1 ized and maintained all human diseases, when
many academic and commercial online systems are sharing
2 Among
many accessible tools in diagnostic imaging, IVIM MRI ar
3 urprising because antibiotic action involves
many additional effects downstream of drug-target bindin
4 Many AF-associated genetic variants reside in noncoding
5 Many analyses of hydrocarbon mixtures instead characteri
6 Many animal embryos pull and close an epithelial sheet a
7 been reproduced across multiple studies and
many appear highly context-specific.
8 s, the ubiquitous use of cloth swipes across
many application areas could benefit from this convenien
9 aking their identifications indispensable in
many applications of life science.
10 techniques for screening and diagnosis, but
many are expensive, less feasible or have harmful side-e
11 ibed methodology could be a valuable tool in
many areas of biological and medical research.
12 Single-cell sequencing (SCS) has impacted
many areas of cancer research and improved our understan
13 ntaining biaryls are ubiquitous scaffolds in
many areas of chemistry, and efficient methods for their
14 The identification of ACE2 in as
many as 72 tissues suggests that extrapulmonary invasion
15 Nerve growth factor (NGF) regulates
many aspects of neuronal biology by retrogradely propaga
16 nd SIRT1 activities, respectively, affecting
many associated biological pathways.
17 IAVs infect
many avian species wherein they maintain a diverse natur
18 Pseudomonas aeruginosa, like
many bacilliforms, are not limited only to swimming moti
19 Many bacteria cycle between sessile and motile forms in
20 While
many bacterial mechanisms for overcoming nutritional imm
21 c or redox stress confirmed that KEAP1 sheds
many basal interactions and becomes associated with know
22 elations result from the poor reliability of
many behavioral measures and the distinct response proce
23 However, it is crucial for
many biological applications such as the design of guide
24 latedness of biological entities is vital to
many biological applications, such as protein-protein in
25 Many biological processes are based on interfacial prote
26 Multivalent binding is essential to
many biological processes because it builds high-affinit
27 Water and lipids are key participants in
many biological processes, but there are few non-invasiv
28 regulation of gene expression is central to
many biological processes.
29 ely limits the tissue culturing potential of
many bioreactors.
30 Higher-order
many-
body errors are small in both SCAN and self-interac
31 ance and extend progression-free survival in
many cancer indications.
32 Interestingly, prognostic outcomes of
many cancer types have been linked with the expression l
33 that the expression of BMI1 is increased in
many cancer types, the mechanism of BMI1 upregulation is
34 However,
many cancers are not fully recognized via NK cell recept
35 Theranostic compounds are likely to impact
many cancers in the near future, not only through improv
36 Despite these described associations,
many cases of familial WT remain unexplained.
37 t modification types simultaneously and find
many cases of incomplete modification.
38 ng bridged ions, as well as their ability in
many cases of spreading out the positive charge over sev
39 In
many cases, it is unclear which experimental features or
40 In
many cases, phase separation appears to either underly o
41 In
many cases, these peptide-based catalysts have enabled n
42 rs were determined spectroscopically and, in
many cases, using single-crystal X-ray crystallography.
43 gmatis growth range from mild to severe, but
many cause irreversible loss of viability.
44 Trypanosoma cruzi infects
many cell types but preferentially persists in muscle, a
45 s underlying the development and function of
many cell types, tissues, organs and systems.
46 However,
many cells with genetically deleted cyclin Ds, which act
47 brane necks, a process that is essential for
many cellular functions, from cell division to lysosome
48 Among the
many cellular mechanisms that regulate mRNA fate, covale
49 They are utilized in nature to accomplish
many cellular tasks.
50 with a hybrid suite remains prohibitive for
many centers.
51 Many circulating thymus-associated B cell clones were in
52 ular chaperone important for the activity of
many client proteins.
53 e underlying molecular basis for each of the
many clinical features of DS, it also provides opportuni
54 triplicated genes or groups of genes to the
many clinical manifestations in DS.
55 Improving this practice is challenging since
many clinicians did not train where CM is frequent, resu
56 and wastewater services are still lacking in
many colonias.
57 ility-driven transmission frequently occurs:
many communities export and import strains.
58 correlations reported in the literature for
many complex traits, the non-transferability of polygeni
59 e lowest method detection limits to-date for
many compounds, including highly toxic iodinated, bromin
60 e-dependent regulation while still retaining
many computational advantages of FBA.
