ライフサイエンスコーパス: mark

1 ly enriched for poised and bivalent enhancer marks.

2 patially distant mRNA regions and maturation marks.

3 ased on parent-of-origin specific epigenetic marks.

4 did not improve insulin sensitivity despite marked (~20%) weight loss.

5 The reduced Health Utilities Index Mark 3 score correlated with 5.5 average lifetime qualit

6 D1-G93A mice at 12 weeks was paralleled by a marked ~50% increase in motoneuron volume and a near-nor

7 even a certain stability toward water, which marks a big leap forward in metal alkylidyne chemistry i

8 able artificial atoms into phase-stable PICs marks a key step towards multiplexed quantum repeaters(7

9 The peopling of the Americas marks a major expansion of humans across the planet.

10 The Great Unconformity marks a major gap in the continental geological record,

11 ful use of isocyanate comonomers in this way marks a new direction for the field of ROCOP while provi

12 orter expression indicates SMOC2 dynamically marks a range of dental and bone progenitors.

13 e report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells

14 ncy and oncogenesis, and suggest that sGRP78 marks a stem-like population in breast cancer cells that

15 Rubicon, attenuation of autophagic flux, and marked accumulation of autophagosomes.

16 plete lack of testosterone in XY-KO mice and marked accumulation of progesterone in XX-KO mice.

17 e) of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and transiently-unpaire

18 as histone H3 lysine 4 (H3K4) trimethylation marks active gene promoters(6).

19 eployed this technique to describe the scent marking activity of 3 guardian dogs as they defend lives

20 We found marked advance of liver fibrosis (chronic damage), as we

21 s, including extensive changes in epigenetic marks, allow a somatic nucleus to become totipotent afte

22 DNA methylation, a prominent epigenetic mark, also changes over a lifetime as part of an "epigen

23 modulation, only Diclofenac exposure shows a marked alteration of these intracellular parameters, lea

24 and alpha oscillations that are linked with marked alterations in self-referential processing.

25 months of the start of the pandemic, it will mark an unprecedented achievement for noninfluenza viral

26 Our work marks an important step towards enabling application-spe

27 levels of the repressive H3K27me3 chromatin mark and leads to suppression of the key transcription f

28 cumented 8-oxoG serves as an epigenetic-like mark and OGG1 modulates gene expression in oxidatively s

29 se separation orchestrated by the epigenetic marking and operated by proteins that bind to chromatin.

30 tem cells erase constitutive heterochromatin marks and display a primed chromatin landscape, with biv

31 onclude that the relationship between active marks and gene expression is conserved across land plant

32 ta decreases H3K27 trimethylation repressive marks and increases beta-catenin occupancy at a site 4 k

33 icate that the human ZSCAN4 is enriched for, marks and is co-expressed with CSC markers in HNSCC.

34 chy were more enriched in classical boundary marks and more conserved across cell lines and tissues.

35 NA-guided deposition of repressive chromatin marks and transcriptional silencing of piRNA targets.

36 Marked antidepressant activity and dose-dependent recept

37 At present, histone marks are used to identify and define enhancers but do n

38 Digital videoscope images were made of the marked areas using only white light and also with only a

39 fferent (heterotypic) types of cells, with a marked asymmetry within heterotypic pairs.

40 anscriptionally activating H3R17me2a histone mark at those loci; this effect was not seen in the non-

41 ented the EndMT-induced reduction of H3K9me3 marks at these promotors and further repressed these End

42 ating local deposition of repressive histone marks at these transposons.

43 ith some hydroxy fatty acids, which deserved marked attention due to their health-promoting activitie

44 Herein, we have generated the global histone mark based epigenomic and transcriptomic cartogram of SC

45 pHLIP ICG is non-toxic, marks blood flow for hours after injection, and effectiv

46 profiles particularly for methylated histone marks but is not optimized for H3K27ac profiling.

47 g in ESCs reveals hundreds of messenger RNAs marked by 5hmC at sites characterized by a defined uniqu

48 ls exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity.

49 The immunodeficiency was marked by a pronounced actin polymerization defect and a

50 The human lineage is marked by a transition in hand use, from locomotion towa

51 88/1989 North Pacific climate shift that was marked by abrupt northeast Pacific warming, declining te

52 give rise to the "nude" phenotype, which is marked by athymia.

