ライフサイエンスコーパス: mammary gland

1 of primary organotypic cultures of the mouse mammary gland.

2 ve during functional maturation of the adult mammary gland.

3 e growth in size of the primary tumor in the mammary gland.

4 ipocyte fate determination in the developing mammary gland.

5 regulating the postnatal development of the mammary gland.

6 ciated appendages such as hair, eye, and the mammary gland.

7 de range of lineages, including those of the mammary gland.

8 uce multipotency during tumorigenesis in the mammary gland.

9 nd pathways regulated by progesterone in the mammary gland.

10 the ErbB2 oncogenic signaling pathway in the mammary gland.

11 specifying the functional maturation of the mammary gland.

12 ng in nutrient-regulatory genes in the adult mammary gland.

13 is during development and postnatally in the mammary gland.

14 nally differentiated epithelial cells in the mammary gland.

15 lved in HIF-regulated differentiation of the mammary gland.

16 ng E. coli vaccine-induced protection of the mammary gland.

17 cells, the second major cell lineage of the mammary gland.

18 hormonal action on critical targets like the mammary gland.

19 s necessary for long-term maintenance of the mammary gland.

20 n of polar lipids is highly regulated in the mammary gland.

21 ent, and secretory function in the lactating mammary gland.

22 me and bacterial load in cows with a healthy mammary gland.

23 IgA in the serum, gut, feces, and lactating mammary gland.

24 partment in an intact and normally developed mammary gland.

25 nal epithelial cell populations in the adult mammary gland.

26 except for Glutathione Peroxidase), brain or mammary glands.

27 rganized epithelial compartment within their mammary glands.

28 already operational before the appearance of mammary glands.

29 d ability to generate mammospheres in normal mammary glands.

30 orphological alterations in nulliparous mice mammary glands.

31 xmp2 was detected in the stroma of wild-type mammary glands.

32 r proliferation and growth of the uterus and mammary glands.

33 and molecular clock gene expression in mouse mammary glands.

34 a key role for MMP14 and MMP15 in regulating mammary gland adipocyte differentiation.

35 umented, and immune responses protecting the mammary gland against E. coli are not completely underst

36 vestigate the role of super-enhancers in the mammary gland, an organ characterized by exceptional gen

37 autophagy and cell death in both the normal mammary gland and BC cells.

38 levated serotonin concentrations in both the mammary gland and circulation compared to controls.

39 rom mice with spontaneous tumor formation of mammary gland and conditional deletion of the type II TG

40 e fates of phenylalanine and tyrosine in the mammary gland and could be used as part of a more comple

41 benzo-a-pyrene (BaP) metabolism in the mouse mammary gland and develop a circadian in vitro model for

42 anching morphogenesis are exemplified by the mammary gland and feathers.

43 gly, this signature is present in the normal mammary gland and is progressively lost in patients with

44 Plk2 is highly expressed in the mammary gland and is required for proper mammary gland d

45 vide new insights into the role of SEMA3B in mammary gland and provides a new branch of GATA3 signali

46 rowth-hormone concentrations that may affect mammary gland and pubertal development.We evaluated the

47 AP2C/AP-2gamma influences development of the mammary gland and regulates patterns of gene expression

48 t, WAP-Cre x Tph1 (FL/FL) dams had decreased mammary gland and serum serotonin concentrations compare

49 ) on mammary cell fate in the pre-neoplastic mammary gland and show that the cell of origin of PIK3CA

50 t lymphangiogenesis occurs in the postpartum mammary gland and suggest that tumors within this mammar

51 uggest that GPR109A is a tumor suppressor in mammary gland and that pharmacologic induction of this g

52 regulates mitotic spindle orientation in the mammary gland and that this might account for its sugges

53 exposure influences BaP metabolism in mouse mammary glands and describe an in vitro model that can b

54 Dams were euthanized on d10 postpartum and mammary glands and duodenal tissue were harvested.

55 report that Fgf20 is expressed in embryonic mammary glands and is regulated by the Eda pathway.

