ライフサイエンスコーパス: maternal effect

1 ryo development phenotypes are a result of a maternal effect.

2 These genes may be related to maternal effect.

3 hood infection status, indicating a specific maternal effect.

4 ective embryogenesis of the mpk6 mutant is a maternal effect.

5 growth through an adaptive hormone-mediated maternal effect.

6 nction in High LG offspring, eliminating the maternal effect.

7 ng environments failed to evolve randomizing maternal effects.

8 DT, extends directly to the investigation of maternal effects.

9 valid tests for significant dominance and/or maternal effects.

10 parate estimation of X-linked, dominance and maternal effects.

11 environment, suggesting either dominance or maternal effects.

12 three genotypes were present to control for maternal effects.

13 ernal grandparents yields an LRT specific to maternal effects.

14 ssociations were stronger in the presence of maternal effects.

15 ining information, in an independent LRT for maternal effects.

16 embryonic Tgfbkm2 genotype, also depends on maternal effects.

17 nt source of genetic variance contributed by maternal effects.

18 ential response to selection in the event of maternal effects.

19 to contribute to adaptation than randomizing maternal effects.

20 lities involving the Y (or W) chromosome and maternal effects.

21 arising from confounding sources, including maternal effects.

22 ese studies have not controlled for possible maternal effects.

23 les of phytohormone signalling in regulating maternal effects.

24 hich most likely reflects the dissipation of maternal effects.

25 logical contexts that favor the evolution of maternal effects.

26 .5-21.5 years after gestation to investigate maternal effects.

27 methodological implications for the study of maternal effects.

28 development and for early embryogenesis via maternal effects.

29 protein is likely to be responsible for the 'maternal' effect.

30 r male behavior during breeding by adjusting maternal effects according to prenatal conditions.

31 however, the genotype of the mother via its maternal effect accounts for a considerable portion of t

32 The hypothesis that maternal effects act as an adaptive bridge in translatin

33 e or actuarial senescence; this implies that maternal effect aging is a fundamentally distinct demogr

34 n throughout development, using a semiviable maternal-effect allele and wild-type or dominant-negativ

35 Z-linked maternal-effect alleles that help sons and harm daughter

36 own nearby susceptibility locus, or a direct maternal effect alone.

37 e at or near the RHD locus and from a direct maternal effect alone.

38 We show that this is a maternal effect and is not attributable to the defects i

39 JIL-1 has a strong maternal effect and JIL-1 activity is required at all st

40 ell formation and cytokinesis in a series of maternal effect and zygotic anillin alleles.

41 ied in nearly saturating genetic screens for maternal effect and zygotic lethals is particularly nota

42 ress in understanding the pattern formation, maternal effects and evolution of this essential unit of

43 Mutations with both sporophytic maternal effects and gametophytic maternal effects have

44 We further demonstrate how maternal effects and imprinting effects can be distingui

45 The presence of maternal effects and phenotypic plasticity could have mu

46 on screen in the zebrafish, we identified 47 maternal-effect and five paternal-effect mutants that ma

47 Here it is shown that maternal-effect and zygotic genes are subject to conflic

48 We describe the maternal-effect and zygotic phenotypes of null mutations

49 ost-associated fitness, ruled out nongenetic maternal effects, and discuss the maintenance of ecologi

50 Common environmental effects, maternal effects, and philopatry did not explain these r

51 ons hinges on the existence of deterministic maternal effects, and that such deterministic maternal e

52 highlights the importance of studying these maternal effects, and they enhance our concern over the

53 indings consistent with this prediction, but maternal effects are an important confounding variable.

