ライフサイエンスコーパス: mannose 6-phosphate

1 -methyl-mannoside but not in the presence of mannose 6-phosphate.

2 tors because their glycans are modified with mannose 6-phosphate.

3 could permit rotation of the C-2-C-3 bond of mannose 6-phosphate.

4 ins 1-3, was solved in the presence of bound mannose 6-phosphate.

5 normal liver growth and secreted enzyme with mannose 6-phosphate.

6 alpha-galactosidase, which contains 117 pmol mannose 6-phosphate.

7 , human alpha-galactosidase A, that contains mannose 6-phosphate.

8 of the secreted gI ectodomain was blocked by mannose 6-phosphate.

9 dent of perforin and could not be blocked by mannose-6-phosphate.

10 Either 100 mul of 600 mM Mannose-6-Phosphate (29 animals), or 100 mul of phosphat

11 uding beta-D-fructose 6-phosphate and beta-D-mannose 6-phosphate, a precursor and an intermediate of

12 PMI), which catalyzes the interconversion of mannose 6-phosphate and fructose 6-phosphate.

13 de reduction (PerT-GUS) eliminated uptake by mannose 6-phosphate and mannose receptors in cultured ce

14 in in 6.75 M trifluoroacetic acid to release mannose 6-phosphate and quantitation of the released man

15 rin/heparin sulfate, N-acetyl-D-glucosamine, mannose-6-phosphate, and laminarin were found to inhibit

16 yme uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphoryl

17 e of interconverting mannose 1-phosphate and mannose 6-phosphate, as well as glucose 1-phosphate and

18 hosphotransferase, the enzyme that initiates mannose 6-phosphate biosynthesis.

19 nd more specifically to HSCs, we synthesized mannose 6-phosphate-bovine serum albumin (M6P-BSA) by ph

20 SCs) of fibrotic rats after conjugation with mannose 6-phosphate-bovine serum albumin.

21 role in the trafficking of newly synthesized mannose 6-phosphate-containing acid hydrolases to the ly

22 or type 2 (IGF2) receptor (IGF2R) recognizes mannose 6-phosphate-containing molecules and IGF2 and pl

23 lycoforms, which differed in sialic acid and mannose-6-phosphate content.

24 taining N-linked carbohydrates modified with mannose 6-phosphate groups.

25 PMM2 (mannose 6-phosphate --> mannose 1-phosphate) and MPI (ma

26 omal enzyme, alpha-l-iduronidase, from which mannose 6-phosphate had been removed.

27 The mannose 6-phosphate/IGF-2 receptor has been proposed to

28 (IGFII) was prepared for endocytosis by the mannose 6-phosphate/IGFII receptor.

29 s been developed to quantitate the amount of mannose 6-phosphate in glycoproteins using high-pH anion

30 The amount of mannose 6-phosphate in the electroblots following hydrol

31 ase was taken up by MPS VII fibroblasts in a mannose 6-phosphate-independent manner, and its uptake w

32 c proteins were additionally endocytosed via mannose-6-phosphate-independent routes.

33 These data support a role for LIMP-2 as the mannose-6-phosphate-independent trafficking receptor for

34 Further, it carries mannose 6-phosphate, indicating lysosomal sorting via ma

35 The mannose 6-phosphate/insulin-like growth factor 2 recepto

36 CD222, also known as the cation-independent mannose 6-phosphate/insulin-like growth factor 2 recepto

37 The cation independent mannose 6-phosphate/insulin-like growth factor 2 recepto

38 on assays with radiolabeled CTGF and soluble mannose 6-phosphate/insulin-like growth factor 2 recepto

39 act of one of the Plg binding molecules, the mannose 6-phosphate/insulin-like growth factor 2 recepto

40 Cell surface mannose 6-phosphate/insulin-like growth factor II recept

41 The mannose 6-phosphate/insulin-like growth factor II recept

42 a in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II recept

43 To explore a possible role for the mannose 6-phosphate/insulin-like growth factor II recept

44 gen activator receptor (uPAR) binding by the mannose 6-phosphate/insulin-like growth factor II recept

