ライフサイエンスコーパス: maternally

1 n the paternal genome and may be transmitted maternally.

2 eas lin28b is expressed both zygotically and maternally.

3 most eukaryotes, mitochondria are inherited maternally.

4 By 52 weeks of age, the majority of maternally acquired antibodies had waned and vaccine Env

5 The kinetics of enhancing activity by maternally acquired DENV antibodies was determined in se

6 Maternally acquired DENV-3 NAbs disappeared in >90% of t

7 high DNA-lactia and lower GA, regardless of maternally acquired neutralizing antibody levels.

8 a complete lack of genetic structure in both maternally and biparentally inherited markers.

9 Inherited mtDNA diseases transmit maternally and cause severe phenotypes.

10 owth factor promotion and regulation of both maternally and fetally derived molecules.

11 result in offspring that carry a mixture of maternally and paternally derived copies of the genome;

12 ing trios to investigate differences between maternally and paternally derived DNMs and study the und

13 Here, we assess maternally and paternally derived protection in a monarc

14 genes were enriched for coexpressed pairs of maternally and paternally expressed genes, showed accele

15 F1R causes down-regulated expression of both maternally and paternally expressed imprinted genes and

16 imprinting rely on an asymmetry between the maternally and paternally inherited alleles at a locus t

17 s; however, as there is no asymmetry between maternally and paternally inherited alleles in this mode

18 f-origin specific differential expression of maternally and paternally inherited alleles.

19 between reciprocally imprinted genes on the maternally and paternally inherited chromosomes.

20 DNA result in maternally inherited diseases; maternally and somatically acquired mutations also accum

21 We show that interference with the maternally and ubiquitously expressed zebrafish Ccr7 or

22 , fish lacking both Cnrip1a and Cnrip1b both maternally and zygotically are viable and fertile and no

23 errogate the function of mRNAs that are both maternally and zygotically expressed, it is common to ex

24 nnecessary for the extensive accumulation of maternally biased small RNA (sRNA) molecules detected in

25 parental species and thus will be inherited maternally, but the chromosome that houses the sex-deter

26 feeding was recorded prospectively by using maternally completed feeding diaries.

27 The role of maternally contributed and zygotically transcribed genes

28 ough the structure of the synapse is normal, maternally contributed CaMKII does not localize to synap

29 ogical role of the nematode mir-35 family of maternally contributed essential microRNAs.

30 es share similar dynamics to those in mouse, maternally contributed methylation is divergently target

31 Maternally contributed microRNAs may therefore play impo

32 ion repression to its biological role in the maternally controlled stages of vertebrate embryogenesis

33 ygote and embryo development being primarily maternally controlled, and subsequent steps being govern

34 gene that causes Angelman syndrome (AS) when maternally deleted and is associated with autism when ma

35 ons in population size were observed between maternally density-stressed and density-unstressed offsp

36 Embryos maternally depleted of any one of the three PIWI protein

37 Here, we characterize the maternally deposited and zygotically expressed small RNA

38 ophila embryo, we sought to count individual maternally deposited bicoid mRNA molecules and compare v

39 at which Drosophila embryos synthesize DNA, maternally deposited dNTPs can generate less than half o

40 dispensable for embryonic development, while maternally deposited gdf3 is required for mesendoderm fo

41 ternal to zygotic transition (MZT), in which maternally deposited messenger RNAs are degraded while z

42 enylation may contribute to the clearance of maternally deposited microRNAs during MZT.

43 cific 3' end nontemplate oligoadenylation of maternally deposited microRNAs that is conserved between

44 cer activity in downregulating the levels of maternally deposited mRNAs to fine-tune the expression o

45 fertilization, development is controlled by maternally deposited products, and it is not until later

46 early development, animal embryos depend on maternally deposited RNA until zygotic genes become tran

47 ates zebrafish hoxb1a transcription, we find maternally deposited TALE proteins at the hoxb1a promote

48 In the Drosophila early embryo, maternally deposited TE-derived PIWI-interacting small R

49 ly shown to be bound in early embryos by the maternally deposited transcription factor Zelda, suggest

50 ed microRNAs, target a significant number of maternally deposited transcripts.

