ライフサイエンスコーパス: maternal age

1 crossover interference levels decreased with maternal age.

2 d adaptive function, as well as paternal and maternal age.

3 for age, sex, study, maternal education, and maternal age.

4 tological malignancies by either paternal or maternal age.

5 hy oocyte aneuploidy increases with advanced maternal age.

6 F fertility treatments, after adjustment for maternal age.

7 number of embryos transferred in relation to maternal age.

8 environmental factors rather than solely to maternal age.

9 ns are strikingly associated with increasing maternal age.

10 ures for - errors associated with increasing maternal age.

11 diabetes odds of 10% per 5-year increase in maternal age.

12 and that the effect increases with advancing maternal age.

13 ent years could be explained by increases in maternal age.

14 to support the Wilcox-Russell hypothesis for maternal age.

15 tial intended place of delivery, region, and maternal age.

16 ot the result of bias due to missing data on maternal age.

17 for year of birth, socioeconomic status, and maternal age.

18 atistically significant after adjustment for maternal age.

19 ty, increased gestational age, and increased maternal age.

20 ses of maternal meiosis I origin, grouped by maternal age.

21 not completely, attenuated by adjustment for maternal age.

22 e performance declines rapidly with advanced maternal age.

23 lowing fertilisation declines with advancing maternal age.

24 nging demographics associated with advancing maternal age.

25 idence in humans increases dramatically with maternal age.

26 e incidence of de novo mutations relating to maternal age.

27 1]), birth length (1.28 [1.11-1.48]), higher maternal age (1.13 [1.02-1.25]), and paternal age (1.12

28 0.07 standard deviations lower than that for maternal ages 25-29 years (P < 0.001).

29 When compared with maternal ages 25-29 years in between-family models, mate

30 diabetes (hazard ratios = 3.96 and 8.88 for maternal ages 25-34 and > or = 35 years, respectively, c

31 98 births to AYA cancer survivors (mean [SD] maternal age, 31 [5] years) were included.

32 infants who received active care (mean [SD] maternal age, 32 [6] years), 58 (67%) survived until hos

33 factor infertility, unexplained infertility, maternal age 38 years or older, low oocyte yield, and 2

34 no diabetes; AOR, 2.50 [95% CI, 1.39-4.48]); maternal age 40 years or older (4.5% stillbirths, 2.1% l

35 For example, maternal ages 40-44 years were associated with an offspr

36 cations for prenatal diagnosis were advanced maternal age (46.6%), abnormal result on Down's syndrome

37 ered the joint association of UTIs and young maternal age, a synergistic effect was observed.

38 d no association with offspring IQ; however, maternal ages above 30 years were inversely associated w

39 052 nmol/L; 95% CI: 0.050, 0.053 nmol/L) and maternal age (adjusted mean difference: -0.018 nmol/L; 9

40 of screening for Down's syndrome than use of maternal age alone (51% detection rate, 14% false-positi

41 as not only limited to advancing paternal or maternal age alone but also to differences parental age

42 luences the birth weight distribution and 2) maternal age also affects infant mortality directly, but

43 Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth restr

44 cores on the "healthy" diet, whereas younger maternal age and a lower educational level were associat

45 onditional risk) for 14 groups stratified by maternal age and ART procedure.

46 Data for maternal age and at least one outcome were available for

47 /ethnicity, extracardiac anomalies, sex, and maternal age and education on survival.

48 Adjusting for sample storage time, maternal age and education, and both child asthma and vi

49 transmission, neonatal tetanus vaccination, maternal age and education, and household wealth.

50 sted for urinary creatinine and thiocyanate, maternal age and education, ethnicity, and gestational a

51 conditional logistic regression adjusted for maternal age and education.

52 Mean maternal age and gestation were 29.7 years (range, 19-42

53 Younger maternal age and higher birth order increased the odds o

54 Live-birth rates declined with increasing maternal age and increasing cycle number with autologous

55 At baseline, adjusting for maternal age and intelligence, plasma ferritin, head cir

56 ly models, the relationship between advanced maternal age and low birth weight or preterm birth is st

57 Maternal age and maternal height were associated with a

58 ntake significantly interacted with advanced maternal age and metabolic conditions; combined exposure

59 We examined associations between maternal age and offspring birthweight, gestational age

60 nce intervals, adjusted for confounders (eg, maternal age and parity).

