ライフサイエンスコーパス: mannose-binding lectin

1 ding protein, as well as to a novel partner, mannose-binding lectin.

2 -binding lectins A and C, or in both C1q and mannose-binding lectins.

3 ype 1 transmembrane protein with homology to mannose-binding lectins.

4 PLN included genes encoding proteins such as mannose binding lectin 1, lysozyme, alpha-1 catenin, cad

5 pulmonary and circulating opsonins, SP-D and mannose binding lectin 2, respectively.

6 variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with col

7 sociations were observed for two SNPs in the mannose-binding lectin 2 (ML2) gene and risk of glioma (

8 reviously studied modifier genes, coding for mannose-binding lectin 2 and TGF-beta1, influence pulmon

9 and regulated complement activation through mannose-binding lectin 2.

10 The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associat

11 The frequency of the mannose-binding lectin-2 codon 54 allele was significant

12 To examine the physiological functions of mannose-binding lectin A (MBL-A), we generated mice that

13 mice genetically deficient in either C1q or mannose-binding lectins A and C, or in both C1q and mann

14 his novel pathway is specific to C1q because mannose-binding lectin, a related collectin, failed to u

15 To investigate the role of mannose-binding lectin-A (MBL-A) in protection against i

16 controlled cortical impact using anti-mouse mannose-binding lectin-A and mannose-binding lectin-C an

17 ose-binding lectin deletion in wild-type and mannose-binding lectin-A and mannose-binding lectin-C do

18 The extent of mannose-binding lectin-A expression was lower when compa

19 The reduced sequelae associated with mannose-binding lectin absence suggest that mannose-bind

20 Mannose binding lectin and lung surfactant protein A, ot

21 for surface-coated mannose derivatives with mannose binding lectins and antibodies.

22 levels of mannose-binding lectin and C1q-C4 were measured to exami

23 ns that are structurally homologous to SP-A, mannose-binding lectin and complement protein 1q, did no

24 noglobulin G may induce association with the mannose-binding lectin and contribute to the pathology.

25 codon 52 was associated with a low level of mannose-binding lectin and impaired mannose-binding lect

26 binding of the key lectin pathway components mannose-binding lectin and mannose-binding lectin-associ

27 Systematic reviews of procalcitonin, mannose-binding lectin and molecular amplification techn

28 Other collectins, such as mannose-binding lectin and the collectin-like C1q, have

29 c organelles of adhesion composed of FimH, a mannose-binding lectin, and a shaft composed primarily o

30 cific ICAM-3-grabbing nonintegrin (DC-SIGN), mannose-binding lectin, and heparan sulfate, enhance the

31 served also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA.

32 e component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that bo

33 Using anti-human mannose-binding lectin antibody, we evaluated mannose-bi

34 3 activation when C4 or C1q, or both C1q and mannose-binding lectins, are absent.

35 We have tested the application of high-mannose-binding lectins as analytical reagents to identi

36 d to activation of the complement pathway by mannose-binding lectin, as suggested by in vitro studies

37 The mannose-binding lectin associated-protease-3 (MASP-3) is

38 The serum of mannose-binding lectin-associated serine protease (MASP)

39 Until now the autoactivating mannose-binding lectin-associated serine protease (MASP)

40 ne-targeted mice deficient in the complement mannose-binding lectin-associated serine protease-1 and

41 athway components mannose-binding lectin and mannose-binding lectin-associated serine protease-2 (MAS

42 binds DNA more effectively than do SP-A and mannose-binding lectin at physiological salt conditions.

43 In addition to ligands for galectins and mannose-binding lectins, azido functionality could be re

44 ed by the collectins surfactant protein D or mannose binding lectin because of a paucity of glycan at

45 Mannose-binding lectins bind to rough variants, but lect

46 Mannose-binding lectin bound avidly to G0 IgG, but lecti

47 In contrast, the collectin mannose binding lectin C (MBL-C) but not MBL-A led to ef

48 sing anti-mouse mannose-binding lectin-A and mannose-binding lectin-C antibodies.