54 Although maternal effects are common, evidence for their adaptive

55 However, in most of these analyses maternal effects are confounded with genomic imprinting

56 ng-lived species, it has been suggested that maternal effects are masked by environmental variables a

57 t is reasonable to hypothesize that diabetic maternal effects are mediated by 1 or more pathways acti

58 aternal effects, and that such deterministic maternal effects are more likely to contribute to adapta

59 While maternal effects are well documented, the longevity and

60 g sex chromosomes, cytoplasmic elements, and maternal effects, are likely to play an important role i

61 ssfully differentiate between imprinting and maternal effects as the cause of apparent parent-of-orig

62 not be explained by genetic modifiers or by maternal effects, as these divergent phenotypes were dis

63 ic tra mRNA in eggs as predicted by this tra maternal effect, but not predicted by the prevailing vie

64 ion, tested the allergen independence of the maternal effect by using a second allergen, casein, for

65 erally, it provides important information on maternal effects by showing how environmental cues exper

66 Thus, strong maternal effects can account for frequently observed, bu

67 enetic models show that senescence for these maternal effects can evolve in the absence of reproducti

68 er, brief periods of increasingly beneficial maternal effects can evolve when fertility increases wit

69 Yet-unidentified maternal effects can have a pronounced influence on plan

70 ght-related traits in mice to illustrate how maternal effects can mimic imprinting.

71 trait maternal effects shows that individual maternal effects cannot be studied in isolation, and tha

72 s, we simulate the evolution of multivariate maternal effects (captured by the matrix M) in a fluctua

73 t-offspring regressions provide evidence for maternal effects, comparable in magnitude to those repor

74 Maternal effects, crossgenerational influences of the mo

75 The magnitude of these maternal effects decreased with age.

76 Fourth, hybrid sterility does not involve a maternal effect, despite earlier claims to the contrary.

77 Thus, the maternal-effect DNMT1o protein is uniquely poised during

78 tral patterning, indicating that the fusilli maternal effect does not depend on germ-line expression

79 Maternal-Effect Dominant Embryonic Arrest ("Medea") fact

80 Mutations in gon-2 have a partial maternal effect: either maternal or zygotic expression i

81 seed traits are proposed, with inclusion of maternal effects, embryo or endosperm effects of QTL, en

82 In genetic screens for temperature-sensitive maternal effect embryonic lethal (Mel) mutants, we have

83 In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant

84 phenotypes-germ-line proliferation defects, maternal-effect embryonic lethality, and somatic gonad d

85 Interestingly, the maternal-effect embryonic lethality, larval lethality, a

86 These maternal effects, evidently stimulated by high-quality t

87 selection on other traits, large cross-trait maternal effects evolve from those maternal traits that

88 alone at a normal dose is sufficient for the maternal effect function of pum.

89 -genetic findings are compatible with strong maternal effects; G x E correlations likely underestimat

90 ed by a transcriptional network comprised of maternal effect, gap, pair-rule, and segment polarity ge

91 Thus, Npm2 is a maternal effect gene critical for nuclear and nucleolar

92 that the oocyte- and early embryo-restricted maternal effect gene Mater (Nlrp5) localizes to, and is

93 Females lacking the maternal effect gene Mater are sterile.

94 Differentiation of the EVL requires the maternal effect gene poky/ikk1 in EVL cells prior to est

95 We find dHIP14 to be an essential maternal effect gene required for photoreceptor synaptic

96 hese findings indicate that Setd1b serves as maternal effect gene through regulation of the oocyte ge

97 xperiments indicate that CTCF is a mammalian maternal effect gene, and that persistent transcriptiona

98 DPPA3/Stella/PGC7, encoded by a maternal effect gene, is present in the nucleus and cyto

99 When aposematism is controlled by a maternal effect gene, the difficulty of initial rarity m

100 n ovulated eggs, indicating that MOEP19 is a maternal effect gene.

101 also known as NLRP5), which is encoded by a maternal effect gene.

102 may function as a previously uncharacterized maternal effect gene.

103 It qualifies as a maternal-effect gene because the source of pre-implantat

104 We find that mutations in the maternal-effect gene emb-4 cause defects in both PIE-1 d

105 discontinuous actin hexagon (dah) is a maternal-effect gene essential for the formation of cort

106 nd molecular identification of the zebrafish maternal-effect gene mission impossible (mis).

