ライフサイエンスコーパス: manageable

1 ile of adverse reactions (which are mild and manageable).

2 to cycles of booms and busts, and thus less manageable.

3 Toxicities were generally mild and manageable.

4 Pregnancy complications were few and manageable.

5 toxicities with olaparib were low grade and manageable.

6 re infrequent and typically asymptomatic and manageable.

7 nfusion-related reactions (IRRs), which were manageable.

8 ted primarily of myelosuppression, which was manageable.

9 emotoxicity complication rate is limited and manageable.

10 troviral therapy, and the disease has become manageable.

11 rombocytopenia, anemia, and neutropenia-were manageable.

12 events (AEs) associated with cediranib were manageable.

13 anemia and peripheral neuropathy, which were manageable.

14 testinal adverse effects and fatigue, proved manageable.

15 ausea, fatigue, and hand-foot syndrome, were manageable.

16 Toxicities were manageable.

17 Such values are small enough to be manageable.

18 Toxicities were mild to moderate and were manageable.

19 Toxicities were manageable.

20 rash, 1% v 0%, respectively), but they were manageable.

21 ologic toxicity was usually grade 1 to 2 and manageable.

22 were reported in 15 (60%) patients and were manageable.

23 n arm 2, and toxicities were as expected and manageable.

24 g positions of modified nucleotides is fully manageable.

25 f the biochemotherapy was high but generally manageable.

26 Toxicity profiles of DCF were considered manageable.

27 Toxicity was manageable.

28 e that allograft vasculopathy may finally be manageable.

29 liplatin to CPT-11/FU/LV are significant but manageable.

30 py than with IFN-alpha monotherapy, most are manageable.

31 ld or moderate, and hematologic toxicity was manageable.

32 frequent, and hematologic toxic effects were manageable.

33 fter G-CSF administration are well known and manageable.

34 us morbidity associated with Campath-1H more manageable.

35 n from a terminal condition into one that is manageable.

36 fects of the use of transgenic plants may be manageable.

37 ies were hematologic and, in general, easily manageable.

38 ects without clinical benefit and keep costs manageable.

39 with additional toxicity that was generally manageable.

40 iving volasertib were mainly hematologic and manageable.

41 xpected AEs were identified and toxicity was manageable.

42 was well tolerated, and infusion events were manageable.

43 vents were identified and toxic effects were manageable.

44 s encouraging, and toxicities were generally manageable.

45 he nephrotoxicities of 3a-c to be clinically manageable.

46 eligible patients and the safety profile is manageable.

47 lenge to keep data load and acquisition time manageable.

48 py has moderate activity against MDS, with a manageable adverse effect profile.

49 Aldoxorubicin therapy exhibited manageable adverse effects, without unexpected events, a

50 Four patients experienced manageable adverse effects.

51 dest antitumor activity in advanced HCC with manageable adverse effects.

52 Ro 31-7453 was well tolerated, with manageable adverse effects.

53 partial responses and disease control with a manageable adverse event profile.

54 monotherapy produces durable responses with manageable adverse events in patients with relapsed/refr

55 s of this trial demonstrate the efficacy and manageable adverse-event profile of sunitinib as a singl

56 Toxicities in both groups were manageable after administration of prophylactic low-mole

57 While toxicities were manageable, all patients developed grade 3/4 neutropenia

58 in obstacles of GVHD and graft rejection are manageable, allowing readily available stem-cell donors

59 The platform is manageable and affordable even for smaller labs.

60 inib suggested that toxicities are typically manageable and apparent early during drug development.

61 At these doses, toxicities are manageable and clinical activity is promising.

62 Toxicities are predictable and manageable and comparable to those seen with bortezomib

63 The safety profile of this combination was manageable and consistent with its individual components

64 with weekly paclitaxel was tolerable, with a manageable and distinct toxicity profile.

65 nce-daily (initial dose) on schedule 4-2 was manageable and efficacy results were encouraging, partic

66 Atopic dermatitis is not always easily manageable and every physician should be familiar with t

67 detanib experienced adverse events that were manageable and generally consistent with inhibition of E

68 Adverse effects, predominately pain, were manageable and improved with subsequent courses.

69 Adverse events were manageable and included respiratory tract infections, ga

70 Toxicity was manageable and mostly hematologic, although a few patien

71 These were manageable and not generally associated with clinical sy

72 ent-related adverse events in the study were manageable and primarily grade 1/2.

