ライフサイエンスコーパス: mammary tissue

1 ts in structurally and functionally impaired mammary tissue.

2 athways emanating from gp130 are utilized in mammary tissue.

3 ressed in the Golgi, is induced in lactating mammary tissue.

4 d significantly in non-neoplastic WAP-CRD-BP mammary tissue.

5 s obtained in Cx32-null mice and in Cx43KI32 mammary tissue.

6 clones with approximately 6000 obtained from mammary tissue.

7 is the only isoform detected in normal human mammary tissue.

8 ifferentiation, were compared with wild-type mammary tissue.

9 te to mediate the effects of beta-catenin in mammary tissue.

10 and protein are readily detectable in normal mammary tissue.

11 observed in DeltaE3 beta-catenin transgenic mammary tissue.

12 enesis collected directly from fresh ex vivo mammary tissue.

13 antly higher than in aged-matched, wild-type mammary tissue.

14 arched for genes preferentially expressed in mammary tissue.

15 promoter is restricted to liver, muscle, and mammary tissue.

16 r showed wild-type infection of lymphoid and mammary tissue.

17 l growth factor (EGF), can activate Stat5 in mammary tissue.

18 of 1500 duplicated genes isolated from mouse mammary tissue.

19 n important role in the normal remodeling of mammary tissue.

20 ng mice, but not in nonpregnant/virgin mouse mammary tissue.

21 ry human breast cancers compared with benign mammary tissue.

22 c delay of involution occurred in Stat3 null mammary tissue.

23 that genistein acts as an estrogen in normal mammary tissue.

24 nomic sequence specifically expressed in the mammary tissue.

25 that are needed for infection of adolescent mammary tissue.

26 ssess higher telomerase activity than normal mammary tissue.

27 ypes have been identified in mouse and human mammary tissue.

28 ributors to tumorigenesis in BRCA1-deficient mammary tissue.

29 d the 'responsible' isoforms using data from mammary tissue.

30 enes Adfp, Fabp4, and Pdhk4 in preneoplastic mammary tissue.

31 he lowest uptake in benign tumors and normal mammary tissue.

32 in vivo disposition in rat serum, liver, and mammary tissue.

33 f insulin and IGF-I receptors in transformed mammary tissue.

34 E form that typically is expressed in normal mammary tissue.

35 rvival of five cell lines derived from human mammary tissue.

36 ediated matrix degradation and remodeling of mammary tissue.

37 ells compared with cells derived from normal mammary tissue.

38 the progression from normal to preneoplastic mammary tissue.

39 , cyclooxygenase-2 (COX-2), and aromatase in mammary tissue.

40 e results in loss of Ramp3 expression in non-mammary tissues.

41 a-catenin signaling pathways in premalignant mammary tissues.

42 OX-2 expression in both normal and malignant mammary tissues.

43 of Ptc1 transcripts was observed in Shh-null mammary tissues.

44 ive breast cancer cases compared with normal mammary tissues.

45 and activity of p53 were examined in normal mammary tissues.

46 plifications were found in any preneoplastic mammary tissues.

47 ncy and involution cycle in rodent and human mammary tissues.

48 In normal mammary tissue, 24 Ets factors were expressed.

49 ccurs in vivo during the involution of mouse mammary tissues, a morphogenic process requiring cellula

50 or the absence of the other, specifically in mammary tissue, adipose tissue, muscle, and heart.

51 t role for these genes in the development of mammary tissue after pregnancy.

52 zed mRNA in both bovine and murine lactating mammary tissue and associates with microsomal membranes

53 expression was low or undetectable in normal mammary tissue and benign lesions, approximately two-thi

54 (SERM), which acts as an antiestrogen in the mammary tissue and displays estrogenic activity in other

55 skin and tongue epithelia, adipose, lung and mammary tissue and has been found upregulated in several

56 LGD1069 inhibits the expression of COX-2 in mammary tissue and in normal human mammary epithelial ce

57 in cellular membranes from lactating bovine mammary tissue and in the milk-fat-globule membrane.

