ライフサイエンスコーパス: markedly reduce

1 in 2 in lesional skin of these patients were markedly reduced.

2 Levels of Abeta peptides and plaques were markedly reduced.

3 ssociation of both CD79a and CD79b to IgM is markedly reduced.

4 absent, both colonization and virulence were markedly reduced.

5 c T-cell responses following vaccination was markedly reduced.

6 ients with destabilizing STAT3 mutations was markedly reduced.

7 t and migration to recipient lymph nodes was markedly reduced.

8 stasis in triple-negative breast cancer were markedly reduced.

9 , and variability and noise correlations are markedly reduced.

10 ed by necrotic Il1a(-/-) cardiomyocytes were markedly reduced.

11 phosphorylation in patients' lymphocytes was markedly reduced.

12 proliferation and survival of CRPC cells is markedly reduced.

13 lative to baseline, depressive symptoms were markedly reduced 1 week (mean QIDS difference -11.8, 95%

14 ons that were affected clinically and showed markedly reduced [(18) F]FDG uptake.

15 Gene expression of TNFalpha was markedly reduced (80%), whereas IL-6 gene expression was

16 neurons in the presence of astrocytes showed markedly reduced AbetaO binding and synaptopathy.

17 The Y315A mutant also showed a markedly reduced ability to assemble into viral particle

18 ), but not IFN-gamma(-/-), CD4 T cells had a markedly reduced ability to cause tissue damage in liver

19 s with R47H TREM2 mutations, microglia had a markedly reduced ability to envelop amyloid deposits.

20 s using electron transfer dissociation (ETD) markedly reduced adduct loss.

21 increased disorder of the middle module and markedly reduced affinity for Pol II.

22 the enamel Ca/P ratio and microhardness were markedly reduced after miR-224 agomir administration.

23 ith Chlamydia, CCR7-deficient mice displayed markedly reduced Ag-specific CD4 T cell responses within

24 ed, effectively blocking HIV replication and markedly reducing AIDS morbidity and mortality.

25 concomitant administration of ascorbic acid markedly reduces AKI risk, allowing safer use of colisti

26 ministration of exogenous recombinant Sema3E markedly reduced allergen-induced neutrophil recruitment

27 (MASP)-1/3(-/-) mice contains pro-FD and has markedly reduced alternative pathway activity.

28 Knockdown of eIF4GI also markedly reduces an equol-mediated increase in IRES-depe

29 f CHF and found that muscle regeneration was markedly reduced and that this was accompanied by blunte

30 A single overnight fast, which markedly reduces anxiety-like behavior in rats, reduces

31 e-specific APE1 mutant Y128A, which displays markedly reduced AP-DNA complex stability, did not exhib

32 ession of a dominant-negative Rab5 construct markedly reduced APP-induced axonal blockage in Drosophi

33 Both serpins markedly reduce arterial inflammation and plaque in rode

34 ssion of both the mutant SDR9C7 proteins was markedly reduced as compared to wild-type protein, sugge

35 Evolocumab markedly reduces atherogenic lipoproteins in patients wi

36 lective small-molecule MAP4K4 inhibitor also markedly reduces atherosclerotic lesion area.

37 isplatin together, but not as single-agents, markedly reduces BC growth and metastasis.

38 and found they were smaller in size and have markedly reduced bone mass compared to WT.

39 binant AAV-mediated transgene expression was markedly reduced, both in vitro and in vivo.

40 ith CpG sites, whose methylation levels were markedly reduced by 5-Aza-dC.

41 was accompanied by C5a upregulation and was markedly reduced by C5a receptor (C5aR1) knock-out or tr

42 ion in vitro, because osteoclastogenesis was markedly reduced by IL-8-specific neutralizing antibodie

43 decreases in pH are preceded by Na(+) entry, markedly reduced by inhibition of Na(+)/HCO3(-) cotransp

44 ar [Au(CN)2](-) when the open probability is markedly reduced by introducing a second mutation, G1349

45 ht phase centred on ca. 1.8-1.1 ka BP led to markedly reduced C accumulation and potentially a hiatus

46 Nanomolar concentrations of C1572 markedly reduced c-MYC (MYC) protein levels via a protea

47 Mutating these highly conserved residues markedly reduces c-di-GMP binding and biofilm formation

48 2L; numbered including the start-Met), which markedly reduces CaM Ca(2+) binding.

