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1 an did those whose intake episode was purely manic.
2 ound that 5-nitro-6-methylamino-isocytosine (MANIC; 3), which inhibits another B. anthracis folate sy
3 pecificity of the prospective association of manic and depression episodes that is a hallmark of bipo
5 c, predominantly depressive, and across both manic and depressive episodes, showing essentially paral
8 a key theory of the pathophysiology of both manic and depressive phases of the illness for over four
10 bilizer if it has efficacy in treating acute manic and depressive symptoms and in prophylaxis of mani
14 ADHD and have greater levels of subthreshold manic and depressive symptoms than children of compariso
15 order, had significantly more severe current manic and depressive symptoms than comparison offspring.
16 d the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antid
17 ionate these into components associated with manic and depressive symptoms, and characterize the impa
20 SM-5 criterion A decreases the prevalence of manic and hypomanic episodes but does not affect longitu
22 le modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 acti
23 t time we have demonstrated that, similar to Manic and Lunatic, Radical fringe is also a fucose-speci
24 isorder type I for respondents in which both manic and major depression symptoms were reported (n = 4
26 suggesting that the familial transmission of manic and major depressive episodes is independent despi
27 pisodes; addition of severity dimensions for manic and major depressive episodes; and removal of the
28 he strong familial specificity of psychotic, manic and MDEs in this largest controlled contemporary f
30 s prescribed more frequently for the bipolar manic and mixed subtypes, and there was a secular increa
31 er are more common in bipolar I disorder and manic and psychotic presentations occur earlier in the p
39 ion was defined as the absence of psychotic, manic, and severe depressive symptoms for at least 1 wee
40 tructure is primarily depressive rather than manic, and subsyndromal and minor affective symptoms pre
43 that the link between neuroinflammation and manic behavior may be mediated by actions on serotonergi
44 together with near-scan PGBI-10M, a score of manic behaviors, depressive behaviors and sex, explained
45 aytime increases in VTA dopamine activity to manic behaviors, we developed a novel optogenetic stimul
46 ipolar disorder are defined as depressive or manic, but depressive and manic symptoms can combine in
50 comes investigated included risk of relapse (manic, depressive, and total) as well as risk of specifi
52 1.05-3.64; P = .03; AR, 6.9/10,000 persons), manic-depressive disorder (HR, 4.35; 95% CI, 1.56-12.09;
53 sk of suicide included male sex, depression, manic-depressive disorder, heavy or binge drinking, and
54 ing which our major diagnostic categories of manic-depressive illness (MDI) and dementia praecox were
57 ood modulation, molecular pathophysiology of manic-depressive illness, and therapeutic mechanism of m
58 y used mood stabilizers for the treatment of manic-depressive illness, stimulated the ERK pathway in
60 n psychiatric nosology that contained DP and manic-depressive insanity (MDI)--Kraepelin's key categor
61 lin's new categories of dementia praecox and manic-depressive insanity were too broad and too heterog
64 -IV bipolar I disorder experiencing an acute manic episode (baseline Young Mania Rating Scale score >
65 n view of the efficacy in prevention of both manic episode and depressive episode relapse or recurren
66 5, all patients with a diagnosis of a single manic episode or bipolar disorder between January 1, 199
68 tance of long-term prophylaxis after a first manic episode to lessen episode recurrence, allow cognit
70 orders (major depressive episode, dysthymia, manic episode), anxiety (panic, separation anxiety, over
71 isorder can be diagnosed on the basis of one manic episode); bipolar disorder type II (depressive and
73 had both a major mental disorder (psychosis, manic episode, or major depressive episode) and a substa
74 was clustered in later adult age groups for manic episode, phobias, alcohol use disorders, and gener
76 sodes significantly increased risk of Wave 2 manic episodes (AOR: 2.2; 1.7-2.9) and anxiety disorders
78 .89, 1.45-2.48, p<0.0001), greater number of manic episodes (seven studies, 3909 participants; 1.26,
79 attributable to the familial specificity of manic episodes after adjusting for both proband and rela
80 mong subjects 18.0 years or older, 44.4% had manic episodes and 35.2% had substance use disorders.
