ライフサイエンスコーパス: mangabey

1 evolutionary ancestor with SIVsm (from sooty mangabeys).

2 ues, pig-tailed macaques, baboons, and sooty mangabeys).

3 set, and a preliminary assembly of the Sooty mangabey.

4 unodeficiency virus (SIV) infection of sooty mangabeys.

5 lly SIV-infected and five SIV-negative sooty mangabeys.

6 s analogous to what occurs naturally in SIV+ mangabeys.

7 ues, cynomolgus macaques, baboons, and sooty mangabeys.

8 hocytes ranged between 0.11% and 3.26% in 13 mangabeys.

9 n, on monocytes, and on neutrophils of sooty mangabeys.

10 level viral replication in both macaques and mangabeys.

11 report of SIV-specific CTL epitopes in sooty mangabeys.

12 fic CTL activity in naturally infected sooty mangabeys.

13 rol or persistence of SIV infection in sooty mangabeys.

14 an that reported in naturally infected sooty mangabeys.

15 nificantly lower in naturally infected sooty mangabeys.

16 infected and three SIVmac239-infected sooty mangabeys.

17 elationship with different species groups of mangabeys.

18 eladas on the other with different groups of mangabeys.

19 ut was sustained and broadly directed in the mangabeys.

20 39 were detected in the macaques but not the mangabeys.

21 SIVsm-infected feral and household pet sooty mangabeys.

22 ntry pathways, as has been observed in sooty mangabeys.

23 o longer detected in the lymph node of sooty mangabeys.

24 on of African green monkeys (AGMs) and sooty mangabeys.

25 and CD8 T cells in rhesus macaques and sooty mangabeys.

26 al mucosa of chronically infected SIV+ sooty mangabeys.

27 umans, and SIV-infected and uninfected sooty mangabeys.

28 ture of nonpathogenic SIV infection in sooty mangabeys.

29 not observed in naturally SIV-infected sooty mangabeys.

30 ues and nonpathogenic SIV infection of sooty mangabeys.

31 ma viremia was observed in both macaques and mangabeys; 8 to 20 weeks later, CTL activity declined in

32 in human PBMC of SIV(rcm) (from a red-capped mangabey), a virus which uses CCR2 but not CCR5 for entr

33 he first time, we treated SIV-infected sooty mangabeys, a natural host for the infection, with a pote

34 Natural SIV hosts (for example, sooty mangabeys, African green monkeys and mandrills) share ma

35 ifferent species of natural SIV hosts (sooty mangabeys, African green monkeys, mandrills, sun-tailed

36 identified in the peripheral blood of sooty mangabeys also did not show evidence of increased turnov

37 ious Old World monkeys: a pigtail macaque, a mangabey and 12 rhesus macaques.

38 the CAG repeats is 13-14 in macaques, 16 in mangabey and 14-20 in chimpanzees.

39 mary SIV infection of the natural host sooty mangabey and the non-natural host pig-tailed macaque.

40 family, three GAA repeats were found in the mangabey and two in the rhesus macaque.

41 ancestors with viruses infecting red-capped mangabeys and a subset of guenon species.

42 that for other monkeys, including red-capped mangabeys and closely related guenon species, such an ep

43 virus (SIV) SIVsm replication, we inoculated mangabeys and nonnatural rhesus macaque hosts with an id

44 T lymphocytes in viremic SIV-infected sooty mangabeys and protect against progression to AIDS.

45 sociated with the divergent outcome in sooty mangabeys and rhesus macaques.

46 ant for stabilizing healthy T-cell levels in mangabeys and that timely administration of exogenous IL

47 IV infection in sooty mangabeys, three sooty mangabeys and three rhesus macaques were inoculated intr

48 of four SIV proteins were detected in all 25 mangabeys and were comparable in magnitude to those of 1

49 3 orangutans, 1 gorilla, 1 rhesus macaque, 1 mangabey, and 1 tamarin were analyzed.

50 unodeficiency virus of rhesus macaque, sooty mangabey, and HIV-2 (SIVsmm/SIVmac/HIV-2) lineage packag

51 ques, 5 of 11 pigtail macaques, 2 of 4 sooty mangabeys, and 0 of 1 chimpanzee.