49 n wild-type and mannose-binding lectin-A and mannose-binding lectin-C double-knockout mice.

50 Similarly in mice, we observed mannose-binding lectin-C-positive immunoreactivity in th

51 ression was lower when compared with that of mannose-binding lectin-C.

52 Deposits of C4d, mannose-binding lectin, C1q, IgM, and C5b-9 were scored

53 3, C4, factor B (fB), factor properdin (fP), mannose-binding lectin, C3aR, C5aR, or Ig and assessed r

54 extracts of kidney bean and hyacinth bean a mannose-binding lectin, called FRIL, and provide here ev

55 in the genes of several Toll-like receptors, mannose-binding lectin, CD14, killer immunoglobulin-like

56 The labels were recognized by the mannose-binding lectin, Con A, and the biotin-binding pr

57 oteins (SPs) SP-A and SP-D and serum protein mannose-binding lectin, could recognize nucleic acids, p

58 Mannose-binding lectin deficiency (defined as a mannose-

59 An association between mannose-binding lectin deficiency and anti-Saccharomyces

60 ts with systemic lupus erythematosus who had mannose-binding lectin deficiency associated with homozy

61 We evaluated the effects of mannose-binding lectin deletion in wild-type and mannose

62 cortical impact and (2) to evaluate whether mannose-binding lectin deletion is associated with reduc

63 f the Escherichia coli that is composed of a mannose-binding lectin domain and a fimbria-incorporatin

64 s of a fimbria-associated pilin domain and a mannose-binding lectin domain, with the binding pocket p

65 ng (pilin) domain of FimH interacts with the mannose-binding (lectin) domain and causes a twist in th

66 ion of Salmonella-specific antibody, but not mannose-binding lectin, enabled NTS killing.

67 Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specifi

68 Goals were (1) to investigate mannose-binding lectin expression after human and experi

69 annose-binding lectin antibody, we evaluated mannose-binding lectin expression in tissue samples from

70 Mannose-binding lectin expression was documented after t

71 Mannose-binding lectin, Ficolin-1, and Ficolin-3 were me

72 ited because of the efficient degradation of mannose-binding lectin, ficolin-2, ficolin-3, and C4 by

73 ent pathways due to efficient degradation of mannose-binding lectin, ficolin-2, ficolin-3, and C4, wh

74 Mannose-binding protein (MBP; mannose-binding lectin) forms part of the innate immune

75 um concentrations of mannose-binding lectin, mannose-binding lectin functional activity, MBL2 and NOD

76 Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lect

77 gated the effect of genetic variation in the mannose-binding lectin gene, MBL2, on susceptibility and

78 (-/-) mice, whereas deficiency of C4, Ig, or mannose-binding lectin had no effect.

79 mannose-binding protein (MBP; also known as mannose-binding lectin) have been revealed by introducti

80 LP) might play a more dominant role than the mannose-binding lectin-lectin pathway in the pathomechan

81 nose-binding lectin deficiency (defined as a mannose-binding lectin level of <500 ng/mL) did not infl

82 Golgi transport through interaction with the mannose-binding lectin LMAN1.

83 relationship between serum concentrations of mannose-binding lectin, mannose-binding lectin functiona

84 level of mannose-binding lectin and impaired mannose-binding lectin-mannose-associated serine proteas

85 Mannose binding lectin (MBL) is a central component of t

86 Here we provide evidence that C1q and mannose binding lectin (MBL), a member of the collectin

87 Here we focused on mannose binding lectin (MBL), which is one of several pr

88 tation is found in the collagenous domain of mannose binding lectin (MBL).

