ライフサイエンスコーパス: mannose receptor

1 rolytic enzymes, are normally cleared by the mannose receptor).

2 (as determined by siRNA gene silencing of AM mannose receptors).

3 were rapidly cleared from the plasma by the mannose receptor.

4 in their low association with the macrophage mannose receptor.

5 complement receptors CR1, CR3, CR4, and the mannose receptor.

6 brin or the endocytic collagen receptor, the mannose receptor.

7 pendent mannose 6-phosphate receptor and the mannose receptor.

8 n-binding lectin, C-reactive protein and the mannose receptor.

9 parable with those found for cell-associated mannose receptor.

10 ycan by CD1b requires antigen uptake via the mannose receptor.

11 of trophic forms were not due to ligation of mannose receptor.

12 ocytic collagen receptors uPARAP/Endo180 and mannose receptor.

13 nt upregulated the M2 markers arginase 1 and mannose receptor.

14 Pneumocystis, including dectin-1, TLR2, and mannose receptor.

15 nocytosis or cellular entry via scavenger or mannose receptors.

16 upon the efficient uptake of mannoprotein by mannose receptors.

17 different receptors from the complement and mannose receptors.

18 ng their affinities for FimH and eight human mannose receptors.

19 abbing non integrin (DC-SIGN) and macrophage mannose receptor 1 (MMR-1).

20 We show that mannose receptor 1 (MRC1; CD206) is involved in CpG ODN

21 sis factor alpha, Mx-1, IFNgamma, CXCL9, and mannose receptor 1 gene expression.

22 sh-a2 tumors showed a reduced expression of mannose receptor-1 (CD206), interleukin-10, transforming

23 h early downregulation of surface receptors (mannose receptor-1 (MRC1) and C-type lectins), and subse

24 was characterized by elevated expression of mannose receptor-1, Arginase-1, interleukin-10 and trans

25 Mannose receptor 2 (Mrc2) expresses an extracellular fib

26 The macrophage mannose receptor, a pattern recognition molecule and com

27 intensity detected by anti-human macrophage mannose receptor Abs, indicating that IL-13, like IL-4,

28 Mannose receptor affinity was unaltered, and mRNA levels

29 ocystis (Pc) organisms predominantly through mannose receptors, although the molecular mechanism medi

30 lecular pathway that links engagement of the mannose receptor, an important pattern recognition recep

31 hese include the antiinflammatory macrophage mannose receptor and arginase-1.

32 ophages expressed C-lectins CD206/macrophage mannose receptor and CD209/DC-SIGN, as well as costimula

33 In addition, both mannose receptor and DEC-205 targeting elicited specific

34 terminus of two human mAbs against the human mannose receptor and DEC-205, both internalizing molecul

35 Multiple receptors including mannose receptor and low-density lipoprotein receptor-re

36 mechanisms including the M-6-P receptor, the mannose receptor and LRP.

37 ukin-10, and macrophage-specific transcripts mannose receptor and S100 calcium-binding protein A9, wh

38 hain, and the scavenger receptors macrophage mannose receptor and sortilin.

39 ectin-1-dependent pathways that involved the mannose receptor and spleen tyrosine kinase.

40 f M. tuberculosis by engaging the macrophage mannose receptor and subsequently binds to intracellular

41 Importantly, competitive inhibition of mannose receptor and targeted short interfering RNA-medi

42 The macrophage mannose receptor and the complement receptor type 3 beta

43 the serum as a consequence of binding to the mannose receptor and/or the asialoglycoprotein receptor

44 tyl-<cmd SC>d<cmd /SC> -glucosamine) through mannose receptors and produce IL-12, IL-18, and TNF-alph

45 CD68 (macrophage marker), M2 markers (CD206 (mannose receptor) and CD163 (scavenger receptor)), secre

46 resolution of inflammation, Dectin-1, CD206 (mannose receptor), and IL-4R.

47 ocytosis, reduced expression of MARCO and of mannose receptor, and absent expression of scavenger rec

48 for innate immunity, including MHC class I, mannose receptor, and beta(2)-microglobulin.

