ライフサイエンスコーパス: maternal

1 lly to support fetoplacental development and maternal adaptation to pregnancy.

2 urodevelopment, which propose that antenatal maternal adversity operates through the biological pathw

3 ABSTRACT: Advanced maternal age (>/=35 years) is associated with increased

4 Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth restr

5 NHS was independently associated with lower maternal age (odds ratio [OR], 0.87; 95% CI, 0.78-0.94),

6 V viral load but was associated with younger maternal age (P = .02).

7 Maternal age and maternal height were associated with a

8 nce intervals, adjusted for confounders (eg, maternal age and parity).

9 To test whether advanced maternal age at birth independently increases the risk o

10 This suggests that maternal age can influence the timing of birth and proce

11 While advancing maternal age increased risk of leukemia and central nerv

12 Overall, each 5-year increment in maternal age was associated with a 3% increase in incide

13 98 births to AYA cancer survivors (mean [SD] maternal age, 31 [5] years) were included.

14 he number of incident neonatal infections by maternal age, and we generated separate estimates for ea

15 tios (aRRs) and 95% CIs, after adjusting for maternal age, country of origin, educational level, coha

16 logistic regression analyses, adjusting for maternal age, ethnicity, birth country and weight, as we

17 ght gain, and preterm birth rate, but not in maternal age, parity, socioeconomic or behavioral charac

18 ts, but only when the mutations occur on the maternal allele.

19 To study whether maternal allergen sensitization affects offspring suscep

20 r-order chromatin structure from a condensed maternal and a naive paternal genome to generate a totip

21 grated strategy for community engagement and maternal and child health immunisation campaigns in inse

22 vention and treatment, water and sanitation, maternal and child health, basic education and literacy,

23 ices, and contracting out important areas of maternal and child healthcare led to a reduction in neon

24 stimated odds ratios for subsequent onset of maternal and child mental health problems associated wit

25 alth and sanitation interventions related to maternal and children's health.

26 We collected maternal and cord blood at delivery, measured manganese

27 corticosterone) were measured by LC-MS/MS in maternal and cord plasma from 259 Caucasian women at del

28 Both maternal and cord serum samples were assayed for levels

29 We therefore used different combinations of maternal and embryo SERT Ala56 genotypes to examine effe

30 l ablation of BAT prior to conception caused maternal and fetal hyperlipidemia, and consequently larg

31 ence or prevalence data to estimate cases of maternal and fetal infection/stillbirth, and infants wit

32 of r-AKI associated with subsequent adverse maternal and fetal outcomes, including preeclampsia.

33 eling and diagnostic evaluation to determine maternal and fetal risk but also on how to manage them o

34 in cord blood were inversely associated with maternal and GPx levels in cord blood as well as materna

35 Maternal and infant anthropometry were followed until th

36 es were adjusted for potentially confounding maternal and infant variables, children born at 23 to 24

37 Maternal and inherited (ie, case) genetic factors likely

38 that GBS is a leading contributor to adverse maternal and newborn outcomes, with at least 409000 (UR,

39 This study compared maternal and offspring anthropometry for moderately maln

40 on the neurobiological mechanisms underlying maternal and paternal care, especially in rodents, and d

41 Both maternal and paternal older ages were associated with ri

42 models demonstrates the influence that both maternal and paternal stress exposures have in changing

43 ely 5% of pregnancies, is a leading cause of maternal and perinatal death.

44 sulfadoxine-pyrimethamine (SP) in preventing maternal and placental malaria.

45 Combined maternal and zygotic knockout further revealed Aire's cr

46 ared siblings while adjusting for pregnancy, maternal, and paternal traits, first-trimester antidepre

47 Our findings suggest that differences in maternal anthropometrics, gestational weight gain, and p

48 ncy Tdap vaccination significantly increases maternal antibody concentrations in consecutive infants.