56 ecific binding of (64)Cu-DOTA-alendronate in mammary glands and mammary tumors.

57 IF4E govern its biologic output in lactating mammary glands and that eIF4E overexpression in the cont

58 the different cell types that constitute the mammary gland, and discuss how these cell types arise an

59 reased progressively during gestation in the mammary gland, and GAPDH binding was nucleotide-specific

60 EMT in vivo, in developing mouse embryos and mammary gland, and in vitro, in cultured 3D cell aggrega

61 e effects of 17beta-estradiol (E2) in normal mammary gland, and it is a key participant in breast can

62 in untreated human breast carcinomas, normal mammary gland, and peripheral blood.

63 in-induced alveolar unit contractions in the mammary gland, and we demonstrated that in this model mi

64 ermal organs, such as teeth, hair follicles, mammary glands, and salivary glands.

65 transporter ZnT2 is critical for appropriate mammary gland architecture, and ZnT2 deletion is associa

66 The ducts and acini of the human mammary gland are prototypical heterogeneous and dynamic

67 e findings are the first to demonstrate that mammary glands are lateralized organs, and, moreover, th

68 in advance of foetal energetic demands; the mammary glands are primed for milk production in advance

69 y influence infant post-natal growth via the mammary gland as it does pre-natally via the placenta.

70 cells that initially appear in the embryonic mammary gland at around E17.5 coincident with the segreg

71 (V) chains are an abundant product of normal mammary gland basal cells, and that alpha3(V) ablation i

72 al organs such as teeth, hair follicles, and mammary glands begin their development as placodes.

73 We analyze stress signaling in mammary gland biology taking into account the interrelat

74 reast biology is key to the understanding of mammary gland biology.

75 iption factors important in keratinocyte and mammary gland biology.

76 to genes influencing the reproductive tract, mammary glands, bone, brain, fat differentiation, pituit

77 and epithelial-mesenchymal transition of the mammary gland both in vitro and in vivo and together wit

78 y that SHARPIN regulates the normal invasive mammary gland branching morphogenesis in an epithelial c

79 properties of stem cells that participate in mammary gland branching morphogenesis remain contested.

80 in the thymus, stomach, adrenal medulla, and mammary gland but not in other organs typically sensitiv

81 thermore, during the life of the female, the mammary gland can undergo many rounds of expansion and p

82 feration and 24% of multiparous mice develop mammary gland cancer.

83 ne cancer pain was induced by implanting rat mammary gland carcinoma cells (Walker256) into the tibia

84 he forces required for efficient invasion by mammary gland carcinoma cells.

85 isplay convergent co-option by placental and mammary gland cell types to optimize offspring success.

86 effect and the mechanism of low-dose BPA in mammary gland cells.

87 Wild-type mammary glands cleared of endogenous epithelium at 3 wee

88 served that Robo1 ablation in the developing mammary gland compromised actin stress fiber assembly an

89 mutation carriers and BRCA1-deficient mouse mammary glands contain an abnormal population of mammary

90 junctions is not symmetrical; in the murine mammary gland, Cx26, Cx30 and Cx32 are expressed only in

91 r studies revealed that MMTV-Cre, Grp94(f/f) mammary glands, despite GRP94 deficiency, exhibited norm

92 ow-dose effects include persistent delays in mammary gland development (perfluorooctanoic acid; PFOA)

93 -1 (mCripto-1) expression that occurs during mammary gland development and a stage-specific function

94 LBH is expressed during mammary gland development and aberrantly overexpressed i

95 ry tumors which were associated with delayed mammary gland development and alterations in mammary miR

96 s a new regulator of epithelial cell fate in mammary gland development and breast cancer.

97 The p53 family member, p63, is critical for mammary gland development and contains transactivation d

98 unctions are restricted to prolactin-induced mammary gland development and function.

99 y proliferative luminal subset necessary for mammary gland development and homeostasis.

100 have revealed its specific roles in pubertal mammary gland development and potential contributions to

101 the signaling pathways important for normal mammary gland development and stem cell self-renewal.

