ライフサイエンスコーパス: mammary bud

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1 lial-mesenchymal signaling in the developing mammary bud.

2 e examined IRS-1/2 double knockout embryonic mammary buds.

3 that BMP4 can rescue outgrowth of PTHrP(-/-) mammary buds.

4 in signaling, is expressed in the developing mammary bud and in luminal epithelial cells in the adult

5 ization in the developing E14.5day embryonic mammary bud and within the ducts, terminal end buds (TEB

6 PTHrP is made in the epithelial cells of the mammary bud and, during embryonic mammary development, i

7 ify a hitherto unknown function for Fgf20 in mammary budding and branching morphogenesis.

8 actions of BMP4, triggering outgrowth of the mammary buds and inducing MSX2 expression, which, in tur

9 elays formation of Eda-induced supernumerary mammary buds and normalizes the embryonic and postnatal

10 gnaling is important for outgrowth of normal mammary buds and that BMP4 can rescue outgrowth of PTHrP

11 trast, PPR1 expression is not limited to the mammary bud, but is found generally within the subepider

12 ion of mammary mesenchyme markers and allows mammary bud cells to revert to an epidermal fate.

13 We developed a mammary bud culture system that allowed us to manipulate

14 mary marker expression and lack two pairs of mammary buds, demonstrating that Gli3 is essential for m

15 istologically, suggesting that initiation of mammary bud development occurs.

16 deletion exhibit major defects in embryonic mammary bud development.

17 Mouse mammary buds dissected at E14 and cultured for 5 days sh

18 iol (E2) resulted in monotonic inhibition of mammary buds ductal growth.

19 ttern, first in the epithelium overlying the mammary bud during embryogenesis and then in the myoepit

20 ough p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal

21 ds, demonstrating that Gli3 is essential for mammary bud formation and preceding patterning events.

22 ells underlying the ventral epidermis during mammary bud formation.

23 e mammary gland development, we transplanted mammary buds from genetically rescued ErbB2(-/-) embryos

24 ede mammary gland induction, but compromises mammary bud growth, as well as TEB formation, ductal out

25 wth that is responsible for transforming the mammary bud into the rudimentary mammary duct system.

26 i2 promoter in Gli3(xt/+) mice, also induces mammary bud loss.

27 of the HoxD complex, are transcribed during mammary bud (MB) development.

28 esenchymal interactions necessary to sustain mammary bud morphogenesis.

29 cient embryos also displayed a similar small mammary bud phenotype.

30 ErbB2(-/-) mammary buds transplanted to a wild-type mammary fat pad

31 The density of mammary buds was significantly increased in BPA-exposed

32 s of homozygous deletion of p190A, embryonic mammary buds were rescued by transplantation into the cl

33 ion of the TOPGAL-C reporter and resulted in mammary buds with reduced expression of mammary mesenchy

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