58 ggering an intense influx of leukocytes into mammary tissue and increased concentrations of IL-6, IL-

59 Stra6 mRNA was also observed in hyperplastic mammary tissue and mammary gland tumors from transgenic

60 th genes are most highly expressed in normal mammary tissue and mammary tumors from several transgeni

61 omparison of Ets factor expression in normal mammary tissue and mammary tumors identified significant

62 uberculosis also has been reported to infect mammary tissue and milk, and we showed that M. avium sub

63 ereas GATA5 is minimally expressed in normal mammary tissue and more strongly expressed in two breast

64 , is expressed transgenically on both normal mammary tissue and spontaneous mammary carcinomas.

65 mammary tissue but were also found in virgin mammary tissue and, interestingly, spleen and thymus.

66 we show that GPR109A is expressed in normal mammary tissue and, irrespective of the hormone receptor

67 east carcinomas, adjacent tissues and normal mammary tissues and bladder transitional cell carcinomas

68 in situ cancers growing within primary human mammary tissues and is also required for metastasis in v

69 Pten altered the steady-state biology of the mammary tissues and the expression profiles of genes inv

70 otein expression levels compared with normal mammary tissues and there is an inverse correlation betw

71 f overweight fathers, was activated in their mammary tissues and tumors.

72 ivo effects of hCG on Cx26 expression in rat mammary tissues and used its effect on the expressions o

73 Kcs abundance and activity, most markedly in mammary tissue, and are both radiosensitive and suscepti

74 have fewer blood vessels, less blood in the mammary tissue, and impaired alveolar coverage of the fa

75 helium is the progenitor for hair follicles, mammary tissue, and prostate.

76 ere found in the pancreas, pituitary, brain, mammary tissue, and skin.

77 cript is present in both virgin and pregnant mammary tissue, and SMC synthesis is induced rapidly in

78 ial, strong mitogenic effect in the fat-rich mammary tissues, and this effect was not observed with E

79 ith compliances comparable to that of normal mammary tissue, are protective against EMT, whereas stif

80 for inducing tumor formation in the fat-rich mammary tissues as compared with the uterus.

81 e ITAM mutation in Env infected lymphoid and mammary tissue at the same level as wild-type MMTV and w

82 e., trimethylated histone H3 at K4) marks in mammary tissues at early and midpregnancy and at parturi

83 nic mice exhibit alveolar hyperplasia in the mammary tissue but do not develop spontaneous mammary tu

84 induced during pregnancy was low in immature mammary tissue but increased with epithelial differentia

85 nt kinase inhibitor, was expressed in normal mammary tissue but was not detected in the mammary carci

86 transcripts were not restricted to lactating mammary tissue but were also found in virgin mammary tis

87 breast epithelial cells and in normal human mammary tissue, but at lower levels in various breast ca

88 mice decreased lipid synthesis in lactating mammary tissue, but the mechanism of S14's action is unk

89 ry epithelial cells were found in the normal mammary tissue, but the resulting mammary tumors were al

90 expression was absent or very low in normal mammary tissue, but was high in 44% of primary breast ca

91 t and maintenance of female reproductive and mammary tissues, but is also involved in maintenance of

92 of BRCA1 function in cell lines derived from mammary tissue caused rapid amplification and fragmentat

93 Analyses of preneoplastic mammary tissue collected 1 month after DFMO treatment de

94 After treatment with 4-OHE2, rat mammary tissue contained 1.4 micromol of adduct/mol DNA-

95 3,4-Q (200 nmol) at four mammary glands, the mammary tissue contained 2.3 micromol 4-OHE2-1(alpha, be

96 Mammary tissue containing epithelium from inhibitor kapp

97 Developmental exposure in immature mammary tissue continues to affect tumor onset even afte

98 erized by amplification of the EGFR ErbB2 in mammary tissue, correlates with a marked up-regulation o

99 In mammary tissue, Cx26 and Cx32 are present in the secreto

100 Transplantation of neonatal mammary tissue derived from TGFbeta3 null mutant mice in

101 Mammary tissue developed normally in these mice.

102 aturated fatty acid, is essential for normal mammary tissue development, at least in part because it

103 d variable tumor severity and differences in mammary tissue development.