61 Analyses were stratified according to maternal age and performed with the use of both optimist

62 eflecting the published relationship between maternal age and SCZ risk in offspring by McGrath et al

63 ions that described the relationship between maternal age and SCZ risk in offspring in Denmark.

64 dence of aneuploidy rises significantly with maternal age and so there is much interest in understand

65 We studied the relation between maternal age and the risk of unaffected mothers having a

66 We noted no relation between maternal age and the risk of unaffected mothers having c

67 The relationship between increasing maternal age and trisomy has been recognized for over 50

68 files (n = 12990) with frequency matching on maternal age and year of delivery.

69 reduced vision with parental education, sex, maternal age, and birth order suggest that other environ

70 r adjusting for other independent variables, maternal age, and education.

71 Preterm delivery, early maternal age, and ethnic group were also associated with

72 Female sex, maternal age, and high maternal educational level were f

73 lies, adjusted for birth year, birth weight, maternal age, and self-reported maternal race/ethnicity.

74 Adjusting for household income, maternal age, and smoking exposure, postconceptual age a

75 sex, age, ethnic origin, parental education, maternal age, and study, to estimate odds ratios (ORs) a

76 ted strong associations between birth order, maternal age, and suicide, but these results might have

77 es not only with paternal age, but also with maternal age, and that some genome regions show enrichme

78 NA deletion disorders does not increase with maternal age, and unaffected mothers are unlikely to hav

79 estic product, unemployment rate, education, maternal age, and underlining temporal trends.

80 he number of incident neonatal infections by maternal age, and we generated separate estimates for ea

81 After adjustment for maternal IQ, maternal age, antiepileptic-drug dose, gestational age a

82 Women of advanced maternal age are considered to be at higher risk of poor

83 d to an increase in aneuploidy with advanced maternal age are largely unclear.

84 This study tests if advancing paternal and maternal ages are independently associated with ASD risk

85 ed risk of loss is inconclusive, and data on maternal age-, ART type-, and gestational age-specific r

86 ants with reduced activity may contribute to maternal age-associated fertility loss in humans.

87 Together, these results demonstrate that the maternal age-associated increase in aneuploidy is often

88 stfeeding, as well as maternal education and maternal age at birth and family breakdown, parenting pr

89 e sought to examine the relationship between maternal age at birth and prevalence of asthma in a nati

90 me and percent college educated), as well as maternal age at birth and year of birth.

91 To test whether advanced maternal age at birth independently increases the risk o

92 Younger maternal age at birth is associated with increased risk

93 Advanced maternal age at birth is considered a major risk factor

94 c regression models to examine the effect of maternal age at birth on asthma in offspring overall and

95 nce with infant feeding, parental education, maternal age at birth, birth weight, sex, birth order, a

96 body mass index at school entry, gravidity, maternal age at birth, pregnancy-induced hypertension, a

97 uicide risk between siblings and studied how maternal age at child birth and birth order influenced r

98 explain the associations of birth order and maternal age at child birth with suicide risk.

99 For each 10-year increase in maternal age at child birth, the offspring's suicide ris

100 age, retinopathy of prematurity occurrence, maternal age at childbirth, mother smoking, breastfeedin

101 ression adjusting for potential confounders (maternal age at conception, paternal age at conception,

102 , 7 (63.6%) were female, and the median (SD) maternal age at delivery was 25 (6) years.

103 objective of this study was to test whether maternal age at delivery, child's birth order, cesarean

104 sociation was not modified by year of birth, maternal age at diabetes onset, or diabetes duration, an

105 the number of heteroplasmies in a child and maternal age at fertilization, likely attributable to oo

106 After adjusting for maternal age at menarche, daughter's age, and body mass

107 gender, gestational age at delivery, parity, maternal age at oral glucose tolerance test (OGTT); Mode

108 Increased maternal age at reproduction is often associated with de

109 We used maternal age at reproduction, brood size and survival ra

110 1.5-3.8, P=.0007); the SMR did not vary with maternal age at the first trisomy.