49 d to matriptase was that hepsin demonstrated markedly reduced capacity to activate proteinase-activat

50 , with FXXN motifs replaced by SXXV, shows a markedly reduced capacity to form oligomers.

51 id anti-miRNA inhibitors of these six miRNAs markedly reduced cardiac RNA-induced cytokine production

52 es, whereas therapeutically, GM-CSF blockade markedly reduces cardiac disease.

53 le WNT inhibitors in mouse and rat CC models markedly reduced CC proliferation and increased apoptosi

54 oluble IL-33 receptor (IL-33 decoy receptor) markedly reduced CCI-induced hyperalgesia.

55 in total kidney volume and cystic index and markedly reducing CD45-positive cell infiltration.

56 This Ca(2+) depletion was followed by markedly reduced cell proliferation rates and morphologi

57 Furthermore, knockdown of SMILR markedly reduced cell proliferation.

58 mal maturation in the Golgi complex and show markedly reduced cell-surface expression.

59 ducts with excellent coverage uniformity and markedly reduced chimerism compared with products of liq

60 tease compromised VAC digestive function and markedly reduced chronic infection.

61 Disruption of C17orf89 markedly reduced CI activity, and its depletion is found

62 and mice expressing human APOC3 A43T display markedly reduced circulating apoC-III levels.

63 CpG-high infected mice also showed markedly reduced clinical severity, minimal weight loss

64 e five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and H

65 h frequent cardiac rupture, as the result of markedly reduced collagen fibril formation in the infarc

66 ckdown of 12-HETER1 in prostate cancer cells markedly reduced colony formation and inhibited tumor gr

67 tors, perfused through microdialysis probes, markedly reduced cortex susceptibility to CSD, but also

68 -azacytidine and the HDAC inhibitor butyrate markedly reduced CSC abundance and increased the overall

69 l kinase inhibition and NF-kappaB inhibition markedly reduced cyclobutane pyrimidine dimers-positive

70 reatment with tolvaptan or pasireotide alone markedly reduced cyst progression and in combination sho

71 genes in graft-versus-host disease skin and markedly reduced dermal IFN-alpha levels.

72 nhanced encephalographic slow-wave activity, markedly reduced diffuse axonal damage in the cortex and

73 the contrast-modulated gratings, albeit with markedly reduced discrimination performance.

74 Depletion of CD11c(+) cells markedly reduced disease severity due to impaired enrich

75 e find that in vivo administration of PRN694 markedly reduces disease progression, T cell infiltratio

76 interaction, modestly reduced stability, and markedly reduced DNA binding in gel shift assays and as

77 reas hypertonic and isotonic enemas provided markedly reduced drug retention in colorectal tissue.

78 Visual sensitivity is markedly reduced during an eye movement.

79 strated that plasma clearance of cortisol is markedly reduced during critical illness, explained by s

80 dularity-a measure of network segregation-is markedly reduced during episodic memory retrieval relati

81 Adverse reactions were markedly reduced during OIT escalation in omalizumab-tre

82 pared to that in RW, spatial selectivity was markedly reduced during random foraging and goal-directe

83 etion of this element in cultured human SMCs markedly reduced endogenous ARHGAP42 expression.

84 in NCKX4(-/-);CNGB1(DeltaCaM) mice displayed markedly reduced EOG amplitude accompanied by alteration

85 se DDI-1-dependent degradation, resulting in markedly reduced expression at presynaptic terminals.

86 We show that there is markedly reduced expression of E1B 20K in Ad14p1-infecte

87 s that are induced during quiescence despite markedly reduced expression of Exportin-5, a protein req

88 ng short hairpin RNA against PKCalpha showed markedly reduced expression of PKCalpha, but normal PKCz

89 Intriguingly, NO markedly reduced expression of the E3 ubiquitin ligase s

90 ibits xenograft cancer growth accompanied by markedly reduced expression of TNBC signature genes.