104 MTV long terminal repeat (LTR) disappears as mammary tissue differentiates during lactation.

105 Mutant mammary tissue displayed precocious lobulo-alveolar deve

106 Decreasing this ratio in mammary tissue diverted RA from PPARbeta/delta to RAR an

107 rrelation was observed between leukocyte and mammary tissue DNA methylation for most of the analyzed

108 Methylation levels observed in leukocyte and mammary tissue DNA were close to the 50% expected for mo

109 le of IGF-I and IGFBP-3 in the remodeling of mammary tissue during involution.

110 nly detected in alveolar epithelial cells of mammary tissue during lactation.

111 and human IGF binding protein-3 (IGFBP-3) to mammary tissue during late pregnancy and throughout lact

112 se mice increase expression of VEGF(165)b in mammary tissue during mammary development.

113 of two STAT proteins, Stat5a and Stat5b, in mammary tissue during pregnancy suggests an active role

114 aling and controls functional development of mammary tissue during pregnancy.

115 , we find that HDR is particularly robust in mammary tissue during puberty and pregnancy, accounting

116 r expression is maintained in the transgenic mammary tissue even without circulating ovarian estrogen

117 Furthermore, Wnt5a(-/-) mammary tissue exhibits an accelerated developmental cap

118 on of LBH, mice exhibit pronounced delays in mammary tissue expansion during puberty and pregnancy, a

119 uman breast cancers, in contrast with normal mammary tissue, express the intracellular tyrosine kinas

120 NA for the protein is most abundant in human mammary tissue followed by kidney and testis, with lower

121 Analysis of mammary tissue following 10 weeks of C75 treatment revea

122 uration (10 weeks) with syngeneic Trp53-null mammary tissue fragments and monitored for one year.

123 om virgin transgenic rats but is detected in mammary tissue from certain lines of mid-pregnant transg

124 profiles of mammary tumors and preneoplastic mammary tissue from MMTV-Neu transgenic mice to expressi

125 Mammary tissue from multiparous matrilysin-expressing mi

126 reduction of Cav-1 expression as compared to mammary tissue from normal FVB/N mice, suggesting that i

127 To test this hypothesis, we examined mammary tissue from normal women for evidence of p16 pro

128 than 8 kb and are specifically expressed in mammary tissue from pregnant and lactating mice from the

129 associated with ErbB2 in these cells and in mammary tissue from pregnant rats.

130 This approach allowed for the growth of mammary tissue from the injected cells and transient act

131 pression profiling of parous and nulliparous mammary tissue from these four strains yielded a common

132 rbonic anhydrase III, is highly expressed in mammary tissue from virgin and pregnant mice and in gene

133 of the transgenic mRNAs is not detectable in mammary tissue from virgin transgenic rats but is detect

134 erential ras gene expression was examined in mammary tissue from virgin, pregnant, and lactating rats

135 l because it was differentially expressed in mammary tissues from BALB/c-Trp53(+/-) and C57BL/6-Trp53

136 A were observed between the undifferentiated mammary tissues from wild-type and mutant mice, indicati

137 This allowed for mammary tissue growth, transient activation of the WAP-C

138 Normal mammary tissue had a distinctive pattern of expression:

139 Rbp1(-/-) mouse mammary tissue has disrupted retinoid homeostasis that r

140 Rbp1(-/-) mammary tissue has epithelial hyperplasia, stromal hyper

141 As a result, mammary tissue has reduced lipid content and the milk pr

142 These findings suggest that loss of Mnt in mammary tissue has similarities to Myc overexpression.

143 potential role for the ER-p53 interaction in mammary tissue homeostasis and cancer formation.