45 Mannose 6-phosphate/insulin-like growth factor II recept

46 In the present study, we have identified the mannose 6-phosphate/insulin-like growth factor II recept

47 racellular sorting of lysosomal enzymes, the mannose 6-phosphate/insulin-like growth factor II recept

48 Among the 15 extracellular domains of the mannose 6-phosphate/insulin-like growth factor-2 recepto

49 We show that CREG binds directly to the mannose-6-phosphate/insulin-like growth factor II recept

50 ble for the initial step in the synthesis of mannose 6-phosphate is UDP-N-acetylglucosamine:lysosomal

51 cluding a multidrug efflux homolog (yitG), a mannose-6-phosphate isomerase gene (yjdE), and loci invo

52 -phosphate --> mannose 1-phosphate) and MPI (mannose 6-phosphate <--> fructose 6-phosphate) deficienc

53 he enzyme that initiates the addition of the mannose 6-phosphate lysosomal sorting signal on acid hyd

54 ates the second step in the synthesis of the mannose 6-phosphate lysosomal targeting signal on acid h

55 Subsequent modeling of mannose 6-phosphate (M6P) into the active site of the en

56 previously showed that the neonate uses the mannose 6-phosphate (M6P) receptor to transport phosphor

57 or (IGF2R), also known as cation-independent mannose 6-phosphate (M6P) receptor, is a transmembrane g

58 FIIR) as a binding protein for CD26 and that mannose 6-phosphate (M6P) residues in the carbohydrate m

59 PMM converts mannose 6-phosphate (M6P) to mannose-1-phosphate, a prec

60 ke growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respect

61 bition assay was used to analyze whether the mannose 6-phosphate (M6P)/IGF2 receptor that also binds

62 The Tat motif allowed for mannose-6-phosphate (M6P) independent uptake in vitro an

63 Mannose-6-phosphate (M6P) is an essential precursor for

64 tional tagging with N-glycans terminating in mannose-6-phosphate (M6P) residues.

65 s the phosphomannomutase (Pmm) that converts mannose-6-phosphate (M6P) to mannose-1-phosphate (M1P).

66 We have determined the effect of applying Mannose-6-Phosphate (M6P), a scar reducing agent, to a s

67 Mannose-6-phosphate (M6P)-terminated oligosaccharides ar

68 Four VZV envelope glycoproteins contain mannose 6-phosphate (Man 6-P), and Man 6-P blocks infect

69 the CI-MPR (Dom1-3His) which contains both a mannose 6-phosphate (Man-6-P) and plasminogen binding si

70 le that only one of the two extracytoplasmic mannose 6-phosphate (Man-6-P) binding domains is necessa

71 The two mannose 6-phosphate (Man-6-P) binding domains of the ins

72 e receptor (CI-MPR), which contains multiple mannose 6-phosphate (Man-6-P) binding sites that map to

73 e) deficiencies reduce the metabolic flux of mannose 6-phosphate (Man-6-P) into glycosylation, result

74 The mannose 6-phosphate (Man-6-P) lysosomal targeting signal

75 al receptor that binds to a diverse array of mannose 6-phosphate (Man-6-P) modified proteins as well

76 Two distinct mannose 6-phosphate (Man-6-P) receptors (MPRs), the cati

77 Nowhere is this better illustrated than the mannose 6-phosphate (Man-6-P) recognition system that me

78 non-lysosomal glycoproteins reported to bear mannose 6-phosphate (Man-6-P) residues on its N-glycans.

79 ellular sorting of lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) residues to the lysosome a

80 onlysosomal proteins have been shown to bear mannose 6-phosphate (Man-6-P) residues.

81 PMM converts mannose 6-phosphate (man-6-P) to mannose-1-phosphate (ma

82 which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate b

83 to the lysosome by binding newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

84 argeting system that binds newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

85 targeting system that bind newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

86 intracellular delivery of newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases

87 Mannose 6-phosphate (Man-6-P)-dependent trafficking is v

88 oteins are delivered to the lysosome via the mannose 6-phosphate (Man-6-P)-targeting pathway.