53 The lymphoid-primed IRF8(hi) pathway, marked by CD123 and BTLA, carried pDC, cDC1, and DC2 tra

54 is beige APC population is proliferative and marked by cell-surface proteins, including PDGFRalpha, S

55 for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes.

56 ymerase II pausing in resting macrophages is marked by co-localization of the negative elongation fac

57 inflammatory bowel disease (IBD) that may be marked by debilitating symptoms of abdominal pain and ob

58 stem and vocabulary for human regulatory DNA marked by DHSs, and provide a new global perspective on

59 Examination of genomic regions marked by differential chromatin states and associated w

60 ocampal encoding versus retrieval states, as marked by distinct network connectivity between hippocam

61 Diabetes-associated organ fibrosis, marked by elevated cellular senescence, is a growing hea

62 cytokine storm in its severest form has been marked by elevation of IL-6, IL-10, TNF-alpha, and other

63 s more frequent in early S phase, in regions marked by euchromatin.

64 t a +4 stem cell (SC) in the gastric antrum, marked by expression of Cck2r (a GPCR) and Delta-like li

65 conditional knockdown in Hh-receiving cells (marked by Gli1+) during E8 to E10.5, a previously establ

66 4(+) T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability t

67 composition at bivalently modified promoters marked by H3K4me3 and H3K27me3.

68 ens centromeres are of similar structure and marked by high abundance of retroelements unlike in vasc

69 Moreover, their chemical signals were marked by high proportions of octadecanoic acid, oleic a

70 hin NKT subsets, however, stage 3 NKT cells, marked by higher NK1.1 expression, were significantly mo

71 We live in a research era marked by impressive new tools powering the scientific m

72 T cell exhaustion is marked by inhibitory molecule upregulation and the devel

73 These beige fat progenitors are marked by PDGFRalpha, Sca1, and CD81 and proliferate upo

74 iscovered that formative TF target genes are marked by permissive epigenomic signatures in the naive

75 tatitis frequently progresses to chronicity, marked by recurrent episodes interspersed with asymptoma

76 herapeutically effective only for conditions marked by reduced inhibition, and it is also unclear whe

77 They were marked by relatively high phytoplanktonic productivity a

78 rogram and a fetal gene expression signature marked by Sca1, but upon injury are unable to generate S

79 n (p = 0.415), but STEV quantitative signal, marked by syncytin-1 specific EVs, was significantly dec

80 was confined to tissues and disease subtypes marked by TDP-43 inclusions.

81 thies including Alzheimer's disease (AD) are marked by the accumulation of aberrantly modified tau pr

82 Upon serum deprivation, a subset of AEs pre-marked by the activity-dependent neuroprotector homeobox

83 fy a regionally localized pial subpopulation marked by the expression of mu-crystallin.

84 Mitotic chromosome reorganization is marked by the general attenuation of transcription on ch

85 Gravettian manufacturers and a discontinuity marked by the Last Glacial Maximum (LGM).

86 e Tonian and Cryogenian periods, an interval marked by two global glaciations with strong consequent

87 FACT knockdown also increases epigenetic marking by dCas9-based transcriptional effectors with a

88 nes all types of mechanosensory neurons with marked cell-class dependence.

89 The histone H3 variant CENP-A marks centromeres epigenetically and is essential for mi

90 Furthermore, the marked change in bone points coincides with a change in

91 E STATEMENT Animal studies consistently show marked changes in action potential waveform during epile

92 ransformations during foraging that leads to marked changes in both the motivation to hunt for prey a

93 a surrogate state of depressed CA, leads to marked changes in dynamic CA, that are entirely explaine

94 However, Neu5Gc was not associated with marked changes in infant immune markers, in contrast wit

95 Marked changes in TCC protein expression profiles were o

96 Vascular disease is associated with marked changes in the S-sulfhydration of endothelial cel

97 Despite marked changes in this neural circuitry and extinction l

98 adaptations within the mother(1), including marked changes within the immune system(2).

99 in a non-western developed setting with less marked confounding by socioeconomic position.