61 dual and population scales is fundamental to
many concepts in ecology [1], including migration [2, 3]
62 post hoc tailoring of analysis windows under
many conditions.
63 phila, a powerful genetic system that shares
many conserved genes and pathways with humans.
64 focuses primarily on ex vivo tissues, though
many considerations are relevant in vivo as well.
65 Because
many coral species spawn only once per year during a nar
66 s a helpful tool used to diagnose and manage
many corneal conditions, but its use has not been report
67 Improving diets is affordable in
many countries but for many people would require some co
68 ence rates of this disease have increased in
many countries in recent decades.
69 In this phase of the pandemic
many countries showed an almost linear growth of confirm
70 Yet,
many current in vitro chemical assays to characterize an
71 of heterotrimeric G proteins is modulated by
many cytoplasmic proteins.
72 mates using frozen tissue samples, including
many data sets from our own group, were often collected
73 s and/or by rare but severe coding variants,
many de novo.
74 k of COVID-19 pandemic traces its roots back
many decades and is worsened by a number of ill-conceive
75 er this umbrella definition, culture was for
many decades the exclusive province of the humanities an
76 for patients with valvular heart disease for
many decades, but transcatheter heart valve therapy has
77 At the broadest temporal scales (
many decades, centuries and beyond), continued shifts in
78 that has been standard in this reaction for
many decades, however, is air-sensitive, prone to photod
79 itions, including cancer, but they also pose
many delivery challenges.
80 controlling cell fate and differentiation in
many developmental and adult processes.
81 integrin-mediated adhesion is important for
many developmental migration events.
82 In response,
many diagnostic manufacturers have developed molecular a
83 Antibiotics have
many different 'mechanisms of action' that converge to i
84 of the molecular pathways that underlie the
many different causes of kidney failure.
85 spheric pressure conditions, the presence of
many different chemicals, and an electrical discharge.
86 Many different enzymes in intermediate metabolism dynami
87 sing the most suitable model also depends on
many different factors, and we consider how to make thes
88 lementary data sources can be implemented in
many different high-throughput settings to ultimately im
89 n combining multiple pieces of evidence from
many different sources, it is important to consider the
90 actly phytochemical diversity is and how its
many dimensions impact ecological and evolutionary proce
91 Many discoveries are recent, and the findings described
92 nd in vivo demonstrates promising results in
many disease models, in which autophagy upregulation is
93 developmental pathways, implicating them in
many diseases besides cancer, including lung, renal, and
94 l types, dysfunction of which contributes to
many disorders.
95 ve enabled discovery of novel inhibitors for
many distinct protein targets of therapeutic value.
96 t passing through a boundary is important to
many diverse applications.
97 rtical parallel processing streams segregate
many diverse features of a sensory scene.
98 ure mixtures frequently occur in data across
many domains, particularly in the fields of environmenta
99 es alter the functioning and biodiversity of
many ecosystems.
100 own superior activity and/or selectivity for
many energy- and environment-related reactions, but thei
101 The activity of
many enzymes is regulated by associative processes.
102 hat connects the N- and C-terminal halves in
many eukaryotic ABC transporters, allowing all four cons
103 he fact that we have so many materials opens
many exciting avenues but also create new challenges.
104 ls for patients with COVID-19 is increasing,
many exclude pregnant women as participants or do not ad
105 Unlike
many existing methods, the proposed method does not impo
106 While the proposed models harmonize with
many experimental findings, gaps and inconsistencies in
107 In addition,
many expressed one or more neuropeptides, and two expres
108 n of Lp-PLA(2) by darapladib is dependent on
many factors such as concentrations of detergents or lip
109 s not improved as a result of screening, and
many false-positive results required additional, subsequ
110 a at single cell level is urgently needed in
many fields including clinical diagnosis and environment
111 The anterior body of
many fishes is shaped like an airfoil turned on its side
112 te wear and tear on the body and may lead to
many forms of disease.
113 Bacterial dormancy can take
many forms, including formation of Bacillus endospores,
114 ogy with diabetes is a complex area in which
many further questions remain, especially regarding the
115 Many gaps in our understanding of Alzheimer's disease re
116 Although
many genes are known to regulate those processes, the mo
117 In response to the COVID-19 pandemic,
many governments have taken drastic measures to avoid an
118 Many GPCR AAs modulate receptor signaling, but molecular
119 United States and around the world, leaving
many grieving the sudden loss of family members.