89 specifically labels lysosomal proteins with mannose 6-phosphate (Man-6-P).

90 sferase, which tags lysosomal enzymes with a mannose 6-phosphate marker for transport to the lysosome

91 a linear relationship between the amount of mannose 6-phosphate measured and the amount of alpha-gal

92 Mannose 6-phosphate modification of wild-type and mutant

93 in human fibrosarcoma cells, due to impaired mannose 6-phosphate modification.

94 hosphate receptor (IGF2R) include IGF-II and mannose 6-phosphate modified proteins.

95 n of insulin-like growth factor 2 (IGF2) and mannose 6-phosphate modified proteins.

96 Mannose 6-phosphate-modified N-glycans are the determina

97 sphomonoesters (Man-6-P) or phosphodiesters (mannose 6-phosphate N-acetylglucosamine ester, Man-P-Glc

98 The assay was also linear when measuring mannose 6-phosphate on electroblots.

99 nzyme replacement therapy are the absence of mannose 6-phosphate on recombinant human NAGLU and the b

100 wly synthesized lysosomal enzymes containing mannose 6-phosphate on their N-linked oligosaccharides.

101 e carbohydrate moieties, such as mannose and mannose 6-phosphate, on the enzymes.

102 arides harboring mono- and bisphosphorylated mannose 6-phosphates onto rhGAA (neo-rhGAA) significantl

103 The addition of mannose 6-phosphate or octyl glucoside, a nonionic deter

104 H patients contained mutations in either the mannose 6-phosphate or the IGF2 binding domain of the M6

105 M6P and mannose 6-phosphate-poly[N-(2-hydroxyethyl)-acrylamide]

106 sorting nexin 1 (SNX1), as well as decreased mannose 6 phosphate receptor (M6PR), suggesting the impa

107 The cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component

108 The 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) plays a key role i

109 increased expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR), which is partiall

110 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46 kDa cat

111 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46-kDa cat

112 ii) Cells transduced with cation-independent mannose 6-phosphate receptor (CI-MPR) block apoptosis in

113 mplex, which recycles the cation-independent mannose 6-phosphate receptor (CI-MPR) from endosomes to

114 h the distribution of the cation-independent mannose 6-phosphate receptor (CI-MPR) has been well stud

115 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) is a multifunction

116 The cation-independent mannose 6-phosphate receptor (CI-MPR) mediates sorting o

117 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) mediates the intra

118 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical r

119 h affinity ligand for the cation-independent mannose 6-phosphate receptor (CI-MPR), and we analyzed t

120 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR), which contains mu

121 be because of inefficient cation-independent mannose 6-phosphate receptor (CI-MPR)-mediated endocytos

122 rk (TGN) transport of the cation-independent mannose 6-phosphate receptor (CI-MPR).

123 e cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR).

124 erouted AP-1, endocytosed cation-independent mannose 6-phosphate receptor (CIMPR) accumulated in a pe

125 25 ArfGAPs for effects on cation-independent mannose 6-phosphate receptor (CIMPR) localization.

126 anges the distribution of cation-independent mannose 6-phosphate receptor (CIMPR) without affecting t

127 The insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/MPR) is a type I gl

128 on-independent insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-IIR) with IGFs and man

129 Ligands of the IGF-II/mannose 6-phosphate receptor (IGF2R) include IGF-II and

130 The insulin-like growth factor II/mannose 6-phosphate receptor (IGF2R) interacts with lyso

131 binds more tightly to the cation-independent mannose 6-phosphate receptor (K(D) = 1 microm) than to t

132 (D) = 1 microm) than to the cation-dependent mannose 6-phosphate receptor (K(D) = 3 microm).