91 were virtually absent in cones and displayed markedly reduced F-actin content in rods, suggesting tha

92 ) mice displayed normalized estrogen levels, markedly reduced fat accumulation, and improved glucose

93 RVXB markedly reduced fibrin deposition, suggesting reduced i

94 hicle had lower cardiac weights (P<0.01) and markedly reduced fibrosis in peri-infarct and remote myo

95 and phagocytic cup formation, but displayed markedly reduced filopodia formation.

96 angiogenesis, and epidermal hyperplasia were markedly reduced following irradiation.

97 Consequently, FOXA1 binding events are markedly reduced following TET1 depletion.

98 in platelet-leukocyte complex formation and markedly reduced generation of factor Xa and thrombin on

99 Here, we report markedly reduced glucose-responsive plasma insulin and C

100 Notably, sTLR2 treatment markedly reduced Gram-positive and -negative bacteria-in

101 o systemic passive immunization, we observed markedly reduced (>/=80-90%) hippocampal insoluble patho

102 We found that microbial metabolism markedly reduces gut pH and redox potential through the

103 Feeding hamsters HCHFD markedly reduced hepatic Acsl1 mRNA and protein levels a

104 Depletion of Tpr markedly reduces HIV infectivity, but not the level of i

105 F573 markedly reduced human and mouse islet apoptosis after i

106 The pan-caspase inhibitor F573 markedly reduces human and mouse islet apoptosis and imp

107 In contrast, BAFF overexpression markedly reduced hypercholesterolemia and atherosclerosi

108 In purified stimulated human B cells, 9cRA markedly reduced IgE production and enhanced IgA product

109 Our findings suggest that GABA production is markedly reduced in a subset of boutons in the PFC of sc

110 C6) and the related family member HDAC10 are markedly reduced in adipose tissues of obese animals and

111 This phosphorylation was markedly reduced in assays using a palmitoylation-defect

112 wever, hepatic HNF1alpha protein levels were markedly reduced in BBR-treated animals as compared with

113 ity for oxidative damage repair of mtDNA was markedly reduced in both XPD-suppressed human osteosarco

114 Notably, proliferation was markedly reduced in breast biopsies from BRCA1-mutation

115 rogated in FcRgamma chain-deficient mice and markedly reduced in C5aR1-deficient mice.

116 Finally, basal levels of autophagy were markedly reduced in C9ALS/FTD patient-derived iNeurons.

117 n of the Per2-regulatory miRNA, miR-92a, was markedly reduced in CD34(+) cells from individuals with

118 a compared with resting basal conditions and markedly reduced in classically activated polarized cell

119 natural killer T cells and neutrophils were markedly reduced in ConA-treated HSC-depleted mice compa

120 2+) ]i responses in medullary astrocytes was markedly reduced in conditions of MeCP2 deficiency, wher

121 rast to EoE, eotaxin-3 mRNA and protein were markedly reduced in EoE-like disease (P < 0.05).

122 (54)Mn uptake after intragastric gavage was markedly reduced in ffe/+ mice (0.0187 vs. 0.0066% dose;

123 necessary for clearing damaged myelin, were markedly reduced in GALC +/- animals.

124 LKB1 expression was markedly reduced in human plaques when compared with non

125 e of Mo-mediated AKI and subsequent CKD were markedly reduced in IL-34-deficient mice compared with c

126 osphine oxide-1-sensitive K(+) currents were markedly reduced in isolated vascular smooth muscle cell

127 ator of mesenchyme proliferation, Hbegf, was markedly reduced in Jag1-mutant valves.

128 genesis and luminal cell differentiation, is markedly reduced in mammary epithelial cells of transgen

129 er, HlyA-induced [Ca(2+)]i oscillations were markedly reduced in medullary thick ascending limbs isol

130 ow that hepatic carboxylesterase 2 (CES2) is markedly reduced in NASH patients, diabetic db/db mice,

131 In addition, viral transcription was markedly reduced in neurons latently infected with VOka

132 d nuclear localization of activated STAT1 is markedly reduced in NOD CD11c(+) cells, consistent with

133 increased and long-chain acylcarnitines were markedly reduced in PAH versus controls.

