ライフサイエンスコーパス: maternal mRNA

1 of Cad mRNA, and that are not represented in maternal mRNA.

2 he translation of the FGF receptor-1 (XFGFR) maternal mRNA.

3 e by precise control of the stability of the maternal mRNA.

4 ine-rich motif required for stability of the maternal mRNA.

5 nd MAP kinase activities, and recruitment of maternal mRNAs.

6 st approach to study the function of dormant maternal mRNAs.

7 lyadenylation-induced translation of dormant maternal mRNAs.

8 n the localization and on-site expression of maternal mRNAs.

9 terile mutants for defects in translation of maternal mRNAs.

10 f and binding partners direct degradation of maternal mRNAs.

11 scription and the degradation of a subset of maternal mRNAs.

12 e unmasking, translation, and degradation of maternal mRNAs.

13 were annotated as germline mRNAs and many as maternal mRNAs.

14 timing of polyadenylation and translation of maternal mRNAs.

15 ments in the 3' untranslated region (UTR) of maternal mRNAs.

16 -binding proteins and translationally masked maternal mRNAs.

17 e differentiation to repress glp-1 and other maternal mRNAs.

18 2, but did not affect maintenance of several maternal mRNAs.

19 polyadenylation of an early class of Xenopus maternal mRNAs.

20 skin as the key factor for the repression of maternal mRNA, a second mechanism must exist, since mask

21 cortex embryos, indicating that the block in maternal mRNA activation is specific to a class of mRNAs

22 Using the localized maternal mRNA An2 as a target, we have shown that chimer

23 ryos decelerates the decay of m(6)A-modified maternal mRNAs and impedes zygotic genome activation.

24 nce of transcription and instead relies upon maternal mRNAs and proteins deposited in the egg during

25 During the development of Xenopus laevis, maternal mRNAs and proteins stored in the egg direct ear

26 pid mitotic divisions that are controlled by maternal mRNAs and proteins that accumulate during oogen

27 is a unique quiescent cell, prepackaged with maternal mRNAs and proteins that have functions in early

28 Knockdown of Ago2 stabilizes one set of maternal mRNAs and reduces zygotic transcripts of anothe

29 We find that repressed maternal mRNAs and their regulators localize to P body-l

30 tes, LIMP is translated in the ookinete from maternal mRNA, and later in the sporozoite.

31 is, selective recruitment and degradation of maternal mRNA, and pronuclear development.

32 cortical granule exocytosis, recruitment of maternal mRNAs, and cell cycle resumption.

33 cortical granule exocytosis, recruitment of maternal mRNAs, and cell cycle resumption.

34 anslational regulators and a specific set of maternal mRNAs, and prevents those mRNAs from being degr

35 During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but inte

36 mental progression during which thousands of maternal mRNAs are cleared by post-transcriptional mecha

37 he maternal-to-zygotic transition (MZT) when maternal mRNAs are degraded and zygotic transcription be

38 e maternal-to-zygotic transition (MZT), when maternal mRNAs are destroyed, high-level zygotic transcr

39 In oocytes, nontranslated maternal mRNAs are packaged by protein into messenger ri

40 Finally, we demonstrate that maternal mRNAs are required for different modes of zygot

41 In eggs, maternal mRNAs are stored and selectively activated duri

42 Although some maternal mRNAs are targeted for degradation by microRNAs

43 maturation in Xenopus, previously quiescent maternal mRNAs are translationally activated at specific

44 During early metazoan development, certain maternal mRNAs are translationally activated by elongati

45 volved in OET and identified novel motifs in maternal mRNAs associated with transcript stability.

46 s mechanism may involve the translation of a maternal mRNA at the time of the MBT, as suggested previ

47 tages revealed that Hnrnpa1 dissociates from maternal mRNAs at ZGA and instead regulates the nuclear

48 These results suggest that binding of intact maternal mRNA by MSY2 is required for its cytoplasmic re

49 These proteins govern expression from maternal mRNAs by an unknown mechanism.

50 Xenopus, translational activation of stored maternal mRNAs by cytoplasmic polyadenylation requires b

51 Codon composition shapes maternal mRNA clearance during the maternal-to-zygotic t

52 d maternally driven mechanism that regulates maternal mRNA clearance during zebrafish MZT, highlighti

53 n and plakoglobin directly, by depleting the maternal mRNAs coding for each of them in developing Xen

54 We propose that the 3'UTR of maternal mRNAs contains a combinatorial code that determ

55 trophoblast outgrowth in vitro, reflecting a maternal mRNA contribution, which has been shown to pers

56 These results reveal a previously unknown maternal mRNA control system that is specific to late st

57 sumption, and degradation and recruitment of maternal mRNAs; cortical granule exocytosis, however, di

58 ding site suggesting that the translation of maternal mRNAs could be either limited by or independent

59 the poly(A)-dependent recruitment of several maternal mRNAs (cyclin B1, c-Mos, D7, and B9) during mei

60 Recent evidence has shown that one maternal mRNA, cyclin B1, is concentrated on mitotic spi

61 A dominant inhibitory form of Musashi blocks maternal mRNA cytoplasmic polyadenylation and meiotic ce

62 , a reader of N(6)- methylation, facilitates maternal mRNA decay, introducing an additional facet of

63 s spatially and temporally with the onset of maternal mRNA degradation.

