ライフサイエンスコーパス: mannosidase I

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1 wild type and mutant forms of human ER alpha-mannosidase I.

2 ncoding the resident Golgi protein alpha-1,2 mannosidase I.

3 e encodes an enzyme previously designated ER mannosidase I.

4 Interestingly, inhibition of mannosidase I also results in prolonged association betw

5 lycoprotein processing inhibitors that block mannosidase I and increase the amount of protein-bound M

6 me reactions using a combination of human ER mannosidase I and recombinant Golgi mannosidase IA indic

7 proteins as well as vesicle cargo molecules (mannosidase I and sialyltransferase-yellow fluorescent p

8 selective trimming of N-glycans by ER alpha-mannosidase I and subsequent recognition by the ER degra

9 ached to misfolded glycoproteins by ER alpha-mannosidase I and subsequent recognition by the ER degra

10 g five active eukaryotic proteins, including mannosidases I and II, N-acetylglucosaminyl transferases

11 wild type and mutant forms of human ER alpha-mannosidase I as well as by structural analysis of a co-

12 teolytically driven checkpoint control of ER mannosidase I contributes to the establishment of an equ

13 ibition of human endoplasmic reticulum alpha-mannosidase I (ER Man I) and mouse Golgi alpha-mannosida

14 , including endoplasmic reticulum (ER) alpha-mannosidase I (ERManI) and Golgi alpha-mannosidase IA (G

15 d how, modification by endoplasmic reticulum mannosidase I (ERManI) contributes to the preferential s

16 ER mannosidase I (ERManI) is a quality control factor that

17 Endoplasmic reticulum alpha1,2 mannosidase I (ERManI), a central component of ER qualit

18 alnexin (CNX) and calreticulin (CRT), and ER mannosidase I in apo(a) intracellular targeting.

19 g the participation of endoplasmic reticulum mannosidase I in the disposal process.

20 rent primary cells or in the presence of the mannosidase I inhibitor deoxymannojirimycin dramatically

21 In addition, ER mannosidase I inhibitor kifunensine and down-regulation

22 cells cultured in the presence of the alpha-mannosidase-I inhibitor kifunensine.

23 ral serine kinase inhibition implied that ER mannosidase I is subjected to regulated proteolysis.

24 MAN1B1 gene product MAN1B1, also known as ER mannosidase I, is to function within the ER similar to t

25 ene of Drosophila melanogaster encodes Golgi mannosidase I (MAS-1), and flies homozygous for small de

26 d by the sequential action of Golgi alpha1,2-mannosidase I (MIa,b,c), MGAT1, alpha1,2-mannosidase II

27 abidopsis (Arabidopsis thaliana) Golgi alpha-mannosidase I, Nicotiana tabacum beta1,2-N-acetylglucosa

28 Unexpectedly, mannosidase I redistributed from the Golgi complex to co

29 endent on mannose trimming and inhibition of mannosidase I stabilizes Ii.

30 igosaccharides by endoplasmic reticulum (ER) mannosidase I targets misfolded glycoproteins for disloc

31 haride modification by endoplasmic reticulum mannosidase I, the latter of which occurred as PI Z was

32 sly isolated for Saccharomyces cerevisiae ER mannosidase I, the oligosaccharide in the active site of

33 Redistribution of mannosidase I was also observed in cells incubated at 15

34 Herein the intracellular fate of human ER mannosidase I was monitored to determine whether a post-

35 in which processing by endoplasmic reticulum mannosidase I, which attenuates the removal of glucose f

36 Inhibition of ER mannosidase I with deoxymannojirimycin or kifunensine ha

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