133 domains of the insulin-like growth factor II/mannose 6-phosphate receptor (Man-6-P/IGF2R), located in

134 brane protein LIMP-2 has been a paradigm for mannose 6-phosphate receptor (MPR) independent lysosomal

135 fEndosome-to-Golgi retrieval of the mannose 6-phosphate receptor (MPR) is required for lysos

136 OCRL1 and IPIP27A localize to mannose 6-phosphate receptor (MPR)-containing traffickin

137 in maintaining Golgi structure and tethering mannose 6-phosphate receptor (MPR)-containing transport

138 R) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).

139 he acid hydrolases to the cation-independent mannose 6-phosphate receptor allows sufficient sorting t

140 ecreased affinity for the cation-independent mannose 6-phosphate receptor and failed to bind to the c

141 itutive (transferrin receptor) and regulated mannose 6-phosphate receptor and GLUT4 trafficking to th

142 r, and low amounts of the cation-independent mannose 6-phosphate receptor and the lysosome-associated

143 e receptors including the cation-independent mannose 6-phosphate receptor and the mannose receptor.

144 gnition by the insulin-like growth factor II/mannose 6-phosphate receptor are predicted by sequence a

145 of the interaction of recombinant TIP47 with mannose 6-phosphate receptor cytoplasmic domains.

146 receptors, including the cation-independent mannose 6-phosphate receptor for lysosomal enzymes.

147 ates the retrieval of the cation-independent mannose 6-phosphate receptor from endosomes to the trans

148 1 causes a mislocalization of both furin and mannose 6-phosphate receptor from the trans-Golgi networ

149 st time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain prese

150 n, the N-terminal part of Yos9 including the mannose 6-phosphate receptor homology domain mediates th

151 Inactivation of the mannose 6-phosphate receptor homology domain of OS9 had

152 We postulate that the mannose 6-phosphate receptor homology domain of the gamm

153 trates that in the majority of instances the mannose 6-phosphate receptor homology domain of the gamm

154 lysosomal membranes, the accumulation of the mannose 6-phosphate receptor in and the recruitment of t

155 ired incorporation of the cation-independent mannose 6-phosphate receptor into clathrin-coated vesicl

156 These vesicles contain the mannose 6-phosphate receptor involved in targeting prote

157 The insulin-like growth factor II/mannose 6-phosphate receptor is a multifunctional recept

158 receptor tyrosine kinase, whereas the IGF-2/ mannose 6-phosphate receptor is a single transmembrane d

159 on the trafficking of the cation-independent mannose 6-phosphate receptor or the GLUT1 glucose transp

160 ficking of an endocytosed cation-independent mannose 6-phosphate receptor reporter from early endosom

161 All three GGAs (1, 2, and 3) bind to the mannose 6-phosphate receptor tail via their VHS domains,

162 six knockdowns cause the cation-independent mannose 6-phosphate receptor to become trapped in cluste

163 y sequence alignment to the cation-dependent mannose 6-phosphate receptor to reside within domains 3

164 for the retrieval of the cation-independent mannose 6-phosphate receptor to the TGN.

165 pe C cell membranes, which in turn, disrupts mannose 6-phosphate receptor trafficking.

166 nt that is independent of cation-independent mannose 6-phosphate receptor trafficking.

167 GA3 but not GGA2 bind the cation-independent mannose 6-phosphate receptor very poorly because of auto

168 eficient hepatocytes, whereas that of 46-kDa mannose 6-phosphate receptor was decreased to 30% of con

169 The steady-state level of 300-kDa mannose 6-phosphate receptor was slightly lower in LAMP-

170 uolar protein sorting 35 homolog), and M6PR (mannose 6-phosphate receptor) blocked PrP(C) internaliza

171 rs of transport vesicles (cation-independent mannose 6-phosphate receptor), late endosomes (Ras-assoc

172 nto cells via sortilin or cation-independent mannose 6-phosphate receptor, and facilitated the acidif

173 ach other and to the 46 kDa cation-dependent mannose 6-phosphate receptor, assemble into a compact st