49 Maternal antidepressant medication use during pregnancy

50 To examine the association of maternal antidepressant medication use during pregnancy

51 Maternal asthma increased the risk of preeclampsia.

52 for breast cancer in her mother, sister, and maternal aunt.

53 No linear association was observed between maternal B12 levels in pregnancy and birth weight, but B

54 tanding of processes and mechanisms by which maternal behavior influences the developing human brain

55 sults of this study suggest that synchronous maternal behavior is associated with increased dopamine

56 tal Flt1 mRNA levels strongly correlate with maternal blood pressure.

57 lasts, cells that lie in direct contact with maternal blood, and show that these cells recapitulate t

58 alysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in ne

59 An estimated 45% of the association between maternal BMI and rates of cerebral palsy in full-term ch

60 e aimed to determine if associations between maternal body mass index (BMI) and offspring systemic ca

61 of the fundamental components comprising the maternal brain are innate and sex specific.

62 mental differences in neural activity in the maternal brain reflect the building of parental capacity

63 the trade-offs associated with the length of maternal care in leopards in the Sabi Sand Game Reserve,

64 rd trimester of pregnancy would prevent most maternal cases.

65 Here we examined the effect of maternal CB intake on mouse hippocampal interneurons lar

66 ge, birthweight, parity and breast feeding), maternal characteristics (mother's age and place of birt

67 Infant and maternal characteristics, including receipt of perinatal

68 hat extent this association is confounded by maternal characteristics.

69 mprinting (LOI) at the IGF2/H19 locus on the maternal chromosome is associated with the developmental

70 ental vitamin D metabolism and its impact on maternal circulating vitamin D concentrations in humans.

71 amin D metabolism and its role in modulating maternal circulating vitamin D metabolites during pregna

72 nd whether transthyretin is carried into the maternal circulation via placental extracellular vesicle

73 endothelial cells, which disturbed the feto-maternal circulation.

74 Maternal CMV viruria was not associated with mean CD4 ce

75 magnitudes of associations were present for maternal compared with paternal BMI across these associa

76 Maternal complications included cardiogenic shock (24%),

77 mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and

78 decidua appears to be an initial step in the maternal component of the disease as well as bacterial t

79 in delivery-related variables and associated maternal conditions based on the place of delivery and t

80 ve to larval and pupal stages due to a large maternal contribution of CaMKII mRNA, which consists of

81 en BPA and 8-isoPF2alpha levels, and between maternal CRP levels and HNE-MA levels.

82 We recorded similar patterns for all other maternal death indicators, including the maternal mortal

83 Colonization of the maternal decidua appears to be an initial step in the ma

84 e is considerable T cell infiltration of the maternal decidua, the functional properties of this T ce

85 n regressions were used, with adjustment for maternal demographic, lifestyle, and dietary factors.Ref

86 erapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DNAC), in a mouse mode

87 cing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhes

88 Maternal DHT exposure, regardless of diet, decreased fet

89 Chicks from both maternal diet groups were fed the same diet after hatch.

90 Maternal diet-induced obesity increased miR-126 expressi

91 crease the risk of FGR, one of which is poor maternal diet.

92 We used a mouse model of maternal-diet induced obesity to define predictive corre

93 posure in wild-type offspring under standard maternal dietary fat amounts to test the effects of low

94 These results demonstrate that the maternal dietary fatty acid profile programs offspring a

95 in mothers having male offspring suggests a maternal disease specific mechanism.

96 The associations between maternal diseases and ADHD in offspring were analyzed us

97 ts from analyses assessing associations with maternal dispensations before pregnancy and with paterna

98 on, regulation of immunity and inflammation, maternal DNA inheritance, metabolism, and cellular survi

99 known modifiers, including low birth weight, maternal education, seizure disorder, kidney disease dur

100 his is replaced by what we have described as maternal educational immunity such that by young adultho

101 ells in the pup spleen were produced through maternal educational immunity.