52 fic CTL activity in SIVmac239-infected sooty mangabeys, and high viral loads with generally weak or a

53 with studies of SIVsmm, which infects sooty mangabeys, and SIVagmVer, which infects vervet monkeys,

54 bon was also observed in Nigerian red-capped mangabeys, and SIVrcmNG411, like SIVrcmGB1, used CCR2B a

55 Sooty mangabeys are a natural host of simian immunodeficiency

56 t immune responses to SIV infection in sooty mangabeys are likely to be an important determinant of h

57 SIVcpz from chimpanzees and SIVsm from sooty mangabeys, are the cause of acquired immunodeficiency sy

58 utes to the lack of immunopathology in sooty mangabeys as opposed to species with pathogenic lentivir

59 limited decrease of alpha1 circle numbers in mangabeys as well as in macaques.

60 ed that while the viruses of all eight sooty mangabeys belonged to the SIVsm/HIV-2 family, each was w

61 lop an animal model for leprosy, three black mangabeys (BkMs) (Lophocebus aterrimus) were inoculated

62 Sooty mangabeys bred to homozygosity for the deletion allele w

63 he lymph node paracortex in immune-competent mangabeys but were seen in both the paracortex and the g

64 CD25 declined during SIV infection, while in mangabeys, CD25-expressing CD4(+) T lymphocytes increase

65 in CD4 domain 1, present in human and sooty mangabey CD4 orthologs, largely restored rhCD4-Ig neutra

66 ound that, after in vitro stimulation, sooty mangabey CD4(+) T cells fail to upregulate CCR5 and that

67 ta suggest that low CCR5 expression on sooty mangabey CD4(+) T cells favors the preservation of CD4(+

68 Sooty mangabey CD4(+) T(CM) cells that express low amounts of

69 V-2 has been clearly identified as the sooty mangabey (Cercocebus atys), the origin of HIV-1 remains

70 or with that of SIVrcm, an SIV in red-capped mangabey (Cercocebus torquatus), it remains unclear whet

71 atural hosts of SIV infection, such as sooty mangabeys (Cercocebus atys), which typically do not prog

72 (SIVs) that are natural infections of sooty mangabeys (Cercocebus torquatus atys).

73 us (SIV) strains from wild-caught red-capped mangabeys (Cercocebus torquatus torquatus) from Nigeria

74 n of CD4(+)CCR5(+) T cells is lower in sooty mangabeys compared to humans and macaques.

75 f specific retrovirus restriction factors in mangabey-derived macrophages.

76 This study demonstrates that mangabey-derived MDMs are more resistant to SIV infectio

77 The sooty mangabey-derived simian immunodeficiency virus (SIV) str

78 ian T-cell lymphotropic virus-infected sooty mangabey (designated FGb) to rhesus and pig-tailed macaq

79 In two SIVs from sooty mangabeys discovered about 100 miles (ca. 161 Km) from e

80 and persistent T-cell proliferation, whereas mangabeys displayed little T-cell proliferation, suggest

81 ese studies indicate that SIV-infected sooty mangabeys do not appear to rely entirely on CD4(+) T cel

82 immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to AIDS despite high-level vir

83 tural reservoir hosts for SIV, such as sooty mangabeys, do not progress to AIDS and show a lack of ab

84 SIV-induced CD4(+) T cell depletion in sooty mangabeys does not result in immune dysfunction and prog

85 ly interleukin-10 in a concurrently infected mangabey during acute SIV infection.

86 This is similar to reports of aged sootey mangabeys dying from diseases typically associated with

87 Moreover, all CD4-low sooty mangabeys elicited a de novo immune response following i

88 Rhesus macaques and sooty mangabeys express orthologues of HLA-A, -B, and -E, but

89 Thus, red-capped mangabeys from distant geographic locations harbor a com

90 deletion previously described in red-capped mangabeys from Gabon was also observed in Nigerian red-c

91 Previous studies have determined that SIV+ mangabeys generally maintain healthy levels of CD4+ T ce

92 Nonetheless, all sooty mangabeys generated SIV-specific antibody and T cell res

93 containing CAG at the sixth position and the mangabey had AAG at the ninth position.

94 Sierra Leone, where both feral and pet sooty mangabeys harbor divergent members of the human immunode

95 Some sooty mangabeys harbored near-identical viruses (<2% interstra

96 n marker Ki-67 by flow cytometry showed that mangabeys harbored proliferating T cells at a level of 3

97 Here we show that sooty mangabeys have substantially reduced levels of innate im

98 Primary activated lymphocytes from mangabeys heterozygous for the deletion allele expressed

99 To understand how natural sooty mangabey hosts avoid AIDS despite high levels of simian

100 d immunopathology is absent in natural sooty mangabey hosts.

