeres or elsewhere in the mammalian genome is poorly understood.

235 The number of imprinted genes in the mammalian genome is predicted to be small, yet we show h

236 The mammalian genome is punctuated by CpG islands (CGIs), wh

237 , and claims that almost the entirety of the mammalian genome is transcribed into functional noncodin

238 A large fraction of the mammalian genome is transcribed into long noncoding RNAs

239 Targeted gene addition to mammalian genomes is central to biotechnology, basic res

240 elopment of new methods for gene addition to mammalian genomes is necessary to overcome the limitatio

241 mount of regulatory information contained in mammalian genomes is organized in precise 3D chromatin s

242 he functional role of repetitive elements in mammalian genomes is still largely unexplored.

243 ymethylcytosine (hmC), the sixth base of the mammalian genome, is increasingly recognized as an epige

244 ished role of L1 retrotransposons in shaping mammalian genomes, it becomes an important task to track

245 The avian genomes lack TLR9, whereas mammalian genomes lack TLR21.

246 There are two orthologs of Lgl in mammalian genomes: Llgl1 and Llgl2.

247 RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in

248 Reprogramming of mammalian genome methylation is critically important but

249 t PRMT5-mediated H4R3me2s uniquely marks the mammalian genome, mostly at G + C-rich regions, and inde

250 collagen (I) gene transcripts from available mammalian genomes or mass spectrometrically derived sequ

251 undamental insights into the rules governing mammalian genome organization.

252 t cohesin-dependent loop extrusion organizes mammalian genomes over multiple scales from the one-cell

253 CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base composition

254 In diploid mammalian genomes, parental alleles can exhibit differen

255 illion rNMPs transiently incorporated in the mammalian genome per cell cycle.

256 ecades the compositional organization of the mammalian genome posed a formidable challenge to molecul

257 rong heterogeneity of SCU induced by gBGC in mammalian genomes precludes any optimization of the tRNA

258 he recent discovery that the human and other mammalian genomes produce thousands of long non-coding R

259 (5hmC) is a recently discovered base in the mammalian genome, produced upon oxidation of 5-methylcyt

260 With the progress of mammalian genome projects, information on the MIC, ULBP,

261 s, in combination with the wealth of TSSs in mammalian genomes, provide a framework with which evolut

262 thousands of replication origins throughout mammalian genomes, providing an unprecedented opportunit

263 anscription at multiple enhancers within the mammalian genome raises critical questions regarding whe

264 d by, genetic drift or positive selection in mammalian genomes remain poorly defined.

265 cation of functional regulatory sequences in mammalian genomes remains a major challenge.

266 Methylation of cytosines in the mammalian genome represents a key epigenetic modificatio

267 rvey methylation at about one-third of all a mammalian genome's CpGs.

268 ggest that our approach will scale to future mammalian genome-sequencing efforts, saving both time an

269 dition, with the availability of a number of mammalian genomes, similarities in phenotype between dis

270 Replication of mammalian genomes starts at sites termed replication ori

271 Modified DNA bases in mammalian genomes, such as 5-methylcytosine ((5m)C) and

272 Our findings establish RNase H2 as a key mammalian genome surveillance enzyme required for ribonu

273 -dC (cadC) are newly discovered bases in the mammalian genome that are supposed to be substrates for

274 lly important epigenetic modification of the mammalian genome that has widespread influences on gene

275 priority genomes, especially human and other mammalian genomes that are rich in noncoding sequences.

276 we identify endogenous retroviral fossils in mammalian genomes that share a unique recombinant struct

277 sociated long non-coding RNAs encoded by the mammalian genome, the Uph-Hand2 regulatory partnership o

278 Although the HNMT-like gene is absent in mammalian genomes, the activity of carnosine N-methyltra

279 In mammalian genomes, the central E-box CpG has the potenti

280 Unlike the two ligands encoded by mammalian genomes, the zebrafish genome contains three g

281 Although thousands of NATs are encoded by mammalian genomes, their functions in innate immunity ar

282 catalyze the integration of plasmid DNA into mammalian genomes, there is still an unmet need for enzy

283 essential to remove ribonucleotides from the mammalian genome to prevent DNA damage.

284 ccessively oxidize 5-methylcytosine (5mC) in mammalian genomes to 5-hydroxymethylcytosine (5hmC), 5-f

285 Mammalian genomes typically contain hundreds of thousand

286 Mammalian genomes undergo epigenetic modifications, incl

287 some association are highly conserved across mammalian genomes, underscoring their possible biologica

288 Here we calculate 3D structures of entire mammalian genomes using data from a new chromosome confo

289 ecificity of long-range chromatin looping in mammalian genomes, using protocadherin (Pcdh) and beta-g

290 in replicating single-stranded templates in mammalian genomes, warranting prereplicative repair of t

291 -length Golem, found as a few copies in many mammalian genomes, was found abundantly in horse.

292 omparison to the eight mglurs present in the mammalian genome, we identified 13 different mglur genes

293 testing a human model on the nine different mammalian genomes, we provide the first evidence that k-

294 a, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on c

295 hat GeoCas9 is an effective tool for editing mammalian genomes when delivered as a ribonucleoprotein

296 strategy to detect complete loss of CNEs in mammalian genomes while strictly controlling for artifac

297 roteins that compose approximately 4% of the mammalian genome whose members share a common membrane t

298 een limited to fungal systems due to lack of mammalian genome-wide deletion collections.

299 reby establishing the feasibility of in vivo mammalian genome-wide investigations to dissect tissue d

300 e in suppressing retrotransposon activity in mammalian genomes, yet there are stages of mammalian dev