174 argo, sortilin, SorLA and cation-independent mannose 6-phosphate receptor, in rodent primary neurons

175 y into the endosomal/lysosomal system by the mannose 6-phosphate receptor, N- and C-terminal proseque

176 fficking to the lysosome, presumably via the mannose 6-phosphate receptor, the 110-kDa precursor unde

177 membranes along with clathrin, giantin, the mannose 6-phosphate receptor, transferrin, and the early

178 ilure of fission caused defective sorting of mannose 6-phosphate receptor, with consequently disrupte

179 at interact with the cytoplasmic tail of the mannose 6-phosphate receptor, yet its sequence is highly

180 r to that of avidin and the cation-dependent mannose 6-phosphate receptor, yet only domain 11 binds I

181 These results implicate MMR-independent and mannose 6-phosphate receptor-independent pathways in phL

182 o numerous ligands and plays a major role in mannose 6-phosphate receptor-independent transport of ly

183 Two such proteins, mannose 6-phosphate receptor-interacting protein TIP47 a

184 Here, we demonstrate that mannose 6-phosphate receptor-mediated cellular uptake an

185 enzyme is delivered to neonatal brain after mannose 6-phosphate receptor-mediated transcytosis.

186 tion, the induction of tolerance may require mannose 6-phosphate receptor-mediated uptake because alp

187 by repeated high doses of enzyme depends on mannose 6-phosphate receptor-mediated uptake or whether

188 r and failed to bind to the cation-dependent mannose 6-phosphate receptor.

189 protein had altered binding affinity for the mannose 6-phosphate receptor.

190 the bifunctional, IGF-II cation-independent mannose 6-phosphate receptor.

191 state localization of the cation-independent mannose 6-phosphate receptor.

192 ecause of uptake of enzyme from blood by the mannose 6-phosphate receptor.

193 rane proteins such as the cation-independent mannose 6-phosphate receptor.

194 ith high affinity for the cation-independent mannose 6-phosphate receptor.

195 e cytoplasmic tail of the cation-independent mannose 6-phosphate receptor.

196 ile ectopic expression of cation-independent mannose-6 phosphate receptor blocks apoptosis induced by

197 CD36, nitric oxide synthase type 2, and the mannose-6 phosphate receptor) that are known to be palmi

198 nclusion that the interacting protein is the mannose-6 phosphate receptor.

199 tein NPC2, a cargo of the cation-independent mannose-6-phosphate receptor (CI-M6PR).

200 ograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin.

201 The cation-independent mannose-6-phosphate receptor (CI-MPR) follows a highly r

202 as been attributed to low cation-independent mannose-6-phosphate receptor (CI-MPR) in skeletal muscle

203 attributed to inefficient cation-independent mannose-6-phosphate receptor (CI-MPR) mediated uptake.

204 to-Golgi retrieval of the cation-independent mannose-6-phosphate receptor (CI-MPR), a receptor for ly

205 clenbuterol treatment on cation-independent mannose-6-phosphate receptor (CI-MPR)-mediated uptake an

206 tion between SNX5 and the cation-independent mannose-6-phosphate receptor (CI-MPR).

207 -like growth factor-II receptor (IGF-IIR), a mannose-6-phosphate receptor (M6PR) that binds to cathep

208 alization of specific cargo proteins (furin, mannose-6-phosphate receptor (M6PR), and M6PR lacking a

209 Uptake of recombinant enzyme is via the mannose-6-phosphate receptor (M6PR).

210 y transient but dramatic upregulation of the mannose-6-phosphate receptor (MPR) on the tumor cell sur

211 endosomal membranes as that followed by the mannose-6-phosphate receptor (MPR), and consistent with

212 oteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such

213 mes to the TGN, but not for the retrieval of mannose-6-phosphate receptor from late endosomes.

214 tracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-bindin

215 is an ER-resident glycoprotein containing a mannose-6-phosphate receptor homology domain, which is a

216 nked dimer, the majority is directed via the mannose-6-phosphate receptor pathway to endocytic compar

217 ts and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes.