49 blocked by saccharides or Abs reactive with mannose receptor, and is dependent upon the state of mat

50 Macrophage mannose, mannose receptor, and scavenger receptors (SR-As) were a

51 ecognition receptors tested (CD11b/CD18, the mannose receptor, and the N-formyl-methionyl-leucyl-phen

52 MUC1 uptake is mediated by the mannose receptor, and the protein is then retained long

53 ion receptors for fungi include dectin-1 and mannose receptor, and these mediate phagocytosis, as wel

54 receptor type 3 (CR3), fibronectin receptor, mannose receptor, and transferrin receptor.

55 ently than N or P by mechanisms depending on mannose receptor- and dendritic cell-specific intercellu

56 monstrate that FDM restricts binding of anti-mannose receptor antibody to macrophages by approximatel

57 ges through glucose transporters and because mannose receptors are expressed on a subset of the macro

58 ll receptor, integrin alphaM, and macrophage mannose receptor, are engaged in N-glycan ligand recogni

59 een after infection and expressed macrophage mannose receptors, arginase-1 activity, and IL-10.

60 m the identification of the CR region of the mannose receptor as a lectin.

61 dhesion molecule-3-grabbing nonintegrin, and mannose receptor as well as inflammatory cytokines.

62 dhesion molecule-3-grabbing nonintegrin, and mannose receptor as well as the inflammatory markers CD6

63 ctor functions, the present study identifies mannose receptors as pattern recognition receptors capab

64 alleles) and mediated predominantly through mannose receptors (as determined by siRNA gene silencing

65 Capture appeared dependent on mannose receptors, as competitive mannosylated inhibitor

66 ly by complement and partially by macrophage mannose receptors, as demonstrated by in vitro assays.

67 erfere with the arrival of newly synthesized mannose receptors at the cell surface, also attenuated m

68 lly resulting in decreased levels of surface mannose receptor available for Ag or pathogen capture.

69 sylation had no effect on the development of mannose receptor binding activity.

70 e studies was to characterize the macrophage mannose receptor binding and pharmacological properties

71 taining the cysteine-rich (CR) domain of the mannose receptor, binds to marginal zone metallophilic m

72 lecule-3 grabbing non-integrin (DC-SIGN) and mannose receptor, bound to FL surface immunoglobulin (sI

73 at sMR was produced by cleavage of an intact mannose receptor by a matrix metalloprotease or ADAM met

74 ides corti, we have investigated the role of mannose receptor C type 1 (MRC1), a CLR which recognizes

75 th MaR1 showed a significant upregulation of mannose receptor C, type 1 mRNA expression, an M2 macrop

76 inity for both the insulin receptor (IR) and mannose receptor C-type 1 (MR), which functions to clear

77 ferator-activated receptor gamma (PPARG) and mannose receptor C-type 1 (MRC1), suggesting that PRMT1

78 he parasite load was reduced in mice lacking mannose receptor C-type 1.

79 macrophages expressing arginase 1 (ARG1) and mannose receptor, C type 1 (MRC1).

80 egfp)(y251) transgenic zebrafish that uses a mannose receptor, C type 1 (mrc1a) promoter to drive str

81 human urine: cadherin 11 (CDH11), macrophage mannose receptor C1 (MRC1), and phospholipid transfer pr

82 Fc chimeras revealed that LRP, DC-SIGN, and mannose receptor can bind to FVIII; however, we did not

83 associated with AA-MPhis (e.g., arginase-1, mannose receptor, CCL2, CCL17, and CCL22).

84 eath ligand-1 (PD-L1), Mac-2, and macrophage mannose receptor (CD206) and producing Klf4, Il10, Retnl

85 s demonstrated a significant increase in the mannose receptor (CD206) and the CD14(+)/CD206(+) double

86 mannoprotein was captured by the macrophage mannose receptor (CD206), these data suggest that multip

87 e activation including arginase-1 (ARG1) and mannose receptor (CD206).

