ライフサイエンスコーパス: mannose 6-phosphate receptor

1 the bifunctional, IGF-II cation-independent mannose 6-phosphate receptor.

2 ecause of uptake of enzyme from blood by the mannose 6-phosphate receptor.

3 state localization of the cation-independent mannose 6-phosphate receptor.

4 patocytes, suggesting diffuse uptake via the mannose 6-phosphate receptor.

5 lin-like growth factor II/cation-independent mannose 6-phosphate receptor.

6 that Asn-175 mutants could interact with the mannose 6-phosphate receptor.

7 proton pump, but lacking cation-independent mannose 6-phosphate receptor.

8 rane proteins such as the cation-independent mannose 6-phosphate receptor.

9 asmic granules by a mechanism other than the mannose 6-phosphate receptor.

10 signals of the transferrin receptor or large mannose 6-phosphate receptor.

11 ith high affinity for the cation-independent mannose 6-phosphate receptor.

12 e cytoplasmic tail of the cation-independent mannose 6-phosphate receptor.

13 r and failed to bind to the cation-dependent mannose 6-phosphate receptor.

14 protein had altered binding affinity for the mannose 6-phosphate receptor.

15 nclusion that the interacting protein is the mannose-6 phosphate receptor.

16 2 chimera containing a cytosolic domain of a mannose-6-phosphate receptor.

17 ng the basis for lysosomal transport via the mannose-6-phosphate receptor.

18 lular distribution of the cation-independent mannose-6-phosphate receptor.

19 r to those containing the cation-independent mannose-6-phosphate receptor.

20 ous to the recycling signal of the mammalian mannose-6-phosphate receptor.

21 s competent for lysosomal uptake through the mannose-6-phosphate receptor.

22 argeted to the lysosome independently of the mannose-6-phosphate receptor.

23 glycosaminoglycans and a cation-independent mannose-6-phosphate receptor.

24 upstream of the steady-state distribution of mannose 6-phosphate receptors.

25 tifs present in the cytoplasmic tails of the mannose 6-phosphate receptors.

26 the cation-independent and cation-dependent mannose 6-phosphate receptors.

27 the cation-independent and cation-dependent mannose 6-phosphate receptors.

28 e, resulting in the peripheral dispersion of mannose 6-phosphate receptors.

29 lization with transferrin receptors and some mannose 6-phosphate receptors.

30 -phosphate, indicating lysosomal sorting via mannose 6-phosphate receptors.

31 osis of lysosomal enzymes via the mannose or mannose 6-phosphate receptors.

32 human GGA3 complexed with signals from both mannose-6-phosphate receptors.

33 trast to wild-type ASA, which is taken up by mannose-6-phosphate receptors, all chimeric proteins wer

34 he acid hydrolases to the cation-independent mannose 6-phosphate receptor allows sufficient sorting t

35 de transferrin, fluid phase markers, and the mannose-6-phosphate receptor, although in the perinuclea

36 ndependent mechanisms, but are devoid of the mannose 6-phosphate receptor and cathepsin L.

37 ecreased affinity for the cation-independent mannose 6-phosphate receptor and failed to bind to the c

38 itutive (transferrin receptor) and regulated mannose 6-phosphate receptor and GLUT4 trafficking to th

39 d by two distinct MPRs: the cation-dependent mannose 6-phosphate receptor and the insulin-like growth

40 r, and low amounts of the cation-independent mannose 6-phosphate receptor and the lysosome-associated

41 e receptors including the cation-independent mannose 6-phosphate receptor and the mannose receptor.

42 chinery that mediates the trafficking of the mannose 6-phosphate receptors and associated cargo from

43 nd lysosomal acid phosphatases but also with mannose 6-phosphate receptors and cathepsin L.

44 ow visualization of endocytosis of mod2B via mannose 6-phosphate receptors and delivery of mod2B to l

45 s of GCC185 triggers enhanced degradation of mannose 6-phosphate receptors and enhanced secretion of

46 the cation-independent and cation-dependent mannose 6-phosphate receptors and is required for their

47 s Rab9 GTPase and the cytoplasmic domains of mannose 6-phosphate receptors and is required for their

48 rectly leads to impaired recycling of 46-kDa mannose 6-phosphate receptors and partial mistargeting o

49 p40 cofractionates with endosomes containing mannose 6-phosphate receptors and the Rab9 GTPase.