120 Among the
many host genes identified, there was an enrichment in g
121 and wheat, are detectable in breastmilk for
many hours or days after ingestion.
122 ison to the TVB-N and TVC method which takes
many hours to complete involving many sophisticated step
123 hree key features of HPA aging identified in
many human studies: increased average levels, a blunted
124 Under these conditions,
many hydrophobic surfaces on proteins may be transiently
125 The proposed framework unites
many ideas of tinnitus pathophysiology and may catalyze
126 6-directed therapies are highly effective in
many iMCD patients, but additional therapies are require
127 MALT1 mediates signaling from
many immune receptors in mammals, but was not previously
128 evel mechanics are the coordinated output of
many individual cellular behaviors.
129 Yet since AF is often asymptomatic,
many individuals with AF may be unaware and do not recei
130 acterizes frontotemporal dementia and ALS in
many individuals with these neurodegenerative diseases.
131 ams, which remain first-line antibiotics for
many infections, is an important part of efforts to addr
132 the preferred method for rapid diagnosis of
many infectious diseases.
133 icating that GM-CSF is a potential target in
many inflammatory/autoimmune conditions.
134 is an attractive target for antibiotics and
many inhibitors are in clinical development.
135 Importantly,
many instances of accelerated phenotypic evolution are d
136 ox properties for analyte detection that, in
many instances, involve chemical modification of samples
137 should be considered syndromes comprised of
many interacting traits, and that elucidating the geneti
138 and quantitatively dramatic upregulation of
many ISGs, which confers broad viral infection resistanc
139 curves is consistent with observations from
many jurisdictions.
140 We show that our assembly model reproduces
many key features of ecological systems, such as the rol
141 life show surprising levels of diversity at
many levels-ranging from cell cycle organization to chro
142 Although
many ligands were predicted based on sequence signatures
143 We find that
many local officials favor refugee resettlement, regardl
144 In response, marine resource managers in
many locations have established marine protected areas o
145 e to urban poor populations is a priority in
many low- and middle-income countries.
146 ritability enrichments are driven largely by
many low-effect common SNPs.
147 ns in newborn survival have been achieved in
many low-income and middle-income countries, reductions
148 Additionally,
many luciferase-luciferin pairs emit light that is poorl
149 Many lysosome functions are determined by a lumenal pH o
150 Due to PTMs' extremely important roles,
many major PTMs have been studied, while the functional
151 nd communication in the ocean for humans and
many marine animals.
152 In this review, we show that having so
many materials allows us to use big-data methods as a po
153 The fact that we have so
many materials opens many exciting avenues but also crea
154 data processing and wireless transmission in
many medical and clinical settings.
155 F and its peptides have been associated with
many metabolic and neurological disorders.
156 will drive an increase in the production of
many metals, creating new mining threats for biodiversit
157 Many microbial agents have been implicated as contributo
158 Many microbiome/metagenomic studies follow a longitudina
159 Many microRNAs (miRNAs) have been associated with asthma
160 established in informing biological systems,
many models are often informed by data sourced from mult
161 Many molecular dynamics simulations have investigated ph
162 process involves assembly and disassembly of
many molecules in multiple cellular compartments and the
163 In one pancreatic tumor, there were
many more L1 insertions in aneuploid than in euploid tum
164 only a more user-friendly web interface and
many more plasmid vectors, but also new links of the pla
165 urately capture the biology and behaviour of
many mosquito vectors that refeed frequently (every 2-3
166 However,
many motile cells rely on both signaling modules and act
167 only to swimming motility but rather possess
many motility strategies.
168 Many multi-parent populations have been constructed in c
169 roach is generalizable and can be applied to
many multicomponent fluorescence lifetime imaging target
170 een homoeologous chromosomes was reported in
many nascent allopolyploids.
171 pecifically bind amyloid fibrils formed from
many natural peptides and proteins.