102 The work reveals impaired mammary gland development as a new category of peroxisom

103 Mammary gland development begins with the appearance of

104 gly, WAP-Int3/Rbpj knockout mice have normal mammary gland development but still developed mammary tu

105 pendent Wnt signaling coactivator, regulates mammary gland development by expanding epithelial stem/p

106 e studies showed that it is not required for mammary gland development during puberty, it is not clea

107 nal cell phenotype during carcinogenesis and mammary gland development have remained elusive.

108 not alter puberty in male and female rats or mammary gland development in female rats.

109 Mmp14 and Mmp15 targeting on early postnatal mammary gland development in mice.

110 se environmental chemical exposure on normal mammary gland development in rats to motivate and evalua

111 the roles that these proteinases play during mammary gland development in vivo remain undefined.

112 function of Xbp1 in epithelial cells during mammary gland development is unknown.

113 Examination of mammary gland development revealed that retarded mammary

114 a novel mechanism for Cripto-1 regulation of mammary gland development through direct effects on prog

115 HeyL(-/-) mice have defective mammary gland development with fewer terminal end buds.

116 Here, we examined the role of SHARPIN in mammary gland development, a process strongly regulated

117 be used to study the hormonal regulation of mammary gland development, and to test newly synthesized

118 federal testing programs, including altered mammary gland development, Her2 activation, progesterone

119 en ERalpha and c-src are required for normal mammary gland development, it was hypothesized that expr

120 In mammary gland development, mathematical modeling has bee

121 During mouse mammary gland development, the estrogen growth factor re

122 that should further understanding of normal mammary gland development, the molecular mechanism of ho

123 FGF signaling is essential for mammary gland development, yet the mechanisms by which d

124 nt stem/progenitor cells contribute to adult mammary gland development.

125 onogenic luminal progenitors is required for mammary gland development.

126 cific function of mCripto-1 signaling during mammary gland development.

127 cks proliferation and differentiation during mammary gland development.

128 e how the tissue microenvironment influences mammary gland development.

129 the mammary gland and is required for proper mammary gland development.

130 volved in energy homeostasis, ovulation, and mammary gland development.

131 onstrate a novel role for Plk2 in regulating mammary gland development.

132 ity, decreased female fertility, and delayed mammary gland development.

133 imply GRP78, but not GRP94, is required for mammary gland development.

134 showed that estrogens directly altered fetal mammary gland development.

135 licate FOXC1 as a new important regulator of mammary gland development.

136 emokines, is differentially expressed during mammary gland development.

137 show that Ackr2(-/-) mice display precocious mammary gland development.

138 RA1-dependent transcription programme during mammary gland development.

139 action between BRCA1 and COBRA1 during mouse mammary gland development.

140 lts provide a global, unbiased view of adult mammary gland development.

141 aling pathway and of the p53-p21 axis during mammary gland development.

142 The postnatal mammary gland develops extensively through cycles of pro

143 During puberty, the mouse mammary gland develops into a highly branched epithelial

144 uss how we discovered that integrins control mammary gland differentiation and explore the role of in

145 Interestingly, MMTV-Cre, Grp78(f/f) mammary glands displayed only slightly reduced GRP78 pro

146 hypoplastic uteri, abnormal ovaries, stunted mammary gland ductal development, and abnormal pituitary

147 he SNAT2 promoter gradually increased in the mammary gland during gestation and that maximal binding

148 on of the transgene was only detected in the mammary gland during lactation, with higher levels at mi

149 Serotonin is a homeostatic regulator of the mammary gland during lactation.

150 for developmental changes that occur in the mammary gland during pregnancy, lactation, and involutio

151 gh a number of studies have investigated the mammary gland effects after high-dose BPA exposure, the

152 activated myofibroblasts, counterpart normal mammary gland endothelial cells (NEC) showed little chan

153 In genetic studies in normal mammary gland epithelial and carcinoma cells, GARP expre

154 t has minimal or less effect on normal human mammary gland epithelial cells (HMECs) and estrogen rece

155 aureus- and Escherichia coli-infected bovine mammary gland epithelial cells.