50 oteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such

51 nto cells via sortilin or cation-independent mannose 6-phosphate receptor, and facilitated the acidif

52 l G-proteins, including Ras, up-regulate the mannose-6-phosphate receptor, and induce apoptosis.

53 d lysosomal marker proteins, including Rab7, mannose-6-phosphate receptor, and LAMP-1.

54 the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor are palmitoylated via thioe

55 gnition by the insulin-like growth factor II/mannose 6-phosphate receptor are predicted by sequence a

56 Cation-independent mannose 6-phosphate receptors are enriched in the Rab9 d

57 also stimulates the initial rate with which mannose 6-phosphate receptors are transported from late

58 the cation-independent and cation-dependent mannose-6-phosphate receptors, are recognized by the GGA

59 ach other and to the 46 kDa cation-dependent mannose 6-phosphate receptor, assemble into a compact st

60 s, the GGAs appear to mediate sorting of the mannose 6-phosphate receptors at the trans-Golgi network

61 targeted to the lysosome through binding to mannose 6-phosphate receptors because their glycans are

62 5 min, then contained the cation-independent mannose 6-phosphate receptor between 2.5 and 7.5 min, an

63 t monitors the transport of cation-dependent mannose 6-phosphate receptors between endosomes and the

64 47 kDa (TIP47; also known as perilipin-3 and mannose-6-phosphate receptor-binding protein 1), a membe

65 uolar protein sorting 35 homolog), and M6PR (mannose 6-phosphate receptor) blocked PrP(C) internaliza

66 ile ectopic expression of cation-independent mannose-6 phosphate receptor blocks apoptosis induced by

67 e studies show TGN localization of furin and mannose-6-phosphate receptor, but not TGN46, is strictly

68 Mannose 6-phosphate receptors carry newly synthesized ly

69 lysosome is mediated by the cation-dependent mannose 6-phosphate receptor (CD-MPR) and the insulin-li

70 cid cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor (CD-MPR) contains a signal(

71 luble truncated form of the cation-dependent mannose 6-phosphate receptor (CD-MPR) encoding only the

72 The cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component

73 The 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) plays a key role i

74 increased expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR), which is partiall

75 The cation-dependent and cation-independent mannose 6-phosphate receptors (CD- and CI-MPRs) bind the

76 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46 kDa cat

77 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46-kDa cat

78 ii) Cells transduced with cation-independent mannose 6-phosphate receptor (CI-MPR) block apoptosis in

79 mplex, which recycles the cation-independent mannose 6-phosphate receptor (CI-MPR) from endosomes to

80 ramatic redistribution of cation-independent mannose 6-phosphate receptor (CI-MPR) from its normal pe

81 h the distribution of the cation-independent mannose 6-phosphate receptor (CI-MPR) has been well stud

82 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) is a multifunction

83 The cation-independent mannose 6-phosphate receptor (CI-MPR) mediates sorting o

84 The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) mediates the intra

85 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical r

86 h affinity ligand for the cation-independent mannose 6-phosphate receptor (CI-MPR), and we analyzed t

87 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR), which contains mu

88 be because of inefficient cation-independent mannose 6-phosphate receptor (CI-MPR)-mediated endocytos

89 rk (TGN) transport of the cation-independent mannose 6-phosphate receptor (CI-MPR).

90 e cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR).

91 ity of the cation-independent and -dependent mannose 6-phosphate receptors (CI-MPR and CD-MPR) for hi

92 early endosomes, and the cation-independent mannose-6-phosphate receptor (CI-M6PR), a component of l

93 n ATPase (V-ATPase), the calcium-independent mannose-6-phosphate receptor (CI-M6PR), or cathepsin D.

94 tein NPC2, a cargo of the cation-independent mannose-6-phosphate receptor (CI-M6PR).

95 ograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin.

96 The cation-independent mannose-6-phosphate receptor (CI-MPR) follows a highly r

97 as been attributed to low cation-independent mannose-6-phosphate receptor (CI-MPR) in skeletal muscle

98 attributed to inefficient cation-independent mannose-6-phosphate receptor (CI-MPR) mediated uptake.

99 to-Golgi retrieval of the cation-independent mannose-6-phosphate receptor (CI-MPR), a receptor for ly

100 clenbuterol treatment on cation-independent mannose-6-phosphate receptor (CI-MPR)-mediated uptake an

101 tion between SNX5 and the cation-independent mannose-6-phosphate receptor (CI-MPR).