134 of combined use, levonorgestrel exposure was markedly reduced in participants who received efavirenz-

135 lear factor 4alpha (HNF4alpha) and CES1 were markedly reduced in patients with alcoholic steatohepati

136 tal muscle strength, velocity, and power are markedly reduced in patients with heart failure, which c

137 We also found that p53 expression is markedly reduced in PCBP4-deficient MEFs and mouse tissu

138 ffect of pKa on the rate of dark recovery is markedly reduced in PixD.

139 exon 5 of RASGRP2 CalDAG-GEFI expression was markedly reduced in platelets from all patients, and by

140 The total leukocyte content was markedly reduced in SCLC compared with lung ADCA, which

141 PD-1 and CTLA-4 expression was significantly markedly reduced in T cells by both agents.

142 The CCDC3 expression is markedly reduced in TAp63-null mouse embryonic fibroblas

143 that association of TbTim17 with mHSP70 was markedly reduced in TbTim62 KD mitochondria.

144 is), neurodegeneration, and cell death, were markedly reduced in Tg-C73A and dasatinib-treated non-Tg

145 of histone tails at H4R3 and H3R2/8/17 were markedly reduced in the 2- and 4-cell embryos.

146 damage or by PLK4 or CDK2 overexpression was markedly reduced in the absence of C-NAP1.

147 ncidence of spreading depolarization (SD) is markedly reduced in the absence of microglia.

148 ls and the total number of Gr1(+) cells were markedly reduced in the bone marrow, along with an incre

149 find XDH1 activity or tRNA thiolation to be markedly reduced in the grxs17-1 mutant.

150 syndrome, GABAergic terminal projections are markedly reduced in the Kolliker-Fuse nucleus (KF) in th

151 hermore, podocyte endocytosis of albumin was markedly reduced in the presence of gentamicin, a compet

152 rgely due to K63-linked ubiquitin chains and markedly reduced in the substantia nigra compared with t

153 ccumulation and M1 chemokine expression were markedly reduced in these knock-out mice.

154 e depolarization, and Ca(2+) fluxes were all markedly reduced in transgenic mouse islets, whereas glu

155 ltant population, designated CMG28, displays markedly reduced in vitro dependence on centrifugation f

156 n by occlusion of the middle cerebral artery markedly reduced infarct size, and this correlated with

157 Notably, blockade of TIM-3 markedly reduces infarct size, neuronal cell death, oede

158 resistance after antibiotic treatment could markedly reduce infections, particularly those caused by

159 roglia from miR-155(-/-) mice, we observed a markedly reduced inflammatory response to alpha-syn fibr

160 chain p33, with or without C-terminal KDEL, markedly reduced inhibitory activity.

161 Substitution of the Lys residues to Glu markedly reduced integrin binding of E128K IL-1beta, sug

162 Section of the corpus callosum markedly reduced interhemispheric functional connectivit

163 Intestine HIF-2alpha inhibition markedly reduced intestine and serum ceramide levels.

164 , CCR2 deficiency in mdx(5cv)-Ccr2(-/-) mice markedly reduced intramuscular Ly6C(hi) MPs at all stage

165 ibodies recognizing the integrin alpha5beta1 markedly reduced invasion, suggesting an important role

166 icantly increased the half-life of PIM1, and markedly reduced its ubiquitylation.

167 eletion of the gene encoding MMCP-4 (Mcpt4), markedly reduced late, but not early, infarct size by su

168 out-of-hospital cardiac arrest do not have a markedly reduced left ventricular ejection fraction.

169 urine model of alcoholic steatohepatitis and markedly reduced lethality following endotoxin-mediated

170 Furthermore, E6201 markedly reduced leukemia burden and improved the surviv

171 Indeed, although R36A(pc-) exhibited a markedly reduced level of inhibition of the IgG response

172 of the PVT1 gene, as a circular RNA showing markedly reduced levels in senescent fibroblasts.

