ライフサイエンスコーパス: maternally inherited

1 genetically variable and adaptive trait, is maternally inherited.

2 conflict, should the mitochondrial genome be maternally inherited.

3 tozoa, and GFP expression in the embryos was maternally inherited.

4 ations in mitochondrial DNA (mtDNA) that are maternally inherited.

5 ing revealed a subset of pri-miRNAs that are maternally inherited.

6 .2, indicating that defects in this gene are maternally inherited.

7 hers, suggesting that these mutations can be maternally inherited.

8 with rearrangements < 6 Mb, unless they were maternally inherited.

9 tinalis to show that levels of buffering are maternally inherited.

10 ased thyroid-stimulating hormone levels when maternally inherited.

11 t by an average of 1.83 cm (-0.31 s.d.) when maternally inherited.

12 uclear differentiation, either stochastic or maternally inherited.

13 KCNQ1 influence diabetes susceptibility when maternally inherited.

14 A novel, heteroplasmic, maternally inherited 12SrRNA point mutation (T1095C) was

15 Maternally inherited 15q11-13 chromosomal triplications

16 tudies demonstrated preferential loss of the maternally inherited 1p homologue in NBs with 1p loss of

17 t MYCN amplification: 13 had deletion of the maternally inherited 1p, whereas 16 had deletion of the

18 This child carries a maternally-inherited ~86 kb FREM1 deletion that affects

19 Loss of function of the maternally inherited allele for the UBE3A ubiquitin liga

20 olk sac endoderm, which occurs only from the maternally inherited allele in a female embryo, had the

21 d that Ube3a is primarily expressed from the maternally inherited allele in myelinated large-diameter

22 developmental disorder caused by loss of the maternally inherited allele of UBE3A.

23 s multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including the largest miRNA

24 s abnormal activation of the normally silent maternally inherited allele.

25 protein, is expressed predominantly from the maternally-inherited allele and acts to restrict foetal

26 EA gene is imprinted, so that paternally and maternally inherited alleles are differentially expresse

27 s and mammals [3,4], in which paternally and maternally inherited alleles may be differentially expre

28 The maternally inherited alpha-proteobacterium Wolbachia has

29 Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad ran

30 Naturally occurring activin receptor mRNA is maternally inherited and contains within its 3' untransl

31 They are maternally inherited and in humans contain a 16,569-base

32 Mitochondrial disease is maternally inherited and refractory to treatment, but as

33 ermatogenesis, whereas class II 26G RNAs are maternally inherited and silence gene expression during

34 family showed that the expressed allele was maternally inherited and that the distinct clinical pres

35 a also suggest that JME may be predominantly maternally inherited and that the HLA-linked form is mor

36 ated into the cotton chloroplast genome were maternally inherited and were not transmitted via pollen

37 rray of diverse disorders, most of which are maternally inherited, and all of which are associated wi

38 female-biased line, sex ratio distortion was maternally inherited, and occurred in conjunction with a

39 Wolbachia are intracellular maternally inherited bacteria that can spread through in

40 WOLBACHIA are maternally inherited bacteria, which are very common in

41 ulation, thereby promoting the spread of the maternally inherited bacteria.

42 s and proteins from the aphid's obligate and maternally inherited bacterial endosymbiont, Buchnera, w

43 Wolbachia is a common maternally inherited bacterial symbiont able to induce c

44 Before maternally inherited bacterial symbionts like Wolbachia,

45 Maternally inherited bacterial symbionts of arthropods a

46 infection of Drosophila melanogaster by this maternally inherited bacterium restores fertility to fem

47 er's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease characterized by d

48 e its ligand, HLA-C2, was paternally but not maternally inherited by a fetus (p = 0.005, odds ratio =

49 a duplication of seven base pairs, which was maternally inherited, c.844_851dupCCATGCA, predicting p.

50 Although present in a variety of eukaryotes, maternally inherited characters are especially prominent

51 Maternally inherited chlorophyll deficiency, or albinism

52 astid ribosome deficiency (PRD) also lead to maternally inherited chlorophyll deficiency.

53 iparentally inherited nuclear loci and three maternally inherited chloroplast fragments from all dipl

54 In conclusion, maternally inherited chromosome 15q11-13 deletions produ

55 D/MPV that arose de novo specifically on the maternally inherited chromosome and delete lung-specific

56 we show that deletion of the IG-DMR from the maternally inherited chromosome causes bidirectional los

57 on, the IG-DMR, which is unmethylated on the maternally inherited chromosome, is necessary for the re

58 H19 is expressed almost exclusively from the maternally inherited chromosome, while Igf2 expression i

59 ng snoRNAs and microRNAs, expressed from the maternally inherited chromosome.