144 icant role for stromal TGF-beta signaling in mammary tissue homeostasis and mammary tumor progression

145 Hsp72 KO mice, expression of Her2 instead of mammary tissue hyperplasia led to suppression of duct de

146 Subtractive analysis of mammary tissue identified which Ets factors were predomi

147 gate the effects of GH/IGF-I augmentation on mammary tissue in a model relevant to aging humans, we t

148 Mammary tissue in these mice was severely underdeveloped

149 mor cells in tumors developing directly from mammary tissue in transgenic models, we have evaluated t

150 and the N-ras proto-oncogene in lymphoid and mammary tissues in an in vivo model.

151 e first cells that migrated intensely to the mammary tissue, in line with an early production of CXCL

152 nced phosphorylation of IR/IGF-IR and Akt in mammary tissue, in the context of three different mouse

153 hat were preferentially expressed in MK-PTEN mammary tissue, including the IGF-binding protein-5 (Igf

154 elium, as transplantation of EphA2-deficient mammary tissue into wild-type recipient stroma recapitul

155 remic C3H/HeN females, even though the I/LnJ mammary tissue is not refractory to MMTV infection.

156 Normal or malignant mammary tissue isolated from these mice exhibited increa

157 henotypically and functionally distinct from mammary tissue macrophages (MTMs).

158 essentially the entire Ets family in normal mammary tissue, mammary-related cell lines, and mammary

159 -/2-hydroxyestradiol formation in neoplastic mammary tissue may therefore provide a useful marker of

160 e of demarcation between necrotic and viable mammary tissue (mean lesion volume, 14.24 cm(3); largest

161 2F1 in regulating cell cycle progression and mammary tissue morphogenesis.

162 Our objective was to study mammary tissue mRNA expression via quantitative PCR of 4

163 t did not affect total fat deposition in the mammary tissue nor the extent of epithelial invasion int

164 R2) were analyzed in DNA from leukocytes and mammary tissue (normal, benign diseases, or malignant tu

165 to explore the bovine transcriptome from the mammary tissue of 12 Chinese Holstein cows with 6 extrem

166 ur in focal patches of histologically normal mammary tissue of a substantial fraction of healthy, can

167 lation machinery and methylation patterns in mammary tissue of all three EE2 generations.

168 MMPRIN cDNA and injected orthotopically into mammary tissue of female NCr nu/nu mice.

169 Moreover, virus produced in vivo in the mammary tissue of mA3 knockout and BALB/c mice was more

170 Here, we used virions from the mammary tissue of MMTV-infected inbred wild-type mice wi

171 dantly expressed in the brain, liver and the mammary tissue of pregnant mice.

172 No obvious phenotype was observed in mammary tissue of pubescent virgin mice.

173 gastrointestinal tract but not the lactating mammary tissue of the mother.

174 Eighteen RF treatments were performed in the mammary tissue of three domestic swine under ultrasonogr

175 transcript was detected in RNA isolated from mammary tissue of transgenic females.

176 phosphorylation of Akt and cyclin D1 in the mammary tissue of transgenic mice vulnerable to carcinog

177 Mammary tissues of Cdc25A(+/-);MMTV-neu mice before tumo

178 c mice, loss of Pak1 prolonged survival, and mammary tissues of such mice showed loss of beta-catenin

179 The preneoplastic mammary tissues of the PyMT/Fet-/- mice showed intense p

180 and breast tumour cell lines, but not normal mammary tissue or benign lesions.

181 rget (colon) and nontarget (liver, lung, and mammary tissues) organs of female CD rats injected with

182 rograms promote stemness and thereby support mammary tissue outgrowth and tumors of basal origin.

