ライフサイエンスコーパス: mannosylated

1 ure CPO are partially (40-50%) or completely mannosylated.

2 tococcus neoformans are dependent on heavily mannosylated Ags termed mannoproteins.

3 paired Pneumocystis carinii phagocytosis and mannosylated albumin uptake.

4 or extracellular matrix protein binding to O-mannosylated alpha-dystroglycan that is lacking in secon

5 In this report, functionalized mannosylated aniline polymer (manno-PANI) was investigat

6 Cryptococcal mannoproteins (MP) are highly mannosylated antigens which elicit T-cell responses in i

7 -lipid IVA, functions as an acceptor, but is mannosylated at less than 1% the rate of Kdo2-lipid IVA.

8 d reveal that the WSXWS motif of IL-21R is C-mannosylated at the first tryptophan.

9 bset of IgM(+) FL samples, displaying highly mannosylated BCR, efficiently bound dendritic cell-speci

10 n/activation molecules, were able to take up mannosylated bovine serum albumin more efficiently than

11 sfer was inhibited by the addition of excess mannosylated bovine serum albumin to the culture medium

12 at was found to endocytose rhodamine-labeled mannosylated BSA (rMBSA), though the receptor was not in

13 l aspartic proteinase inhibitor pepstatin to mannosylated BSA via a cleavable disulfide linker.

14 ositol residue methylated are recognized and mannosylated by the GPI biosynthetic pathways of Trypano

15 e to cyanovirin's ability to bridge gp120 to mannosylated cell surface proteins.

16 Mycobacterium tuberculosis contains mannosylated cell wall components which are important in

17 We report that static quenching of a mannosylated conjugated polymer (sugar-PPE) by Concanava

18 Our results further define the functional O-mannosylated glycan structure and indicate that B4GAT1 i

19 A and LC-MS analysis, we identified a novel mannosylated glycoprotein phosphoribosyltransferase, enc

20 ll is composed of an outer layer enriched in mannosylated glycoproteins (mannan) and an inner layer e

21 FimH, the type 1 adhesin, binds mannosylated glycoproteins on the surface of human and m

22 tip of bacterial type 1 pili, interacts with mannosylated glycoproteins on the urothelial mucosa.

23 anthamoeba trophozoites bind specifically to mannosylated glycoproteins upregulated on the surfaces o

24 appendages that carry adhesins specific for mannosylated glycoproteins.

25 Inositol deacylation of the fully mannosylated GPI intermediate allows further processing,

26 Inositol acylation of the non-mannosylated GPI intermediate D-GlcNalpha1-6-D-myo-inosi

27 The subsequent inositol deacylation of fully mannosylated GPI intermediates is inhibited by both phen

28 characterization of novel inositol-acylated mannosylated GPI intermediates.

29 biosynthesis, we found that the assembly of mannosylated GPI species was impaired when purified ER p

30 in the conversion of GlcN-PI to H5 (a singly mannosylated GPI structure containing one phosphoethanol

31 appendages that carry adhesins specific for mannosylated host glycoconjugates.

32 We have now identified mannosylated IgM at the surface of primary lymphoma cell

33 duced a DC-SIGN-dependent adhesion of highly mannosylated IgM(+) FL B cells and triggered BCR-associa

34 of the mannose receptor (MR) or DC-SIGN bind mannosylated Igs in vitro and bind to FL cells, signalin

35 We demonstrate that Mid2 is not mannosylated in a pmt2 mutant and that this modification

36 there must be additional proteins that are O-mannosylated in the mammalian brain.

37 ha-PI(C8) and GlcNalpha-acyl-PI(C8) could be mannosylated in vitro, but mannosylation of the latter w

38 pendent on mannose receptors, as competitive mannosylated inhibitors and calcium chelators each inter

39 ed here identify key novel inositol-acylated mannosylated intermediates, allowing the formulation of

40 In contrast, terminally mannosylated LAM (ManLAM) binds the macrophage mannose r

41 Both terminally mannosylated LAM isolated from Mtb and LAM lacking the t

42 In contrast, terminally mannosylated LAM isolated from Mycobacterium bovis BCG f

43 antibodies enhanced FimH-mediated binding to mannosylated ligands and increased by severalfold bacter

44 onstrate an extended ligand binding site for mannosylated ligands and the significant contribution of

45 e to assess macrophage receptor activity for mannosylated ligands in vivo.

46 r binding of the N-terminal lectin domain to mannosylated ligands on host cells.

47 mans supernatants to stimulate X5A3 and (ii) mannosylated ligands to competitively inhibit this stimu

48 6-phosphate receptor (IGF-IIR) with IGFs and mannosylated ligands was analyzed in real time.