64 miR-430 is crucial for the clearance of maternal mRNA during maternal zygotic transition in embr

65 n the translational activation of a specific maternal mRNA during oocyte maturation.

66 ial process that controls the translation of maternal mRNAs during early development and depends on t

67 cilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.

68 e required to trigger the destabilization of maternal mRNAs during egg activation.

69 our findings for translational regulation of maternal mRNAs during embryogenesis and for the activati

70 regulating the stability and translation of maternal mRNAs during mouse oogenesis.

71 RNA-binding proteins regulates expression of maternal mRNAs during oogenesis, the oocyte to embryo tr

72 and represses the expression of thousands of maternal mRNAs during the Drosophila MZT.

73 nylation controls the translation of several maternal mRNAs during Xenopus oocyte maturation and requ

74 The SpCOUP-TF mRNA, the first sea urchin maternal mRNA encoding a transcription factor that is sp

75 Here, we show that the maternal mRNA encoding the cell-fate regulatory protein

76 of the oocytes; prevented the recruitment of maternal mRNAs encoding cyclin B1, c-Mos, D7, and B9; an

77 nesis, in which RBPs control expression from maternal mRNAs encoding key cell fate determinants.

78 requires the correct temporal translation of maternal mRNAs encoding key regulatory proteins.

79 h the use of Drosophila lines that express a maternal mRNA for the yeast transcription factor GAL4.

80 ts are occurring, including transcription of maternal mRNAs for storage in the mature egg, global tra

81 The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in th

82 bifunctional 3' UTR sequence that maintains maternal mRNA in a dormant state in oocytes and activate

83 ygotic microRNAs coordinate the clearance of maternal mRNA in animals to facilitate developmental tra

84 ment for IBEs in the regulation of localized maternal mRNAs in D. melanogaster and X. laevis.

85 Translational regulation of maternal mRNAs in distinct temporal and spatial patterns

86 sults support a role for MSY2 in stabilizing maternal mRNAs in growing oocytes, a process essential t

87 and is a trans-acting factor for the TCS in maternal mRNAs in immature Xenopus oocytes.

88 ation of the stability and/or translation of maternal mRNAs in the mouse oocyte.

89 The translational activation of several maternal mRNAs in Xenopus laevis is dependent on cytopla

90 yadenylation and translational activation of maternal mRNAs in Xenopus laevis.

91 prominent example of this is localization of maternal mRNAs in Xenopus oocytes, a process requiring r

92 ducts accumulate that promote degradation of maternal mRNAs, including string and twine; and (4) cons

93 Early metazoan development is programmed by maternal mRNAs inherited by the egg at the time of ferti

94 Although translational regulation of maternal mRNA is important for proper development of the

95 We show that Nasonia otd maternal mRNA is localized at both poles of the embryo,

96 FGF receptor-1 (XFGFR) maternal mRNA is present in immature oocytes, but the pr

97 Degradation of maternal mRNA is thought to be essential to undergo the

98 Translational recruitment of maternal mRNAs is an essential process in early metazoan

99 (m(6)A) modified, and the clearance of these maternal mRNAs is facilitated by an m(6)A-binding protei

100 s between 0.5 and 1.0 microM, recruitment of maternal mRNAs is only partially stimulated at injected

101 and invertebrates, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylati

102 nopus development, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylati

103 The translation of many maternal mRNAs is regulated by dynamic changes in poly(A

104 The translation of specific maternal mRNAs is regulated during early development.

105 The translational regulation of maternal mRNAs is the primary mechanism by which stage-s

106 ng proteins modulates poly(A) tail length of maternal mRNAs, leading to asymmetric expression of a ce

107 y also suggest that mechanisms that regulate maternal mRNAs, like TCE-mediated repression, may functi

108 Inherited as a maternal mRNA localized only in vegetal cells, VegT acti

109 GFbeta superfamily member, is expressed as a maternal mRNA localized to prospective endoderm, and mat

110 vel observations: first, XPACE4 is stored as maternal mRNA localized to the mitochondrial cloud and v

111 nt studies have documented the importance of maternal mRNA (MmRNA) and its correct recruitment for de

112 The maternal mRNA nos-2 is maintained in germ granules, but

113 ount for the range of temporal inductions of maternal mRNAs observed during Xenopus oocyte maturation

114 ion and translational activation of multiple maternal mRNAs occur in a CPE- and CPEB-independent mann

115 equires that the translation of pre-existing maternal mRNAs occur in a strict temporal order.