73 Toxicities were manageable and principally hematologic.

74 64% of patients (grade 3 in 3%), but proved manageable and resolved in 85% within a median of 98 day

75 ure that contaminant profiles are minimal or manageable and that the same diaper and cotton ball bran

76 re unsuitable for intensive chemotherapy was manageable and typical of a cytotoxic agent in patients

77 These components comprise manageable and widely applicable ways to reduce health-c

78 the number of single step connections can be manageable, and

79 he toxicity profile of VSLI was predictable, manageable, and comparable to standard VCR despite the d

80 Hematologic toxicity was manageable, and except for a 15% incidence of herpes sim

81 obimetinib and vemurafenib was tolerable and manageable, and no new safety signals were observed with

82 ther prognostic factors that are potentially manageable are prediabetes and the metabolic syndrome, n

83 rences were nondysplastic and endoscopically manageable, but continued surveillance after RFA is esse

84 These irAEs are often low grade and manageable, but severe irAEs may lead to prolonged hospi

85 sting the protein production rates to levels manageable by available chaperones.

86 ia (44%), and anemia (39%) and was typically manageable by dose reduction.

87 Barr virus reactivation is increased, but is manageable by prospective monitoring and the use of ritu

88 r cytologically confirmed breast cancer, not manageable by radiotherapy or systemic treatment, with s

89 rs (TKIs) have turned a fatal disease into a manageable chronic condition.

90 treatment has helped to transform HIV into a manageable chronic disease, yet at the same time has res

91 es to turn a rapidly fatal malignancy into a manageable chronic disease.

92 e increasing number of survivors of this now manageable chronic illness merits further study.

93 rom an almost uniformly fatal disease into a manageable chronic illness.

94 iagnosis from a likely death sentence into a manageable chronic infection.

95 transforming this deadly ailment into a more manageable chronic infection.

96 eneral scientific community with an easy and manageable client-server application that can be install

97 es the scientific community with an easy and manageable client-server Windows application with graphi

98 We show that our method produces small, manageable clusters that encapsulate many known, experim

99 ession to detect epistatic interactions with manageable complexity by exploiting the prior knowledge

100 ol after PBT remained good with increasingly manageable complications and fewer secondary enucleation

101 e search spaces can be eliminated leading to manageable computational affords.

102 structive pulmonary disease (COPD), a common manageable condition, is a leading cause of death.

103 ostate cancer is transformed into a chronic, manageable condition.

104 to be framed as both a serious and medically manageable condition.

105 ve treatments have turned both diseases into manageable conditions, and in the case of hepatitis C, a

106 Toxicity was manageable, consisting primarily of flu-like symptoms.

107 100,000-1,000,000 genotypes per sample) at a manageable cost, there is growing interest in the possib

108 in a clinically relevant time frame and with manageable costs comes the question of whether we ought

109 ysis is fully automated and generates easily manageable databases of standardized fingerprints that c

110 similarity helps organize all sequences into manageable datasets and reduces sampling bias and overre

111 as very low, and the nature of most SAEs was manageable, demonstrating a low-risk safety profile for

112 an inevitably fatal condition to a chronic, manageable disease in some settings.

113 on, which can now be viewed as a chronic and manageable disease.

114 s transformed HIV-1 infection into a chronic manageable disease; however, drug resistance remains a c

115 A successful solution will give rise to manageable enhanced wave-matter interaction, freewheelin

116 have minimal toxicity itself and minimal or manageable enhancement of radiation toxicity.

117 al treatment presented here yields a simple, manageable expression which can be compared with experim

118 systematic approach will make the task more manageable for anyone who writes grants.

119 ddresses progress in making these approaches manageable for nutrition research.

120 ly expanded ABA core signaling but was still manageable for systematic analysis.

121 However, large data sets are no longer manageable for visualization and investigation using the

122 ring by making amiRNA a more predictable and manageable genetic and functional genomic technology.

123 tment-emergent adverse events were primarily manageable grade 1/2 gastrointestinal events and rash.

124 pRAIT showed antitumor activity, with manageable hematologic toxicity in progressive MTC.

125 4 infectious episodes or adverse events and manageable hematologic toxicity.

126 nsitive ovarian cancer, with significant but manageable hematologic toxicity.

127 ve evolved from toxic, nontargeted agents to manageable, highly targeted therapies.