172 Many neurodegenerative and neurological diseases are roo
173 n 43 (TDP-43) has emerged as a key player in
many neurodegenerative pathologies, including frontotemp
174 BBB dysfunction, however, is evident in
many neurological disorders including ischemic stroke, t
175 l biology is entering an exciting time where
many new high-resolution structures of large complexes a
176 Research in the last decade has uncovered
many new paramyxoviruses, airborne agents that cause epi
177 However,
many next-generation batteries are limited by electrolyt
178 However,
many NF-kappaB-mediated pathways for cell survival and a
179 Many non-ant parasites of ant colonies are known to mimi
180 ytic leukemia protein (PML) bodies, sites of
many nuclear processes including protein quality control
181 The antiviral efficacy of
many nucleoside analogues is strongly dependent on their
182 Many of apo(a)'s potential pathological properties, such
183 However,
many of the automated algorithms still require significa
184 rowth of virtual conferences has highlighted
many of the disadvantages associated with the in-person
185 Many of the enzymes responsible for regulating protein a
186 Many of the identified susceptibility genes for asthma a
187 y a pronounced decrease in the expression of
many of the key genes required for intracellular accommo
188 TRiC) is a multi-subunit complex that folds
many of the proteins essential for cancer development.
189 Fortunately,
many of these AF drivers are potentially reversible, and
190 Many of these associations are unexpected based on effic
191 GPCRs are co-expressed in the same tissues,
many of these channels can inhibit GPCR desensitization.
192 ated with cell wall growth and turnover, and
many of these control activities depend upon PASTA-domai
193 other proteins, have also been reported, but
many of these noncanonical roles remain enigmatic.
194 Many of these processes are performed in topologically e
195 n particular at neutral and higher pHs where
many of these proteins phase separate, we compared (13)C
196 Many of these reduction steps require the presence of a
197 Many of these sweeps coincide with genes associated with
198 rs, rashes, and mucosal symptoms observed in
many of these syndromes, patients are likely to present
199 However,
many of these traits are unavailable in archaeological a
200 Many of these variants cause complete loss of NHE6 expre
201 Contrary to
many of those claims, this paper uses observational mult
202 ted in the description of several new phyla,
many of which are globally distributed and are among the
203 antropical genus with more than 250 species,
many of which are highly threatened due to overexploitat
204 sorder accompanied by brain-related changes,
many of which are still to be discovered or refined.
205 veral previously unknown halophilic viruses,
many of which exhibit transcriptional activity indicativ
206 microbiota synthesize hundreds of molecules,
many of which influence host physiology.
207 identified over 70 putative SNX-BAR ligands,
many of which play critical roles in apoptosis, cell adh
208 also to alleviate pain, nausea, and anxiety,
many of which target GPCRs.
209 gical damage with possible clinical utility,
many of which whose presence in blood is likely linked t
210 etween breadth-spreading our capacity across
many options-and depth-gaining more information about a
211 caused by Plasmodium falciparum manifests in
many organ-specific fatal pathologies, including cerebra
212 Many organic and main-group compounds, usually acids or
213 Many organisms are experiencing changing daily light reg
214 the biological function of metaphosphates in
many organisms.
215 nces have not been identified, together with
many "
orphan" receptors without known ligands.
216 Many other AAA+ proteins function by threading macromole
217 rmation, thus validating our approach; plus,
many other candidate RA target genes were found.
218 he process is likely generally applicable to
many other lactones, lactides, anhydrides, epoxides, and
219 ged behind advances made in the treatment of
many other malignancies over the past few decades.
220 d deafness is a neurocristopathy but, unlike
many other neurocristopathies, it is not syndromic.
221 The data show that in contrast to
many other proteins that use substrate selectivity to pr
222 Many other regulatory mechanisms can influence RNA metab
223 ch a drug would raise the hope for a cure to
many P2X7-dependent pathologies, including inflammatory,
224 Many parts of the visuomotor system guide daily hand act
225 growing burden of cardiometabolic disease in
many parts of the world.
226 splantation (LT) in the United States and in
many parts of the world.
227 perfectly model the human disease, it shares
many pathological features.
228 Due to over-reporting of BL allergies,
many patients may not receive guideline-directed cephalo
229 advancements, it's prognosis remains poor as
many patients with heart failure experience symptoms tha
230 Many people who survive PML are left with neurological s
231 iets is affordable in many countries but for
many people would require some combination of higher inc
232 Like
many peptide hormones, OCN is subjected to post-translat
233 This PCSK9 inhibitor is one of
many peptides that could benefit from bioactive cyclizat
234 There are
many pharmacokinetic challenges associated with administ
235 me critical for the long-term persistence of
many plant species and communities.
236 yses of MADS-box genes have been reported in
many plant species, but its identification and character
237 and deletion-only MMEJ-mediated mutations in
many plant species.