107 Zar1 is the first identified oocyte-specific maternal-effect gene that functions at the oocyte-to-emb

108 ly established by bicoid, a rapidly evolving maternal-effect gene, working with hunchback, which is e

109 SCMC) that contains four proteins encoded by maternal effect genes (Mater, Filia, Floped and Tle6).

110 The products of at least 11 maternal effect genes have been shown to be essential fo

111 uccino genetic loci were first identified as maternal effect genes in Drosophila.

112 Maternal effect genes play critical roles in early embry

113 Maternal effect genes produce mRNA or proteins that accu

114 ation exemplifies a large class of so-called maternal effect genes that regulate key events during ea

115 stella is thus one of few known mammalian maternal effect genes, as the phenotypic effect on embry

116 The optimal sex ratios for maternal-effect genes and zygotically expressing genes a

117 anisms is determined by interactions between maternal-effect genes and zygotically expressing genes.

118 basonuclin is a new member of the mammalian maternal-effect genes and, interestingly, differs from t

119 In both cases, maternal-effect genes are selected to bias sex determina

120 ffers from the previously reported mammalian maternal-effect genes in that it also apparently perturb

121 Selection on maternal-effect genes may substantially alter the evolut

122 Maternal-effect genes typically produce products (e.g.,

123 the general understanding of the dynamics of maternal-effect genes, including how selection acts on t

124 Encoded by maternal-effect genes, these factors accumulate during o

125 Here we define meg-1 and meg-2 (maternal-effect germ-cell defective), which are expresse

126 The MEG (maternal-effect germline defective) proteins are germ pl

127 The characterization of many gametophytic maternal effect (GME) mutants affecting seed development

128 lighted between the two populations once the maternal effects had been diminished after several gener

129 ely cued for their light environment through maternal effects have 3.4 times greater fitness than oth

130 porophytic maternal effects and gametophytic maternal effects have been identified.

131 asures of maternal condition to determine if maternal effects have long-lasting influences on male of

132 e studies that have attempted to control for maternal effects have only considered differential mater

133 These maternal effect hypomorphic phenotypes are associated wi

134 predicts that the evolution of deterministic maternal effects (i.e., anticipatory maternal effects or

135 In contrast, randomizing maternal effects (i.e., diversifying and conservative be

136 rete-trait analysis, we found evidence for a maternal effect in chromosome region 10p12 across the th

137 hanism was supported by the observation of a maternal effect in reciprocal crosses between the wild t

138 ll but one of the mutations recovered show a maternal effect in their interaction with ftz.

139 Finally, there were significant maternal effects in a range of traits, particularly for

140 In addition, evidence of maternal effects in both traits adds to a growing body o

141 ur approach can easily be adapted to examine maternal effects in different systems, and because it do

142 rcomes this challenge to separate direct and maternal effects in intact families through an analysis

143 s, we find a striking pattern of cross-trait maternal effects in which maternal characters influence

144 l for more studies that measure multivariate maternal effects in wild populations.

145 al sciences, the principle of minimal shared maternal effects, in light of the growing awareness that

146 Extension to incorporate maternal effect is also given.

147 We provide evidence that this maternal effect is due to the necessity of a maternal st

148 The striking maternal effect is greatest for women with young age at

149 a single character, whereas the evolution of maternal effects is poorly understood in the presence of

150 eonatal survival, we find that selection for maternal effects is the product of age-specific fertilit

151 H-1 function causes sterility that is mainly maternal effect, is manifested predominantly at elevated

152 MAB1 resembles the animal key ACD regulator Maternal Effect Lethal 26 (MEL-26).

153 embryos whose mothers are homozygous for the maternal effect lethal mutation gnu (GNU embryos) under

154 identified in Drosophila through screens of maternal effect lethal mutations for defects in spindle

155 t a completely penetrant zygotic semisterile/maternal effect lethal phenotype, characterized by the p

156 e adaptors is the BTB-domain protein MEL-26 (maternal effect lethal).