49 Recent work has indicated that mannosylated lipoarabinomannan (ManLAM) isolated from My

50 oglycan (LPG) and Mycobacterium tuberculosis mannosylated lipoarabinomannan (ManLAM), modulate essent

51 Another important mannosylated lipoglycan on the M. tuberculosis surface i

52 nctional PMM involved in the biosynthesis of mannosylated lipoglycans that participate in the associa

53 hages are depleted with either unmodified or mannosylated liposomes encapsulating dichloromethylene d

54 y suggest that a subset of the presumptively mannosylated M. leprae glycoproteins act as ligands for

55 The recent expansion of well-characterized O-mannosylated mammalian proteins beyond the archetypical

56 injury; (2) Polyman2, the newly synthesized mannosylated molecule selected for its binding to MBL, i

57 Mannosylated molecules on the Mycobacterium tuberculosis

58 rotein and the first complete structure of a mannosylated mycobacterial protein, and establishes the

59 NC5A contain WxxWxxWxxC motifs that can be C-mannosylated on all tryptophans.

60 through the plasma membrane and are highly O-mannosylated on their extracellular domains.

61 The glycoprotein GC was mainly highly mannosylated on tick cell-derived viral progeny.

62 NT1-only site is sufficient to convert the O-mannosylated peptide to a substrate for POMGNT2.

63 emonstrate that POMGNT1 is promiscuous for O-mannosylated peptides, whereas POMGNT2 displays signific

64 ibe the design, synthesis, and evaluation of mannosylated phenylalanine grafted chitosan (Man-CS-Phe)

65 summary, we show that a novel mycobacterial mannosylated phosphoribosyltransferase acts as a virulen

66 structural configuration for cell uptake of mannosylated poly(ethylene glycol)-conjugate type NCs wa

67 Complexes were formed between the mannosylated polylysine and oligonucleotides and added t

68 consisting of an irrelevant plasmid bound to mannosylated polylysine or the expression plasmid bound

69 pression can be achieved using the antisense mannosylated polylysine system.

70 elivery, a molecular conjugate consisting of mannosylated polylysine that exploits endocytosis via th

71 synthetic molecular conjugate, consisting of mannosylated polylysine that exploits endocytosis via th

72 M-A), lipoarabinomannan (Cg-LAM) and a multi-mannosylated polymer (Cg-LM-B) based on a 1,2-di-O-C(16)

73 glycoprotein epithelial (E)-cadherin as an O-mannosylated protein and establish a functional link bet

74 ation sites, and it is possible that it is a mannosylated protein like the major polar tube protein (

75 ave shown that Acanthamoeba interacts with a mannosylated protein on corneal epithelial cells and sti

76 also reflected in their binding to selected mannosylated proteins and in their ability to promote se

77 FimH-mediated cellular adhesion to mannosylated proteins is critical in the ability of urop

78 that facilitates adhesion of trophozoites to mannosylated proteins on corneal epithelial cells.

79 We show that contact lens wear upregulates mannosylated proteins on the corneal epithelium, stimula

80 ults suggest that binding of trophozoites to mannosylated proteins on the corneal surface induces A.

81 thamoeba keratitis is profoundly affected by mannosylated proteins on the ocular surface, which stimu

82 g tropism and bound equally to all cells and mannosylated proteins tested.

83 1 (MR), which functions to clear endogenous mannosylated proteins, a principle used to endow insulin

84 ia pastoris, resulting in unglycosylated and mannosylated proteins, respectively.

85 uroepithelial cells and for various soluble mannosylated proteins.

86 ng to acute urinary tract infection, yet the mannosylated receptor for type 1 pili on the squamous ep

87 o form IBCs even though it bound normally to mannosylated receptors in the urothelium.

88 ause urinary tract infections by adhering to mannosylated receptors on the human urothelium via the c

89 Mannosylated scFv also bound to DC-SIGN on the surface o

90 Mannosylated scFv bound specifically to the lectin domai

91 per enzyme to prevent the vast majority of O-mannosylated sites on proteins from becoming modified wi

92 de, with little labeling in the more complex mannosylated sphingolipids, whereas disruption of ELO2 r

93 Langerhans cells, would recognize the highly mannosylated structures in pathogenic Mycobacterium spp.

94 to HIV-1 virions via the abundant and highly mannosylated sugar moieties of HIV-1 envelope glycoprote

95 HIV-1, Mycobacterium tuberculosis expresses mannosylated surface structures and exploits C-type lect

96 As simulated cells progress along a mannosylated surface under flow, the fimbriae bend and b

97 FimH is able to interact with mannosylated surface via a shear-enhanced catch bond mec

98 udy the length of time that E. coli pause on mannosylated surfaces and report a double exponential de

99 low type 1 fimbriated bacteria to move along mannosylated surfaces under relatively low flow conditio

100 n, FimH, mediates shear-dependent binding to mannosylated surfaces via force-enhanced allosteric catc

101 ia, such as Escherichia coli when binding to mannosylated surfaces via the adhesive protein FimH, adh

102 Replacement of mannosylated Trp residues in TSR1 with either Ala or Phe

103 erium tuberculosis (M.tb) envelope is highly mannosylated with phosphatidyl-myo-inositol mannosides (