173 ranasal instillation of the allergen induced markedly reduced levels of airway eosinophils, CD4(+) ly

174 n, dual solution cross-maze) and also showed markedly reduced levels of anxiety (elevated plus maze,

175 In contrast, it markedly reduced levels of both plasma ketone bodies and

176 ng, mutants of some of these genes exhibited markedly reduced levels of eDNA and a concomitant reduct

177 tion required for antibody functionality and markedly reduced levels of endotoxin contamination.

178 describe a new noise reduction approach that markedly reduces LF-DFM image artifacts to allow sensiti

179 Here we show that a diverse microbiota markedly reduces Listeria monocytogenes colonization of

180 e, muscarinic acetylcholine (ACh) activation markedly reduced locomotor activity in DD mice.

181 ich are highly expressed by retinal neurons, markedly reduced loss of neurons and optic nerve axons i

182 protein convertase subtilisin/kexin type 9), markedly reduces low-density lipoprotein cholesterol acr

183 IRF5 deficiency markedly reduced lupus disease severity.

184 led to impaired mitochondrial function, with markedly reduced maximum respiration rate, reserve respi

185 his uptake resulted in enhanced survival and markedly reduced metastasis.

186 3 cells displayed glycolytic dependence with markedly reduced mitochondrial and glycolytic reserve, f

187 Metformin treatments markedly reduced mitochondrial fragmentation, mitigated

188 Cyp-D and pharmacologic inhibition of Cyp-D markedly reduced mitochondrial transcription to 18 +/- 5

189 tochondrial tRNA(Ser(AGY)) undetectable, and markedly reduced mitochondrial translation, except polyp

190 ile along the flagellar shaft and displays a markedly reduced mobility near the flagellar tip.

191 ciated with significant organ protection and markedly reduced mortality compared with nontreated cont

192 Despite markedly reduced mRNA and intracellular H2-K levels, we

193 rosis factor-alpha (TNF-alpha) secretion and markedly reduced neuronal viability compared with neuron

194 CC0417 treatment markedly reduced neutrophil, macrophage, and platelet ac

195 Postinjury inflammation markedly reduces newborn neuron survival.

196 e, UUO-treated IL-36 knockout mice exhibited markedly reduced NLRP3 inflammasome activation and macro

197 In contrast, mice that have markedly reduced numbers of nonclassical monocytes (CX3C

198 e E64K ground-state stabilizing substitution markedly reduced or ablated soluble CD4 (sCD4) induction

199 The expression of all KIRs tended to be markedly reduced or absent in NKTCL, except for the KIR

200 ersal infant immunization-related benefit of markedly reduced overt HBV infection.

201 ssion, and dual knockdown of TEAD3 and TEAD4 markedly reduced p16 expression in heterozygous HAoSMCs.

202 ] to 687 [533-882] cells/mm3; P < .001), and markedly reduced percentages of circulating activated CD

203 in wild-type and Tph1(-/-) mice, which have markedly reduced peripheral serotonin levels.

204 vitro, Met(fl/fl); Wnt1Cre+ mouse bowel had markedly reduced peristalsis in response to mucosal defo

205 ubfractions; at either A3GALT2 or NRG4, with markedly reduced plasma insulin C-peptide concentrations

206 n monoclonal antibody that targets IL-1beta, markedly reduces plasma levels of IL-6, hsCRP, and fibri

207 Laparoscopy has been associated with markedly reduced postoperative pain but has not been wid

208 Partial model calibration (stages 2-4) markedly reduced prediction errors of the full model ens

209 ctively taking the perspective of others can markedly reduce prejudice for at least 3 months.

210 Adiponectin knock-out mouse colons had markedly reduced proliferation and increased epithelial

211 ed by high concentrations of inhibitors that markedly reduce proteasome activity [4].

212 ted muscles increased protein synthesis, but markedly reduced protein degradation only in innervated

213 ne operation, had normal clotting times, but markedly reduced prothrombin consumption.