89 Serum factors, including mannose binding lectins (MBL), influence innate response

90 novel mouse that expresses functional human mannose-binding lectin (MBL) 2 under the control of Mbl1

91 Mannose-binding lectin (MBL) activates the lectin pathwa

92 We now demonstrate that the serum collectins mannose-binding lectin (MBL) and conglutinin have less a

93 lement pathway activation molecules comprise mannose-binding lectin (MBL) and ficolin-1, -2, and -3 i

94 In the lectin pathway, mannose-binding lectin (MBL) and ficolins bind to pathog

95 ng from acute hyperglycemia are dependent on mannose-binding lectin (MBL) and lectin complement pathw

96 te recognition domains (CRDs) of human serum mannose-binding lectin (MBL) and pulmonary surfactant pr

97 The role of mannose-binding lectin (MBL) and the lectin complement p

98 Oxidative stress increases endothelial mannose-binding lectin (MBL) binding and activates the l

99 Mannose-binding lectin (MBL) deficiency is associated wi

100 C1q/mannose-binding lectin (MBL) double-deficient mice, howe

101 Mannose-binding lectin (MBL) enhances opsonization and a

102 in pathway as well as interaction of IgM and mannose-binding lectin (MBL) in pig-to-human xenotranspl

103 Mannose-binding lectin (MBL) is a circulating immune fac

104 Mannose-binding lectin (MBL) is a circulating serum prot

105 Mannose-binding lectin (MBL) is a humoral pattern-recogn

106 Mannose-binding lectin (MBL) is a key component of innat

107 Mannose-binding lectin (MBL) is a key mediator of innate

108 Mannose-binding lectin (MBL) is a pattern-recognition mo

109 Human mannose-binding lectin (MBL) is a serum protein of the i

110 Mannose-binding lectin (MBL) is a serum protein that pla

111 Mannose-binding lectin (MBL) is an evolutionarily conser

112 The mannose-binding lectin (MBL) is an evolutionary conserve

113 Mannose-binding lectin (MBL) is an important complement-

114 Mannose-binding lectin (MBL) is an important component o

115 Mannose-binding lectin (MBL) is an integral part of the

116 The deposition of complement components and mannose-binding lectin (MBL) on the bacterial surface wa

117 The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human ph

118 with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infe

119 pathway of activation leading to injury, the mannose-binding lectin (MBL) pathway might also play a c

120 The mannose-binding lectin (MBL) pathway of the complement c

121 Mannose-binding lectin (MBL) plays a key role in the act

122 Human mannose-binding lectin (MBL) provides a first line of de

123 Mannose-binding lectin (MBL) targets diverse microorgani

124 The mannose-binding lectin (MBL), a circulating pattern reco

125 The in vivo impact of mannose-binding lectin (MBL), a molecule involved in inn

126 We postulate that genetic variants of mannose-binding lectin (MBL), a plasma opsonin that init

127 Mannose-binding lectin (MBL), a soluble mediator of inna

128 genes encoding tumor necrosis factor (TNF), mannose-binding lectin (MBL), and Fcgamma receptor IIa (

129 Binding of complement factors C3b, IgM, C1q, mannose-binding lectin (MBL), and properdin to LDL and a

130 C1q, mannose-binding lectin (MBL), and pulmonary surfactant p

131 The complement protein C1q, mannose-binding lectin (MBL), and pulmonary surfactant p

132 The innate immune mediator, mannose-binding lectin (MBL), enhances phagocytosis of p

133 We investigated the binding of the PRMs mannose-binding lectin (MBL), ficolin-1, ficolin-2, and

134 CP), which is initiated by deposition of the mannose-binding lectin (MBL), is largely responsible for

135 Here, we document the pivotal role of mannose-binding lectin (MBL), one of the recognition mol

136 reased amounts in rheumatoid arthritis, bind mannose-binding lectin (MBL), providing a potential rout

137 nd function of the innate humoral component, mannose-binding lectin (MBL), was investigated.