102 DPPA3/Stella/PGC7, encoded by a maternal effect gene, is present in the nucleus and cyto

103 vpr-1 null mutants are maternal effect sterile due to arrested gonadogenesis fo

104 so resulted in aberrant egg morphology and a maternal-effect on embryonic chromosome segregation and

105 les of phytohormone signalling in regulating maternal effects.

106 Transplacental maternal engraftment (TME), the presence of maternal T c

107 The ability of maternal exercise to improve the metabolic health of fem

108 Maternal experience of abiotic environmental factors suc

109 Prospective questionnaires provided maternal exposure data; case status was established from

110 programming and transgenerational effects of maternal exposure to early-life stress on several phenot

111 ty to define predictive correlations between maternal factors and offspring insulin resistance.

112 postnatal life, influenced by both prenatal maternal factors and postnatal developmental cues.

113 Immunisation reduced maternal febrile influenza-like illness with an overall

114 sider regional differences, which may affect maternal, fetal, and/or neonatal health and physiology.

115 ry cytokines, which could ultimately perturb maternal-fetal tolerance during pregnancy.

116 es, with at least 409000 (UR, 144000-573000) maternal/fetal/infant cases and 147000 (UR, 47000-273000

117 ASD risk appears to increase with maternal fever, particularly in the second trimester.

118 d to an in-utero infection, acquisition from maternal flora, or postnatal acquisition from the hospit

119 Maternal folic acid (FA) protects against developmental

120 also propose a molecular "hand-off" between maternal Foxh1 and zygotic Foxa at these CRMs to maintai

121 ling in the CeL prevented the suppression of maternal freezing.

122 required for establishment of methylation at maternal gametic DMRs.

123 of preterm birth (<37 weeks' gestation) and maternal GBS colonization (GBS isolation from vaginal, c

124 Our adjusted estimate for maternal GBS colonization worldwide was 18% (95% confide

125 partmental model to estimate (1) exposure to maternal GBS colonization, (2) cases of infant invasive

126 nancies as the denominator, the incidence of maternal GBS disease was 0.38 (95% confidence interval [

127 derive pooled estimates of the incidence of maternal GBS disease.

128 ngly favor a genetic continuity model in the maternal gene pool.

129 It is known that maternal generation influences the development of next-g

130 Zygotic transcription was primarily from the maternal genome and included genes for basic cellular pr

131 matic nuclear RNAi but instead requires both maternal germline nuclear RNAi and chromatin-modifying a

132 birth (P = 0.001), but not parental age nor maternal gestational weight gain, were associated with N

133 A), and PFHxS were inversely associated with maternal glucose.

134 -alpha levels were inversely associated with maternal GPx levels.

135 However, maternal haemoglobin was not associated with risk of chi

136 ow-up, and more HBV genotype C infection and maternal HBsAg seropositivity.

137 ction is ongoing, the unique epidemiology of maternal HCMV infections appears discordant with strateg

138 additional 56 prespecified outcomes measured maternal health-care use, content of care, patient exper

139 Maternal age and maternal height were associated with a positive effect o

140 In healthy human pregnancies, maternal hepcidin concentrations are suppressed in the s

141 Inappropriately increased maternal hepcidin during pregnancy can compromise the ir

142 Ability of the tool to predict maternal HIV acquisition was assessed using the area und

143 The development of an effective maternal HIV-1 vaccine that could synergize with antiret

144 kely to be attributed to reduced exposure to maternal hyperglycaemia.

145 easing interest in the possible link between maternal hypothyroidism in the perinatal period and chil

146 agment receptor (FcRn)-dependent transfer of maternal IgG and OVA immune complexes (IgG-IC) via breas

147 Maternal immune activation (MIA) via infection during pr

148 We provide evidence that maternal immune activation hits a key neurodevelopmental

149 Findings support the role of maternal immune activity in fetal neurodevelopment, exac

150 The results suggest an association between a maternal immune response to NLGN4Y and subsequent sexual

151 fection will require the characterization of maternal immune responses capable of blocking transmissi

152 uterine mucosa without being rejected by the maternal immune system.