102 ome-to-Golgi retrieval of cation-independent mannose-6-phosphate receptors (CI-MPR) in the soma is di

103 erouted AP-1, endocytosed cation-independent mannose 6-phosphate receptor (CIMPR) accumulated in a pe

104 25 ArfGAPs for effects on cation-independent mannose 6-phosphate receptor (CIMPR) localization.

105 anges the distribution of cation-independent mannose 6-phosphate receptor (CIMPR) without affecting t

106 eficient form of the bovine cation-dependent mannose 6-phosphate receptor complexed to pentamannosyl

107 of the interaction of recombinant TIP47 with mannose 6-phosphate receptor cytoplasmic domains.

108 und to be taken up by uncorrected cells in a mannose-6-phosphate receptor-dependent manner.

109 The enzyme is delivered by a mannose-6-phosphate receptor-dependent mechanism to the

110 e sulfotransferase and monitors transport of mannose 6-phosphate receptors engineered to contain a co

111 receptors, including the cation-independent mannose 6-phosphate receptor for lysosomal enzymes.

112 ates the retrieval of the cation-independent mannose 6-phosphate receptor from endosomes to the trans

113 f drug had no effect on the transport of the mannose 6-phosphate receptor from late endosomes to the

114 1 causes a mislocalization of both furin and mannose 6-phosphate receptor from the trans-Golgi networ

115 TIP47 functions in the delivery of mannose 6-phosphate receptors from endosomes to the tran

116 rt processes, their role in the transport of mannose 6-phosphate receptors from endosomes to the tran

117 o transport assay that measures transport of mannose 6-phosphate receptors from endosomes to the tran

118 Rab9 GTPase is required for the transport of mannose 6-phosphate receptors from endosomes to the tran

119 We study the transport of mannose 6-phosphate receptors from late endosomes to the

120 ab9A and its effectors regulate recycling of mannose 6-phosphate receptors from late endosomes to the

121 ab9A and its effectors regulate transport of mannose 6-phosphate receptors from late endosomes to the

122 ated cholesterol on Rab9-dependent export of mannose 6-phosphate receptors from this compartment.

123 mes to the TGN, but not for the retrieval of mannose-6-phosphate receptor from late endosomes.

124 This protein was known to transport mannose-6-phosphate receptors from endosome to trans-Gol

125 tracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-bindin

126 st time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain prese

127 n, the N-terminal part of Yos9 including the mannose 6-phosphate receptor homology domain mediates th

128 Inactivation of the mannose 6-phosphate receptor homology domain of OS9 had

129 trates that in the majority of instances the mannose 6-phosphate receptor homology domain of the gamm

130 We postulate that the mannose 6-phosphate receptor homology domain of the gamm

131 is an ER-resident glycoprotein containing a mannose-6-phosphate receptor homology domain, which is a

132 lin-like growth factor II/cation-independent mannose 6-phosphate receptor (IGF-II/CI-MPR).

133 g sites of the insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/MPR) have been loca

134 The insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/MPR) is a type I gl

135 on-independent insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-IIR) with IGFs and man

136 The insulin-like growth factor II/mannose 6-phosphate receptor (IGF2R) carries out multipl

137 Ligands of the IGF-II/mannose 6-phosphate receptor (IGF2R) include IGF-II and

138 The insulin-like growth factor II/mannose 6-phosphate receptor (IGF2R) interacts with lyso

139 g the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor (IGF2R), is frequently inac

140 lysosomal membranes, the accumulation of the mannose 6-phosphate receptor in and the recruitment of t

141 However, mutant PPT enzymes did not bind to mannose 6-phosphate receptors in a blotting assay.

142 altered the steady-state distribution of the mannose-6-phosphate receptor in the cell.

143 argo, sortilin, SorLA and cation-independent mannose 6-phosphate receptor, in rodent primary neurons

144 , endocytic markers delivered to vacuoles by mannose 6-phosphate receptor-independent mechanisms, but

145 These results implicate MMR-independent and mannose 6-phosphate receptor-independent pathways in phL

146 o numerous ligands and plays a major role in mannose 6-phosphate receptor-independent transport of ly

147 Two such proteins, mannose 6-phosphate receptor-interacting protein TIP47 a

148 ired incorporation of the cation-independent mannose 6-phosphate receptor into clathrin-coated vesicl

149 two proteins may cooperate in packaging the mannose 6-phosphate receptors into clathrin-coated vesic

150 etwork to lysosomes and the incorporation of mannose-6-phosphate receptors into CCVs.

