ライフサイエンスコーパス: mannosyl

1 und that alpha-mannnosyl1-3 (6'-O-acyl alpha-mannosyl)-1-1 monoacylglycerol and cholesteryl 6'-O-acyl

2 ansferase 7 (beta3GnT7), Mgat5, and possibly mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylgluc

3 NGT occurs in close proximity to mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylgluc

4 e first time close proximity between NGT and mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylgluc

5 s yet perfectly controlled displays of alpha-mannosyl (alpha-Man) and beta-lactosyl (beta-Lact) anten

6 mpounds have been obtained by coupling alpha-mannosyl and alpha-N-acetyl-glucosamine phosphoramidite

7 contain oligosaccharides with both terminal mannosyl and mannose 6-phosphate residues.

8 rates a specific N-glycan structure of seven mannosyl and two N-acetylglucosamine residues (Man7GlcNA

9 ated donor on O3 is a highly alpha-selective mannosyl and, after radical fragmentation, alpha-d-rhamn

10 structure precisely corresponds to mammalian mannosyl beta-1-phosphodolichol (MPD), but contains an u

11 Responses to mannosyl-beta1-phosphodolichols were common among CD1c-r

12 -phosphoisoprenoids and structurally related mannosyl-beta1-phosphodolichols.

13 athogenic Mycobacterium tuberculosis antigen mannosyl-beta1-phosphomycoketide (MPM).

14 tide (PM) shows similarities to that of CD1c-mannosyl-beta1-phosphomycoketide in that the A' pocket a

15 ted approximately 6 A in relation to that of mannosyl-beta1-PM.

16 hed glycans, but its ability to synthesize O-mannosyl-branched glycans is unknown; conversely, althou

17 SP-A monoclonal antibodies and by the use of mannosyl-BSA, which blocked the suppression of RNI level

18 tereoselectivity of the desired beta-allyl-C-mannosyls by moving to a sulfoxide mannosyl donor, which

19 The development of a positive charge at mannosyl C1, as the oxocarbenium-like transition state i

20 f this compound with mannose caps (producing mannosyl-capped LAM [ManLAM]) in M. tuberculosis or with

21 The extensive mannosyl capping of arabinose termini of ManLAM may unde

22 ntermediate oxocarbenium ions, including the mannosyl cation, as well as consideration of steric effe

23 Except for a moderate enrichment of mannosyl compounds and glycogen, heterozygous mice were

24 ups of hepatocytes with increased content of mannosyl compounds and glycogen, some of them undergoing

25 of newly raised antibodies specific for an O-mannosyl-conjugated epitope revealed that these glycans

26 The building block for the mannosyl constituents of these components is GDP-mannose

27 nversion of beta1,4-mannobiose to 4-O-beta-d-mannosyl-d-glucose in mannan metabolism.

28 WbdD phosphorylates 2-alpha-d-mannosyl-d-mannose (2alpha-MB), a short mimic of the O9a

29 peptide synthesis methods, two units of the mannosyl derivative 1 (shown as L-Tyr[C-Ac(4)-alpha-D-Ma

30 ) mixture of isosulfan blue and (99m)Tc-DTPA-mannosyl-dextran (7.4 MBq, 0.3 nmol).

31 d colonic submucosal injection, (99m)Tc-DTPA-mannosyl-dextran demonstrated high sentinel node uptake

32 Tc-Diethylenetriaminepentaacetic acid (DTPA)-mannosyl-dextran is a new radiotracer labeled with (99m)

33 (99m)Tc-DTPA-mannosyl-dextran uptake by colonic sentinel nodes (n = 4

34 To test this model, we disrupted IPT1, the mannosyl-diinositolphosphoryl-ceramide synthase of S. ce

35 and sec14-1(ts) sac1-22 strains showed that mannosyl-diinositolphosphoryl-ceramide synthesis was not

36 nthesis and, in particular, the synthesis of mannosyl-diinositolphosphoryl-ceramide with concomitant

37 hosphatidylinositol 4-phosphate, rather than mannosyl-diinositolphosphoryl-ceramide, accumulates in t