51 hey were affected by shared genetic signals, maternally-deposited yolk hormones or other transient in

52 was associated with increased diabetes when maternally derived (odds ratio [OR], 1.92; P = 4.1 x 10(

53 ing demonstrated that she is a carrier for a maternally derived 5T/12TG variant.

54 Similarly, the presence of maternally derived anti-brain autoantibodies found in 2

55 Similarly, the presence of maternally derived anti-brain autoantibodies found in ~2

56 However, if maternally derived antibodies adversely affect the immun

57 8 weeks of age correlated with a decrease in maternally derived antibodies.

58 A maternally derived C allele also was associated with a 2

59 r is critically dependent on uncharacterized maternally derived chemosensory ligands.

60 wnstream site is used more frequently on the maternally derived chromosome.

61 Maternally derived copy number gains of human chromosome

62 that some genome regions show enrichment for maternally derived DNMs.

63 sbred to generate homozygous NOS3(-/-) (KO), maternally derived heterozygous NOS3(+/-) (KOM: mother w

64 the transfer of helminth antigens but rather maternally derived IFN-gamma during the acute phase of i

65 ines administered to young pigs that possess maternally derived immunity.

66 sure was associated with a faster decline of maternally derived immunoglobulin G antibody to both the

67 e, when the IgA antibodies are predominantly maternally derived in breast-fed children.

68 Whereas approximately 10% were maternally derived in the first few weeks after weaning,

69 In Pima Indians, the effect of maternally derived KCNQ1 variants appears to be mediated

70 s to offspring, many studies have focused on maternally derived protection.

71 Maternally derived RSV-specific antibodies play a role i

72 Differentiation of the maternally derived seed coat epidermal cells into mucila

73 fertilization products are surrounded by the maternally derived seed coat, whose development prior to

74 osperm, which is in turn enclosed within the maternally derived seed coat.

75 d collected at delivery); however, at birth, maternally derived serotype-specific antibody concentrat

76 wed as a single unified dynamic system where maternally derived size-dependent information interprete

77 s represent the first evidence of a role for maternally derived WNT regulators during this period and

78 The cish.a gene was maternally derived, with transcripts present throughout

79 esting great effort to determine the role of Maternally-Derived Stress (MDS) as an inducer of phenoty

80 Here we assess the role of maternally directed learning of migratory habitats, or m

81 ndent RNA decay as a previously unidentified maternally driven mechanism that regulates maternal mRNA

82 Most human aneuploidies originate maternally, due in part to the presence of highly string

83 y deleted and is associated with autism when maternally duplicated has recently been shown to regulat

84 evealed two temporal degradation programs: a maternally encoded early-onset program and a late-onset

85 d pre-mRNA splicing of early zygotic but not maternally encoded transcripts.

86 Depletion of these maternally-encoded transcripts frequently results in fai

87 To test this, we maternally exposed developing mice in utero to gestation

88 ty of African infants, particularly in those maternally exposed to HIV.

89 f 4 miRNAs (e.g., miR-377, miR-379) from the maternally expressed 14q32 chromosome region.

90 s MALAT1, taurine upregulated gene 1 (TUG1), maternally expressed 3 (MEG3), linc00657, and linc00493.

91 Xenopus development, gtpbp2 transcripts are maternally expressed and localized to the egg animal pol

92 ation revealed that zebrafish scube1 mRNA is maternally expressed and widely distributed during early

93 NAs, including miR-127, are processed from a maternally expressed antisense Rtl1 transcript (Rtl1as)

94 lthough genetic screens have identified many maternally expressed cell fate-controlling RNA-binding p

95 Maternally expressed gene 3 (MEG3) is an imprinted gene

96 Among them, the lncRNA maternally expressed gene 3 (Meg3) was found to be mostl

97 essed genes (PEGs), while endosperm-specific maternally expressed genes (endo-MEGs) were associated w

98 In the rice endosperm, we identified 162 maternally expressed genes (MEGs) and 95 paternally expr

99 However, only approximately 14% of maternally expressed genes (MEGs) and approximately 29%

100 The majority of maternally expressed genes (MEGs) were shared among all

101 genes at this stage, while nearly 80% of the maternally expressed genes (MEGs) were specific to 10 DA

102 role for IPW in modulating the expression of maternally expressed genes in trans, which has important

103 gulates imprinted expression of a cluster of maternally expressed genes on human chromosome 11p15.5.