100 3K27(ac)), but not the histone modifications marking constitutive (H3K9(me3)) or facultative (H3K27(m

101 ame bond length) found in amorphous PCMs, in marked contrast to existing viewpoints.

102 In marked contrast to Fos immunoreactivity, neuroanatomical

103 This is in marked contrast to the minimal phototoxicity required in

104 In marked contrast, short-chain Vi (9.5 to 42.7 kDa) conjug

105 In marked contrast, very few of these compounds are able to

106 ty in infected chicken cells, accompanied by marked cytotoxicity, requires the full-length protein.

107 f circadian timekeeping in the brain display marked daily changes in neuronal morphology.

108 a transient increase in 3-HIB followed by a marked decrease after bariatric surgery and weight loss.

109 itinib-treated EpsilonC-betaKO mice showed a marked decrease in microvessel density, and reduced new

110 atures of both events were (1) an abrupt and marked decrease in salinity (from > 30ppt to < 5ppt) due

111 Microdialysis revealed marked decreases in cocaine-induced dopamine and glutama

112 eceptor transcription factors accompanied by marked decreases of both rod- and cone-specific gene exp

113 However, a marked deepening of the redoxcline and a reduced frequen

114 Marked deficits in glucose availability, or glucoprivati

115 e that RAD50-deficient fibroblasts exhibit a marked delay in mitotic progression that can be rescued

116 decreased granularity by flow cytometry and marked depletion of intracytoplasmic granules by light m

117 Using c-Fos to mark DG neuron activation, we identified a group of embr

118 This marked difference in reactivity reflects the ability of

119 fective for such substrates; presumably, the marked difference is attributable to the lesser crowding

120 RNA-seq identified marked differences among NM, TC-TAM, and IM-TAM.

121 atforms, and these characteristics displayed marked differences between subtypes.

122 d-expiration and forced inspiration revealed marked differences between the groups.

123 We found marked differences in accuracy and intra- and inter-meth

124 during the social preference test, we reveal marked differences in behavioral dynamics between the st

125 onfailing hearts from brain-dead donors show marked differences in circadian clock gene expression pa

126 r among biomes (geographical units that have marked differences in environment and species compositio

127 ies such as lemon, mandarin and pummelo with marked differences in fruit pigmentation and content of

128 We also detect marked differences in miRNA expression between populatio

129 Comparative analysis revealed marked differences in protocol performance.

130 Patients with PSC showed marked differences in the abundance of genes related to

131 However, no marked differences were observed in the lung sound param

132 , unbiased gene expression analyses revealed marked differences, including pathways related to steril

133 ielding due to the bulky P-substituent gives marked different reactivities at the 2- and 7-positions,

134 hich is associated with MYC upregulation and marked downregulation of MYC's negative regulator miR-34

135 s, with these features becoming increasingly marked during regression.

136 on of the intramonomeric disulfides triggers marked dynamical heterogeneity, interfacial wettability,

137 ulin and high-dose T. muris infection caused marked dysbiosis, with expansion of the Firmicutes and P

138 ses across animal generations, predominantly marking each generation with the corresponding combinati

139 These lasting and marked effects of M(1) receptor stimulation reinforce ou

140 tional relevance of DDR1 is supported by its marked elevation in HCC which is inversely associated wi

141 Marked elevation in the brain concentration of N-acetyl-

142 ays, the myocardium of female mice developed marked elevations in free fatty acids, ceramides and dia

143 t 14 days of recovery in females, there were marked elevations in myocardial free fatty acids, cerami

144 A marked enrichment of the transcription factor Runx3 as w

145 rotein that enables spatiotemporally precise marking, erasing, and remarking of active neuron populat

146 demethylates histone H3 Lys4, an epigenetic mark for active genes, but requires the CoREST repressor

147 We propose that this use of genetic marking for microanatomical regions of interest can be p

148 activator that specifically determines leaf marking formation depending on its C-terminal activation

149 facilitates RH1 function in leaf anthocyanin marking formation.

150 Foundation, Nancy Lurie Marks Foundation, Mather's Foundation, and the NIH.

151 proliferation, metabolic re-programming and marked gene alteration resembling the remodeling phase o

152 rs related to tissue-specific functions, and marked genes functionally enriched for tissue-specific p

153 iating colocalization of BAHCC1 and H3K27me3-marked genes.