101 c and macrophages can be infected, and sooty mangabeys, i.e., natural SIV hosts in which the infectio

102 longitudinal assessment of 6 SIVsm-infected mangabeys identified an early increase in plasma IL-7 le

103 IV through cross-species transfer from sooty mangabeys in captivity.

104 is of gag region sequences showed that feral mangabeys in one small troop harbored four distinct SIVs

105 nity of approximately 120 free-ranging sooty mangabeys in the Tai Forest, Cote d'Ivoire.

106 arly uncoupled from CCR5 expression in sooty mangabeys in vivo during acute SIV infection and the hom

107 ntrast to apathogenic SIV infection in sooty mangabeys in which levels of immune activation, TGF beta

108 test this hypothesis, SIVs from eight sooty mangabeys, including six new viruses from West Africa, w

109 ence of AIDS in naturally SIV-infected sooty mangabeys is independent of a strong cellular immune res

110 depletion and AIDS, thus indicating that in mangabeys limited immune activation is a key mechanism t

111 In a study of mangabey locomotion and skeletal anatomy, we have identi

112 nese macaques [Macaca fuscata], gray-cheeked mangabey [Lophocebus albigena], rhesus macaques [Macaca

113 terns of asymptomatic SIV infection in sooty mangabeys: low viral loads with vigorous SIV-specific CT

114 Here we show that in sooty mangabey lymphocytes, infection is mediated by the alter

115 The means by which the SIVsm-infected mangabeys maintain CD4+ T-cell levels despite high rates

116 nfected patients; and (6) SIV-infected sooty mangabeys maintain healthy frequencies of Th17 cells in

117 We report here that SIV-infected mangabeys maintain preserved T lymphocyte populations an

118 These natural hosts of SIV, like sooty mangabeys, maintain high levels of SIV replication but h

119 ammadelta T cells from SIV-positive (SIV(+)) mangabeys maintained or increased their ability to expre

120 ore, in nonpathogenic SIV infection of sooty mangabeys, microbial translocation did not seem to occur

121 as well as from wild armadillos and a sooty mangabey monkey.

122 , with an allele frequency of 0.04, in sooty mangabey monkeys (Cercocebus torquatus atys), a natural

123 by simian immunodeficiency virus from sooty mangabey monkeys (SIV(SM)).

124 mac, which both originated from SIV of sooty mangabey monkeys (SIVsmm), suggesting that the A3G bindi

125 Many strains of SIV from sooty mangabey monkeys are susceptible to resistance by common

126 Mangabey monkeys have been shown to rely on memory of re

127 In contrast, sooty mangabey monkeys that represent natural hosts for SIV in

128 mian immunodeficiency virus (SIV) from sooty mangabey monkeys to humans.

129 imate that is phylogenetically distinct from mangabey monkeys, and clustered with other primate lenti

130 The SIV(+) sooty mangabey natural hosts, which do not proceed to clinical

131 Sooty mangabeys naturally infected with simian immunodeficienc

132 Sooty mangabeys naturally infected with simian immunodeficienc

133 st closely related to the albigena-aterrimus mangabeys, now commonly placed in the genus Lophocebus.

134 V CTL epitopes were identified in five sooty mangabeys: one in Gag and three each in Nef and Envelope

135 unodeficiency virus (SIV) infection in sooty mangabeys or chimpanzees does not exhibit these hallmark

136 from a second SIV lineage, SIV of red-capped mangabeys or mandrills (SIVrcm/mnd-2), increased HIV inf

137 s used in the macaque model evolved in sooty mangabeys over millennia.

138 With 6.8x mapped coverage of mangabey PacBio long-reads we addressed 97% of gaps and

139 related to the torquatus-galeritus group of mangabeys placed in the genus Cercocebus, whereas baboon

140 ute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells (pDCs) produce mar

141 Normal T-cell turnover in SIV-infected mangabeys provides an explanation for the long-term main

142 infections in the eastern part of the sooty mangabey range.

143 receptor 5 (CCR5) of 11 out of 15 red-capped mangabeys (RCMs), Cercocebus torquatus torquatus, both i

144 s SIVrcm, which naturally infects red-capped mangabeys (RCMs), is the only SIV that uses CCR2 as its

145 ned by lower SIV-directed immune activity in mangabeys relative to HIV-1-directed immunity in humans.