218 l G-proteins, including Ras, up-regulate the mannose-6-phosphate receptor, and induce apoptosis.

219 d lysosomal marker proteins, including Rab7, mannose-6-phosphate receptor, and LAMP-1.

220 47 kDa (TIP47; also known as perilipin-3 and mannose-6-phosphate receptor-binding protein 1), a membe

221 The enzyme is delivered by a mannose-6-phosphate receptor-dependent mechanism to the

222 ces, and can be taken up by distal cells via mannose-6-phosphate receptor-mediated endocytosis.

223 argeted to the lysosome independently of the mannose-6-phosphate receptor.

224 glycosaminoglycans and a cation-independent mannose-6-phosphate receptor.

225 2 chimera containing a cytosolic domain of a mannose-6-phosphate receptor.

226 ng the basis for lysosomal transport via the mannose-6-phosphate receptor.

227 of endo-lysosomes, as well as impairment of mannose-6-phosphate-receptor trafficking.

228 ity of the cation-independent and -dependent mannose 6-phosphate receptors (CI-MPR and CD-MPR) for hi

229 n cell lines deficient in cation-independent mannose 6-phosphate receptors (MPRci).

230 the cation-dependent and cation-independent mannose 6-phosphate receptors (MPRs) and is required for

231 olgi network (TGN) is mediated by binding to mannose 6-phosphate receptors (MPRs) and subsequent capt

232 in a late endosome microdomain together with mannose 6-phosphate receptors (MPRs) and the tail-intera

233 Mannose 6-phosphate receptors (MPRs) are transported fro

234 Mannose 6-phosphate receptors (MPRs) are transported fro

235 n-independent (CI) and cation-dependent (CD) mannose 6-phosphate receptors (MPRs) bind specifically t

236 Mannose 6-phosphate receptors (MPRs) deliver lysosomal h

237 Mannose 6-phosphate receptors (MPRs) deliver newly synth

238 ns (GGAs) are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) in the Golgi and ha

239 Mannose 6-phosphate receptors (MPRs) participate in the

240 olases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between

241 is required for Rab9-dependent recycling of mannose 6-phosphate receptors (MPRs) to the Golgi and fo

242 was taken up by a combination of mannose and mannose 6-phosphate receptors (MR and M6PR, respectively

243 chinery that mediates the trafficking of the mannose 6-phosphate receptors and associated cargo from

244 ow visualization of endocytosis of mod2B via mannose 6-phosphate receptors and delivery of mod2B to l

245 s of GCC185 triggers enhanced degradation of mannose 6-phosphate receptors and enhanced secretion of

246 s Rab9 GTPase and the cytoplasmic domains of mannose 6-phosphate receptors and is required for their

247 rectly leads to impaired recycling of 46-kDa mannose 6-phosphate receptors and partial mistargeting o

248 Cation-independent mannose 6-phosphate receptors are enriched in the Rab9 d

249 s, the GGAs appear to mediate sorting of the mannose 6-phosphate receptors at the trans-Golgi network

250 targeted to the lysosome through binding to mannose 6-phosphate receptors because their glycans are

251 TIP47 functions in the delivery of mannose 6-phosphate receptors from endosomes to the tran

252 ab9A and its effectors regulate recycling of mannose 6-phosphate receptors from late endosomes to the

253 ab9A and its effectors regulate transport of mannose 6-phosphate receptors from late endosomes to the

254 ated cholesterol on Rab9-dependent export of mannose 6-phosphate receptors from this compartment.

255 However, mutant PPT enzymes did not bind to mannose 6-phosphate receptors in a blotting assay.

256 two proteins may cooperate in packaging the mannose 6-phosphate receptors into clathrin-coated vesic

257 h-muscle cell interaction may be mediated by mannose 6-phosphate receptors present on monocytes.

258 ck in Rab6-dependent retrograde transport of mannose 6-phosphate receptors to the Golgi.