60 the non-coding RNAs are not repressed on the maternally inherited chromosome.

61 novo 1p36 terminal deletions arose from the maternally inherited chromosome.

62 estimation to a population of paternally and maternally inherited chromosomes 21.

63 its extensive localized DNA demethylation on maternally inherited chromosomes.

64 ntial gene expression from paternally versus maternally inherited chromosomes.

65 ces with blue eggs are distinguished only by maternally inherited components of the genome, which mai

66 of the X chromosome evoke the P cytotype, a maternally inherited condition that regulates the P-elem

67 nd TP6 are associated with the P cytotype, a maternally inherited condition that represses P-element-

68 genomes and also by having the P cytotype, a maternally inherited condition that strongly represses P

69 ising from loss-of-function mutations in the maternally inherited copy of the UBE3A gene, and is char

70 l disorder caused by loss of function of the maternally inherited copy of UBE3A, an imprinted gene ex

71 3, 4, or 5 unlinked autosomal markers with a maternally inherited cytoplasmic marker illustrate how n

72 c acidosis and stroke-like episodes (MELAS), maternally inherited deafness and diabetes (MIDD) and pr

73 well as the precise pathogenic mechanism of maternally inherited deafness and its exacerbation by en

74 Maternally inherited deafness associated with the A1555G

75 The A1555G mtDNA mutation that causes maternally inherited deafness disrupts mitochondrial rib

76 A methylation-dependent retrograde signal in maternally inherited deafness pathology and shedding sig

77 ked to mitochondrial dysfunctions leading to maternally inherited deafness, aminoglycoside sensitivit

78 ochondrial transcription and a novel link to maternally inherited deafness.

79 Mice carrying a similar, maternally inherited deletion of the Nesp55 DMR (DeltaNe

80 phenotype was seen with either paternally or maternally inherited deletions and with either complete

81 w that germ cells can be specified either by maternally inherited determinants (preformation) or by i

82 consistent family relationships (n = 7), and maternally inherited diabetes and deafness (n = 5).

83 nd stroke-like episodes) and MIDD syndromes (maternally inherited diabetes and deafness).

84 ffected father, but this is not explained by maternally inherited diabetes and/or deafness (MIDD) cau

85 tions in mitochondrial genes as the cause of maternally inherited diseases affecting tissues that rel

86 new insights into the molecular mechanism of maternally inherited diseases and a step toward therapeu

87 gh frequencies of pathogenic mtDNA result in maternally inherited diseases; maternally and somaticall

88 cidosis, and stroke-like episodes (MELAS), a maternally inherited disorder, is usually associated wit

89 ermine the clinical phenotype of CHI in this maternally inherited dominant mutation.

90 Rare maternally inherited duplications at 15q11-13 are observ

91 Wolbachia are maternally inherited endocellular bacteria, widespread i

92 s suggest that PGCs are unable to respond to maternally inherited endoderm determinants because RNAPI

93 Theory suggests that maternally inherited endosymbionts can promote their spr

94 Wolbachia are the most abundant maternally inherited endosymbionts of insects and cause

95 Male-killing bacteria are maternally inherited endosymbionts that selectively kill

96 tracellular Wolbachia bacteria are obligate, maternally-inherited, endosymbionts found frequently in

97 In many arthropods, maternally inherited endosymbiotic bacteria can increase

98 ited CNVs, specifically for small (<100 kb), maternally inherited events (P = 0.01) that are enriched

99 d selection, demographic history, and/or any maternally inherited factor such as the bacterial symbio

100 We show that the sea star first likely uses maternally inherited factors and the Wnt and Delta pathw

101 ataxia, and retinitis pigmentosa and with a maternally inherited form of Leigh's syndrome.

102 Mutational analysis of COL17A1 identified a maternally inherited G-to-T transversion at the -1 posit

103 inherited genes might be inactivated because maternally inherited genes are adapted to function harmo

104 favor demanding more from the mother, while maternally inherited genes favor restraint.

105 Mitochondrial diseases include a group of maternally inherited genetic disorders caused by mutatio

106 length polymorphism (RFLP) analysis of three maternally inherited genomes (mitochondrial DNA and plas

107 tance dispersal) on the genetic structure of maternally inherited genomes and the colonization rate o

108 d systems such as Drosophila and Xenopus use maternally inherited germ determinants to specify germ c

109 Specification through maternally inherited germ plasm occurs in many well-char

110 se observations suggest that Gryllus lacks a maternally inherited germ plasm, in contrast with many h

111 at growth hormone deficiency associated with maternally inherited gingival fibromatosis is an allelic

112 patients with growth hormone deficiency and maternally inherited gingival fibromatosis.

113 rnal-specific patterns of DNA methylation on maternally inherited GNAS1 alleles.

