ライフサイエンスコーパス: mating type

1 plete gene pairs representing each potential mating type.

2 ; however, >99% of isolates are of the alpha mating type.

3 and even examples in which organisms switch mating type.

4 age of diploids and the rarely reported MATa mating type.

5 ut appeared to be more virulent than the (-) mating type.

6 on of yeast cells with those of the opposite mating type.

7 clinical isolates presented belonged to (-) mating type.

8 induced by crossing two strains of the same mating type.

9 hism due to balancing selection on sexes and mating types.

10 eukaryote Tetrahymena thermophila has seven mating types.

11 a transmembrane domain that is shared by all mating types.

12 s capable of sexual reproduction between two mating types.

13 istinct and alternate forms, called sexes or mating types.

14 alternate alleles that determine compatible mating types.

15 Basidiomycota), which has only two alternate mating types.

16 mation and pathological effects of different mating types.

17 species can switch between MATa and MATalpha mating types.

18 duced an asymmetric response of the opposite mating types.

19 show fixed sequence differences between the mating types.

20 k of male/female roles associated with their mating types.

21 romones secreted by opaque cells of opposite mating type [8] or the hypoxic condition of host niches

22 Kat1 induces mating-type switching from mating type a (MATa) to MATalpha in the yeast K. lactis.

23 ERAD substrates, mutated transporter of the mating type a pheromone, Ste6* (sterile), and cystic fib

24 The presence of both mating types a and alpha in AD hybrids did not affect th

25 Exposure of haploid yeast cells, carrying mating type "a," to "alpha pheromone" stimulates polariz

26 Budding yeast cells exist in two mating types, a and alpha, which use peptide pheromones

27 lure to differentiate into gametes of either mating type after nitrogen deprivation.

28 S. pombe, the S. japonicus cells switch cell/mating type after undergoing two consecutive cycles of a

29 (94%) of the strains possessed the MATalpha mating type allele, and five were MATa.

30 stercoreus has a higher estimated number of mating-type alleles (MAT-A= 39, MAT-B= 24) than other sp

31 We speculate that the increased number of mating-type alleles is the result of a recent range and

32 elevated temperature, or expression of both mating-type alleles, the rad57 defect in spontaneous SCR

33 t site at the nearly silent or poorly active mating type alpha (MATalpha) locus and expresses Ho endo

34 on from vegetative and gametic cells of each mating type and from zygotes.

35 The ratios of each mating type and the proportion of haploids were comparab

36 ole in shaping LD in potato: the outcrossing mating type and the very limited number of meiotic gener

37 has a bipolar mating system with a and alpha mating types and occurs as A (haploid), D (haploid), and

38 code regulators of the two different haploid mating types and of the diploids formed by their conjuga

39 enome evolution at important loci, including mating-type and effector loci.

40 rph, revealed conserved and seemingly intact mating-type and meiosis loci typical of Ustilaginales.

41 re is no overlap between mutations affecting mating-type and telomeric silencing, suggesting that Rap

42 ity, mitochondrial inheritance linked to the mating type, and a highly selfing mating system in Micro

43 provides insights into the impact of ploidy, mating type, and serotype on virulence and the impact of

44 This chromosome determines a yeast's mating type, and the concentration of haploinsufficient

45 amydomonas reinhardtii, with two equal-sized mating types, and oogamous multicellular species such as

46 Although (+) mating type appeared to be more virulent, most of our cl

47 hlamydomonas reinhardtii, the plus and minus mating types are controlled by a complex locus, MT, wher

48 ing mate-recognition system in which the two mating types are under different levels of purifying sel

49 nly when they recognize cells of a different mating type as non-self.

50 ly, homothallic yeast cells can switch their mating type as often as every generation by a highly cho

51 ndings showed that both species exist in two mating types at similar ratios and produce gliotoxin.

52 d M. irregularis is heterothallic having two mating types - bearing either SexP or SexM allele.