104 ic expression of Kcnq1ot1 and suppression of maternally expressed genes.

105 However, unlike in mammals, Meg1 is a maternally expressed imprinted gene that surprisingly ac

106 Maternally expressed imprinted genes are enriched for hy

107 Maternally expressed members of the Transforming Growth

108 afish futile cycle gene is shown to encode a maternally expressed membrane protein required for nucle

109 In addition, 35 maternally expressed non-coding RNAs exhibited the same

110 nal knockout (cKO) of Smc5 demonstrated that maternally expressed SMC5 protein is essential for early

111 ethal underdominance (UD(MEL)), in which two maternally expressed toxins, located on separate chromos

112 ontaining 1 gene (ZMIZ1), and H19, imprinted maternally expressed transcript gene (H19) were associat

113 eurogenetic disorder caused by deficiency of maternally expressed ubiquitin-protein ligase E3A (UBE3A

114 Furthermore, we show that the maternally expressed zebrafish Kinesin-1 Kif5Ba is a bin

115 ted in bi-allelic expression of the normally maternally expressed Zim2, whereas the maternal transmis

116 Zebrafish tbl3 is maternally expressed, but later in development its expre

117 studies reveal that both genes are required maternally for egg laying, mitotic progression in early

118 h localized to the epigenetically regulated, maternally imprinted chromosome 14q32 region.

119 ents with mutations (W100G and R102X) in the maternally imprinted epsilon-sarcoglycan (SGCE) gene and

120 Herein we show that the maternally imprinted gene Zac1 is a critical regulator o

121 eural lineage progression, we focused on the maternally imprinted gene Zac1.

122 or 2 (IGF2), a developmentally regulated and maternally imprinted gene, is frequently overexpressed i

123 For instance, transcripts for the maternally imprinted MEST and PLAGL1, were high in oocyt

124 The maternally imprinted MEST gene, the nonimprinted glucoco

125 ifically, Alb/AEG-1/c-Myc mice overexpressed maternally imprinted noncoding RNAs (ncRNAs), such as Ri

126 portion of cases are due to mutations in the maternally imprinted SGCE gene.

127 H19 is abundantly expressed maternally in embryonic tissues but is strongly represse

128 Mitochondria are inherited maternally in most animals, but the mechanisms of select

129 These phenotypes were transmitted maternally, indicating the etiological role of the mitoc

130 e disorder.SIGNIFICANCE STATEMENT People who maternally inherit a deletion or nonfunctional copy of t

131 t period owes to conflict, between a woman's maternally inherited (MI) and paternally inherited (PI)

132 Maternally inherited 15q11-13 chromosomal triplications

133 d that Ube3a is primarily expressed from the maternally inherited allele in myelinated large-diameter

134 s multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including the largest miRNA

135 The maternally inherited alpha-proteobacterium Wolbachia has

136 Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad ran

137 They are maternally inherited and in humans contain a 16,569-base

138 Mitochondrial disease is maternally inherited and refractory to treatment, but as

139 Wolbachia are intracellular maternally inherited bacteria that can spread through in

140 er's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease characterized by d

141 e its ligand, HLA-C2, was paternally but not maternally inherited by a fetus (p = 0.005, odds ratio =

142 iparentally inherited nuclear loci and three maternally inherited chloroplast fragments from all dipl

143 D/MPV that arose de novo specifically on the maternally inherited chromosome and delete lung-specific

144 its extensive localized DNA demethylation on maternally inherited chromosomes.

145 ces with blue eggs are distinguished only by maternally inherited components of the genome, which mai

146 ising from loss-of-function mutations in the maternally inherited copy of the UBE3A gene, and is char

147 l disorder caused by loss of function of the maternally inherited copy of UBE3A, an imprinted gene ex

148 c acidosis and stroke-like episodes (MELAS), maternally inherited deafness and diabetes (MIDD) and pr

149 ked to mitochondrial dysfunctions leading to maternally inherited deafness, aminoglycoside sensitivit

150 nd stroke-like episodes) and MIDD syndromes (maternally inherited diabetes and deafness).