156 mapping of accessible chromatin in the mouse mammary gland epithelial EpH4 cell line and its Ras-tran

157 hand, HeyL transgenic mice show accelerated mammary gland epithelial proliferation and 24% of multip

158 The mammary gland epithelium consists of differentiated lumi

159 dates resulted in the hyper-proliferation of mammary gland epithelium.

160 keratin-8-positive cells of the adult mouse mammary gland evokes cell dedifferentiation into a multi

161 We demonstrate here that the developing mammary gland expresses high levels of inflammatory CC-c

162 s effective and alternative samples to study mammary gland expression without the need to perform a t

163 The mammary gland extracellular matrix (ECM) is comprised of

164 Therefore, genes involved in mammary gland FA and PL metabolism and their resulting m

165 into wild-type stroma, fully repopulate the mammary gland fat pad, undergo unperturbed ductal outgro

166 tent activator of early involution, into the mammary gland fat pads of lactating mice increased ZnT2

167 onstrate that Cdc42 plays essential roles in mammary gland function post pregnancy, where it helps to

168 robe the specific role of Cdc42 during adult mammary gland function.

169 potential candidate genes for milk traits or mammary gland functions include ERCC6, TONSL, NPAS2, ACE

170 ngiogenic microenvironment of the postpartum mammary gland has potential as a target to inhibit metas

171 accessory organs such as hair follicles and mammary glands has proved elusive, a likely consequence

172 ntracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% pe

173 are lateralized organs, and, moreover, that mammary glands have L-R differential susceptibility to H

174 ases basal levels of autophagy in the normal mammary gland, highlighting the potential of vitamin D a

175 essing EMT-associated genes in normal murine mammary gland homeostasis and human breast cancer still

176 uggest that Zpo2 plays a significant role in mammary gland homeostasis and that deregulation of Zpo2

177 pithelial cell differentiation and maintains mammary gland homeostasis.

178 delta (PKCdelta) regulates apoptosis in the mammary gland, however, the functional contribution of P

179 flat facial appearance, skeletal anomalies, mammary gland hypoplasia, and reduced growth.

180 To improve our knowledge of mammary gland immune protection, cows immunized either i

181 Conditional knock-out of Hif1a in the mouse mammary gland impairs lobuloalveolar differentiation dur

182 enitor cells able to reconstitute a complete mammary gland in vivo.

183 ted cells failed to give rise to repopulated mammary glands in de-epithelialized recipient mice.

184 s are enriched for cells that can regenerate mammary glands in secondary transplants.

185 As a result, lactating mammary glands in these mice produce less milk protein,

186 oviral expression of ZnT2 in lactating mouse mammary glands in vivo increased Zn in lysosomes and mit

187 ed in the regeneration of hyperproliferative mammary glands in vivo.

188 heir morphologic symmetry, left versus right mammary glands in wild-type mice have baseline differenc

189 Fgf20 deficiency does not impede mammary gland induction, but compromises mammary bud gro

190 tivity was significantly higher in milk from mammary glands infected with RS-PCR banding type 1 (RSP

191 t ZnT2-mediated Zn transport is critical for mammary gland involution in mice.

192 Mammary gland involution is the most dramatic example of

193 nesis was upregulated during weaning-induced mammary gland involution.

194 cterized by dynamic tissue remodeling in the mammary gland involving ductal elongation, resolution in

195 The female mammary gland is a very dynamic organ that undergoes con

196 The mammary gland is a very dynamic organ that undergoes con

197 Branching morphogenesis in the mammary gland is achieved by the migration of epithelial

198 her analysis of the function of TAp63 in the mammary gland is critical for improved diagnosis and pat

199 An important feature of the mammary gland is its ability to undergo profound morphol

200 An important feature of the mammary gland is its ability to undergo repeated morphol

201 indicate that overexpression of Nanog in the mammary gland is not sufficient to induce mammary tumor.

202 The development of the mammary gland is unique: the final stages of development

203 eus-induced mastitis, an inflammation of the mammary gland, is unclear.