151 These vesicles contain the mannose 6-phosphate receptor involved in targeting prote

152 The insulin-like growth factor II/mannose 6-phosphate receptor is a multifunctional recept

153 receptor tyrosine kinase, whereas the IGF-2/ mannose 6-phosphate receptor is a single transmembrane d

154 binds more tightly to the cation-independent mannose 6-phosphate receptor (K(D) = 1 microm) than to t

155 (D) = 1 microm) than to the cation-dependent mannose 6-phosphate receptor (K(D) = 3 microm).

156 Antibodies directed to the mannose-6-phosphate receptor labeled vacuole membranes.

157 rs of transport vesicles (cation-independent mannose 6-phosphate receptor), late endosomes (Ras-assoc

158 istribution of markers of the TGN (TGN38 and mannose 6-phosphate receptors) led us to propose that GG

159 athepsin D) and late endosomal markers (anti-mannose-6-phosphate receptor), lysosomal markers (CD-63)

160 sorting nexin 1 (SNX1), as well as decreased mannose 6 phosphate receptor (M6PR), suggesting the impa

161 -like growth factor-II receptor (IGF-IIR), a mannose-6-phosphate receptor (M6PR) that binds to cathep

162 alization of specific cargo proteins (furin, mannose-6-phosphate receptor (M6PR), and M6PR lacking a

163 Uptake of recombinant enzyme is via the mannose-6-phosphate receptor (M6PR).

164 domains of the insulin-like growth factor II/mannose 6-phosphate receptor (Man-6-P/IGF2R), located in

165 but not with Rab7 or the cation-independent mannose 6-phosphate receptor, markers for late endosomal

166 Here, we demonstrate that mannose 6-phosphate receptor-mediated cellular uptake an

167 enzyme is delivered to neonatal brain after mannose 6-phosphate receptor-mediated transcytosis.

168 tion, the induction of tolerance may require mannose 6-phosphate receptor-mediated uptake because alp

169 by repeated high doses of enzyme depends on mannose 6-phosphate receptor-mediated uptake or whether

170 ces, and can be taken up by distal cells via mannose-6-phosphate receptor-mediated endocytosis.

171 g pathways for insulin-like growth factor-II/mannose 6-phosphate receptor (MPR) and transferrin recep

172 brane protein LIMP-2 has been a paradigm for mannose 6-phosphate receptor (MPR) independent lysosomal

173 fEndosome-to-Golgi retrieval of the mannose 6-phosphate receptor (MPR) is required for lysos

174 OCRL1 and IPIP27A localize to mannose 6-phosphate receptor (MPR)-containing traffickin

175 in maintaining Golgi structure and tethering mannose 6-phosphate receptor (MPR)-containing transport

176 R) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).

177 y transient but dramatic upregulation of the mannose-6-phosphate receptor (MPR) on the tumor cell sur

178 endosomal membranes as that followed by the mannose-6-phosphate receptor (MPR), and consistent with

179 or subpopulation of mature lysosomes lacking mannose-6-phosphate receptors (MPR) and smaller populati

180 n cell lines deficient in cation-independent mannose 6-phosphate receptors (MPRci).

181 the cation-dependent and cation-independent mannose 6-phosphate receptors (MPRs) and is required for

182 n-dependent (CD) and cation-independent (CI) mannose 6-phosphate receptors (MPRs) and is required for

183 olgi network (TGN) is mediated by binding to mannose 6-phosphate receptors (MPRs) and subsequent capt

184 in a late endosome microdomain together with mannose 6-phosphate receptors (MPRs) and the tail-intera

185 Mannose 6-phosphate receptors (MPRs) are transported fro

186 Mannose 6-phosphate receptors (MPRs) are transported fro

187 n-independent (CI) and cation-dependent (CD) mannose 6-phosphate receptors (MPRs) bind specifically t

188 Mannose 6-phosphate receptors (MPRs) deliver lysosomal h

189 Mannose 6-phosphate receptors (MPRs) deliver newly synth

190 Mannose 6-phosphate receptors (MPRs) deliver soluble aci

191 ns (GGAs) are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) in the Golgi and ha

192 Mannose 6-phosphate receptors (MPRs) participate in the

193 Mannose 6-phosphate receptors (MPRs) play an important r

194 olases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between

195 is required for Rab9-dependent recycling of mannose 6-phosphate receptors (MPRs) to the Golgi and fo

196 Mannose 6-phosphate receptors (MPRs) transport newly syn

197 oated vesicles that form on the TGN, are the mannose 6-phosphate receptors (MPRs).