38 for mannosylinositol phosphorylceramides or mannosyl diphosphoinositol ceramides on growth and viabi

39 GDP-Man, the mannosyl donor for most Man-containing polymers is forme

40 ichol-phosphate mannose (Dol-P-Man) is a key mannosyl donor for the biosynthesis of N-linked oligosac

41 The critical mannosyl donor for these reactions is the nucleotide sug

42 n transfer of Man from GDPMan to Dol-P, is a mannosyl donor in pathways leading to N-glycosylation, g

43 doplasmic reticulum (ER), and functions as a mannosyl donor in the biosynthesis of Glc(3)Man(9)GlcNAc

44 The activation of this polymer-supported mannosyl donor is achieved at -60 degrees C in dichlorom

45 a-allyl-C-mannosyls by moving to a sulfoxide mannosyl donor, which could be activated at low temperat

46 n analogue (C7) of the benzylidene-protected mannosyl donor, which is investigated in terms of diaste

47 2,3-di-O-benzyl-4, 6-O-benzylidene protected mannosyl donors and draw attention to the subtle interpl

48 he C2-O2 and C3-O3 bonds in the glucosyl and mannosyl donors and of the influence of this interaction

49 4-trifluoromethylbenzenepropargyl)-protected mannosyl donors are extremely beta-selective.

50 Mannosyl donors were highly alpha-selective despite the

51 ing 4,6-O-benzylidene-protected glucosyl and mannosyl donors, which are alpha- and beta-selective, re

52 by means of 4,6-O-benzylidene-protected beta-mannosyl donors.

53 ined starting from imidazolium cation-tagged mannosyl fluoride and thiomannoside using block coupling

54 cNAc transfer activity toward N-linked and O-mannosyl glycan core structures and that its brain-speci

55 Here, we show that O-mannosyl glycan epitopes recognized by these antibodies

56 at-315 and 3F8 were demonstrated to detect O-mannosyl glycan modifications on RPTPzeta/phosphacan.

57 which is reported to be the most abundant O-mannosyl glycan on alpha-DG.

58 l analyses, we identified a phosphorylated O-mannosyl glycan on the mucin-like domain of recombinant

59 in and establish a functional link between O-mannosyl glycans and cadherin-mediated cell-cell adhesio

60 cell-aggregation assays demonstrated that O-mannosyl glycans are crucial for cadherin-based cell adh

61 O-mannosyl glycans are known to play an important role in

62 ing mass spectrometry, we demonstrate that O-mannosyl glycans are present on E-cadherin, the major ce

63 Despite the critical role of O-mannosyl glycans for arenavirus binding under normal con

64 GnT-V is involved in synthesizing branched O-mannosyl glycans in brain, but the function of these bra

65 In mammals, biosynthesis of O-mannosyl glycans is initiated by a complex of mutually i

66 yltransferase LARGE, of the phosphorylated O-mannosyl glycans on alpha-dystroglycan that is required

67 feature of these disorders is the lack of O-mannosyl glycans on alpha-dystroglycan, resulting in abn

68 Thus, modifications by LARGE but not O-mannosyl glycans themselves are most likely the crucial

69 ylglucosaminyltransferase 1) that modifies O-mannosyl glycans.

70 hosphate (M6P) is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosa

71 e results suggest that these microbial alpha-mannosyl glycolipids are capable of being recognized by

72 The potentially antigenic alpha-mannosyl glycolipids contributed to the protection of mi

73 Several microbial alpha-mannosyl glycolipids, in which the 2'-OH group is in the

74 the preparation of unusual phosphorylated O-mannosyl glycopeptides derived from alpha-DG by a strate

75 -3), odds ratio = 4.8) maps to the alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransfe

76 ts up-regulate the transcription of beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransfe

77 The calculated free energy of activation for mannosyl glycosylation (23 kcal/mol) agrees very well wi

78 Mutations in genes involved in protein O-mannosyl glycosylation give rise to a group of neurodeve

79 glycosyltransferases that act early in the O-mannosyl glycosylation pathway.

80 ) caused by mutations in genes involved in O-mannosyl glycosylation.

81 muscular dystrophies caused by defects in O-mannosyl glycosylation.