204 er, when coexpressed with Wnt-1 in the mouse mammary gland, it promotes mammary tumorigenesis and met

205 Here, we show that, in mouse mammary gland, kidney, and human prostate, these feature

206 In mouse models, PELP1 overexpression in the mammary gland leads to premalignant lesions and eventual

207 uring the involution window decreased normal mammary gland lymphangiogenesis, mammary tumor-associate

208 multipotent SCs, only unipotent SCs mediate mammary gland (MG) development and adult tissue remodeli

209 al sites, but its role in the defense of the mammary gland (MG) has seldom been investigated, althoug

210 Since the mammary gland (MG) is the only organ developing predomin

211 trolled variables across tumor and non-tumor mammary gland microvasculature with and without applicat

212 m and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly

213 nuclear function of Gal-1 in the context of mammary gland morphogenesis and in cancer progression.

214 , MMPs) and such changes facilitated altered mammary gland morphogenesis and tumor progression.

215 rough c-src and ERalpha that is required for mammary gland morphogenesis at puberty.

216 Mammary gland morphogenesis depends on a tight balance b

217 ignaling-deficient receptor showed defective mammary gland morphogenesis during pregnancy.

218 e examined the requirement of Fgfr2 in mouse mammary gland morphogenesis using a postnatal organ rege

219 The mammary gland niche must support its associated stem cel

220 ant three-dimensional model of normal murine mammary gland (NMuMG) epithelial cells.

221 In the human mammary gland, Numb is a tumor suppressor and regulates

222 Preventive infusion of antibiotics in the mammary gland of cows consumes 11 tons/year of medically

223 cal to prevent new infections in the healthy mammary gland of cows.

224 The mammary gland of K5-Cx26 female mice developed normally

225 Because the mammary gland of K5-Cx26 mothers contained excessive mil

226 es estrogen-dependent gene expression in the mammary gland of mice.

227 The mammary gland of Numb-knockout mice displays an expansio

228 ing phenylalanine and tyrosine uptake by the mammary gland of the lactating dairy cow is constructed

229 expression of the ErbB2DeltaEx16 variant in mammary gland of transgenic mice results in the rapid de

230 ession of these proteins was evident also in mammary glands of mice subjected to gamma-irradiation an

231 In mammary glands of Orai1 knockout mice, these contraction

232 l in cultured breast cancer cells and in the mammary glands of ovariectomized rats.

233 a, PKM2, and aromatase were increased in the mammary glands of p53 null versus wild-type mice.

234 At 3 days post lactational involution, the mammary glands of Snai2-deficient mice exhibited lower l

235 in, recapitulating the observations from the mammary glands of Tg mice.

236 Histologically, the mammary glands of the lactating knockout mice were disti

237 ulated) were differentially expressed in the mammary glands of the two groups.

238 f stress signaling pathways and its roles in mammary gland organogenesis, how they contribute to norm

239 helial, stromal and systemic roles in murine mammary gland organogenesis, yet specific functions rema

240 d the testing of estrogen's direct effect on mammary gland organogenesis.

241 dependent in the prostate as well as in the mammary gland, our data suggest that PI3K isoform depend

242 central transcription factor that regulates mammary gland physiology and a key driver in breast canc

243 inal and basal epithelial cells of the adult mammary gland proliferate and differentiate resulting in

244 greater reliance on HDR in the proliferating mammary gland, rather than a specific dependence on BRCA

245 ahexaenoic acid (DHA) and little evidence of mammary gland regulation to maintain individual fatty ac

246 previously unidentified involvement in male mammary gland rejection during embryogenesis.

247 E2f3a levels are elevated in TAMs from PyMT mammary glands relative to controls, suggesting a differ

248 the absence of pregnancy hormones, impaired mammary gland remodeling following the cessation of lact

249 mpaired apoptosis and a significant delay in mammary gland remodeling.