238 poral trends indicate that concentrations of
many POPs (PCBs, DDT, HCHs, endosulfan) have declined si
239 rm the intermediate state can be mediated by
many possible contacts, but seems to be particularly fav
240 phenotyping of single cells therefore offers
many potential diagnostic applications.
241 sols have rapidly increased because of their
many potential health effects.
242 high costs involved in attending can exclude
many potential participants.
243 Unfortunately, RAR causes
many problems, including (1) bias from temporal trends,
244 Microglia play a critical role in
many processes fundamental to learning and memory in hea
245 critically important for the specificity of
many proteases, but this balance is not yet defined for
246 Many proteins involved in synaptic transmission are well
247 We also found that
many RBPs can bind to multiple distinctly different moti
248 There have been
many recent reviews on: (i) the importance of g(m) for a
249 Many recent studies have shown that the integration of g
250 Many recommendations from the earlier valvular heart dis
251 Many regions regularly inundated with meltwater today ar
252 en the shrinking scope of protected areas in
many regions.
253 Many researchers at the time viewed this effort as folly
254 ic imaging, IVIM MRI aroused the interest of
many researchers in terms of studying its applicability
255 nal efficiency following loss of ARF include
many ribosomal proteins and translation factors.
256 Many single nucleotide polymorphisms (SNPs) associated w
257 In
many situations, these forces are exerted or resisted by
258 n shift from greater energetic investment in
many small offspring towards investing less total energy
259 elated genes (gHFI) determines which and how
many somatic mutations (sM) must occur for malignant tra
260 Cancers harbor
many somatic mutations and germline variants, we hypothe
261 which takes many hours to complete involving
many sophisticated steps.
262 Three times as
many species colonized the monocultures than the high di
263 gies in deep-sea environments is lacking for
many species of fishes.
264 ident for multiple sensory modalities and in
many species.
265 trieval as well as spatial navigation across
many species.
266 r modulators of SIRT6 activity, however, not
many specific activators have been reported.
267 Here, we show that Stattic exerts
many STAT3-independent effects on cancer cells, calling
268 gene cloning in wheat is to manually perform
many steps in a long bioinformatics pipeline.
269 Supporting this theory,
many striatal neurons exhibit such graded changes withou
270 These results reveal
many structural details that were not visible by cryo-ET
271 In addition, we were concerned that
many students from historically underrepresented (HU) gr
272 However,
many studies focused on local anatomy, an approach that
273 Although
many studies have focused on the adult lung, the perinat
274 r role in fission at the late stages of CME,
many studies have suggested that dynamin also plays a re
275 Many such technologies could use in vivo paternal haploi
276 flux comes at the expense of selectivity in
many synthetic filters.
277 appropriate model for these viruses because
many target cells are present, including basal keratinoc
278 ) catalyze posttranslational modification of
many target proteins and have been suggested to play a r
279 These features have led to
many techniques for screening and diagnosis, but many ar
280 persistently 'time poor'-like they have too
many things to do and not enough time to do them.
281 Many tissues are produced by specialized progenitor cell
282 q profiling shows differential expression of
many transcription factors in response to 5,8-diHODE.
283 onclusions at the end or during a trial, for
many treatment strategies, simultaneously.
284 Many treatments for irritable bowel syndrome are availab
285 Similarly, the viability of
many tropical coral populations at higher latitudes is h
286 be a tumor suppressor protein which controls
many tumorigenic events associated with the hedgehog (hh
287 and effective targeted approach to treating
many types of cancer.
288 The membrane is also highly vulnerable to
many types of perturbation, including heat, force, osmot
289 ng a DC library and leads to the creation of
many undesired variants that can quickly outstrip screen
290 he interpretation of test results depends on
many variables and factors, including sensitivity, speci
291 Genome-wide association studies have shown
many variants are found within putative enhancer element
292 uter application, to systematically identify
many violations of the principle of detailed balancing i
293 otential key mechanism of protection against
many viral pathogens, antibodies mediate additional immu
294 e HA proteases involved in the activation of
many viral strains remain unidentified.
295 Many viruses employ ATP-powered motors during assembly t
296 y complexes within infected cells.IMPORTANCE
Many viruses replicate almost entirely in the cytoplasm
297 Despite its significance,
many WAT-related pathophysiogical mechanisms in humans a
298 tosamine is involved in the immune system in
many ways.
299 rves were used to draw conclusions about how
many years earlier patients with diabetes reach the 10-y
300 is information processing only develop after
many years of experience?