111 th the de novo 22q11.2 deletion, the average maternal age at time of conception was 29.5, and this is

112 owed an association between paternal-but not maternal-age at birth and sporadic hematological cancer

113 Male gender, the youngest and oldest maternal age bands, multiple births, and deprivation (In

114 ere not explained by geographic variation in maternal age, birth year, child's sex, community income,

115 Maternal age, body mass index, and smoking during pregna

116 betes, ethnic origin, duration of follow-up, maternal age, body-mass index, and diagnostic criteria.

117 66 to 1.97), and the odds ratio adjusted for maternal age, body-mass index, smoking status, race or e

118 a were 5%-10% higher per 5-year increment in maternal age, but no associations were observed for acut

119 tilisation is largely unchanged by advancing maternal age, but subtle changes in Ca(2+) handling occu

120 sk factor for human aneuploidy is increasing maternal age, but the basis of this association remains

121 hildhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied b

122 The impact of maternal age, calcium intake, race-ethnicity, and vitami

123 sed pregnancies matched on propensity score, maternal age, calendar year, and gestational age (based

124 This suggests that maternal age can influence the timing of birth and proce

125 which influences birth weight, in this case maternal age, can influence infant mortality directly bu

126 son, body mass index, daily milk intake, and maternal age controlled for.

127 Extremes of maternal age could be associated with disturbed offsprin

128 zard ratios (HRs) with 95% CIs, adjusted for maternal age, country of origin, education level, cohabi

129 tios (aRRs) and 95% CIs, after adjusting for maternal age, country of origin, educational level, coha

130 ratios (HRs) and 95% CIs after adjusting for maternal age, country of origin, educational level, coha

131 Further adjustment for maternal age did not materially alter the association.

132 To investigate the hypothesis that maternal age directly influences successful parturition,

133 After controlling for maternal age, education level, family income, pre-pregna

134 stational duration, birth weight, sex ratio, maternal age, education, and socioeconomic status.

135 1.11, 6.97; P = 0.029) with adjustments for maternal age, education, ethnicity, monthly household in

136 t neonatal sample collection, preterm birth, maternal age, education, smoking, fish consumption per w

137 fter adjustment for infant's age and sex and maternal age, educational level, smoking during pregnanc

138 The maternal age effect is unrelated to aneuploidy or a gene

139 ion in SMC1beta (or related proteins) in the maternal age effect of humans.

140 ffect has implications for understanding the maternal age effect on aneuploidies.

141 orates as oocytes age and contributes to the maternal age effect.

142 d by increasing age, leading to the observed maternal age effect.

143 cally as women age, a phenomenon termed the "maternal age effect." During meiosis, cohesion between s

144 oduction-line model is not the basis for the maternal-age effect on trisomy.

145 rovide a plausible explanation for the human maternal-age effect, meaning that-45 years after its int

146 Indeed, one of the earliest models of the maternal-age effect--the "production-line model" propose

147 logistic regression analyses, adjusting for maternal age, ethnicity, birth country and weight, as we

148 hip between having a low level of PAPP-A and maternal age, ethnicity, parity, height, body mass index

149 (n = 318 506) with data on paternal but not maternal age for sensitivity analyses.

150 (n = 132 271) with data on both paternal and maternal age for the primary analysis and the larger sub

151 Maternal age, gestational age, prematurity (<37 weeks' g

152 bles were included in the model: study site, maternal age, gravidity, marital status, education, race

153 independent risk factors for delayed OL were maternal age > or =30 y, body mass index in the overweig

154 ociated with autism (adjusted odds ratio for maternal age > or =35 vs. 25-29 years = 1.3, 95% confide

155 Risk factors for CHD included maternal age >/=40 years (adjusted odds ratio [aOR], 1.4

156 horioamnionitis (OR, 4.6; 95% CI, 2.1-10.4), maternal age >or= 35 (OR, 2.6; 95% CI, 1.6-4.1), and mal