214 he AT2 stem cell population, Etv5 deficiency markedly reduced recovery following bleomycin-induced lu

215 DC-specific deletion of beta-catenin in mice markedly reduced regulatory T-cell responses and delayed

216 and clofarabine treatments (38% +/- 3) but a markedly reduced relapse rate (44% +/- 3 vs 35% +/- 3) i

217 Acetate had similar effects and markedly reduced renal fibrosis.

218 reated proteinuric rats, paricalcitol showed markedly reduced renal lymphangiogenesis.

219 microinjections of glutamatergic antagonists markedly reduced reticulospinal neuron responses, indica

220 , low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis (Ribi).

221 Both groups had markedly reduced rod and cone responses, but nonsyndromi

222 th bevacizumab for treatment of DME, using a markedly reduced sample size relative to a full comparat

223 ta indicate that exposure to house dust mite markedly reduces Sema3E expression in mouse airways.

224 53Q mutation impaired surface expression and markedly reduced sensitivity to glycine.

225 clude that BMT at a very early stage in life markedly reduces signs and symptoms of MPS I before they

226 The AAV treatment markedly reduces SLN expression, attenuates muscle patho

227 The CCT domain defective animals displayed markedly reduced SPAK activity and phosphorylation of NC

228 ation of Srebf-2 in hepatocytes of mice also markedly reduced SREBP-1c and the expression of all gene

229 use model, knocking down endogenous DARPP-32 markedly reduced SRp20 and CD44E protein levels with a d

230 verexpressing fibrosarcoma cells, we found a markedly reduced stretch of cell area, indicative of a s

231 g osteocalcin (Ocn)-expressing cells in vivo markedly reduces T-competent progenitors and thymus-homi

232 A point mutation in this motif markedly reduces TF-FVIIa association with integrins, at

233 a silencing and antibody-mediated inhibition markedly reduce the ability of TOV21G OCC cells to form

234 of potent selective AR degraders (SARD) that markedly reduce the activity of wild-type and splice var

235 d uses the heterogeneity within WGS reads to markedly reduce the dimensionality of next-generation se

236 tegrated quantum optics has the potential to markedly reduce the footprint and resource requirements

237 mice and that combined inhibitor treatments markedly reduce the mRNA translational state of cyclin D

238 intestinal UPEC reservoirs, mannosides could markedly reduce the rate of UTIs and recurrent UTIs.

239 Finally, the presence of ApN markedly reduced the activity of NF-kappaB, a key player

240 hain for activation, phosphorylation of Rlc1 markedly reduced the affinity of Myo2 for actin.

241 l mutations introduced in the same location, markedly reduced the affinity of TREM2 for ApoE.

242 and region I+II (D51/E52/E55/D166A) mutants markedly reduced the attachment between syt-1 and t-SNAR

243 downstream effects of enhanced sodium entry, markedly reduced the burden of AF and ventricular arrhyt

244 ectrophysiology-guided cardiac radioablation markedly reduced the burden of ventricular tachycardia.

245 itters GABA or glutamate within this circuit markedly reduced the capacity for prolactin action both

246 y of Cdkn2a, especially p16Ink4a deficiency, markedly reduced the craniofacial anomalies of TASP1-def

247 Blockade of CD80/CD86 with CTLA-4-Ig markedly reduced the cycling and absolute numbers of MP

248 ajor element regulating sGCbeta1 expression, markedly reduced the efficacy of LBH-589 in augmenting s

249 phosphorylation site for basophilic kinases, markedly reduced the endocytosis, whereas phosphomimetic

250 Treatment also markedly reduced the expression of programmed death-liga

251 n of lipid-associated genes in the liver and markedly reduced the expression of the non-rhythmically

252 The restriction starch hydrolysis rate markedly reduced the GI of biscuits.

253 EV therapy also markedly reduced the large renal transcriptome drift obs

254 Anacetrapib markedly reduced the LDL-ApoB-100 pool size (PS) in both

255 However, TMPAP catalytic activity markedly reduced the magnitude of BOLD fMRI responses tr

256 LPS/IFN-gamma markedly reduced the nuclear level of histone deacetylas

257 vo with the small-molecule inhibitor AZD4547 markedly reduced the number and size of metastatic nodul

258 ABA reuptake blocker in MECP2 deficient mice markedly reduced the occurrence of central apnoeas.

259 eletion of Tgfbr1/2 or Smad3, but not Smad2, markedly reduced the pressure overload-induced fibrotic

260 Similarly, retinoid cycle inhibition markedly reduced the steady-state amplitude of melanopsi

261 Moreover, chemogenetic silencing of AmPir markedly reduced the stress hormone response to predator

262 We found MTX markedly reduced the threshold for AICAR-induced AMPK ac

263 Oxalate-vanadium complexes markedly reduced the vanadinite stability field, with ca

264 nB2 meshwork, impairs neuronal survival, and markedly reduces the cellularity of adult retinas.