114 ce lessened toward term, overall, mothers of maternally inherited H19(Delta13) mutants had significan

115 syndrome region on chromosome 15q, which, if maternally inherited, has been implicated in autism.

116 lasmic mitochondrial tRNA mutation may cause maternally inherited HCM.

117 However, it may also cause maternally inherited hearing loss in the absence of amin

118 To identify a mouse model for maternally inherited hearing loss, we screened reciproca

119 at trophoblast expresses both paternally and maternally inherited HLA-C surface proteins and that mat

120 small noncoding RNA genes expressed from the maternally inherited homolog.

121 cular basis of the disorder by identifying a maternally inherited, homoplasmic m.14674T>C mt-tRNA(Glu

122 according to extreme geographic structure in maternally inherited host mitochondrial DNA, appeared co

123 The function of maternally inherited Hro-nos transcripts remains to be d

124 the same region of paternally inherited and maternally inherited human chromosome 15q, respectively.

125 CF, which binds at multiple sites within the maternally inherited ICR and is required to form a chrom

126 In somatic cells, the hypomethylated maternally inherited ICR binds the insulator protein CTC

127 though a less likely possibility is that the maternally inherited imprinting center acts in trans in

128 n blotting and RT-PCR, Xenopus TIMP3 mRNA is maternally inherited in eggs and midblastula (stage 8) e

129 CTT is eco-friendly because transgenes are maternally inherited in most crop plants.

130 e DNA-containing cytoplasmic organelles, are maternally inherited in the majority of angiosperm speci

131 s showed similarly skewed X inactivation was maternally inherited in this family.

132 ion of a Drosophila simulans population by a maternally inherited insect bacterial parasite, Wolbachi

133 Wolbachia are maternally inherited intracellular bacteria known to man

134 The genus Wolbachia is an archetype of maternally inherited intracellular bacteria that infect

135 The maternally inherited intracellular symbiont Wolbachia pi

136 Wolbachia are obligate, maternally inherited, intracellular bacteria that infect

137 drial inhibitors, or in neurons derived from maternally inherited Leigh syndrome (MILS) patient iPS c

138 S), neuropathy, ataxia, retinitis pigmentosa-maternally inherited Leigh syndrome (NARP-MILS), and Leb

139 ropathy, ataxia and retinitis pigmentosa and maternally inherited Leigh syndrome.

140 tinitis pigmentosa (NARP) to fatal childhood maternally inherited Leigh's syndrome (MILS).

141 hy, ataxia, and retinitis pigmentosa), MILS (maternally inherited Leigh's syndrome), and FBSN (famili

142 , ataxia and retinitis pigmentosa) and MILS (maternally inherited Leigh's syndrome).

143 ia, and retinitis pigmentosa (NARP) and also maternally inherited Leigh's syndrome.

144 nal identity-by-descent sharing, whereas the maternally inherited locus was not linked to the trait (

145 ametophyte and after fertilization only from maternally inherited MEA alleles.

146 duce severe neuromuscular pathologies, cause maternally inherited metabolic diseases, and suppress ap

147 t period owes to conflict, between a woman's maternally inherited (MI) and paternally inherited (PI)

148 Maternally inherited microbes that spread via male-killi

149 Some rare SRS patients carry maternally inherited microduplications spanning the impr

150 ormalities, including the three samples with maternally inherited microduplications.

151 t chirality of this drug response suggests a maternally inherited, microfilament-dependent organizati

152 The evidence strongly suggests that maternally inherited microorganisms cause parthenogenesi

153 (whose genotypes would differ only in their maternally inherited mitichondia and chloroplasts).

154 Maternally inherited mitochondria and other cytoplasmic

155 Maternally inherited mitochondrial (mt)DNA mutations can

156 approximately 1500 genes, 37 encoded by the maternally inherited mitochondrial DNA (mtDNA) and the r

157 plus hundreds to thousands of copies of the maternally inherited mitochondrial DNA (mtDNA).

158 We have analyzed the maternally inherited mitochondrial DNA from each of nine

159 pulation differentiation was much higher for maternally inherited mitochondrial DNA polymorphisms tha

160 oward creating embryos free from the risk of maternally inherited mitochondrial DNA-based disease.

161 and southern Indians were suggested based on maternally inherited mitochondrial DNA.

162 ow is much stronger in nuclear genes than in maternally inherited mitochondrial genes, indicating tha

163 s enhanced by its unique localization in the maternally inherited mitochondrial molecule.

164 Studies of maternally-inherited mitochondrial DNA have provided evi

165 Deleterious CNVs (>400 kb) were maternally inherited more often (up to 64%, p = 10(-15))

166 transcription and are instead controlled by maternally inherited mRNAs and proteins.