157 dgkin lymphoma risk associated with advanced maternal age (> or =40 years) became null when paternal

158 ABSTRACT: Advanced maternal age (>/=35 years) is associated with increased

159 We show that maternal age has a small but significant correlation wit

160 productive success in older females.Advanced maternal age has been associated with lower reproductive

161 Advancing paternal and maternal age have both been associated with risk for aut

162 o adjust for gestational age; fetal sex; and maternal age, height, education, ethnicity, prepregnancy

163 sociations were similar after adjustment for maternal age, height, marital and smoking status, and in

164 (and 95% confidence intervals) adjusted for maternal age, height, smoking habits, education, and tim

165 ciation was not confounded by differences in maternal age, immigrant status, or mode of delivery.

166 We have found that increasing maternal age in C57BL/6J mice is associated with prolong

167 that the number of crossovers increases with maternal age in humans, but others have found the opposi

168 ied models, the protective effect of younger maternal age in Mexican Americans was seen only in child

169 We substituted AFB for maternal age in these functions, one of which was correc

170 across the 20kb intervals, nor any effect of maternal age in weeks on recombination rate in our sampl

171 creta/increta/percreta associated with older maternal age in women without a previous caesarean deliv

172 neuploidy is well documented with increasing maternal age, in particular in human females.

173 While advancing maternal age increased risk of leukemia and central nerv

174 iers on risk remains constant, the effect of maternal aging increases over time.

175 Among women of advanced maternal age, induction of labor at 39 weeks of gestatio

176 After adjustment for maternal age, interval between pregnancies, gestational

177 CI], 1.38-2.07; P < .01) when accounting for maternal age, intravenous drug use, geographic origin, a

178 Maternal age is a risk factor for congenital heart disea

179 ives from errors in maternal meiosis I, that maternal age is a risk factor for most, if not all, huma

180 Both young and advanced maternal age is associated with adverse birth and child

181 is for environmental variables revealed that maternal age is correlated with the risk of membranous a

182 rted that SCZ risk associated with increased maternal age is explained by the age of the father and t

183 In Finland, advanced maternal age is not independently associated with the ri

184 33), which is notable because although young maternal age is the strongest known risk factor for gast

185 hromosome number originate from the egg, and maternal age is well established as the key risk factor.

186 Decreasing oocyte competence with maternal aging is a major factor in human infertility.

187 , adjusting for gestational age at birth and maternal age, is significantly associated with autism (p

188 d aneuploidy in oocytes of women of advanced maternal ages lead to elevated rates of infertility, mis

189 es, chromosome nondisjunction increases with maternal age, leading to disorders such as Down's syndro

190 Advanced maternal age led to an increase in sister kinetochore se

191 Little evidence has emerged to link maternal age--long recognized as the primary risk factor

192 Maternal age < 20 years was significantly associated wit

193 ing status but was significantly modified by maternal age (<20 years OR, 0.98; 95% CI, 0.51-1.88; >/=

194 risk of hepatoblastoma was found for younger maternal age (<20 years vs. 20-29 years: RR = 2.5, 95% C

195 After adjustment for maternal age, marital status, race/ethnicity, and educat

196 xcess or deprivation and specific nutrients, maternal age, maternal and fetal genotype, increased num

197 Maternal age, maternal education, initiation of prenatal

198 regardless of maternal racial/ethnic group, maternal age, maternal education, or sex of the infant.

199 ld and maternal factors (ie, sex, ethnicity, maternal age, maternal educational level, and income) (i

200 etween 74 and 97 days of gestation, based on maternal age, maternal levels of free beta human chorion

201 These findings were not accounted for by maternal age, maternal or parental psychiatric disorders

202 separately for each parent and adjusted for maternal age, maternal prepregnancy body mass index (kil

203 sted for gestational age, sex, birth weight, maternal age, maternal smoking during pregnancy, and com

204 NHS was independently associated with lower maternal age (odds ratio [OR], 0.87; 95% CI, 0.78-0.94),

205 l ages 25-29 years in between-family models, maternal ages of 35-39 years and >/=40 years were associ

206 and lifestyle factors (each about 10%), and maternal age older than 35 years (6.7%).