88 pressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immuno

89 rotein 10, and IRG1 in macrophages that lack mannose receptor, complement receptors 3 and 4, type A s

90 ns 4-7 and a full-length soluble form of the mannose receptor containing all domains external to the

91 A fusion protein of the mannose receptor containing carbohydrate recognition dom

92 Cysteine-rich (CR) domain of the mannose receptor (CR-Fc)(+) DCs are a newly discovered s

93 ulating CEA was preferentially taken up in a mannose receptor-dependent manner and cross-presented by

94 ce PPARgamma expression through a macrophage mannose receptor-dependent pathway.

95 terns that stimulate TLR2, dectin-1, and the mannose receptor, differentially activate NF-kappaB and

96 ting of soluble exogenous tumor Ag to the DC mannose receptor directly contributes to the generation

97 Mannose receptor dissociation constants (Kd) for pGCR an

98 he HIV-1-derived protein Tat in HIV-mediated mannose receptor down-regulation.

99 The possible involvement of the mannose receptor, either cell surface or soluble, in the

100 macrophages from healthy individuals reduced mannose receptor endocytosis to 53.2% (P < 0.05) and P.

101 lowest levels of P. carinii phagocytosis and mannose receptor endocytosis.

102 Mannose receptor expression also was increased on cervic

103 as a model human disease state of reduced AM mannose receptor expression and function) inhibits Pneum

104 HIV infection of AMs (as a model for reduced mannose receptor expression and function) was associated

105 e synthase staining in rodent tissue, and by mannose receptor expression in human breast tissue.

106 ent mechanisms are involved in regulation of mannose receptor expression in these species.

107 mune recognition by the structurally related mannose receptor family and comparison of diverse method

108 ipase A2 receptor (PLA2R) is a member of the mannose receptor family found in podocytes in human kidn

109 f the mammalian phospholipase A2 receptor, a mannose receptor family member, rather than an FcRn or M

110 FcRY shares structural properties with mannose receptor family members, including a head and ta

111 nchymally expressed member of the macrophage mannose receptor family of endocytic receptors, is a key

112 e identification of three new members of the mannose receptor family, additional work on defining the

113 as Endo180 (uPARAP, CD280), a member of the mannose receptor family.

114 lass of Fc receptor related to the mammalian mannose receptor family.

115 competed with the C-type lectins DC-SIGN and mannose receptor for ligand binding and inhibited the bi

116 tron structure was similar to the macrophage mannose receptor gene.

117 n, a preparation that antagonizes macrophage mannose receptors, had minimal effect on TNF-alpha relea

118 Using a mouse model in which the mannose receptor has been deleted, we found that the abs

119 Binding of organisms to beta-glucan and mannose receptors has been shown to stimulate phagocytos

120 ion cloning strategy, the cDNA for the human mannose receptor (hMR) was found to be essential for CD4

121 t of manY corresponds to IIPMan, manZ to the mannose receptor IIBMan, and manX and manW to the single

122 phages, messenger RNA expression of FR-beta, mannose receptor, IL-10, and matrix metalloproteinase-9

123 quirements for sugar binding, a role for the mannose receptor in antigen presentation of lipoglycan a

124 A potential role for the macrophage mannose receptor in human monocyte-derived macrophage fu

125 ligands for the cysteine-rich domain of the mannose receptor in lymph nodes and spleen.

126 nd to investigate the role of the macrophage mannose receptor in mediating this interaction.

127 elated with the levels of CD3 and macrophage mannose receptor in NP tissue.

128 Mannose receptor in the flow-through and eluted fraction

129 eliminated uptake by mannose 6-phosphate and mannose receptors in cultured cells and dramatically slo

130 expression of CD4, CCR5, CXCR4, DC-SIGN, or mannose receptors in tubular cells.

131 s have reduced functions associated with the mannose receptor, including impaired Pneumocystis carini

132 sed to be internalized by cells that express mannose receptors, including macrophages.