151 tions in mitochondrial genes as the cause of maternally inherited diseases affecting tissues that rel

152 gh frequencies of pathogenic mtDNA result in maternally inherited diseases; maternally and somaticall

153 Rare maternally inherited duplications at 15q11-13 are observ

154 In many arthropods, maternally inherited endosymbiotic bacteria can increase

155 ited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched

156 We show that the sea star first likely uses maternally inherited factors and the Wnt and Delta pathw

157 inherited genes might be inactivated because maternally inherited genes are adapted to function harmo

158 favor demanding more from the mother, while maternally inherited genes favor restraint.

159 Mitochondrial diseases include a group of maternally inherited genetic disorders caused by mutatio

160 d systems such as Drosophila and Xenopus use maternally inherited germ determinants to specify germ c

161 Specification through maternally inherited germ plasm occurs in many well-char

162 se observations suggest that Gryllus lacks a maternally inherited germ plasm, in contrast with many h

163 at growth hormone deficiency associated with maternally inherited gingival fibromatosis is an allelic

164 patients with growth hormone deficiency and maternally inherited gingival fibromatosis.

165 However, it may also cause maternally inherited hearing loss in the absence of amin

166 according to extreme geographic structure in maternally inherited host mitochondrial DNA, appeared co

167 the same region of paternally inherited and maternally inherited human chromosome 15q, respectively.

168 The genus Wolbachia is an archetype of maternally inherited intracellular bacteria that infect

169 drial inhibitors, or in neurons derived from maternally inherited Leigh syndrome (MILS) patient iPS c

170 Some rare SRS patients carry maternally inherited microduplications spanning the impr

171 ormalities, including the three samples with maternally inherited microduplications.

172 Maternally inherited mitochondrial (mt)DNA mutations can

173 plus hundreds to thousands of copies of the maternally inherited mitochondrial DNA (mtDNA).

174 Deleterious CNVs (>400 kb) were maternally inherited more often (up to 64%, p = 10(-15))

175 transcription and are instead controlled by maternally inherited mRNAs and proteins.

176 pment depends heavily on accurate control of maternally inherited mRNAs, and yet it remains unknown h

177 Our data thus demonstrate that low levels of maternally inherited mtDNA mutations when present during

178 r the genetics of the thousands of copies of maternally inherited mtDNA, the more than 1,000 nuclear

179 s in CEP104; one of these subjects harbors a maternally inherited nonsense mutation (c.496C>T [p.Arg1

180 tions that disrupted a gene, 82% were either maternally inherited or de novo (p = 4.3 x 10(-3)).

181 ations but females do not, making the use of maternally inherited organelle genes problematic.

182 Because cytochrome b is encoded by the maternally inherited parasite mitochondrion, even outcro

183 led from paternally inherited centrioles and maternally inherited pericentriolar material (PCM) [1].

184 Lrmp is a conserved vertebrate gene whose maternally inherited products are essential for nucleus-

185 a more compact structure characterizing the maternally inherited repressed allele.

186 cal presentations and affected by de novo or maternally inherited single-nucleotide changes.

187 an be rendered asexual by infection with the maternally inherited symbiont Wolbachia.

188 Maternally inherited symbionts are common in arthropods

189 ssociated with severe human diseases and are maternally inherited through the egg's cytoplasm.

190 Breakpoint sequencing of one maternally inherited translocation involving four chromo

191 ome (AS), which is caused by the loss of the maternally inherited UBE3A allele (encoding ubiquitin pr

192 rogenetic disorder caused by deletion of the maternally inherited UBE3A allele and is characterized b

193 l disorder caused by loss of function of the maternally inherited UBE3A allele.

194 used by disrupted neuronal expression of the maternally inherited Ube3A ubiquitin protein ligase, req

195 Furthermore, it identified a pathogenic maternally inherited Xp11.2 duplication.

196 a duplication of seven base pairs, which was maternally inherited, c.844_851dupCCATGCA, predicting p.

197 rRNA gene of human mitochondrial DNA causes maternally inherited, nonsyndromic deafness, an extreme

198 Wolbachia is maternally inherited, resulting in co-inheritance of mit

199 tinalis to show that levels of buffering are maternally inherited.