82 n at C1, as was shown by modeling an alpha-d-mannosyl group into the sugar binding site.

83 a 99mTc-labeled agent having 18 DTPA and 82 mannosyl groups attached to a polylysine of 100 units ([

84 lent to multivalent as the density of mobile mannosyl groups increases; such avidity switching enhanc

85 alization of N-glyans containing nonreducing mannosyl groups, accentuating the GNA vesicular staining

86 by nanopartices presenting a high density of mannosyl groups.

87 GDP-mannose mannosyl hydrolase (GDPMH) from Escherichia coli is a 36

88 GDP-mannose mannosyl hydrolase (GDPMH) is an unusual Nudix family me

89 Escherichia coli GDP-mannose mannosyl hydrolase (GDPMH), a homodimer, catalyzes the h

90 The Nudix hydrolase GDP-mannose mannosyl hydrolase (Gmm) contributes to this diversity b

91 annostatin A best mimics the covalent linked mannosyl intermediate, which adopts a 1S5 skew boat conf

92 Glycosylation of a C-2-O-acetyl mannosyl iodide donor in the presence of silver triflate

93 gest that it does not mirror the behavior of mannosyl iodides lacking bridging acetal protecting grou

94 cosidation of trimethylene oxide (TMO) using mannosyl iodides.

95 e modifies the mannose unit of the substrate mannosyl-Kdo2-1-dephospho-[4'-(32)P]lipid IV(A).

96 uble mutant completely or partially restored mannosyl levels.

97 is highly expressed in brain and branches O-mannosyl-linked glycans.

98 O-Mannosyl-linked glycosylation is abundant within the cen

99 T-Vb activity promotes the addition of the O-mannosyl-linked HNK-1 modification found on the developm

100 The best ligand was mannosyl-lipoarabinomannan, followed by lipomannan, phos

101 ational analysis by NMR has shown that the O-mannosyl modification does not exert major conformationa

102 OMGnT1, which attaches beta(1,2)-GlcNAc to O-mannosyl moietes, whereas the unphosphorylated derivate

103 (111) surfaces onto which are grafted either mannosyl moieties or a mixture of mannose and spacer alc

104 ypical beta-amide bond is present in the Trp-mannosyl moiety.

105 However, the sec14-1(ts) strain had elevated mannosyl-monoinositolphosphoryl-ceramide levels, and the

106 a mannosyl monosaccharide moiety in 2 and to mannosyl monosaccharide and disaccharide moieties in 1,

107 e core of these antibiotics is attached to a mannosyl monosaccharide moiety in 2 and to mannosyl mono

108 was increased by co-expression of protein:O-mannosyl N-acetylglucosaminyltransferase 1.

109 Readily prepared mannosyl n-pentenylorthoesters (NPOEs) serve as donors i

110 ts and isolated a gene that coded a putative mannosyl-oligosaccharide glucosidase (OsMOGS), an orthol

111 Genetic defects in MOGS, the gene encoding mannosyl-oligosaccharide glucosidase (the first enzyme i

112 11 years, with MOGS-CDG and biallelic MOGS (mannosyl-oligosaccharide glucosidase) mutations (GenBank

113 ipoarabinomannan is mediated by the terminal mannosyl oligosaccharides of this lipoglycan.

114 Possible conformations of the mannosyl oxacarbenium ion and an enzyme-linked intermedi

115 ion was also observed under conditions where mannosyl-P-dolichol (Man-P-dol) stimulated the biosynthe

116 ch as lysophosphatidylcholine, sulfatide, or mannosyl-phosophomycoketide, but not lipopeptide ligands

117 Dolichyl mannosyl phosphate synthase is associated with membranes

118 beta-D-mannosyl phosphomycoketide (C32-MPM), a naturally occurr

119 at 24 hr was 2.84 +/- 0.83% for [99mTc]DTPA-mannosyl-polylysine and 0.22 +/- 0.12% for [99mTc] DTPA-

120 ocalize to the Golgi and contribute to the O-mannosyl post-phosphorylation modification of alpha-DG.