153 e of modifications to the local and systemic maternal immune system.

154 Maternal immunisation reduced the rates of low birthweig

155 to better inform GBS interventions including maternal immunization?

156 rrhythmias (OR, 31.8; 95% CI, 4.3-236.3) and maternal in-hospital mortality (OR, 79.1; 95% CI, 23.9-2

157 Rodent models reveal that disrupted maternal-infant interactions yield metabolic and behavio

158 Our findings support a role for gestational maternal infection and innate immune responses to infect

159 ital cytomegalovirus (cCMV) with the type of maternal infection as well as the lack of large-scale ne

160 Miscarriage affects 20% of pregnancies and maternal infections account for 15% of early miscarriag

161 A biological indicator of maternal inflammation (interleukin-6) that has been show

162 Maternal inflammation and diabetes increase the risk for

163 In addition, GDM+MIA heightened the maternal inflammatory state and gave rise to a new, spec

164 fficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenz

165 Maternal inheritance is often presented as the passive o

166 ion during mammalian evolution, possibly via maternal inheritance.

167 HFHS feeding perturbed maternal insulin sensitivity in late pregnancy; hepatic

168 Maternal intake of eicosapentaenoic acid (EPA; 20:5 n-3)

169 Higher average maternal interleukin-6 concentration during pregnancy wa

170 nvestigated the association between prenatal maternal lead exposure and epigenome-wide DNA methylatio

171 at first birth are associated with a longer maternal life span (P 1.4 x 10-3).

172 The change in maternal lipid, leptin and adiponectin concentrations du

173 Maternal loading of piRNAs in oocytes is further require

174 Studies were identified by the Maternal Malaria and Malnutrition (M3) initiative using

175 The maternal-mediated embryo defects are associated with cha

176 radigm, fetal microchimeric cells present in maternal mice were also tracked after parturition and st

177 Our findings show that maternal mito-nuclear incompatibility during Drosophila

178 gent coronary artery bypass surgery (27.5%), maternal mortality (4%), and fetal mortality (2.5%).

179 Maternal mortality declined by 8.9% per year between 199

180 her maternal death indicators, including the maternal mortality rate (1.7 per 1000 women of reproduct

181 lennium Development Goal 5 (75% reduction in maternal mortality ratio between 1990 and 2015).

182 It is the second leading cause of maternal mortality worldwide and may lead to serious mat

183 miR-430 is crucial for the clearance of maternal mRNA during maternal zygotic transition in embr

184 st in kinase activity links development with maternal mRNA translation and ensures irreversibility of

185 ryos decelerates the decay of m(6)A-modified maternal mRNAs and impedes zygotic genome activation.

186 Data from randomised trials suggest that maternal multiple micronutrient supplementation decrease

187 ved cognition suggests present reproductive, maternal, neonatal, and child health programmes focused

188 then routine immunization services and other maternal, neonatal, and child health programs in Africa

189 (collectively termed ODA+) to reproductive, maternal, newborn, and child health for 2013 and complet

190 NTERPRETATION: The increase in reproductive, maternal, newborn, and child health funding over the per

191 or 2013 and complete trends in reproductive, maternal, newborn, and child health support for the peri

192 s who were IUGR at birth because of moderate maternal nutrient reduction.

193 KEY POINTS: Maternal nutrient restriction induces intrauterine growt

194 ABSTRACT: Maternal nutrient restriction induces intrauterine growt

195 udy in 1001 healthy participants in the Pune Maternal Nutrition Study (PMNS), replication studies in

196 Maternal nutritional status is a key determinant of smal

197 birthweight (LBW; <2,500 g) may depend upon maternal nutritional status.

198 nt mechanisms explain why the combination of maternal obesity and offspring obesity leads to the most

199 perimental studies support causal effects of maternal obesity on offspring outcomes, which are mediat

200 Maternal obesity programmed increased adiposity and live

201 the United States leads to an improvement in maternal or child health outcomes.