154 Further, results suggest a marked geographic catchment of malaria admission around

155 PC-like WM displayed marked global hypomethylation and selective overexpressi

156 We conclude that Ub chains mark GPCRs and other unwanted ciliary proteins for recog

157 -wide localization of the repressive histone mark H3K27me3 (mediated via the polycomb histone methylt

158 igh density of the enhancer-specific histone mark H3K4me1 and carry sequences that match enhancer bou

159 f the transcriptionally permissive chromatin mark H3K4me3 (trimethylation of lysine 4 on histone H3),

160 ted to mRNA-seq and ChIP-seq for the histone marks H3K4me3 and H3K27ac.

161 ly exclusive with another repressive histone mark, H3K9me2, that mainly silences transposons in heter

162 d increased levels of the repressive histone mark H3K9me3 in mdx mice compared to wild-type mice, ind

163 re.On physical examination, the child showed marked head lag and did not reach out to objects.

164 Analysis of included studies identified marked heterogeneity in animal models of donor brain dea

165 These observations revealed a marked heterogeneity of release site properties within i

166 Together, our results reveal the marked heterogeneity of TAM populations in different tum

167 Conversely, the euchromatin mark histone 3 lysine 9 acetylation (H3K9ac) is abundant

168 ts experiencing increased appetite exhibited marked immunometabolic dysregulation, with higher insuli

169 f the new analogues, NBD-14270 (8), showed a marked improvement in cytotoxicity, with 3-fold and 58-f

170 treated with benralizumab, which resulted in marked improvement of asthma symptoms and reduced the pe

171 e show the contribution and function of this mark in mouse ESCs and differentiating embryoid bodies.

172 in part by depositing the H3R17me2a histone mark in the vicinity of gene promoters that it regulates

173 nction, suggesting an ancestral role of this mark in transposon silencing.

174 ponse, and that this reduction would be most marked in patients with "residual schizophrenia", in who

175 ll isolation, and different levels of vector marking in the various lineages.

176 E. coli and resolve single epitranscriptomic marks in vitro.

177 va) genome by integrating multiple chromatin marks, including the H2A.Z histone variant, H3K4me3 modi

178 outs for CTI exhibit higher rates of FAS and marked increase in absolute triacylglycerol levels in le

179 ltaneously Isovolumic haemodilution led to a marked increase in brachial artery flow-mediated dilatat

180 untreated guinea pigs was associated with a marked increase in energy metabolism (glycolysis and mit

181 ity of high-quality patches, but exhibited a marked increase in foraging habitat quality over time th

182 Results show a marked increase in HF water use, and depleting groundwat

183 ed in the suppression of Th1 cytokines and a marked increase in lung macrophages displaying an altern

184 a diagnosis of ILD and is associated with a marked increase in mortality.

185 Tumor cell lines exhibited a marked increase in sensitivity to ubidecarenone vs. non-

186 (surface) Bronsted acid sites and observed a marked increase in the conversion relative to three-dime

187 Fermentation also led to a marked increase of antioxidant activity, with the highes

188 ssion of costimulatory molecules on B cells, marked increase of Th17 responses and increased recruitm

189 A marked increase of the RPE65 mRNA was also observed in t

190 This combination of medial SMC loss with marked increases in non-SMC aortic cell mass induced exu

191 only very minor decreases in a few targets, marked increases in the abundances of very stable mRNAs,

192 ourse of hydroxychloroquine, later developed marked inflammatory manifestations with rapid improvemen

193 an previously reported (21/100 000 PY), with marked interethnic variation.