157 ns in the biotin-binding region of bpl-1 are maternal-effect lethal and cause defects in embryonic po

158 Although maternal-effect lethal and female-sterile screens have i

159 rol of spindle orientation, we have screened maternal-effect lethal mutants for alterations in cleava

160 A maternal-effect lethal screen identified mutants in the

161 hold-dependent gene drive system, designated maternal-effect lethal underdominance (UD(MEL)), in whic

162 We previously identified a Drosophila maternal effect-lethal mutant named 'no poles' (nopo).

163 cycle regulators, we identified a Drosophila maternal effect-lethal mutant that we named ;no poles' (

164 A new maternal effect mutation in maize, maternal effect lethal1 (mel1), causes the production of

165 This maternal effect lethality in Drosophila is similar to th

166 BMP pathway components, and (2) significant maternal effect lethality that can be rescued by an incr

167 Similar pharyngeal defects and maternal effect lethality were found in sqv-1, sqv-8, ri

168 ty, growth retardation, brain disorders, and maternal effect lethality, phenotypes commonly observed

169 -9 mutations also had a recessive phenotype, maternal effect lethality, which implicated E(var)3-9 fu

170 The dcap-g and incenp mutations cause maternal effect lethality, with embryos from mutant moth

171 tion, cytoskeletal organization defects, and maternal effect lethality.

172 or Larp (La-related protein) which displayed maternal-effect lethality and male sterility.

173 n ML-IV gene is capable of rescuing both the maternal-effect lethality and the lysosome-accumulation

174 inked with a zygotic antidote able to rescue maternal-effect lethality of the other toxin.

175 er, elevated expression of OVO-A resulted in maternal-effect lethality while the absence of OVO-A res

176 Strong sqv mutations result in maternal-effect lethality, caused in part by the failure

177 Our null mutations in cup-5 cause maternal-effect lethality.

178 dite sterility, and some sqv mutations cause maternal-effect lethality.

179 This genome scan revealed five separate maternal-effect loci that caused a diversity of patterns

180 Spire is a maternal effect locus that affects both the dorsal-ventr

181 protein, particularly intriguing as MEDEA's maternal effects may be a consequence of genomic imprint

182 lyze the relative contribution of direct and maternal effect (ME) QTL to early growth in mice using a

183 Maternal effects mediated by prenatal hormone exposure a

184 wth, but recent studies have also emphasized maternal effects mediated by size or age.

185 Extension of our maternal effects model to other ecological and social co

186 We have used the maternal effect mutant ichabod, which is deficient in ma

187 stunter1 (stt1) is a novel, recessive, maternal effect mutant in maize that displays viable, mi

188 The gametophytic maternal effect mutant medea (mea) shows aberrant growth

189 A similar phenotype is seen in a maternal effect mutant, concertina (cta).

190 fied and characterized a zebrafish recessive maternal effect mutant, ichabod, that results in severe

191 A novel gametophytic maternal-effect mutant defective in early embryo and end

192 dentify key genes involved, we embarked on a maternal-effect mutant screen in the zebrafish.

193 Here we report on a zebrafish maternal-effect mutant, brom bones, which is defective i

194 and phosphorylation are disrupted in another maternal-effect mutant, nuclear-fallout.

195 Maternal-zygotic and maternal-effect mutants demonstrate a crucial requiremen

196 This collection of maternal-effect mutants provides the basis for a molecul

197 d the distribution of PIE-1 and RNAPII-H5 in maternal-effect mutants that disrupt embryonic developme

198 We identified 68 maternal-effect mutants.

199 A new maternal effect mutation in maize, maternal effect letha

200 nuclear fallout (nuf) is a maternal effect mutation that specifically disrupts the

201 A zebrafish maternal effect mutation, in the gene hecate, results in

202 This recessive maternal-effect mutation disrupts the specification of i

203 ta-catenin in dorsal axis formation, but the maternal-effect mutation ichabod disrupts beta-catenin a

204 A female-sterile zebrafish maternal-effect mutation in cellular atoll (cea) results

205 ryos from females homozygous for a recessive maternal-effect mutation in the gene aura exhibit defect

206 To test this hypothesis, we generated a maternal-effect mutation of Brg1, which encodes a cataly

207 s to complement the originally isolated aura maternal-effect mutation, confirming gene assignment.