138 It was investigated whether a deficiency of mannose-binding lectin (MBL), which binds Aspergillus sp

139 acity to activate the complement pathway via mannose-binding lectin (MBL), which could contribute to

140 es and serum factors, such as complement and mannose-binding lectin (MBL), which is a broad-spectrum

141 ads coated with an engineered human opsonin--mannose-binding lectin (MBL)--that captures a broad rang

142 Individuals with serum deficient in mannose-binding lectin (MBL)-an important component of t

143 allenged when it was shown that mice lacking mannose-binding lectin (MBL)-associated serine protease-

144 erminal complement complex was observed with mannose-binding lectin (MBL)-deficient serum.

145 In contrast, mannose-binding lectin (MBL)-null and MBL-associated ser

146 Thus, we hypothesized that the endogenous mannose-binding lectin (MBL)/ficolin-associated protein-

147 Mannose-binding lectin (MBL)/ficolin/collectin-11-associ

148 ch as surfactant protein-A (SP-A), SP-D, and mannose-binding lectin (MBL); phagocyte cytokines, such

149 or lectin pathway, with the latter requiring mannose-binding lectin (MBL, also known as mannose-bindi

150 The mannose-binding lectin (MBL, also known as mannose-bindi

151 Mannose-binding lectin (MBL-2) allele variants are assoc

152 The mannose-binding lectin (MBL; also termed "mannose-bindin

153 even candidate genes (myeloperoxidase [MPO], mannose binding lectin [MBL], Fcgamma receptors IIa, III

154 In mammals, collectin family members (e.g., mannose-binding lectin [MBL]) and the structurally relat

155 immunity to Giardia using mice deficient in mannose-binding lectin (Mbl2) or complement factor 3a re

156 tly in three separate protein families, C1q, mannose-binding lectins (MBLs), and serum ficolins.

157 n C3 or IgG FcRs excluded the implication of mannose-binding lectin-mediated complement activation in

158 Binding of NS1 to MBL protects DENV against mannose-binding lectin-mediated neutralization by the le

159 observed attenuated sensorimotor deficits in mannose-binding lectin (-/-) mice compared with wild-typ

160 cortical cell loss at 5 weeks postinjury in mannose-binding lectin (-/-) mice compared with wild-typ

161 mannose-binding lectin absence suggest that mannose-binding lectin modulation might be a potential t

162 an FRIL shows 78% amino acid identity with a mannose-binding lectin of hyacinth beans.

163 ially important interaction of FL cells with mannose-binding lectins of the innate immune system.

164 ound with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and upt

165 No associations between mannose-binding lectin or Ficolin-1 and graft loss were

166 immune response, whereas the alternative and mannose-binding lectin pathways are activated directly b

167 ntribution compared with the alternative and mannose-binding lectin pathways has not been defined.

168 ecific carbohydrate recognition subcomponent mannose-binding lectin plays an essential role in the pa

169 ng human traumatic brain injury, we observed mannose-binding lectin-positive immunostaining in the in

170 Mannose-binding lectin protein is the activator of the l

171 cently shown that collectins SP-A, SP-D, and mannose binding lectin recognize DNA and RNA via their c

172 IgG1kappa isotypes) were raised against rat mannose-binding lectin (rMBL).

173 mannose-binding protein (MBP, also known as mannose-binding lectin) show increased susceptibility to

174 Similar to C1q and mannose-binding lectin, SP-A and SP-D bound to apoptotic

175 imannosidic proteins displayed affinities to mannose-binding lectin, suggesting immune-related functi

176 Cyanovirin-N (CV-N) is a mannose-binding lectin that inhibits HIV-1 infection by

177 Mannose-binding lectin, together with mannose-associated

178 lupus erythematosus who were homozygous for mannose-binding lectin variant alleles had a fourfold in

179 lectin deficiency associated with homozygous mannose-binding lectin variant alleles.

180 Carbohydrate recognition by monocot mannose-binding lectins was studied via the crystal stru

181 ependent on the recruitment of either C1q or mannose-binding lectin, which are both early complement

182 s is dependent on the recruitment of C1q and mannose-binding lectin, which have known immune modulato

183 MBL2 encodes the mannose-binding lectin, which is a key player in the inn