194 MVA-NP+M1 activated a marked interferon gamma-secreting T-cell response to M1

195 There is marked interindividual variability in metabolism and res

196 da bloodstream infection experienced a prior marked intestinal expansion of pathogenic Candida specie

197 and SIRT1-related cancer stemness networks, marking it a potential therapeutic target in colorectal

198 ith DBSs showed co-localization for both the marks; (iv) only a small fraction (7% for H3K4me3 and 12

199 a major component of adherens junctions and marks Langerhans cells (LC), the only dendritic cell (DC

200 LHP1), for consequent deposition of H3K27me3 marks, leading to repression of DOG1 expression.

201 ssociated with male sex, bileaflet prolapse, marked leaflet redundancy, mitral annulus disjunction (M

202 Our data show evidence of marked levels of tissue repair in the human donor pancre

203 Behaviourally, patients with svPPA manifest marked lexico-semantic impairments including difficultie

204 A single acetylation mark lysine258 on ACO2 functioned as a regulatory motif,

205 ally exclusive home ranges emerge from scent mark-mediated avoidance responses to neighbouring groups

206 of the choroid plexus and ependymal lining, marked meningitis, and 100% mortality within 2 weeks pos

207 Our findings implicate a marked nonvascular disruption in T1D of several essentia

208 le episcleritis are common defined as a good mark of IBD activity.

209 rmed BAF is a fast, accurate, and persistent mark of nucleus rupture whose kinetics are partially dic

210 Evaluating predictive epigenomic marks of smokers in peripheral blood may allow for targe

211 widespread response at episode onset, plus a marked offset response specific to DMN regions.

212 s and spreads repressive histone methylation marks on eukaryotic chromosomes.

213 ding repressive H3K9me3 and H3K27me3 histone marks on extracellular matrix gene promoters and active

214 ansferase responsible for placing activating marks on gene bodies.

215 lar matrix gene promoters and active H3K4me3 marks on interleukin, defensin, and chemokine gene promo

216 and generate 5-hydroxymethylcytosine (5hmC) marks on the genome.

217 acterized by repressive H3K9me3 and H3K27me3 marks on typical dentinogenesis-related genes.

218 e Devonian Frasnian-Famennian (F-F) boundary marks one of the five main extinction intervals of the P

219 transferases mediating inheritance of methyl marks onto nascent DNA over cycles of replication.

220 83 Ma) was a turning point in Earth history, marking permanent changes to terrestrial ecology, geoche

221 ORs for any moderate/marked physician-assessed breast NTE (shrinkage, indurat

222 Frizzled-7 marks platinum-tolerant cancer cells harboring stemness

223 primed chromatin landscape, with bivalently marked primed pluripotency genes.

224 Expression of CD71 marks proliferating neutrophils, which were expanded in

225 ent state transition, with lower ROS content marking proliferative activity and differentiation.

226 Peanut allergy (PA) is associated with marked quality-of-life (QoL) impairment.

227 tion of histone-variant H2AX (gamma-H2AX) to mark radiation-induced foci (RIFs).

228 hether mammalian YTH domains are also methyl mark readers of N6mA DNA.

229 al sea turtle species, combined with capture-mark-recapture data extending over 50 years, we show how

230 We used a 26-year capture-mark-recapture dataset of 3,330 black brent Branta berni

231 in burned and unburned areas using a genetic mark-recapture framework.

232 Abundance and survival were estimated with mark-recapture using PIT tags, and the annual spawning r

233 In addition, KI mice demonstrated a marked reduction in Cfl2 mRNA levels in various tissues

234 which can lead to thrombocytopenia showing a marked reduction in platelet counts, and dengue hemorrha

235 Further metabolomic analyses revealed a marked reduction in storage lipids and an increase in me

236 We find a marked reduction in the evolutionary diversity of commun

237 e virus infection, the MEG-01 cells showed a marked reduction in the surface expression of platelet m

238 synuclein preformed fibrils, and we observed marked reductions in alpha-synuclein aggregation and neu

239 hyla, near elimination of Bacteroidetes, and marked reductions in cecal short-chain fatty acids.

240 Marked reductions in the chemokine Ccl2 and the pro-infl

241 These differentially marked regions showed both losses and gains of 5hmC afte

242 to read H3K27me3 and unmodified H3K4 histone marks, respectively, in Arabidopsis.

243 IR region, performed at 4 degrees C, lead to marked sensitivity improvements over conventional optoac

244 ic cancer cell line screens and discovered a marked sensitivity of hematological cancer cell lines, i

245 The marks serve as sites for candidate cis-regulatory elemen

246 Owing to the marked sexual dimorphism of hepatocellular carcinoma (HC

247 Microbiome signatures showed marked shifts in taxonomic levels in patients with bacte

248 eous, and climatic factors may have driven a marked slowdown observed at higher latitudes.