128 the main toxicities, but they were generally manageable, improved over time, and rarely led to treatm

129 Hematologic toxicity predominated but was manageable in most patients with frequent incorporation

130 Drug-related adverse effects are manageable in most patients.

131 Time to obtain informed consent was manageable in the clinical context.

132 Toxicity was manageable, including neuropathy in 49 subjects (8% grad

133 SSRC is safe and has a manageable learning curve.

134 e pool of possible interacting partners to a manageable level for experimental validation.

135 late morbidity in this model to a clinically manageable level.

136 oping the detection microarray are kept at a manageable level.

137 synthesis that consolidated the effort to a manageable level.

138 predict that resistance can be maintained at manageable levels if: first, the rates at which specific

139 These analyses provide a manageable list of candidate genes for future genetic st

140 ate genes within each QTL from hundreds to a manageable list.

141 Manageable matrix interference was encountered in pond w

142 Toxicities are manageable, mostly consisting of mild cytopenias with no

143 Toxicities were manageable; myelosuppression was the main toxicity (25%

144 d utilizing prioritization rules to ensure a manageable number of 'alarms' each day.

145 plex episodes that could not be reduced to a manageable number of descriptive features with PCA and S

146 ll aid in framing hypotheses to prioritize a manageable number of likely disease-causing SNPs.

147 in metastasis pathogenesis, and we document manageable numbers of candidates for this role.

148 ngth thresholds is unnecessary, as there are manageable numbers of short ORF homologies conserved (wi

149 ansformed CML from a once-fatal disease to a manageable one for the vast majority of patients, only a

150 ng and metabolic pathways and fail to give a manageable overview of the complexity that is often a fe

151 Side effects were limited to readily manageable pain and, less commonly, rash of short durati

152 split into two statistically independent and manageable parts.

153 After being considered a manageable pathogen for decades, C. difficile recently c

154 The lactation stage is a manageable period for improving the health of offspring

155 A design task may be split into manageable pieces in both three-dimensional space and in

156 based on intended levels of specificity and manageable positivity rates.

157 us and Pseudomonas aeruginosa, are generally manageable post-transplantation, and are associated with

158 plexity while operating much faster and with manageable power dissipation, networks based on circuits

159 eps required to prepare a glycan fraction of manageable proportions.

160 PLMM_DPSS also provides manageable pseudoknot folding scenarios for further stru

161 onic obstructive pulmonary disease (COPD), a manageable respiratory condition, is the third leading c

162 lumab demonstrated antitumor activity with a manageable safety profile across the three doses studied

163 Moxetumomab pasudotox showed a manageable safety profile and evidence of activity in re

164 Durvalumab demonstrated a manageable safety profile and evidence of meaningful cli

165 with CHOP or in combination with CHP, had a manageable safety profile and exhibited substantial anti

166 tive targeting of BCL2 with venetoclax had a manageable safety profile and induced substantial respon

167 INTERPRETATION: Nivolumab had a manageable safety profile and no new signals were observ

168 that PD-1 blockade with pembrolizumab has a manageable safety profile and promising antitumor activi

169 Atezolizumab demonstrated a manageable safety profile and promising antitumor activi

170 therapy with nivolumab and ipilimumab had a manageable safety profile and provided clinical activity

171 n BGJ398 at the MTD/RP2D had a tolerable and manageable safety profile and showed antitumor activity

172 atinib compared with erlotinib, along with a manageable safety profile and the convenience of oral ad

173 py with labetuzumab govitecan demonstrated a manageable safety profile and therapeutic activity in he

174 Conclusion IMGN853 exhibited a manageable safety profile and was active in platinum-res

175 unitinib has shown antitumor activity with a manageable safety profile as metastatic renal cell carci

176 ogression-free survival with a tolerable and manageable safety profile in Asian patients with EGFR mu

177 herapy with robust antitumour activity and a manageable safety profile in patients with BRAF(V600E)-m

178 xabepilone demonstrated clear activity and a manageable safety profile in patients with MBC resistant

179 cil and folinic acid extends survival with a manageable safety profile in patients with metastatic pa

180 nically meaningful antitumour activity and a manageable safety profile in patients with previously un

181 stantial and durable clinical response and a manageable safety profile in previously treated patients

182 mab has clinically meaningful activity and a manageable safety profile in previously treated patients

183 Dabrafenib plus trametinib was active with a manageable safety profile in this melanoma population th

184 Axitinib shows clinical activity with a manageable safety profile in treatment-naive patients wi

185 twice daily showed sustained efficacy and a manageable safety profile over 24 weeks.