208 roteins are conserved in humans, and similar maternal effect mutations may result in recurrent embryo

209 wispy (wisp) maternal-effect mutations in Drosophila block developmen

210 Maternal-effect mutations in zebrafish ybx1 lead to dere

211 Maternal-effect mutations of other human NLRP genes, NLR

212 Rho1 (Rho1) gene during a genetic screen for maternal-effect mutations, allowing us to investigate th

213 Thus, the chromosomes act as maternal effect neo-W's, or W-prime (W') chromosomes, wh

214 g the Drosophila eRF1 and eRF3 show a strong maternal-effect nonsense suppression due to readthrough

215 was no evidence for repression by a strictly maternal effect; nor was there any evidence for enhancem

216 minance model, and significant epistatic and maternal effects occurred in most, but not all, of the c

217 GP), a generalisation of more widely studied maternal effects, occurs whenever environmental cues exp

218 The maternal effect of AP2 on seed mass involves the regulat

219 different early life impacts, including (i) maternal effects of length on egg weight, potentially af

220 efore, our results suggest that rank-related maternal effects of prenatal androgen exposure can adapt

221 n population growth and fitness of pike than maternal effects of size on offspring survival.

222 eft study, to now investigate both fetal and maternal effects of the IRF6 gene.

223 ue provides a powerful tool for studying the maternal effects of zygotic lethal mutations.

224 erm-line clones of fusilli mutations have no maternal effect on dorsal-ventral patterning, indicating

225 se alleles (1, 2, 3, 7, 8 and hk21) induce a maternal effect on early embryogenesis and result in the

226 t mothers gives dose-dependent rescue of the maternal effect on embryo hatch rate.

227 The mutation had a profound maternal effect on embryonic viability, revealing an acu

228 dependent memory, suggesting a 'detrimental' maternal effect on neural development.

229 The maternal effect on seed lipid content is attributable to

230 in correlated response in uterine and nurse maternal effects on body weights, with significant genet

231 The maternal effects on both long-term depression and PPD we

232 Experimental evidence for maternal effects on caste determination, the differentia

233 In birds, maternal effects on egg-laying order and offspring growt

234 ale behavior that are critical for mediating maternal effects on offspring development, such as postp

235 e describe generalizes easily to accommodate maternal effects on risk and, in fact, produces powerful

236 For diseases for which there could be maternal effects on risk, the parent-of-origin likelihoo

237 Non-genetic maternal effects on sex determination were negligible in

238 stern breed was used to identify genetic and maternal effects on the acquisition and development gut

239 y is produced by persistent and sex-specific maternal effects on the growth and morphology of offspri

240 juvenile hormone, and vitellogenin regulates maternal effects on the production of alternative phenot

241 so resulted in aberrant egg morphology and a maternal-effect on embryonic chromosome segregation and

242 se embryo suggests that Pms2 deficiency is a maternal effect, one of a limited number identified in t

243 This is a direct maternal effect, operating independently from transgener

244 Consequently, there is no maternal effect or developmental event that sets the pha

245 ly expressed genes could not be explained by maternal effects or by chance differences in the backgro

246 ypes in mutant embryos was not likely due to maternal effects or failure to eliminate gene function.

247 inistic maternal effects (i.e., anticipatory maternal effects or transgenerational phenotypic plastic

248 istinguish between the tuh-lh and the tuh-1g maternal effects other than evaluating their effect on t

249 enetic studies showing that emb30/gnom has a maternal-effect phenotype that is paternally rescuable i

250 ss-of-function genotype is associated with a maternal-effect phenotype that results in drastically re

251 n is the most likely reason for its use as a maternal-effect protein; stable ooplasmic stores of Dnmt

252 P cluster that showed strong association and maternal effects, providing a potential substrate for ep

253 atidiform mole (FBHM) is the only known pure maternal-effect recessive inherited disorder in humans.