53 Interestingly, AD hybrids with only one mating type behaved differently, with the virulence of a

54 research on the fungal life cycle revealed a mating type bias phenomenon.

55 As a result, the identified mating type bias strongly promotes inbreeding, which we

56 Schizosaccharomyces pombe cells switch mating type by replacing genetic information at the expr

57 HAP2 deletion strains of complementary mating types can recognize one another and form pairs; h

58 Haploid strains of either mating type carrying the mutation were severely defectiv

59 xceptions are synIII, which lacks the silent mating-type cassettes, and synXII, specifically when the

60 mating type genes during fusion of opposite mating-type cells and sexual sporulation in the multicel

61 A roulette-like method for mating type choice in Tetrahymena adds an interesting ne

62 of recombination cessation on the dimorphic mating-type chromosomes has been conflictingly reported.

63 The relatively recent discovery of dimorphic mating-type chromosomes in fungi can aid the understandi

64 and pseudoautosomal regions, and then to the mating-type chromosomes of an anther-smut fungus Microbo

65 restriction digest optical maps for the two mating-type chromosomes shows that divergence extends ov

66 r without recombination suppression in their mating-type chromosomes, we inferred the ancestral gene

67 r a range of ages (0.9-2.1 million years) in mating-type chromosomes.

68 ic diploids and AD hybrids with all possible mating type combinations in defined genetic backgrounds,

69 Thus, transcription of two lncRNAs governs mating-type control of gametogenesis in yeast.

70 f two long noncoding RNAs (lncRNAs) mediates mating-type control of sporulation.

71 sion yeast, cells alternate between P- and M-mating type, controlled by the alternate alleles of the

72 itch from mitosis-to-meiosis in the opposing mating type, coupled with the transcriptional induction

73 The strong mating-type-dependent bias in the choice of the donors i

74 at the UPR is tightly interlinked with the b mating-type-dependent signaling pathway that regulates p

75 ognition in both ciliates, the mechanisms of mating type determination differ widely, ranging from Me

76 rangements make this a fascinating system of mating type determination.

77 The mating-type determination circuit in Saccharomyces yeast

78 New multiplex PCR assays were developed for mating-type determination for C. beticola.

79 r understanding of how a master regulator of mating-type determination in an ancestral unicellular sp

80 al growth was not due to known Sir2 roles in mating-type determination or rDNA maintenance but was co

81 ary strata did not include genes involved in mating-type determination.

82 M. violaceum has A1 and A2 mating types, determined by mating-type-specific 'sex ch

83 R) is a key shared property of some sex- and mating-type determining (mat) chromosomes identified to

84 ession as a mechanism for the maintenance of mating-type determining chromosomal regions.

85 h a much higher divergence in and around the mating-type determining pheromone receptor locus in the

86 he transcription factor genes segregate with mating type, discounting the hypothesis of genetic linka

87 Further analyses of the mating type distribution in a-alpha coinfected mice sugg

88 fferentiation of Galphas in conjunction with mating-type diversity.

89 ecombination factors, which is important for mating-type donor selection and for the biased gene conv

90 Mating type E depends on expression of the transmembrane

91 od was subsequently devised to determine the mating type for a set of 47 isolates from across the geo

92 DNA methylation levels in plus versus minus mating type gametes followed by chloroplast DNA hypermet

93 gulation and molecular functions of the matA mating type gene in a homothallic system.

94 The Aspergillus nidulans mating type gene matA and the human SRY (Sex-Determining

95 Differences in mating-type gene expression in haploid and diploid cells

96 Furthermore, the MAT1-1-1 mating-type gene, known primarily for a role in governin

97 fertile and self-sterile strains, found four mating type genes (MAT1-1-1, MAT1-1-5, MAT1-2-1 and MAT1

98 hallism), is determined by the expression of mating type genes at mat loci.