133 locked by the addition of mannan, suggesting mannose receptor involvement in the DC-Coccidioides inte

134 of lipoglycan antigens and evidence that the mannose receptor is associated with a signal transductio

135 The macrophage mannose receptor is believed to play an important role a

136 The mannose receptor is expressed on mature macrophages and

137 by mannose-capped lipoarabinomannan and the mannose receptor is independent of TLR2 and NF-kappaB ac

138 lso found that the surface expression of the mannose receptor is not downregulated during P. carinii

139 icate that the well-characterised macrophage mannose receptor is not essential to host defence agains

140 myeloid promoters, transcription of the rat mannose receptor is regulated by binding of PU.1 and a u

141 The mannose receptor is the prototype of a new family of mul

142 Mannose receptor knockout (MR(-/-)) mice lack the abilit

143 sceptible to P. carinii by CD4(+) depletion, mannose receptor knockout mice (MR-KO) had pathogen load

144 manner, which can be blocked by injection of mannose receptor ligands.

145 4GGnM-R is closely related to the macrophage mannose receptor (Man-R) both antigenically and structur

146 e asialoglycoprotein receptor (ASGR) and the mannose receptor (ManR) are expressed in the liver by pa

147 The mannose receptor (ManR, Mrc1) and asialoglycoprotein rec

148 other alternative state (M2)-specific genes (Mannose receptor, MAO-A, and CD36) and therefore conclud

149 These data suggest that the macrophage mannose receptor may be an essential participant in the

150 r findings suggest that while the macrophage mannose receptor may be important in the recognition of

151 lungs, and that impaired alveolar macrophage mannose receptor-mediated binding and phagocytosis of P.

152 Reduced AM mannose receptor-mediated Cdc42 and Rho activation in th

153 ere highly efficient at Ag capture, via both mannose receptor-mediated endocytosis and macropinocytos

154 f-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to c

155 luorescein isothiocyanate (FITC)-albumin and mannose receptor-mediated endocytosis of FITC-dextran by

156 IL-10 (type 2) cytokines on fluid phase and mannose receptor-mediated endocytosis were assessed by h

157 en uptake: constitutive macropinocytosis and mannose receptor-mediated endocytosis.

158 enhanced cellular uptake of the oligomer via mannose receptor-mediated endocytosis.

159 /mL), rapamycin impairs macropinocytosis and mannose receptor-mediated endocytosis; (2) the effects a

160 The mannose receptor-mediated enhanced cell uptake and high

161 AM mannose receptor-mediated NF-kappaB activation may repre

162 se data provide a molecular mechanism for AM mannose receptor-mediated phagocytosis of unopsonized Pc

163 Taken together, our results indicate that mannose receptor-mediated phagocytosis, but not the rece

164 ptured fluorescent-labeled mannoprotein by a mannose receptor-mediated process.

165 d IL-13 enhanced fluid phase pinocytosis and mannose receptor-mediated uptake by activation of phosph

166 a decreased both fluid phase pinocytosis and mannose receptor-mediated uptake.

167 d Nanobodies directed against the macrophage mannose receptor (MMR) is a useful tool for monitoring a

168 products, whereas the homologous macrophage mannose receptor (MMR), as expected, is found in more pe

169 ster ovary cells expressing human macrophage mannose receptor (MMR), we determined that MP is a MMR l

170 sdAbs) specifically targeting the macrophage mannose receptor (MMR), which has been identified as an

171 chLAL and phLAL were taken up by macrophage mannose receptor (MMR)-positive J774E cells.

172 ypoxic tumor areas highly express macrophage mannose receptor (MMR, CD206).

173 nnosylated LAM (ManLAM) binds the macrophage mannose receptor (MMRc), although the ability of the MMR

174 rophage fusion to form FBGC via a macrophage mannose receptor (MR) -mediated pathway.

175 of serum opsonins, competitive inhibition of mannose receptor (MR) activity on MDM with mannan decrea

176 tions, including up-regulation of macrophage mannose receptor (MR) activity.