259 This blocks retrieval of mannose 6-phosphate receptors to the TGN and impairs cat

260 n-Pick type C membranes, as cation-dependent mannose 6-phosphate receptors were missorted to the lyso

261 istribution of markers of the TGN (TGN38 and mannose 6-phosphate receptors) led us to propose that GG

262 the surface expression or internalization of mannose 6-phosphate receptors, which are required for VZ

263 osis of lysosomal enzymes via the mannose or mannose 6-phosphate receptors.

264 upstream of the steady-state distribution of mannose 6-phosphate receptors.

265 tifs present in the cytoplasmic tails of the mannose 6-phosphate receptors.

266 the cation-independent and cation-dependent mannose 6-phosphate receptors.

267 the cation-independent and cation-dependent mannose 6-phosphate receptors.

268 e, resulting in the peripheral dispersion of mannose 6-phosphate receptors.

269 -phosphate, indicating lysosomal sorting via mannose 6-phosphate receptors.

270 ome-to-Golgi retrieval of cation-independent mannose-6-phosphate receptors (CI-MPR) in the soma is di

271 reduced in hydrolytic enzymes transported by mannose-6-phosphate receptors (MPRs).

272 This protein was known to transport mannose-6-phosphate receptors from endosome to trans-Gol

273 etwork to lysosomes and the incorporation of mannose-6-phosphate receptors into CCVs.

274 This effect was mediated via upregulation of mannose-6-phosphate receptors on the surface of tumor ce

275 trast to wild-type ASA, which is taken up by mannose-6-phosphate receptors, all chimeric proteins wer

276 the cation-independent and cation-dependent mannose-6-phosphate receptors, are recognized by the GGA

277 delivery was independent of high-mannose and mannose-6-phosphate receptors, which are exploited for d

278 1 reaches the vacuole even in the absence of mannose-6-phosphate receptors, which are responsible for

279 human GGA3 complexed with signals from both mannose-6-phosphate receptors.

280 iates the first step in the synthesis of the mannose 6-phosphate recognition marker on acid hydrolase

281 oves a covering N-acetylglucosamine from the mannose 6-phosphate recognition marker on lysosomal acid

282 iates the first step in the synthesis of the mannose 6-phosphate recognition marker on lysosomal acid

283 iates the first step in the synthesis of the mannose 6-phosphate recognition marker on lysosomal acid

284 yzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal enzy

285 sents the key enzyme for the biosynthesis of mannose 6-phosphate recognition marker on soluble lysoso

286 ags newly synthesized lysosomal enzymes with mannose 6-phosphate recognition markers, which are requi

287 tes the initial step in the formation of the mannose 6-phosphate recognition signal on lysosomal acid

288 e, the initial enzyme in the biosynthesis of mannose 6-phosphate residues, is governed by a common pr

289 osaccharides with both terminal mannosyl and mannose 6-phosphate residues.

290 d medaka does not appear to be modified with mannose 6-phosphate residues.

291 , an enzyme involved in the synthesis of the mannose 6-phosphate signal that targets acid hydrolases

292 These genes encode enzymes that generate the mannose-6-phosphate signal, which directs a diverse grou

293 sport of ARSG in the liver is independent of mannose 6-phosphate, sortilin, and Limp2.

294 These hydrolases acquire a mannose 6-phosphate tag by the action of the GlcNAc-1-ph

295 ates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesize

296 ng yolk utilization and the evolution of the mannose 6-phosphate targeting system in vertebrates.

297 der caused by defects in the biosynthesis of mannose 6-phosphate, the carbohydrate recognition signal

298 aining glycoconjugates, is the conversion of mannose-6-phosphate to mannose-1-phosphate, by a phospho

299 6-phosphate and quantitation of the released mannose 6-phosphate using HPAEC with PAD.

300 ribose-5-phosphate, glucose-6-phosphate, and mannose-6-phosphate was achieved by UPLC/multiple-reacti

301 to residue N325, and that it binds MPR, via mannose 6-phosphate, with a similar affinity to that obs