186 efractory metastatic urothelial carcinoma; a manageable safety profile was reported in all avelumab-t

187 ave longer progression-free survival, with a manageable safety profile when treated with lenalidomide

188 ndicates that nilotinib is effective, with a manageable safety profile, and can provide favorable lon

189 shown significant clinical activity, with a manageable safety profile, in patients with relapsed or

190 During dose escalation, nivolumab showed a manageable safety profile, including acceptable tolerabi

191 sis of the improved clinical efficacy with a manageable safety profile, the results of this randomise

192 ging single-agent antitumour activity with a manageable safety profile.

193 /refractory AL amyloidosis, with a generally manageable safety profile.

194 h active RA over 24 weeks and demonstrated a manageable safety profile.

195 ignals identified from the combination and a manageable safety profile.

196 ging single-agent antitumour activity with a manageable safety profile.

197 harmacodynamic biomarker activity, and had a manageable safety profile.

198 ments in progression-free survival and had a manageable safety profile.

199 Both treatments had manageable safety profiles consistent with their known a

200 titumour activity with durable responses and manageable safety profiles in previously treated patient

201 volumab plus ipilimumab therapy demonstrated manageable safety, notable antitumor activity, and durab

202 ntegrate nanostructures at a larger and thus manageable scale into high performance electronic device

203 ming available for human use requires that a manageable set of in vitro tests be agreed on so that th

204 Rev/Dex is a highly active regimen with manageable side effects in the treatment of newly diagno

205 BiRD is an effective regimen with manageable side effects in the treatment of symptomatic,

206 relapsed or refractory aggressive NHL, with manageable side effects.

207 ch14.18 was associated with considerable but manageable side effects.

208 to clinically important improvements with a manageable side-effect profile in treatment-naive patien

209 Osimertinib showed clinical activity with manageable side-effects in patients with EGFR Thr790Met-

210 us tissue dosing, is well tolerated, and has manageable side-effects, the most common of which is rev

211 mg trametinib once a day is tolerable, with manageable side-effects.

212 quires their extensive folding into units of manageable size for the mitotic spindle.

213 t are extracted faster and come in much more manageable sizes than would be obtained in the absence o

214 cause of the need to scale the structures to manageable sizes.

215 y provides a non-optimal but computationally manageable solution to the task of vocal sequence learni

216 This manageable specification is reasonably intuitive for bio

217 validated in real time, consistent with the manageable spectral numbers resulting from LC-MALDI expe

218 e of awareness-before it evolves into a less manageable state.

219 mediator in the progression from clinically manageable steatosis to more severe steatohepatitis and

220 ates the flood of sensory information into a manageable stream, and so understanding how attention is

221 e variants could show robust associations in manageable study samples.

222 a requires an initial pruning step to create manageable subsets of observations that are then used fo

223 reak down a complex engineering problem into manageable tasks.

224 omplex work into the joint effort of several manageable tasks.

225 onal genomics in rice and other cereals more manageable than ever before.

226 As engineered systems are often more manageable than large-scale ecosystems, and because para

227 Adverse events were predictable and manageable; the most common grade 3 or 4 adverse events

228 Neurotoxicity was manageable through six cycles, with appropriate dose red

229 Eribulin demonstrated activity with manageable tolerability (including infrequent grade 3 an

230 In view of the manageable tolerability of marimastat and its ease of ad

231 icacious, with a low incidence of PTDM and a manageable tolerability profile over 24 weeks of treatme

232 y 4 weeks plus tremelimumab 1 mg/kg showed a manageable tolerability profile, with antitumour activit

233 utated NSCLC compared with gefitinib, with a manageable tolerability profile.

234 -mutated patients, and had an acceptable and manageable tolerability profile.

235 refractory mantle cell lymphoma (MCL), with manageable tolerability.

236 single-group trials that showed efficacy and manageable toxic effects.

237 very 28 days-results in clinical benefit and manageable toxic effects.

238 ice for women who require cytoreduction with manageable toxicities and validate ongoing testing of GT

239 er, and their combination was active and had manageable toxicities in a phase 1 trial.

240 osutinib demonstrated acceptable safety with manageable toxicities in Ph(+) leukemia.

241 efficacy demonstrated in clinical trials and manageable toxicities make Campath-1H an appealing agent

242 reast cancer was feasible, with expected and manageable toxicities.

243 ocetaxel is a highly active combination with manageable toxicities.

244 Therapy was well tolerated with manageable toxicities.

245 psed or refractory MCL, with predictable and manageable toxicities.