177 The macrophage mannose receptor (MR) along with complement receptors me

178 Furthermore, antiserum to the mannose receptor (MR) also inhibited HSV, vesicular stom

179 The macrophage mannose receptor (MR) and complement receptor 3 (CR3) ha

180 We investigated the roles of the mannose receptor (MR) and Dectin-2 in resistance to pulm

181 The macrophage mannose receptor (MR) and dendritic cell-specific ICAM-3

182 ound and internalized via its glycans by the mannose receptor (MR) and subsequently impairs protein s

183 The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and

184 The mannose receptor (MR) binds foreign and host ligands thr

185 The pattern recognition mannose receptor (MR) binds to the ManLAM mannose caps a

186 ptor with collagenous structure (MARCO), and mannose receptor (MR) have been identified as nonopsonic

187 ain, by human macrophages is mediated by the mannose receptor (MR) in addition to complement receptor

188 To examine the role of the mannose receptor (MR) in glycoprotein clearance, we gene

189 We investigated how innate sensing by the mannose receptor (MR) influences the development of anti

190 The mannose receptor (MR) is a transmembrane protein that fu

191 The mannose receptor (MR) is an endocytic receptor involved

192 The mannose receptor (MR) is known to be involved in the rec

193 Antisense oligodeoxynucleotide (ODN) to mannose receptor (MR) mRNA inhibited the expression and

194 ficantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood monon

195 Recombinant lectin domains of the mannose receptor (MR) or DC-SIGN bind mannosylated Igs i

196 Members of the well-conserved mannose receptor (MR) protein family have been functiona

197 MSCs also expressed mannose receptor (MR) that was found to endocytose rhoda

198 fied antibodies redirected bacteria from the mannose receptor (MR) to the complement receptor CR3, th

199 The macrophage mannose receptor (MR) was responsible for uptake of LAM.

200 -derived macrophages (BMDMs) in vitro and by mannose receptor (MR)(hi) dermal macrophages in vivo com

201 The mannose receptor (MR), a carbohydrate-binding receptor e

202 art, to increased activity of the macrophage mannose receptor (MR), a pattern recognition receptor fo

203 We demonstrate that the mannose receptor (MR), a type I transmembrane protein, i

204 t of a carbohydrate receptor, the macrophage mannose receptor (MR), and its role in supporting HIV-1

205 MP is its capacity to bind to the conserved mannose receptor (MR), CD206, on dendritic cells (DCs).

206 one marrow-derived macrophages isolated from mannose receptor (MR), complement receptor 3 (CR3), MyD8

207 ular, C-type lectin receptors, including the mannose receptor (MR), facilitate APC-mediated adsorptiv

208 In particular, mannose receptor (MR), through modulation of Toll-like r

209 Mannose receptor (MR)-dependent uptake and lysosomal tar

210 Mannose receptor (MR)-null myotubes were small in size a

211 osclerotic plaque areas enriched in CD68 and mannose receptor (MR)-positive (CD68(+)MR(+)) alternativ

212 lipoarabinomannan (ManLAM) to the macrophage mannose receptor (MR).

213 for zymosan that was distinct from the Mphi mannose receptor (MR).

214 blocking mAb directed toward the macrophage mannose receptor (MR).

215 requires the interaction of ManLAM with the mannose receptor (MR).

216 proteins: macrophage receptors, such as the mannose receptor (MR, CD206), dendritic cell-specific IC

217 at have high expression of the C-type lectin mannose receptor (MR; CD206).

218 ionally, competitive blockade of multilectin mannose receptors (MR) on APCs diminished MP-dependent s

219 nzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets prima

220 ss several cell surface receptors (e.g., the mannose receptor, MR) that may serve as drug delivery ce

221 Macrophage mannose receptor (MRC) is one of the few molecules known

222 Genetic ablation of the collagen receptors mannose receptor (Mrc1) and urokinase plasminogen activa

223 on C-type-lectin receptors (CLRs), including mannose receptor (MRC1; CD206), have been suggested to f

224 interfering RNA-mediated gene suppression of mannose receptor mRNA and protein is associated with com

225 nt vaccine immunogenicity by targeting Ag to mannose receptors (MRs) on dendritic cells.

226 The mannose receptor of macrophages and liver endothelium me

227 nnosides, they are also potential ligands of mannose receptors of the human host system.

228 increases uptake of soluble IgG mediated by mannose receptor on macrophages and dendritic cells.

229 or (CD206), these data suggest that multiple mannose receptors on DC recognize mannoprotein.