83 the strength of associations between Wave 1 manic episodes and Wave 2 depression, anxiety and substa
85 Manual of Mental Disorders, Fourth Edition) manic episodes during the study's 3-year follow-up perio
86 ted in BD-I compared with BD-II and MDD, and manic episodes had focused progressive effect on the CA2
93 ects with child BP-I, the 44.4% frequency of manic episodes was 13 to 44 times higher than population
94 ed relapse to mania, and more weeks ill with manic episodes was predicted by low maternal warmth and
95 xed anxiety depression; replacement of mixed manic episodes with a 'mixed features' specifier applica
96 e monotherapy displayed an increased rate of manic episodes within 3 months of medication initiation
98 ducation, numbers of previous depressive and manic episodes, baseline scores on the Hamilton Rating S
99 polar disorder patients who had had repeated manic episodes, but it does not appear to be secondary t
100 ipramine, an antidepressant that can trigger manic episodes, increased synaptic expression of GluR1 i
101 d unequivocal evidence for efficacy in acute manic episodes, lithium in acute depressive episodes and
102 ity was greater for depressive episodes than manic episodes, with approximately 74.0% of respondents
107 ude: bipolar disorder type I (depressive and manic episodes: this disorder can be diagnosed on the ba
108 19-year-old woman presenting initially with manic excitement followed by a lengthy period of mutism,
109 e report that an established Notch modifier, Manic Fringe (Mfng), is expressed in the putative endocr
110 pathways, including Notch (Notch homolog 2, manic fringe homolog), growth factor (FGF intracellular-
111 an Delta 1 and Jagged1 can be elongated with Manic Fringe in vivo, and Drosophila Delta and Serrate a
116 1, Gbx2), IGF (IGFBP3, IGFBP6, CTGF), Notch (manic fringe, ADAM11), Hedgehog (patched) and Wnt (Frat2
117 s not observed in the published structure of Manic Fringe, and residues predicted to be involved in U
119 1-Dll4-Notch1 signaling, possibly favored by Manic-Fringe, is specifically required for cardiac epith
121 GluR1/2 was essential for the development of manic/hedonic-like behaviors such as amphetamine-induced
122 h a 'mixed features' specifier applicable to manic, hypomanic, and major depressive episodes; additio
123 ith bipolar I or II disorder and a DSM-IV-TR manic, hypomanic, depressive, or mixed episode in the pr
125 pisode; of these, 457 subjects switched to a manic, hypomanic, or mixed episode prior to recovery.
132 ally identified significant associations for manic/hypomanic states during antidepressant therapy, cu
133 of total follow-up weeks) predominated over manic/hypomanic symptoms (8.9% of weeks) or cycling/mixe
134 ve disorder and correlation between lifetime manic/hypomanic symptoms and depressive symptoms in majo
135 er shifting to bipolar disorders; history of manic/hypomanic symptoms in major depressive disorder an
137 ilience and in regulating recovery from both manic-like and depression-like behavioral impairments.
138 scribing a patient's experience of cycles of manic-like behavior and depression while on high-dosage
139 t the PFC, resulted in a profound display of manic-like behavior, characterized by increased stress-i
145 modelling a human SHANK3 duplication exhibit manic-like behaviour and seizures consistent with synapt
146 drug valproate, but not lithium, rescues the manic-like behaviour of Shank3 transgenic mice raising t
147 Delta19 mouse exhibits rapid mood cycling (a manic-like phenotype during the day followed by euthymia
148 exhibit rapid mood-cycling, with a profound manic-like phenotype emerging during the day following a
150 report that the compound is able to reverse 'manic-like' behavior in two mouse models: amphetamine-in
151 ssion were used to code polarity at onset as manic, major depressive, or both (mania and major depres
153 f mammalian fringe proteins (Lunatic [LFng], Manic [MFng], or Radical [RFng] Fringe) increased Delta1
155 nia or hypomania (13.3% compared with 1.2%), manic, mixed, or hypomanic episodes (9.2% compared with
156 iagnostic risk factor for the development of manic, mixed, or hypomanic episodes in the offspring of
157 ought to identify diagnostic risk factors of manic, mixed, or hypomanic episodes in the offspring of
162 disorder (N=227), schizoaffective disorder (manic, N=110; depressed, N=55), their first-degree relat
164 r severity, improve response to treatment of manic or depressive symptoms, or reduce suicidality.
165 ar disorder (i.e., a history of at least one manic or hypomanic episode with euphoric mood) as well a
168 hat in the high-risk offspring, subthreshold manic or hypomanic episodes (hazard ratio=2.29), major d
171 ated according to the characteristics of the manic or hypomanic episodes, and present methods for val
173 e or recurrence of mood episodes in recently manic or hypomanic patients with bipolar I disorder.