207 The impact of maternal age on congenital heart disease can be modelled

208 The adverse effects of advancing maternal age on offspring's health and development are w

209 from any specific cohort about the effect of maternal age on recombination.

210 mortality directly, but 3) the influence of maternal age on the birth weight distribution has little

211 pivotal, albeit under-appreciated, impact of maternal age on uterine adaptability to pregnancy as maj

212 .7% of those whose indications were advanced maternal age or positive screening results.

213 The results do not depend on maternal age or risk of Down's syndrome-affected birth.

214 s significant variables associated with GDM: maternal age (OR = 2.65; 95% CI = 1.97 to 3.56), chronic

215 besity (OR: 1.56; 95% CI: 1.07, 2.29), older maternal age (OR: 1.05; 95% CI: 1.01, 1.08), insulin GDM

216 h versus low education; 95% CI: 1.23, 1.79), maternal age (OR: 1.10, per 5-y increase; 95% CI: 1.04,

217 V viral load but was associated with younger maternal age (P = .02).

218 type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity am

219 with NAFLD in female offspring were younger maternal age (P = 0.02), higher maternal prepregnancy BM

220 h diabetes, after adjustment for birth year, maternal age, parity and education, birth weight, gestat

221 ntly predicted NVP resistance mutations, but maternal age, parity, and time between SD-NVP and the 6-

222 affected infant, up to 10 mothers matched on maternal age, parity, and year of infant's birth.

223 After adjustment for maternal age, parity, education, household income, race/

224 onding 95% confidence interval, adjusted for maternal age, parity, education, smoking, breastfeeding,

225 D-epidemiology collaboration), hypertension, maternal age, parity, ethnicity.

226 Relative risks were adjusted for maternal age, parity, income quintile, chronic hypertens

227 ation on the type of delivery, birth weight, maternal age, parity, maternal schooling, and maternal s

228 atal seizures, adjusted for maternal height, maternal age, parity, mother's smoking habits, education

229 ial negative regression, with adjustment for maternal age, parity, parents' schooling, socioeconomic

230 We adjusted for maternal age, parity, pregnancy conditions, and (for neo

231 ontrolled for gestational age, birth weight, maternal age, parity, prepregnancy body mass index, smok

232 Self-reported data, including TTP, maternal age, parity, prepregnancy height and weight, ma

233 After adjusting for confounding variables of maternal age, parity, race, marital status, education, f

234 sing logistic regression with adjustment for maternal age, parity, residence, and other factors.

235 Risk estimates were adjusted for maternal age, parity, smoking, education, height, mother

236 Difference in maternal age, parity, socioeconomic and behavioral chara

237 ght gain, and preterm birth rate, but not in maternal age, parity, socioeconomic or behavioral charac

238 , gestational age, maternal body mass index, maternal age, paternal age, newborn sex, newborn ethnici

239 rns, higher maternal body mass index, higher maternal age, preeclampsia, higher socioeconomic positio

240 In proportional hazards models adjusted for maternal age, prepregnancy body mass index (weight (kg)/

241 (n=66 980) after controlling for changes in maternal age, prepregnancy diabetes mellitus, preterm pr

242 iotic use, and diarrheal history, as well as maternal age, probiotic use, and smoking.

243 After controlling for maternal age, race or ethnic origin, pre-pregnancy BMI,

244 Logistic regression models were adjusted for maternal age, race, education, body mass index, parity,

245 BDILMs adjusted for maternal age, race, education, prepregnancy obesity, ato

246 Associations of paraxanthine (adjusted for maternal age, race, education, smoking, prepregnancy wei

247 The findings were not confounded by maternal age, race, educational level, gestational age a

248 After adjusting for maternal age, race, family history of T2DM and pre-pregn

249 , and WHZ, respectively), adjusting for age; maternal age, race, prepregnancy BMI; parity; smoking du