230 in pathogenesis, either by interaction with mannose receptors on host cells, or as targets or modula

231 or intra-endosomal degradation compared with mannose receptor or DEC205.

232 l interfering RNA-mediated knockdown of LRP, mannose receptor, or DC-SIGN expression in monocyte-deri

233 arbohydrate remodeling improved targeting to mannose receptors over native enzyme by two orders of ma

234 crophages, although a higher proportion were mannose receptor positive, a characteristic of different

235 tion of CCL18 in CD68(+)/CD163(+)/macrophage mannose receptor-positive M2 macrophages and tryptase-po

236 s exposed to red cells showed an increase in mannose receptor-positive macrophages only when these ce

237 an alternative phenotype being both CD68 and mannose receptor-positive, expressing carbonic anhydrase

238 /reperfusion injury, whereas arginase 1- and mannose receptor-positive, noninflammatory (M2) macropha

239 sistent with a mechanism whereby Tat reduces mannose receptor promoter activity by interfering with t

240 nstruct of USF resulted in a 50% decrease in mannose receptor promoter activity, further establishing

241 ter construct resulted in down-regulation of mannose receptor promoter activity.

242 tion factors Sp1, PU.1, and USF bound to the mannose receptor promoter, but only PU.1 and USF contrib

243 line U937 with a Tat expression vector and a mannose receptor promoter-luciferase reporter construct

244 t the isolation of 854 base pairs of the rat mannose receptor promoter.

245 ishing the role of USF in activating the rat mannose receptor promoter.

246 The mannose receptor recognizes the patterns of carbohydrate

247 Cells lacking mannose receptors showed no susceptibility to the conjug

248 t defence: phagocytic receptors, such as the mannose receptor, signal particle internalization, and t

249 A soluble form of the mannose receptor (sMR) has been found in conditioned med

250 s C, 95% of the total macrophage binding was mannose receptor specific.

251 The macrophage mannose receptor specifically recognizes proteins and pa

252 polysaccharide structure and binding to the mannose receptor, suggesting that polysaccharide conform

253 strated up to an 80% (P < 0.05) reduction in mannose receptor surface expression and endocytosis.

254 Mannose receptor synthesized by cells incubated in brefe

255 n vivo experiments in mice revealed that the mannose receptor system on macrophages also participates

256 an BDCA1+ and monocyte-derived DCs, CD40 and mannose receptor targeted antibody conjugates to early e

257 to macrophages by approximately 35% and that mannose receptor targeting may provide an additional ave

258 have generated a human mAb (B11) against the mannose receptor that is rapidly internalized by DCs thr

259 ted number of phagocytic receptors, like the mannose receptor, that recognize conserved motifs on pat

260 expose terminal mannose residues and target mannose receptors, the uptake of this modified enzyme fo

261 The in vitro binding of the macrophage mannose receptor to a range of different bacterial polys

262 that binding of type 1 fimbriae (pili) to d-mannose receptors triggers a cross talk that leads to do

263 n mannose-binding protein and the macrophage mannose receptor, two mammalian C-type lectins, bind to

264 ulated in culture, whereas macrophage genes, mannose receptor type-1, Cd68, serum amyloid-A3, chemoki

265 We conclude that the mannose receptor undergoes delayed activation following

266 The full-length soluble form of the mannose receptor was able to bind simultaneously both po

267 The mannose receptor was also not involved with invasion aft

268 Labeled mannose receptor was found exclusively in the nonbinding

269 that exploits endocytosis via the macrophage mannose receptor was used.

270 that exploits endocytosis via the macrophage mannose receptor, was constructed and complexed to expre

271 in inflammatory zone 1, Ym1, and macrophage mannose receptor were observed in the lungs of mice infe

272 antigen was chemically deglycosylated or if mannose receptors were blocked with mannans.

273 Mannose receptors were confirmed to be specifically up-r

274 on of strongly adherent bacteria by blocking mannose receptors with a soluble inhibitor actually incr

275 y for uptake of exogenous LPLA(2) is via the mannose receptor, with subsequent translocation into aci