202 No adverse maternal or neonatal events were identified as associate

203 Maternal or zygotic vpr-1 expression is sufficient to in

204 s across pregnancies support a predominantly maternal origin of effect.

205 s associated with the lowest risk of adverse maternal outcomes, whereas the use of LMWH throughout pr

206 Maternal overnutrition increases the risk of long-term m

207 Maternal overweight and obesity are associated with incr

208 we present the first evidence that positive maternal parenting might ameliorate the negative effects

209 es (excluding HIV/AIDS and tuberculosis) and maternal, perinatal, and nutritional causes, non-communi

210 Belgium during 2008-2014 on the kinetics of maternal pertussis antibodies in unvaccinated women and

211 The overall lack of association between maternal PHIV status and preterm delivery or infant BW o

212 odels were used to assess the association of maternal PHIV status with infant outcomes.

213 Among women aged 23-30 years (n = 1770), maternal PHIV was associated with LBW (aRR = 1.74; 95% c

214 ol/L for individuals aged 0-12 years and for maternal PKU, and 120-600 mumol/L for non-pregnant indiv

215 n pregnancy complication that may arise from maternal, placental and/or fetal factors.

216 The low activity allele of the maternal polymorphism, 5HTTLPR, in the serotonin transpo

217 body mass index, smoking, year of delivery, maternal pregestational diabetes, hypertension, and psyc

218 The fact that a relation between maternal prenatal stress and TL was observed in the offs

219 n contrast, higher paternal BMI (P < 0.001), maternal prepregnancy BMI (P < 0.001), and lower family

220 ; 1959-2008), we examined the association of maternal prepregnancy body mass index (BMI; weight (kg)/

221 Maternal prepregnancy weight was self-reported, and curr

222 There were overall no associations between maternal protein intake and offspring fasting insulin an

223 Cord:maternal ratios were calculated.

224 o associations were present between prenatal maternal RBC-Hg and %-5mC at any time point.

225 nt HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most impo

226 d with CON offspring, which was recovered by maternal RES supplementation, along with the appearance

227 y identified potential relationships between maternal residential proximity to agricultural use of ne

228 Maternal resveratrol promotes beige adipocyte developmen

229 Composite maternal risk was lowest with VKA (5%), compared with LM

230 After accounting for maternal RNA contamination, no published genome-wide dat

231 cyte maturation is associated with a wave of maternal RNA degradation, and the resulting relative cha

232 During oogenesis, hundreds of maternal RNAs are selectively localized to the animal or

233 The primary outcome was maternal self-reported adherence to 4 infant safe sleep

234 pport to the argument that predictability of maternal sensory signals causally influences cognitive d

235 udy provides evidence that predictability of maternal sensory signals early in life impacts cognitive

236 Fecal samples from mice with maternal separation and from Sox9(flox/flox)-vil-cre mic

237 sociation studies (GWAS) have not identified maternal sequence variants of genome-wide significance t

238 rdance in epitope specificity between BM and maternal sera ranging from only 13% of sample pairs shar

239 Maternal smoke exposure decreases mesenchymal proliferat

240 s uncovers significant relationships between maternal smoking and ASD risk.

241 t, studies examining the association between maternal smoking and autism spectrum disorder (ASD) in o

242 Both maternal smoking during pregnancy and low birth weight h

243 DNA methylation changes associated with maternal smoking during pregnancy have been described in

244 provide strong support for a causal role of maternal smoking during pregnancy in offspring depressio

245 Maternal smoking during pregnancy was associated with ri

246 bes are known to be strongly associated with maternal smoking during pregnancy, and thus their associ

247 ol consumption, body mass index, smoking and maternal smoking during pregnancy.