250 , teeth, sweat glands, sebaceous glands, and mammary glands, requires the action of the TNF family li

251 Unexpectedly, both Mmp14(-/-) and Mmp15(-/-) mammary glands retain the ability to generate intact duc

252 ived from conditionally deleted E2f3(-/loxP) mammary glands revealed that there is a selection agains

253 y role in controlling the development of the mammary gland's epithelial ductal network.

254 ctodermal appendages such as feathers, hair, mammary glands, salivary glands, and sweat glands form b

255 The lactating mammary gland secretes milk lipid by this mechanism, and

256 The majority of human BRCA1(mut/+) mammary glands showed marked lobular expression of nucle

257 The mammary gland-specific ablation of Stat5 is sufficient t

258 was reduced in the lobulalveoli of mice with mammary gland-specific deletion of Hif1a.

259 pression is elevated in mammary tumours, and mammary gland-specific DNMT1 deletion protects mice from

260 Using a novel mammary gland-specific JAK1 knockout model, we demonstra

261 We generated an inducible, mammary gland-specific PELP1-expressing transgenic (Tg)

262 Thus, SHARPIN is required in mammary gland stroma during development.

263 Moreover, Sharpin(cpdm) mammary gland stromal fibroblasts demonstrated defects i

264 ater selection for genomic imprinting in the mammary gland than in the short-lived placenta.

265 ious differentiation in PELP1-overexpressing mammary glands than in control glands.

266 n of neoplastic cells within the duct of the mammary gland that have not invaded into the surrounding

267 In the normal mammary gland, the basal epithelium is known to be bipot

268 In the mammary gland, the identity and characteristics of quies

269 In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA

270 In the mammary gland, the stromal extracellular matrix (ECM) un

271 for the unique regenerative capacity of the mammary gland throughout adult life.

272 The mammary gland thus provides an excellent model for study

273 xamine five different sources of RNA, namely mammary gland tissue (MGT), milk somatic cells (SC), las

274 non-invasive) to define the transcriptome of mammary gland tissue and milk cells.

275 RCA-/-, p53-/- breast tumor tissue or normal mammary gland tissue with methyl-tert-butyl ether (MTBE)

276 those smaller than 1 mm in size, from normal mammary gland tissues, with 92% sensitivity and 94% spec

277 revealed a shift from high triglycerides in mammary gland to high phospholipid levels in tumors.

278 lycans that are energetically costly for the mammary gland to produce yet indigestible by infants.

279 nslocates small neutral amino acids into the mammary gland to promote cell proliferation during gesta

280 dherin-expressing mammary cell line from the mammary gland to the lung depends on reduced E-cadherin

281 pithelial cells (mMEC) to analyze the bovine mammary gland transcriptome using RNA-Sequencing.

282 investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models

283 The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to

284 te the interactions between CSCs and CAFs in mammary gland tumors driven by combined activation of Wn

285 PKCdelta is essential for the development of mammary gland tumors in a ErbB2-overexpressing transgeni

286 Exposure to chemicals that cause rodent mammary gland tumors is common, but few studies have eva

287 The mammary gland undergoes cycles of growth and regeneratio

288 The mammary gland undergoes significant proliferative stages

289 ingly, C17orf99 expression is induced in the mammary gland upon the onset of lactation, and a C17orf9

290 hat regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(

291 ost importantly, the activity of cSrc in the mammary gland was reduced during early lactation in the

292 ty and plasticity on cell positioning in the mammary gland, we reconstituted its self-organization fr

293 Mammary glands were analyzed for tumor number and immuno

294 Mammary glands were evaluated for myoepithelium integrit

295 e developed an ex vivo culture method of the mammary gland where the direct action of estrogens can b

296 mbryonic and adult development of the murine mammary gland with high levels of expression in mammary

297 Compared to normal mammary glands with a neutral mean pH(e) (7.1 +/- 0.1),

298 uction of PIK3CA(H1047R) expression in mouse mammary glands with constitutive expression of activated

299 clinical reproductive histories, and on rat mammary glands with distinct ovarian hormone exposures.

300 in (PTHrP) in their developing epidermis and mammary glands] with those from wild type, we show that