200 ased thyroid-stimulating hormone levels when maternally inherited.

201 t by an average of 1.83 cm (-0.31 s.d.) when maternally inherited.

202 uclear differentiation, either stochastic or maternally inherited.

203 KCNQ1 influence diabetes susceptibility when maternally inherited.

204 ing revealed a subset of pri-miRNAs that are maternally inherited.

205 with rearrangements < 6 Mb, unless they were maternally inherited.

206 irect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a syn

207 This child carries a maternally-inherited ~86 kb FREM1 deletion that affects

208 a were collected from birth certificates and maternally linked hospital discharge data.

209 However, maternally loaded Gal4 protein is very efficient at gene

210 NAs to knockdown zygotic transcripts and (2) maternally loaded Gal4 protein to drive zygotic shRNA ex

211 s, posits that MBT timing is controlled by a maternally loaded inhibitory factor that is titrated aga

212 In addition to the maternally loaded primary piRNAs, Tribolium embryos prod

213 e phenotypes for genes expressed maternally, maternally loaded shRNAs are not very effective at gener

214 Here, we evaluate the efficacies of: (1) maternally loaded shRNAs to knockdown zygotic transcript

215 vely generate phenotypes for genes expressed maternally, maternally loaded shRNAs are not very effect

216 ated by an imprinting control region that is maternally methylated and silenced.

217 ese to offspring methylation status within 3 maternally methylated imprinted genes: paternally expres

218 The maternally methylated KvDMR1 ICR regulates imprinted exp

219 Cby RNA is supplied maternally, negatively regulated by Snail2 but not Twist

220 e inseminated or microinjected, yet numerous maternally-nucleated cytasters are found.

221 Thus, maternally obtained GlcN may increase substrates for bio

222 the extent to which female elasmobranchs may maternally offload contaminants.

223 that restricts gene expression to either the maternally or paternally inherited allele.

224 we show that vasa and piwi are not required maternally or zygotically for PGC formation but rather a

225 essed genes (endo-MEGs) were associated with maternally preferred H3K4me3 and H3K36me3 peaks.

226 that many developmental enhancers are marked maternally, prior to exposure to extrinsic signals.

227 Our studies indicate that maternally provided aura (mid1ip1l) acts during the reor

228 Bicoid protein molecules, translated from maternally provided bicoid mRNA, establish a concentrati

229 Animal embryos depend upon maternally provided factors until zygotic genome activat

230 ing (induction) or by a derived mechanism of maternally provided germ plasm (preformation).

231 Together, our observations suggest that maternally provided HA stimulates protective antimicrobi

232 g oogenesis, which is when the expression of maternally provided patterning factors is precisely cont

233 n but not its chromodomain and was guided by maternally provided signals.

234 ere we report that zebrafish embryos without maternally provided vg1 fail to form endoderm and head a

235 pment, the level of competition for limited (maternally provided) resources will often depend critica

236 In Drosophila, PGCs are specified by maternally provided, asymmetrically localized cytoplasmi

237 ce interval, 1.06-1.44) that was similar for maternally reported asthma.

238 is, day-care center attendance, birth order, maternally reported common infections in infancy, and br

239 ASD were at significantly increased odds of maternally reported constipation (adjusted odds ratio [a

240 accination was associated with reductions in maternally reported diarrhea (hazard ratio [HR], 0.89; 9

241 In this large prospective cohort, maternally reported GI symptoms are more common and more

242 Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by usin

243 in fecal transplantation experiments: adult maternally separated rats were subjected to water avoida

244 SETDB1 in PWS-specific iPSCs, expression of maternally silenced 116HG RNA is partially restored.

245 used by the absence of paternally expressed, maternally silenced genes at 15q11-q13.

246 Imprinted, maternally silenced insulin-like growth factor-2 is expr

247 MAGEL2 is an imprinted, maternally silenced, gene located at 15q11-13, within th

248 s are specified by using germ plasm-that is, maternally specified germ-line determinants (inheritance

249 tion that restricts the initial, ubiquitous, maternally specified, ANE regulatory state to the most a

250 d in low and high density, and HL and HH for maternally stressed offspring, assigned in low and high

251 d in low and high density, and HL and HH for maternally stressed offspring, assigned in low and high

252 characterize the translational regulation of maternally supplied mom-2 mRNA, which encodes a Wnt liga

253 Maternally supplied mRNAs encode proteins that pattern e

254 atterns in Drosophila embryos, we manipulate maternally supplied patterning determinants and measure

255 s regulated combinatorially by a set of nine maternally supplied RBPs.