249 increasing the percentage of DMPC leads to a marked slowing of CNTP diffusion.

250 Marked snowmelt across the surrounding periglacial envir

251 munity of Aguada Fenix probably did not have marked social inequality comparable to that of San Loren

252 The gut microbial community exhibited marked spatial variation across populations with the low

253 Pax7 expression marks stem cells in developing skeletal muscles and adul

254 Epigenetic marks such as trimethylation of histone H3 lysine 36 (H3

255 common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost.

256 Marked systemic elevation in C5a activity was demonstrat

257 CD29 also marked T cells with cytotoxic gene expression from diffe

258 We evaluated resection specimens with marked target fields from 151 consecutive EC patients tr

259 The marked technical variability, high amounts of missing ob

260 nificant Endocardial-epicardial dissociation marked temporal heterogeneity, discordant and transition

261 itherto been principally restricted to scent-marking territorial animals, so its potential breadth of

262 ated from segmented micrographs and boundary marked tetrahedral meshes which are compatible with simu

263 l than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis

264 entromere protein A (CENPA) is an epigenetic mark that determines centromere identity.

265 of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional

266 ) is essential for maintenance of methyl-DNA marks that stabilize Treg cellular identity by repressin

267 Selective autophagy receptors (SARs) mark the cargo for degradation and, in yeast, recruit At

268 gnitive offloading opportunity: an option to mark the target locations with tokens during the hiding

269 n-state fluctuations, and extended dilations mark the transition to more arousable states.

270 e culinary fat addition whose FA composition marked the meat.

271 that the earliest ribozymes, whose emergence marked the origin of life, were low in activity but high

272 utions represent a turning point in history, marking the beginning of the modern rise of democracy.

273 etazoan diversity and ecological complexity, marking the inception of the Cambrian Explosion.

274 April 22, 2020, marks the 50th anniversary of Earth Day and the birth of

275 This marks the first report where a photoactivatable donor fo

276 This study marks the first use of CRISPR/Cas9 HDR for gene integrat

277 lightly behind the morphogenetic furrow that marks the front of PR differentiation, the migrating SG

278 Their data indicate that seipin/Nem1 marks these sites and provide a detailed working model f

279 vel workflows for the analysis of epigenetic marks, time series experiments, and single cell data.

280 -terminal posttranscriptional modifications (marks) to histone H3 lysines (H3K4me3, H3K4me1, H3K27ac,

281 requires minimum H3K27me3 levels and how the mark transmits faithfully across mammalian somatic cell

282 A less marked trend was seen for diabetes (rate ratio, 1.55; 95

283 mperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas.

284 Ischemia-reperfusion triggered marked unilateral CX3CR1-CCR2 dependent accumulation of

285 In contrast, during NMP, there was marked upregulation OXPHOS genes, but also of a number o

286 In vivo application of secretin induced a marked urinary alkalization, an effect absent in mice la

287 mporary period since 2018; and (3) there was marked variability in allocation of HCV+ hearts at the O

288 tients undergoing PCI treated with MCS, with marked variability in its use and associated outcomes.

289 The authors report marked variation in buffering capacity, correlated with

290 Despite marked variation in tissue architecture and regenerative

291 oximately half of the heart still allows for marked vulnerability to injury.

292 Based on genomic profiles of ten chromatin marks, we conclude that the relationship between active

293 in its resistant NIL; (ii) DBSs for H3K27me3 mark were more abundant (> 80%) in intergenic regions, w

294 RA-regulated epigenetic marks were identified near RA target genes already known

295 shed a high-resolution 3D model of molecular marked whole laryngeal cancer by optimizing the currentl

296 DNA methylation is an epigenetic mark with important regulatory roles in cellular identit

297 d new microtubule growth initiated at puncta marked with fz, dsh, Axin, and Rab5.

298 ipt levels, with more than 2000 genes stably marked with this modification throughout asexual develop

299 eport, here, advances starting from identity marking with a genetically encoded fluorophore.

300 detected, the location and function of this mark within the infectious cycle is unknown.