175 essive symptoms are at least as disabling as manic or hypomanic symptoms at corresponding severity le
177 al depressive symptoms, but not subsyndromal manic or hypomanic symptoms, are associated with signifi
178 more disabling than corresponding levels of manic or hypomanic symptoms; (2) subsyndromal depressive
180 iagnosis of bipolar I disorder and a current manic or mixed episode (confirmed by the Structured Clin
181 ted during their first hospitalization for a manic or mixed episode and were evaluated using diagnost
183 ients achieving symptomatic remission from a manic or mixed episode of bipolar I disorder (Young Mani
185 ed 262 bipolar disorder patients in an acute manic or mixed episode to aripiprazole, 30 mg/day (reduc
186 ears after their first hospitalization for a manic or mixed episode to assess timing and predictors o
187 156 bipolar disorder patients with a current manic or mixed episode who received a mood stabilizer (l
188 Patients with bipolar disorder (n = 344), manic or mixed episode, who were inadequately responsive
193 atment of bipolar disorder patients in acute manic or mixed episodes and was safe and well tolerated
194 ety of olanzapine for the treatment of acute manic or mixed episodes associated with bipolar disorder
195 mg/day) to divalproex (500-2500 mg/day) for manic or mixed episodes of bipolar disorder (N=251).
197 efined as current DSM-IV bipolar I disorder (manic or mixed phase) with at least one cardinal mania c
198 pe was defined as DSM-IV bipolar I disorder (manic or mixed) with at least 1 cardinal symptom (elatio
199 to 18 years of age with bipolar I disorder, manic or mixed, were recruited at 20 centers in the Unit
200 there was at least one family member with a manic or psychotic episode with an onset within 6 weeks
201 time of assessment, bipolar subtype (mixed, manic, or depressed), and treatment group (placebo or va
202 oportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder.
205 a compound that induces relapse in remitted manic patients and mood elevation in normal subjects.
208 nd poor impulse control are hallmarks of the manic phase of bipolar disorder but are also present dur
209 ars with first episode DSM-IV BP-I, mixed or manic phase, with 1 or both cardinal symptoms (elation o
211 ure of mixed states studied as predominantly manic, predominantly depressive, and across both manic a
215 wing disorders: major depressive, dysthymic, manic, psychotic, panic, separation anxiety, overanxious
218 5 (18%) of the 84 subjects had experienced a manic relapse; only six of these subjects were taking an
219 relative risk=0.65, 95% CI=0.50 to 0.84) and manic relapses (relative risk=0.62, 95% CI=0.40 to 0.95)
221 d across the three pairings of schizophrenic-manic, schizophrenic-schizoaffective, and schizoaffectiv
226 examined the risk of antidepressant-induced manic switch in patients with bipolar disorder treated e
228 bitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressa
234 nt than syndromal-level major depressive and manic symptoms (29.9% vs 11.2% of weeks, respectively).
236 ed youth from the Longitudinal Assessment of Manic Symptoms (LAMS) study (n = 85) and healthy youth (
240 -label trial of divalproex sodium to control manic symptoms and to discern the effect of divalproex s
242 ted with mixed amphetamine salts after their manic symptoms are stabilized with divalproex sodium.
244 ric disorders and severity of depressive and manic symptoms at intake in preschool offspring of paren
247 spectrum disorder in part through increased manic symptoms at the visit prior to conversion; earlier
251 ine the frequency and clinical correlates of manic symptoms during episodes of bipolar depression.
252 er prevalence of depressive relative to hypo/manic symptoms during the course of BD illness and the h
253 in family-focused treatment had less severe manic symptoms during year 2 than did those in enhanced
254 Children and adolescents who present with manic symptoms frequently do not meet the full DSM-IV cr
255 ipolar II disorder and concurrent ADHD whose manic symptoms had been stabilized through treatment wit
259 tence or rapid alternation of depressive and manic symptoms in the same episode may indicate a more s
260 later developed a bipolar spectrum disorder, manic symptoms increased up to the point of conversion.
264 depression, family history, and the types of manic symptoms that were present during the most serious
271 presented with two or three protocol-defined manic symptoms were randomly assigned to 6 weeks of doub
277 h BP-NOS, subjects with BP-I had more severe manic symptoms, greater overall functional impairment, a
278 h bipolar depressed episodes had concomitant manic symptoms, most often distractibility, flight of id
279 dependence, with no concurrent psychotic or manic symptoms, no use of concurrent psychotropic medica
280 ss history at baseline of severe depression, manic symptoms, suicidality, subsyndromal mood episodes,
289 ticipants were screened at baseline for five manic symptoms: elevated mood, decreased need for sleep,
290 animal behavioral alterations reminiscent of manic symptoms; these complex behaviors probably depend
291 GluR1/2 receptors in mediating facets of the manic syndrome and offer avenues for the development of
292 time-ever schizophrenic, schizoaffective, or manic syndrome were ascertained from the Maudsley Twin R
294 phrenic-schizoaffective, and schizoaffective-manic syndromes both within probands and within pairs.
295 ng speed, rather than strictly depressive or manic syndromes can provide more homogeneous samples for
298 ematic care programs were more effective for manic than depressive symptoms, whereas family therapy a
300 order (z=-0.77) to schizoaffective disorder (manic z=-1.08; depressed z=-1.25) to schizophrenia (z=-1
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