256 rest is unable to compensate for deficits in maternally supplied rest and uncovers novel temporal req

257 Here we show that in zebrafish, maternally supplied rest regulates expression of target

258 to estimate the effectiveness of alternative maternally targeted vaccination strategies (antenatal de

259 ormation to aid consideration of alternative maternally targeted vaccination strategies and can infor

260 prompted a number of countries to implement maternally targeted vaccination strategies to protect vu

261 Mice acquire both IgG and IgA maternally; the former has primarily been implicated in

262 In most species, mitochondria are inherited maternally through mechanisms that are poorly understood

263 is also highly diverse, and transitions from maternally to embryonically expressed elements.

264 ighly toxic bioaccumulative contaminant, can maternally transfer and elicit deleterious effects on ad

265 the enhancing activity of DENV infection by maternally transferred DENV antibodies occurs at earlier

266 We evaluated the consequences of maternally transferred Hg on a long-lived aquatic omnivo

267 rely stored in lipid rich tissue of eels but maternally transferred into gonads and eggs.

268 Maternally transmitted associations between endosymbioti

269 Numerous arthropods harbor maternally transmitted bacteria that induce the preferen

270 Spiroplasma poulsonii is a maternally transmitted bacterial endosymbiont that is na

271 Male-killing is one strategy used by maternally transmitted bacterial symbionts to boost tran

272 Wolbachia, a maternally transmitted bacterium globally present in art

273 eir germ line either early in development by maternally transmitted cytoplasmic factors (inheritance)

274 ide new insights into the pathophysiology of maternally transmitted deafness that was manifested by a

275 l mental retardation dysmorphism syndrome, a maternally transmitted developmental disorder.

276 The triplications arose de novo from maternally transmitted duplications and caused a more se

277 es of linkage between mitochondria and other maternally transmitted genetic elements, including the r

278 ortion, have well-studied parallels in other maternally transmitted genetic elements, such as bacteri

279 mong transmitters (defined as pairs in which maternally transmitted HIV infection occurred by 12 mont

280 We report the first case to date of maternally transmitted infantile spinocerebellar ataxia

281 Wolbachia are maternally transmitted intracellular bacteria that invad

282 The maternally transmitted microbes consistently include two

283 -dependent disease risk was communicable via maternally transmitted microbiota in both Nod2-deficient

284 Surprisingly, we also found that maternally transmitted mtDNA mutations can cause mild pr

285 Moreover, despite the fact that maternally transmitted mutations are the minority of all

286 Here, we dissected a complex maternally transmitted phenotype, reminiscent of comorbi

287 case study, we discuss a recently discovered maternally transmitted sex ratio distortion in an insect

288 the pea aphid (Acyrthosiphon pisum) and its maternally transmitted symbiont, Buchnera aphidicola Usi

289 Tsetse flies (Glossina spp.) house maternally transmitted symbionts that regulate the devel

290 Wolbachia is a maternally transmitted symbiotic bacterium of insects th

291 p mutation (c.2386C>T; p.R796X), whereas the maternally transmitted variant predicted a missense subs

292 r-growth when the humanised Igf2r allele was maternally transmitted, a phenotype that was rescued by

293 Wolbachia, which is maternally transmitted, invaded and spread through the p

294 Three Gammaproteobacteria species are maternally transmitted.

295 ter was decreased in both twin groups and in maternally underfed singleton fetuses (52, 65, and 55% d

296 tion and increased GR mRNA expression in the maternally underfed singleton group.

297 al populations (referred to as LL and LH for maternally unstressed offspring, assigned in low and hig

298 al populations (referred to as LL and LH for maternally unstressed offspring, assigned in low and hig

299 Early Wnt signaling is provided maternally, whereas BMP ligand expression in the zebrafi

300 Mitochondrial DNA mutations transmitted maternally within the oocyte cytoplasm often cause life-