183 A microarray dataset from bovine mammary tissue over entire lactation cycle was used to f

184 In human mammary tissue, PAX2 expression was coincident with sub-

185 t in the non-lactating period could help the mammary tissue prevent issues with inflammation and udde

186 The defect in pregnancy-associated mammary tissue proliferation was associated with decreas

187 a majority of breast tumors, but not normal mammary tissue, promotes breast carcinoma cell prolifera

188 d targeted deletion of cyclin D1 gene in the mammary tissues protects mice from breast cancer.

189 ressed solely in heart, muscle, adipose, and mammary tissue, remains to be elucidated.

190 capacity, Maspin could potentially regulate mammary tissue remodeling occurring under normal and pat

191 A less profound delay of mammary tissue remodeling was observed in gp130Delta/Del

192 that CrbpI loss disrupts atRA homeostasis in mammary tissue, resulting in microenvironmental defects

193 ession of the placental gene and IAPs in the mammary tissues, RT-PCR showed that LTR sequences are ab

194 proliferation antigen Ki67 were evaluated in mammary tissue sections at approximately d 7 and d 14 of

195 Csk homologous kinase (CHK), expressed as a mammary tissue-specific transgene.

196 was characterized by active histone marks in mammary tissue, STAT5 binding and expression during preg

197 ry breast tumors but never in matched normal mammary tissues, suggesting a contribution of Syk(S) to

198 mBTEB2 transcript is found at high levels in mammary tissue taken from a transgenic mouse overexpress

199 a stronger mitogenic action in the fat-rich mammary tissues than in the uterus.

200 in specific to liver, adipose, and lactating mammary tissues that functions to activate genes encodin

201 osure expression signature in both blood and mammary tissues that is predictive for poor survival amo

202 e results in elevated expression of Ramp3 in mammary tissue through augmented promoter-enhancer inter

203 ion of int-5/aromatase appears to predispose mammary tissue to preneoplastic changes, which may, in t

204 thelium and stroma that could predispose the mammary tissue to tumorigenesis.

205 To delete genes specifically from mammary tissue using the Cre-lox system, we have establi

206 ata demonstrate that the genetic response of mammary tissue varies significantly between 129S1 and C5

207 iogenic regulatory genes in COX-2 transgenic mammary tissue was also potently inhibited by indomethac

208 idered a tumor suppressor gene and Cx26-null mammary tissue was evaluated after five pregnancies.

209 ce that received premalignant AIB3(+/-)/PyMT mammary tissue was much faster than in nude mice that re

210 sdifferentiation, the expression of genes in mammary tissue was profiled in the absence and presence

211 K2alpha, dnGSK3beta and Cyclin D1 transgenic mammary tissues was similar to that in DeltaE3 beta-cate

212 he molecular consequences of Shh deletion in mammary tissue, we compared mRNA levels of patched 1, a

213 rate the physiological role of VEGF(165)b in mammary tissue, we generated transgenic (TG) mice expres

214 abundant Ets factor mRNAs measured in normal mammary tissue were Elk4, Elf1, and Ets2.

215 50 mg/kg BaP at either noon or midnight, and mammary tissues were isolated 4 or 24 hours later.

216 Hematoxylin-eosin-stained slices of mammary tissues were obtained after DCE MR imaging and X

217 Mammary tissues were subsequently labeled and imaged wit

218 nd low RON expression was observed in normal mammary tissue whereas high RON and low or undetectable

219 received transplants of premalignant WT/PyMT mammary tissue, which indicated that the accelerated tum

220 fects were due to massive cell senescence in mammary tissue, which was associated with upregulation o

221 agents antagonize the effects of estrogen on mammary tissue while mimicking the actions of estrogen o

222 Sec amounts were reduced by more than 70% in mammary tissue with either transgene, while in skin and

223 Mammary tissues with active Pak1 also exhibited an incre