146 eficiency viruses from chimpanzees and sooty mangabeys, respectively, and Vifs from these viruses hav

147 SIVmac239 infection of sooty mangabeys resulted in 2- to 4-log-lower viral loads than

148 ection of natural host species such as sooty mangabeys results in high viral replication without clin

149 ed its similarity to SIV isolates from sooty mangabeys, significant amino acid differences in Env and

150 immunodeficiency virus type 2 (HIV-2)-sooty mangabey simian immunodeficiency virus (SIVsm) family, w

151 nd uncultured human (HIV-1 and HIV-2), sooty mangabey (simian immunodeficiency virus SIV(SM)), Africa

152 e SIV isolates from rhesus macaques or sooty mangabeys (SIVmac/sm) and four HIV-2 isolates.

153 equivalent SIV sequences from the red-capped mangabey (SIVrcm), the sabaeus African green monkey (SIV

154 nodeficiency virus (SIV) isolated from sooty mangabey (SIVsm [n = 6]), stumptail (SIVstm [n = 1]), ma

155 ith simian immunodeficiency virus from sooty mangabey (SIVsm) to evaluate the effect of TRIM5alpha re

156 f the simian immunodeficiency virus of sooty mangabey (SIVsm)-HIV-2 lineage, SAMHD1 is counteracted b

157 d simian immunodeficiency viruses from sooty mangabeys (SIVsm) and macaques (SIVmac) comprise a 112-a

158 that the TRIM5alpha-sensitive SIV from sooty mangabeys (SIVsm) clone SIVsmE543-3 acquired amino acid

159 parison with Vpx from SIV that infects sooty mangabeys (SIVsmm) complexed with SAMHD1-DCAF1 identifie

160 Simian immunodeficiency virus of sooty mangabeys (SIVsmm) is recognized as the progenitor of hu

161 set of related viruses originating in sooty mangabeys (SIVsmm).

162 The sooty mangabey (SM) (Cercocebus atys) is the natural host of a

163 ogy was performed on samples from four sooty mangabey (SM) colonies in the United States to character

164 Despite high viral loads, T cells from sooty mangabey (SM) monkeys that are naturally infected with S

165 infection in disease-resistant African sooty mangabeys (SM) and disease-susceptible Asian rhesus maca

166 cted African natural hosts such as the sooty mangabeys (SM) are resistant to disease.

167 African green monkeys (AGM) and sooty mangabeys (SM) are well-studied natural hosts of simian

168 irus (SIV) infection of African-origin sooty mangabeys (SM) generally does not result in simian AIDS

169 Natural-host sooty mangabeys (SM) infected with simian immunodeficiency vir

170 Natural host sooty mangabeys (SM) infected with simian immunodeficiency vir

171 In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain immune res

172 SIV infection in natural hosts such as sooty mangabeys (SM) remains to be defined.

173 ally infected rhesus macaques (RM) and sooty mangabeys (SM) with controlled or uncontrolled SIV infec

174 nfected with SIV, such as chimpanzees, sooty mangabeys (SM), and African green monkeys (AGM).

175 uch as African green monkeys (AGM) and sooty mangabeys (SM), are protected against SIV-induced chroni

176 but not SIV-infected disease-resistant sooty mangabeys (SM), denoting an association of downregulatio

177 tain nonhuman primate species, such as sooty mangabeys (SM), SIV infection does not lead to AIDS.

178 uch as African green monkeys (AGM) and sooty mangabeys (SM).

179 RM) and nonpathogenic SIV infection of sooty mangabeys (SM).

180 hat had been serially passaged in four sooty mangabeys (SMs) (Cercocebus atys).

181 ly shown that chronic SIV infection in sooty mangabeys (SMs) and African green monkeys (AGMs) is asso

182 virus (SIV) SIV(smm) naturally infects sooty mangabeys (SMs) and is the source virus of pathogenic in

183 immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) do not develop AIDS despite high levels

184 tiating nonpathogenic SIV infection of sooty mangabeys (SMs) from pathogenic HIV/SIV infections is th

185 Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus

186 Sooty mangabeys (SMs) naturally infected with simian immunodef

187 Naturally SIV-infected sooty mangabeys (SMs) remain asymptomatic despite high virus r

188 immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) that do not progress to AIDS despite hig

189 unodeficiency virus (SIV) infection of sooty mangabeys (SMs) that typically is nonpathogenic despite

190 unodeficiency virus (SIV) infection in sooty mangabeys (SMs) typically does not result in AIDS, despi

191 nfected humans, naturally SIV-infected sooty mangabeys (SMs) very rarely progress to AIDS.