167 pment depends heavily on accurate control of maternally inherited mRNAs, and yet it remains unknown h

168 Phylogenies of the maternally inherited mtDNA genome and the paternally inh

169 Our data thus demonstrate that low levels of maternally inherited mtDNA mutations when present during

170 equilibrium) of associations was greater for maternally inherited mtDNA than for paternally inherited

171 For maternally inherited mtDNA, each caste is most similar t

172 r the genetics of the thousands of copies of maternally inherited mtDNA, the more than 1,000 nuclear

173 otal of 10 de novo mutations and 3 X-linked (maternally inherited) mutations that had been previously

174 ne mutation at position 1555 associated with maternally inherited non-syndromic deafness and sensitiv

175 s in CEP104; one of these subjects harbors a maternally inherited nonsense mutation (c.496C>T [p.Arg1

176 rRNA gene of human mitochondrial DNA causes maternally inherited, nonsyndromic deafness, an extreme

177 tions that disrupted a gene, 82% were either maternally inherited or de novo (p = 4.3 x 10(-3)).

178 These mutations may be spontaneous, maternally inherited, or a result of inherited nuclear d

179 ations but females do not, making the use of maternally inherited organelle genes problematic.

180 ents required for enhanced expression of the maternally inherited p57 (KIP2) allele lie at a distance

181 Because cytochrome b is encoded by the maternally inherited parasite mitochondrion, even outcro

182 led from paternally inherited centrioles and maternally inherited pericentriolar material (PCM) [1].

183 l library, which may reflect an abundance of maternally inherited pre-formed ribosomes in the yolk.

184 aternally inherited, but not in those with a maternally inherited pref-1-null allele.

185 Lrmp is a conserved vertebrate gene whose maternally inherited products are essential for nucleus-

186 Mechanisms that control maternally-inherited products to spatially and temporall

187 In mice, Ezh2 is detected as a maternally inherited protein in the oocyte but its funct

188 ps in embryonic development are regulated by maternally inherited proteins and mRNAs.

189 a more compact structure characterizing the maternally inherited repressed allele.

190 Wolbachia is maternally inherited, resulting in co-inheritance of mit

191 Maternally inherited rickettsial symbionts of the genus

192 Maternally inherited selfish genetic elements are common

193 osphorylation are present in a pedigree with maternally inherited sensorineural deafness, levodopa-re

194 To this end, the nature and genetics of the maternally inherited sex-ratio trait of Drosophila bifas

195 cal presentations and affected by de novo or maternally inherited single-nucleotide changes.

196 la P-element transposition is regulated by a maternally inherited state known as P cytotype.

197 severely reduced fertility due to a lack of maternally inherited Stella-protein in their oocytes.

198 an be rendered asexual by infection with the maternally inherited symbiont Wolbachia.

199 Maternally inherited symbionts are common in arthropods

200 ex ratio in offspring under the influence of maternally inherited symbionts, but extreme sex ratios o

201 The early Xenopus embryo expresses three maternally inherited Tcf/LEF mRNAs, and their relative r

202 Since they inhabit the cytoplasm and are maternally inherited, these microorganisms can enhance t

203 ssociated with severe human diseases and are maternally inherited through the egg's cytoplasm.

204 ondrial DNA (mtDNA) has been associated with maternally inherited traits of hypersensitivity to strep

205 irect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a syn

206 use embryo is associated with destruction of maternally inherited transcripts, an important process f

207 Breakpoint sequencing of one maternally inherited translocation involving four chromo

208 ome (AS), which is caused by the loss of the maternally inherited UBE3A allele (encoding ubiquitin pr

209 rogenetic disorder caused by deletion of the maternally inherited UBE3A allele and is characterized b

210 l disorder caused by loss of function of the maternally inherited UBE3A allele.

211 Mice with a maternally inherited Ube3a deficiency (Ube3a(m-/p+)) sho

212 umption defects specifically associated with maternally inherited Ube3a deficiency may reveal importa

213 In positive control mice carrying a maternally inherited Ube3a deletion, Ube3a sense transcr

214 opmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquit

215 rder caused by mutations or deletions of the maternally inherited UBE3A gene.

216 used by disrupted neuronal expression of the maternally inherited Ube3A ubiquitin protein ligase, req

217 uced in schizonts and female gametocytes, is maternally inherited where its absence leads to the deve

218 9.9 kb of upstream DNA when this deletion is maternally inherited, with synchronous replication patte

219 Maternally inherited Wolbachia bacteria are extremely wi

220 n brood hatch and promotes the spread of the maternally inherited Wolbachia infection into the host p

221 udy identified preferential selection of the maternally inherited X chromosome in glutamatergic neuro

222 Furthermore, it identified a pathogenic maternally inherited Xp11.2 duplication.