246 used in MM patients requiring dialysis, with manageable toxicities.

247 Dosing was generally tolerated with manageable toxicities.

248 ter HSCT in patients with neuroblastoma with manageable toxicities.

249 and RBV, could increase the rate of SVR with manageable toxicity and drug interactions.

250 n via this system is feasible, with limited, manageable toxicity and evidence of substantial antitumo

251 emetrexed is a multitargeted antifolate with manageable toxicity and has been combined with carboplat

252 that obinutuzumab with either B or FC shows manageable toxicity and has promising activity.

253 ADC brentuximab vedotin was associated with manageable toxicity and induced objective responses in 7

254 nt sorafenib has modest efficacy in HCC, the manageable toxicity and mechanisms of action support a r

255 ication in HIV/HCV-coinfected patients, with manageable toxicity and pharmacologic interactions with

256 ay schedule showed encouraging activity with manageable toxicity and represents a promising treatment

257 romising single-agent clinical activity with manageable toxicity in patients with relapsed classical

258 induced complete and durable responses with manageable toxicity in patients with relapsed or refract

259 produced complete and durable responses with manageable toxicity in patients with relapsed or refract

260 ity with an overall response rate of 70% and manageable toxicity in patients with relapsed WM and off

261 (40 mg/week), has encouraging activity with manageable toxicity in RRMM, including those refractory

262 tivity in patients with advanced PRCC with a manageable toxicity profile and a high response rate in

263 positive gastric cancer, pembrolizumab had a manageable toxicity profile and promising antitumour act

264 ollowed by standard-dose pembrolizumab has a manageable toxicity profile and provides robust anti-tum

265 gression-free survival time, combined with a manageable toxicity profile observed with single-agent i

266 gression-free survival time, combined with a manageable toxicity profile observed with single-agent i

267 This and the manageable toxicity profile suggest that R-INO may be a

268 ZD9331 seems to have a manageable toxicity profile, although it should be used

269 pecitabine to docetaxel 75 mg/m(2), with the manageable toxicity profile, indicate that this combinat

270 l survival (OS) for the eribulin arm, with a manageable toxicity profile.

271 The regimen was well tolerated and had a manageable toxicity profile.

272 nts with indolent non-Hodgkin lymphoma, with manageable toxicity, and is a new treatment option for p

273 FS compared with FAC therapy, in addition to manageable toxicity, especially regarding long-term card

274 zantinib was associated with significant but manageable toxicity.

275 ic responses as well as organ responses with manageable toxicity.

276 survival, and a steroid-sparing effect with manageable toxicity.

277 population is feasible with significant but manageable toxicity.

278 ry germ cell tumors and can be combined with manageable toxicity.

279 dren with progressive low-grade glioma, with manageable toxicity.

280 iotherapy schedule produces considerable but manageable toxicity.

281 efibrotide was generally well tolerated with manageable toxicity.

282 esults AZD1775 plus carboplatin demonstrated manageable toxicity; fatigue (87%), nausea (78%), thromb

283 This effect raises the possibility that less manageable tumors might also arise in other epithelial t

284 thus transforming HIV-1 into a lifelong, but manageable, virus.

285 iple different populations is a flexible and manageable way to collaboratively integrate widely avail

286 a was the most common adverse effect but was manageable with antidiarrheal agents and dose modificati

287 Toxicities were manageable with appropriate dose reductions and supporti

288 Toxicity is manageable with dose adjustment of sorafenib.

289 openia (39%), and anemia (20%), which proved manageable with dose reduction.

290 levels increased in all groups, changes were manageable with lipid-lowering agents and did not warran

291 ually restricted to the anterior segment and manageable with local corticosteroid therapy, which just

292 The observed hypertension was manageable with medication.

293 Toxicity was primarily hematologic but was manageable with only a single case of neutropenic fever.

294 that is already susceptible to anemia but is manageable with recombinant human erythropoietin (epoeti

295 l ipilimumab-induced irAEs that were readily manageable with standard therapies when started in a tim

296 ointestinal toxicities, which were generally manageable with supportive care.

297 st AEs were of mild-to-moderate severity and manageable with supportive treatment and/or dose modific

298 anti-PD-1/PD-L1 therapies and were generally manageable with topical steroids.

299 Toxicity was usually hematologic and manageable, with grade 4 febrile neutropenia in 3% of de

300 Adverse events (AEs) were manageable without cumulative toxicities.