254 Variance attributable to maternal effects, reflecting differences between materna

255 The mechanisms of this maternal effect remain poorly understood.

256 els of nonpaternity (up to 15%), the greater maternal effect remained.

257 cess of germ-cell formation in Drosophila, a maternal-effect screen using the FLP/FRT-ovoD method was

258 Here, we report the creation of maternal-effect selfish genetic elements in Drosophila t

259 We demonstrate that fertility and maternal effect senescence are likely to experience diff

260 Current evolutionary theory considers such maternal effect senescence as part of a unified process

261 The presence of these cross-trait maternal effects shows that individual maternal effects

262 lysis, we found the strongest evidence for a maternal effect (single-point LOD of 2.85; multipoint LO

263 vpr-1 null mutants are maternal effect sterile due to arrested gonadogenesis fo

264 anism is disrupted in animals mutant for the maternal effect sterile genes mes-2, mes-3, mes-4 and me

265 Mutations in these genes cause a maternal-effect sterile (i.e. mes) or grandchildless phe

266 The Maternal-Effect Sterile (MES) proteins are essential for

267 The maternal-effect sterile (MES) proteins are maternally su

268 Four maternal-effect sterile genes, mes-2, mes-3, mes-4, and

269 The Caenorhabditis elegans maternal-effect sterile genes, mes-2, mes-3, mes-4, and

270 ality while the absence of OVO-A resulted in maternal-effect sterility.

271 in mes-2, mes-3, mes-4, and mes-6 result in maternal-effect sterility: hermaphrodite offspring of me

272 methylation of the molecular basis for such maternal effects suggested differences in the epigenetic

273 n addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin

274 anisms underlying the weak influence of this maternal effect, suggesting that these may be general fo

275 signaling, we conducted a genetic screen for maternal-effect suppressors of dpp haplo-insufficiency.

276 ancement has two components: (1). a strictly maternal effect that is transmitted to the females indep

277 ose that mosaicism for paternal alleles is a maternal effect that results from Pms2 deficiency during

278 Most predictions focus, however, on maternal effects that affect only a single character, wh

279 h an ability to manipulate male behavior via maternal effects that alter offspring phenotypes.

280 However, maternal effects that limit the caste of eggs may be mor

281 ailable on larval diapause or the intriguing maternal effects that regulate egg diapause.

282 mptions, such as the absence of dominance or maternal effects, that greatly weaken their discriminato

283 he phenomenon, with particular reference to 'maternal effects', the processes observed in many specie

284 he phenotype and genotype of a locus showing maternal effects, the conclusions are likely to be relev

285 elegans The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and

286 des the C. elegans ortholog of Hth, and that maternal-effect unc-62 mutations can cause severe poster

287 s of the additive, dominance, epistatic, and maternal effects underlying divergence within each cline

288 A maternal effect was detected for 8 sites.

289 than in offspring of male probands, and this maternal effect was restricted to offspring of probands

290 for zygotic lethal mutations associated with maternal effects, we have identified rasp, a novel Droso

291 No significant maternal effects were found.

292 in most of the models, whereas epistatic and maternal effects were less common.

293 nt and that dominance, digenic epistasis and maternal effects were not significant.

294 All mutants showed a maternal effect, whereby seeds inheriting a maternal mut

295 One such cause of phenotypic variation is a maternal effect, which is the influence of the environme

296 diverged populations that take into account maternal effects will shed further light on the true inc

297 Maternal effects, with association confined to maternall

298 We identified split top, a recessive maternal-effect zebrafish mutant that disrupts embryonic

299 We identified brambleberry, a maternal-effect zebrafish mutant that disrupts karyomere

300 y explanations for the observed patterns are maternal effect-zygotic gene incompatibilities or cluste