198 y known to exhibit low and high affinity for mannose-6-phosphate receptors (MPRs), respectively.

199 reduced in hydrolytic enzymes transported by mannose-6-phosphate receptors (MPRs).

200 was taken up by a combination of mannose and mannose 6-phosphate receptors (MR and M6PR, respectively

201 y into the endosomal/lysosomal system by the mannose 6-phosphate receptor, N- and C-terminal proseque

202 This effect was mediated via upregulation of mannose-6-phosphate receptors on the surface of tumor ce

203 on the trafficking of the cation-independent mannose 6-phosphate receptor or the GLUT1 glucose transp

204 nked dimer, the majority is directed via the mannose-6-phosphate receptor pathway to endocytic compar

205 h-muscle cell interaction may be mediated by mannose 6-phosphate receptors present on monocytes.

206 d loss of TC II-R but not cation-independent mannose 6-phosphate receptor protein at the basolateral

207 ficking of an endocytosed cation-independent mannose 6-phosphate receptor reporter from early endosom

208 le form of the insulin-like growth factor II/mannose 6-phosphate receptor (sIGF-II/MPR) is present in

209 skin fibroblasts and/or chondrocytes via the mannose-6-phosphate receptor system, leading to metaboli

210 All three GGAs (1, 2, and 3) bind to the mannose 6-phosphate receptor tail via their VHS domains,

211 CD36, nitric oxide synthase type 2, and the mannose-6 phosphate receptor) that are known to be palmi

212 fficking to the lysosome, presumably via the mannose 6-phosphate receptor, the 110-kDa precursor unde

213 lations of the insulin-like growth factor-II/mannose 6-phosphate receptor, the transferrin receptor,

214 six knockdowns cause the cation-independent mannose 6-phosphate receptor to become trapped in cluste

215 y sequence alignment to the cation-dependent mannose 6-phosphate receptor to reside within domains 3

216 for the retrieval of the cation-independent mannose 6-phosphate receptor to the TGN.

217 ck in Rab6-dependent retrograde transport of mannose 6-phosphate receptors to the Golgi.

218 This blocks retrieval of mannose 6-phosphate receptors to the TGN and impairs cat

219 ts and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes.

220 We used two independent assays of mannose 6-phosphate receptor trafficking to determine th

221 pe C cell membranes, which in turn, disrupts mannose 6-phosphate receptor trafficking.

222 nt that is independent of cation-independent mannose 6-phosphate receptor trafficking.

223 of endo-lysosomes, as well as impairment of mannose-6-phosphate-receptor trafficking.

224 membranes along with clathrin, giantin, the mannose 6-phosphate receptor, transferrin, and the early

225 th Rab9 in terms of its ability to stimulate mannose 6-phosphate receptor transport.

226 GA3 but not GGA2 bind the cation-independent mannose 6-phosphate receptor very poorly because of auto

227 ome-associated membrane protein-2 (LAMP2)(+)/mannose 6-phosphate receptor(-) vesicles that can be dis

228 eficient hepatocytes, whereas that of 46-kDa mannose 6-phosphate receptor was decreased to 30% of con

229 Expression of the cation-dependent 46 kDa mannose 6-phosphate receptor was elevated in pyramidal n

230 The cation-independent mannose 6-phosphate receptor was not colocalized with ei

231 somal-prelysosomal marker cation-independent mannose 6-phosphate receptor was not detectable in the v

232 The steady-state level of 300-kDa mannose 6-phosphate receptor was slightly lower in LAMP-

233 ylation of desialylated cell surface 300-kDa mannose 6-phosphate receptors, we found that receptor en

234 Rab, synaptojanin, and the cation-dependent mannose 6-phosphate receptor were used to explore wild-t

235 n-Pick type C membranes, as cation-dependent mannose 6-phosphate receptors were missorted to the lyso

236 the surface expression or internalization of mannose 6-phosphate receptors, which are required for VZ

237 delivery was independent of high-mannose and mannose-6-phosphate receptors, which are exploited for d

238 1 reaches the vacuole even in the absence of mannose-6-phosphate receptors, which are responsible for

239 ilure of fission caused defective sorting of mannose 6-phosphate receptor, with consequently disrupte

240 o a column of immobilized cation-independent mannose 6-phosphate receptor, with the strongest binding

241 at interact with the cytoplasmic tail of the mannose 6-phosphate receptor, yet its sequence is highly

242 r to that of avidin and the cation-dependent mannose 6-phosphate receptor, yet only domain 11 binds I