121 annomutase involved in the biosynthesis of a mannosyl precursor needed for the biosynthesis of the co

122 dies reactive with both mimotopes and with a mannosyl preparation were observed to bind to envelope p

123 C-glycosylation to provide the alpha-allyl-C-mannosyl product 18 with excellent stereoselectivity.

124 The desired beta-allyl-C-mannosyl products 42 and 43 were obtained, albeit in low

125 bligatory step for the addition of the first mannosyl residue during the biosynthesis of GPIs, our re

126 hed that a glycopeptide having a 6-phospho-O-mannosyl residue is not an acceptor for action by the en

127 e, a third P-EthN group linked to the middle mannosyl residue was found.

128 xyl group at the C-2 position in the central mannosyl residue.

129 dues followed by two or three alpha-6-linked mannosyl residues branched with single alpha-mannopyrano

130 linear LM precursor with approximately 10-12 mannosyl residues followed by additional mannosylation o

131 o inositol has 5-7 unbranched alpha-6-linked-mannosyl residues followed by two or three alpha-6-linke

132 f glycoside hydrolase family 38, cleaves two mannosyl residues from GlcNAcMan(5)GlcNAc(2) as part of

133 The level of mannosyl residues in stem glucomannans decreased by appr

134 solely mediate the priming, the presence of mannosyl residues in the cell wall of C. albicans is nev

135 he misincorporation of glucosyl residues for mannosyl residues into the glycoconjugates of worms and

136 er disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macr

137 ster of nonreducing terminal alpha1,3-linked mannosyl residues, and the other type for complex N-link

138 After these branched mannosyl residues, the alpha-6-linked mannan chain is te

139 inositol anchor containing five alpha-linked mannosyl residues.

140 ents, as does the conformation of the glycon mannosyl ring in the product of the glycosylation reacti

141 brain, but the function of these branched O-mannosyl structures is unresolved using mice that lack t

142 (2-iodophenyl)ethylthiocarbonyl)benzylidene]-mannosyl thioglycosides are first used to introduce the

143 he rough endoplasmic reticulum and catalyzes mannosyl transfer from GDP-mannose to the hydrophobic lo

144 PMT4 encodes a protein mannosyl transferase (pmt) required for O-linked glycosy

145 Protein-O-mannosyl transferase 1 (POMT1) is the first enzyme requi

146 Constructs expressing lpcC display only mannosyl transferase activity.

147 The Candida albicans MNT1/KRE2 mannosyl transferase family is represented by five membe

148 inactivating the respective putative protein mannosyl transferase genes Msmeg_5447 and Rv1002c.

149 The mannosyl transferase is associated with the inner membra

150 racterization of the Rhizobium leguminosarum mannosyl transferase LpcC, which adds a mannose unit to

151 LpcC encodes a highly selective mannosyl transferase that utilizes GDP-mannose to glycos

152 (GDP-D-mannose dehydratase) and rfbZ (first mannosyl transferase), all of which are active in the sy

153 is homologous to Caenorhabditis elegans beta-mannosyl transferase, and it lies between Nup98 and CARS

154 ose:polypeptide mannosyltransferase (protein mannosyl transferase; PMT), was developed.

155 Mutations in the gene coding for protein O-mannosyl-transferase 2 (POMT2) are known to cause severe

156 ctional homolog of the yeast Smp3 GPI fourth mannosyl-transferase.

157 espectively, provide the corresponding alpha-mannosyl triflate as demonstrated by NMR spectroscopy.

158 ng to the formation of an intermediate alpha-mannosyl triflate.

159 d a lot of attention since the corresponding mannosyl triflates often give excellent selectivity.

160 Phosphorylated O-mannosyl trisaccharide [N-acetylgalactosamine-beta3-N-ac

161 saminyltransferase2 (B3GALNT2) to form the O-mannosyl trisaccharide.

162 lipoarabinomannan (LAM) that lacks terminal mannosyl units (AraLAM).

163 e a significant and regulatable precursor of mannosyl units in lipid-linked oligosaccharides and glyc

164 olated from Mtb and LAM lacking the terminal mannosyl units isolated from an avirulent mycobacterium

165 We have determined that the terminal mannosyl units of the M. tuberculosis surface lipoglycan