248 Exposure to maternal smoking during uterine life and low birth weigh

249 to pregnant smokers can lessen the impact of maternal smoking on offspring pulmonary function and dec

250 Maternal smoking with obligatory nicotine inhalation is

251 A could be due to correlation between EA and maternal smoking.

252 f potential confounding variables, including maternal socioeconomic status, obstetric complications,

253 The UBE3A gene demonstrates maternal-specific expression in neurons and loss of mate

254 ic mtDNA transmission between generations by maternal spindle transfer, pronuclear transfer or polar

255 pring, consistent with historical studies on maternal starvation.

256 DM produced a hyperglycemic, hyperleptinemic maternal state, whereas MIA produced significant increas

257 This main effect of maternal status suggests a general difference in vocalis

258 years, and determine effect modification by maternal stress and child sex.

259 To test the hypothesis that maternal stress and/or depression during pregnancy and e

260 search also indicates an association between maternal stress during pregnancy and TL in the offspring

261 It has been suggested that prenatal maternal stress may increase the risk of childhood exter

262 Prenatal maternal stress might partly explain these associations,

263 Maternal stress, depression, and childhood wheezing epis

264 onsumption may serve, in some ways, to mimic maternal stress.

265 We examined the association of maternal stressful life events and social support with r

266 bstantial morbidity and mortality, including maternal suicide.

267 Maternal supplementation with fish oil might have prophy

268 robust, with respect to large variations in maternal supplies, and is essential for normal progressi

269 d pacifier use (any); data were collected by maternal survey when the infant was aged 60 to 240 days.

270 l link explaining the interval delay between maternal symptoms and observed fetal malformations follo

271 ; 95% CI, 6%-19%) completed pregnancies with maternal symptoms or exposure exclusively in the first t

272 maternal engraftment (TME), the presence of maternal T cells in peripheral blood before transplantat

273 Maternal TDF use did not adversely affect perinatal outc

274 etus, dependent on how light interfaces with maternal tissue.

275 growth and metabolic signalling pathways in maternal tissues.

276 rnal and GPx levels in cord blood as well as maternal TNF-alpha levels were inversely associated with

277 In Drosophila, graded expression of the maternal transcription factor Bicoid (Bcd) provides posi

278 mediated by TUT4 and TUT7 sculpts the mouse maternal transcriptome by eliminating transcripts during

279 yos also have strikingly increased levels of maternal transcripts encoding ceramide synthase 2b (Cers

280 y in metal concentrations, likely related to maternal transfer, changes in food sources and starvatio

281 the spatial separation between paternal and maternal trees.

282 l-specific expression in neurons and loss of maternal UBE3A causes Angelman syndrome, a neurodevelopm

283 To better understand how loss of maternal UBE3A function derails brain development, we an

284 evelopment, we analyzed brain structure in a maternal Ube3a knock-out mouse model of AS.

285 in new insights into the mechanisms by which maternal UBE3A loss derails neurotypical brain growth an

286 ivariate models we found that an increase in maternal urine fluoride of 0.5mg/L (approximately the IQ

287 S was detectable (>/=0.1 ng/mL) in 98.24% of maternal urine samples with tertile of urinary TCS level

288 To address the hypothesis that maternal uteroplacental insufficiency (UPI) increases se

289 Maternal vaccination against group B Streptococcus (GBS)

290 ave important implications for the design of maternal vaccination strategies that could synergize wit

291 gaps highlighted by WHO to inform potential maternal vaccination.

292 The timing of GBS disease suggests that a maternal vaccine given in the late second or early third

293 development of preventive measures including maternal vaccines are ongoing efforts designed to reduce

294 he major risk factor for neonatal disease is maternal vaginal colonization.

295 Modeling reveals that the pool of maternal Vg1 enables rapid signaling at low concentratio

296 ldren to facilitate its persistence, and use maternal viral e antigen to educate immunity of the offs

297 ting and causal role in associations between maternal vitamin B12 status and offspring's cognition.

298 plines were used to account for nonlinearity.Maternal weight at each time point had a consistent nonl

299 the latent-class analysis, the highest-order maternal weight trajectory group consisted almost entire

300 al for the clearance of maternal mRNA during maternal zygotic transition in embryonic development.