250 and fetal disproportion or obstructed labor; maternal age, race/ethnicity, and insurance status; and

251 Analyses were adjusted for maternal age, race/ethnicity, education and neighborhood

252 00 g) using logistic regression adjusted for maternal age, race/ethnicity, education, parity, infant

253 In linear regression analyses adjusted for maternal age, race/ethnicity, education, prenatal fine p

254 % confidence intervals while controlling for maternal age, race/ethnicity, education, smoking, folic

255 Logistic regression models were adjusted for maternal age, race/ethnicity, educational level, parity,

256 stic regression evaluated factors, including maternal age, race/ethnicity, substance use, antiretrovi

257 Older maternal age reduces the probability of success in both

258 cytes remains a pivotal question relevant to maternal age-related aneuploidy.

259 female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnanc

260 Maternal age-related miscarriage and birth defects are p

261 After adjustment, older maternal age remained associated with increased risk of

262 After adjustment, associations with younger maternal age remained for low birthweight (odds ratio [O

263 Maternal age represents one factor that may help to expl

264 matched 2:1 to cases by sex, birth year, and maternal age, self-reported race/ethnicity, and county o

265 ucation, race/ethnicity, marital status, and maternal age; separately examining higher- and lower-fun

266 Advancing maternal age showed no association with ASD after adjust

267 cate that among the populations examined, 1) maternal age significantly influences the birth weight d

268 te, maternal and infant serum vitamin B(12), maternal age, smoking and genotype were tested.

269 With adjustment for maternal age, smoking, and first-trimester vaginal bleed

270 l diagnosis with the expected numbers, given maternal age-specific rates (by single year).

271 Maternal age, time postpartum, weight, and body mass ind

272 ; the odds ratio for each 5-year increase in maternal age was 1.06 (95% confidence interval (CI): 1.0

273 and 52% were 13-24 wk postpartum, and median maternal age was 25 y (interquartile range [IQR] 22-28).

274 Median maternal age was 26 yr (interquartile range 22-33) and m

275 Median maternal age was 26.5 years (IQR 23.1-30.3).

276 nal age of 38.7 weeks (50.4% were male, mean maternal age was 26.7 years, and mean duration of follow

277 At study entry, median maternal age was 28 y (interquartile range [IQR] 25-31),

278 The mean (SD) maternal age was 28.1 years (5.8 years) and 32.8% of res

279 The mean maternal age was 30.7 years, and the mean gestational ag

280 Younger maternal age was also associated with increased risk for

281 Overall, each 5-year increment in maternal age was associated with a 3% increase in incide

282 emographic covariates, a 10-year increase in maternal age was associated with a 38% increase in the o

283 In Puerto Ricans, older maternal age was associated with decreased odds of asthm

284 ast to European descent populations, younger maternal age was associated with decreased odds of asthm

285 Although the results confirmed that maternal age was negatively associated with offspring IQ

286 p analyses, the protective effect of younger maternal age was observed only in Mexican Americans (OR

287 t birth was obtained for most of the cohort; maternal age was obtained for a smaller subset.

288 regression models stratified by infant sex, maternal age was positively associated with AGD in male

289 , as without birth year adjustment, advanced maternal age was positively associated with IQ.

290 Increasing maternal age was related to risk of islet autoimmunity a

291 advancing parental age, especially advancing maternal age, was associated with higher pediatric cance

292 the odds ratios for each 5-year increase in maternal age were 1.05 (95% CI: 1.02, 1.07) and 1.14 (95

293 Higher educational level and maternal age were associated with higher scores on the "

294 ounger (</=19 years) and older (>/=35 years) maternal age were associated with lower birthweight, ges

295 Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and

296 Advancing paternal and maternal age were each associated with increased RR of A

297 tic use in infancy, childcare attendance and maternal age were not associated with egg allergy.

298 lationship between SCZ risk in offspring and maternal age when not adjusted for the age of the father

299 m that the recombination rate increases with maternal age, while hotspot usage decreases, with no suc

300 ears to become increasingly deregulated with maternal age, with an increasing fraction of events obse