265 icated that knockdown of endogenous DARPP-32 markedly reduces the expression of CD44 V8-V10 (CD44E).

266 he green fluorescent protein-coding sequence markedly reduces the levels of gfp mRNA expression in S.

267 ncing to show that RKIP expression in tumors markedly reduces the number and metastatic potential of

268 tion of the scaled Deltadelta(15) N approach markedly reduces the previously reported differences in

269 c plaques does not influence lesion size but markedly reduces the relative fibrous cap area in plaque

270 Genetic deletion of TMEM16A markedly reduces the spontaneous activity of IHCs and sp

271 l also describes an alternative strategy for markedly reducing the length and the costs of the differ

272 groups on the MPI by N-ethylmaleimide (NEM) markedly reduced this rate constant to kMPI-NEM=1.3 +/-

273 d compared with controls, the knock-outs had markedly reduced thyroxine levels ( approximately 50-80%

274 Monoclonal antibody treatment markedly reduced tissue pathology, placental and fetal i

275 ncy of the lesion, the bypass efficiency was markedly reduced (to 1-10%) in the isogenic cells defici

276 ype (WT) mice, P-deficient (P(-/-)) mice had markedly reduced total and eosinophil cell counts in BAL

277 BCNPs have superior therapeutic efficacy and markedly reduced toxicity as compared to the nontargeted

278 last lineage (P-Gsalpha(OsxKO) mice) yielded markedly reduced trabecular and cortical bone mass.

279 ) of Micu2(-/-) ventricular tissues revealed markedly reduced transcripts encoding the apelin recepto

280 lay in tumor progression was associated with markedly reduced tumor fibrosis and decreased numbers of

281 se model, keratinocyte-specific D3 depletion markedly reduced tumor growth.

282 sticity and stemness activities in vitro and markedly reduces tumor growth and metastasis in vivo thr

283 pressing CRPC cell line and xenograft models markedly reduces tumor growth through inhibition of mTOR

284 overexpression in head and neck cancer cells markedly reduces tumor growth.

285 atic cancer cells into nude mice resulted in markedly reduced tumorigenicity (P < 0.001) and distant

286 codes antiapoptotic BCL-xL) mRNA levels were markedly reduced upon volasertib treatment in MCF7/LTED

287 dies showed that this mutation resulted in a markedly reduced uptake activity of taurocholic acid.

288 at positions 306 and 314 (termed M1 and M7) markedly reduced V3 antigenicity while improving the pre

289 mosquitoes infected with these strains show markedly reduced vector competence.

290 tudy, and systemic administration of the mAb markedly reduced viral lung titers.

291 led to induce host alkalinization and showed markedly reduced virulence in tomato plants, while elici

292 strain lacking these two effectors exhibits markedly reduced virulence, which is fully restored in B

293 Ophthalmologic findings included markedly reduced visual acuity, bull's eye maculopathy,

294 lung at 5 days postinfection (p.i.) and had markedly reduced weight loss, pulmonary inflammatory cel

295 P21 in the absence of dystroglycan and were markedly reduced when dystroglycan was ablated in adult

296 the right anterior insula and amygdala were markedly reduced when participants received painful ther

297 ; the percentage of intron retention (IR) is markedly reduced whereas that of alternative acceptor si

298 ined for centuries by traditional practices, markedly reduced while the number of woody species, asso

299 The intraepidermal nerve fibre density was markedly reduced with 90.5% of participants having a cou

300 The bacterial community diversity was markedly reduced with elevated Pb concentrations.