192 The Delta24 frequency was 4.1% in 34 sooty mangabeys (SMs), a geographically isolated subspecies th

193 hesus macaques (RMs), SIV infection of sooty mangabeys (SMs), a natural host African monkey species,

194 CD4(+) TCM cells of sooty mangabeys (SMs), a natural host for SIV in which infecti

195 ow that nonpathogenic SIV infection of sooty mangabeys (SMs), a natural host species for SIV, is also

196 SIV infection of sooty mangabeys (SMs), a natural host species, does not cause

197 ng the absence of AIDS in SIV-infected sooty mangabeys (SMs), a natural host species, we performed a

198 s and rhesus macaques (RMs) but not in sooty mangabeys (SMs), a natural host, remains unclear.

199 Sooty mangabeys (SMs), a reservoir host for SIV, do not develo

200 progression to AIDS, and natural host sooty mangabeys (SMs), a species which remains AIDS free, has

201 in studies conducted predominantly in sooty mangabeys (SMs), African green monkeys (AGMs), and mandr

202 in studies conducted predominantly in sooty mangabeys (SMs), African green monkeys (AGMs), and mandr

203 ction of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level of vir

204 during nonpathogenic SIV infection of sooty mangabeys (SMs), neither spontaneous nor experimental CD

205 V-infected humans, and SIVsmm-infected sooty mangabeys (SMs).

206 ate species, rhesus macaques (RMs) and sooty mangabeys (SMs).

207 tudies have reported that SIV-infected sooty mangabeys (SMs; Cercocebus atys) remain disease free for

208 y viruses (SIVs) that naturally infect sooty mangabeys (SMs; Cercocebus atys).

209 mate Research Center (TNPRC) colony of sooty mangabeys (SMs; Cercocebus atys).

210 us macaques [RMs]) and nonprogressive (sooty mangabeys [SMs]) SIV infection.

211 Finding identical deletions in two mangabey subspecies separated for 10,000 years or more d

212 immune responses in naturally infected sooty mangabeys suggests that immune attenuation is neither a

213 ion of CCR5-null alleles in humans and sooty mangabeys suggests that similar negative selection press

214 Natural hosts of SIV, such as sooty mangabeys, sustain high viral loads but do not develop d

215 udy, we determine the sequence of red-capped mangabey tetherin for the first time and directly demons

216 ef is the bona fide antagonist of red-capped mangabey tetherin.

217 nd B-lymphocyte counts in SIV-infected sooty mangabeys than in SIV-negative mangabeys, the turnover r

218 However, sooty mangabeys that are genetically deficient in CCR5 due to

219 Further, studies in sooty mangabeys that do not progress to simian AIDS and that m

220 pheral blood samples from patients and sooty mangabeys that exhibited either a CD4-healthy (>200 CD4(

221 ction after 43 or 71 wk postinfection in two mangabeys that is associated with an extreme, persistent

222 th naturally infected and SIVmac239-infected mangabeys that shared class I MHC alleles.

223 ns but not in chronically SIV-infected sooty mangabeys that show low levels of immune activation.

224 Sooty mangabeys, the natural host of simian immunodeficiency v

225 nfected sooty mangabeys than in SIV-negative mangabeys, the turnover rate of B lymphocytes and CD4(+)

226 Compared with that in SIVmac239-infected mangabeys, the yield of SIV-specific CTL clones was sign

227 basis of apathogenic SIV infection in sooty mangabeys, three sooty mangabeys and three rhesus macaqu

228 500 cells/microL) CD4+ T-cell levels in each mangabey through 37 weeks of infection.

229 uated immune activation enables SIV-infected mangabeys to avoid the bystander damage seen in pathogen

230 he turnover of CD4(+) T lymphocytes in sooty mangabeys was significantly higher (P < 0.01) than that

231 cificity of the CTL response in SIV-infected mangabeys, we characterized CTL epitopes in two naturall

232 e immunologic basis of disease resistance in mangabeys, we compared the effect of SIV infection on T-

233 Sooty mangabeys were observed to have higher percentages of ga

234 why SIV infection is nonpathogenic in sooty mangabeys while it is pathogenic in macaques, and is con

235 Passaging plasma from an SIV-infected sooty mangabey with very few CD4(+) T cells to SIV-negative an

236 nfected humans but not in SIV-infected sooty mangabeys with high viremia, suggesting a direct role fo

237 contains free-living and household pet sooty mangabeys with highly divergent variants of SIVsm.

238 encies of SIV-specific CD8+ T lymphocytes in mangabeys with lower viral loads, a significant inverse

239 es were investigated in a cohort of 25 sooty mangabeys with natural SIV infection.