116 equired both to recruit and also to maintain maternal mRNAs on polyribosomes.

117 lates polyadenylation-induced translation of maternal mRNA once it is phosphorylated on Ser 174 or Th

118 Precise elimination of maternal mRNAs plays a critical role during the maternal

119 thus revealing a differential regulation of maternal mRNA polyadenylation by the MAPK and MPF signal

120 ake an unexpectedly high contribution to the maternal mRNA pool, which persists in cleavage stage emb

121 Our work revealed different profiles of maternal mRNA post-transcriptional regulation prior to z

122 nalyse this model with a spatial gradient of maternal mRNA, rather than being fixed at only the anter

123 is CDC6, which is synthesized from a dormant maternal mRNA recruited during oocyte maturation, and a

124 ivate the cis-linked gene loci to synthesize maternal mRNAs required for early embryogenesis.

125 Translation of a variety of maternal mRNAs requires either the maintenance or cytopl

126 ated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate

127 presence of related proteins in P-bodies and maternal mRNA storage granules suggests this mechanism i

128 this transition requires degradation of two maternal mRNAs, string and twine, which encode Cdc25 pho

129 Unlike maternal mRNAs such as bicoid and oskar that are localiz

130 Bicoid ( bcd ) mRNA is a Drosophila maternal mRNA that is translationally activated by cytop

131 s likely to be coupled to the degradation of maternal mRNA that occurs at that stage.

132 dies have also allowed us to define a set of maternal mRNAs that are deadenylated shortly after ferti

133 ogen activator (tPA, Plat) mRNAs are dormant maternal mRNAs that are recruited during oocyte maturati

134 denylation and translational inactivation of maternal mRNAS that lack cytoplasmic polyadenylation ele

135 es that the normal pattern of degradation of maternal mRNAs that occurs during oocyte maturation is d

136 and translational recruitment/repression of maternal mRNAs that occurs in early development is not f

137 on of poly(A) tail length and translation of maternal mRNAs through sequence-specific association wit

138 ssive ribonucleoprotein particles containing maternal mRNA to facilitate translational activation.

139 s the cytoplasmic polyadenylation of certain maternal mRNAs to permit or enhance their translation.

140 tly influence posttranscriptional control of maternal mRNAs to promote germ cell specification in the

141 entifying the targeted degradation of stored maternal mRNA transcripts including sirtuin 1 and ubiqui

142 st in kinase activity links development with maternal mRNA translation and ensures irreversibility of

143 necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cy

144 lyadenylation is a key mechanism controlling maternal mRNA translation in early development.

145 Our findings suggest that the timing of maternal mRNA translation is controlled through signal t

146 The maturation-dependent stimulation of maternal mRNA translation is correlated with increases i

147 A strict temporal order of maternal mRNA translation is essential for meiotic cell

148 n requires the strict temporal regulation of maternal mRNA translation.

149 regulatory elements to control the timing of maternal mRNA translational activation during oocyte mat

150 CGE), cytoplasmic segregation, cleavages and maternal mRNA translocation, in transcriptionally quiesc

151 l role for Zfp36l2 may have implications for maternal mRNA turnover in normal embryogenesis, and conc

152 translation and subcellular localization of maternal mRNAs underlies establishment of the antero-pos

153 s rely on post-transcriptional regulation of maternal mRNAs until zygotic genome activation (ZGA).

154 AF1 participate in repression and control of maternal mRNAs using Xenopus laevis oocytes.

155 rarchy in the cytoplasmic polyadenylation of maternal mRNAs, we ablated c-mos mRNA with an antisense

156 ) in the 3' untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression i

157 proteins before ZGA was surprising, because maternal mRNAs were found to be fully spliced.

158 Previously recruited maternal mRNAs were removed from polyribosomes following

159 Xenopus oocytes accumulate maternal mRNAs which are then recruited to ribosomes dur

160 iffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized sour

161 The restricted spatiotemporal translation of maternal mRNAs, which is crucial for correct cell fate s

162 arrest of female meiosis, degrading certain maternal mRNAs while initiating the translation of other

163 In a screen for maternal mRNAs whose stability is regulated by this cort

164 Consistent with regulating maternal mRNAs, Zar2 was present throughout oogenesis, a