99 molecular basis of homothallism and role of mating type genes during a self-fertile sexual cycle rem

100 s for receptors, pheromones, G proteins, and mating type genes during fusion of opposite mating-type

101 and pheromones control sexual identity, the mating-type genes (mat A and mat a) must be in two diffe

102 u70 and Sir1 act collectively to silence the mating-type genes at HML and HMR.

103 se is still uncertain, but recent studies of mating-type genes in green algae open a promising new wa

104 attention has been paid to the switching of mating-type genes in Saccharomyces cerevisiae, a process

105 The existence of strata devoid of mating-type genes, despite the lack of sexual antagonism

106 ional sex-related genes, the distribution of mating-type genes, detection of recombination from popul

107 enome sequence also revealed the presence of mating-type genes, providing an indication that Malassez

108 t silences transcription of the alpha- and a-mating-type genes, respectively.

109 mologs elicited sexual reactions like native mating-type genes.

110 e central regions of the agglutinins of both mating types have diverged completely, by selective endo

111 This ploidy effect is independent of mating type heterozygosity and not further enhanced by i

112 ct from the one used to attract the opposite mating type, highlights the existence of a sophisticated

113 In budding yeast, telomeres and the mating type (HM) loci are found in a heterochromatin-lik

114 ly distinct groups that correlate with their mating type; IA(s) values show high linkage disequilibri

115 ent to disrupt chromatin silencing and yeast mating-type identity as indicated by a lack of growth re

116 Although mating type in C. disseminatus is controlled by only the

117 Mating type in Saccharomyces cerevisiae is determined by

118 nformation regulator (Sir) proteins regulate mating type in Saccharomyces cerevisiae.

119 Here we determined the genes controlling mating type in the bipolar mushroom Coprinellus dissemin

120 e is evidence suggesting virulence vary with mating types in fungi, including the Mucorales.

121 ess accounts for the maternal inheritance of mating types in Paramecium tetraurelia, a long-standing

122 of dimorphic sexes and their relationship to mating types in unicellular species are not understood.

123 hCG signaling activates silent mating type information regulation 2 homolog 1 (SIRT1),

124 these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1),

125 sion correlated with increased SIRT1 (silent mating type information regulation 2 homolog 1) levels a

126 ciated with a significant increase in silent mating type information regulation 2 homologue 1 (SIRT1)

127 KEY POINTS: Silent mating type information regulation 2 homologue 1 (SIRT1)

128 tion of two intact but unexpressed copies of mating-type information at the heterochromatic loci, HML

129 late G1 in haploid mother cells to initiate mating-type interconversion.

130 es the differentiation of yeast cells of one mating type into a distinct new cell type.

131 s differentiated from a germline nucleus and mating type is decided by a stochastic process.

132 c closeness and the similarity of their MTL (mating-type like) loci, some Metschnikowia species may p

133 ida albicans must undergo homozygosis at the mating type-like locus MTL[1, 2], then switch from the w

134 their homozygosity or heterozygosity at the mating-type-like locus (MTL).

135 silencing defect was not limited to cryptic mating type loci and was associated with broad changes i

136 the maintenance of silencing at telomere and mating type loci but not at the ribosomal DNA locus.

137 atin at telomeres and the homothallic silent mating type loci require the Sir3 protein.

138 molecular markers of silencing at the silent mating type loci under conditions of limiting Sir3 prote

139 both telomere-proximal genes and the silent mating type loci, and transcriptional activation of hund

140 In Saccharomyces cerevisiae, the two cryptic mating type loci, HML and HMR, are transcriptionally sil

141 ng with unique evolutionary trajectories for mating type loci.

142 The silenced chromatin at the cryptic mating-type loci (HML and HMR) of Saccharomyces cerevisi

143 heterochromatin at telomeres and the silent mating-type loci (HML/HMR).

144 to silence genes contained within the silent-mating-type loci and telomere chromosomal regions.

145 ys distinct roles in silencing at the silent mating-type loci and telomeres.

146 or (Sir) proteins to silencers at the silent mating-type loci and to telomere ends.

147 hesis of genetic linkage between the A and B mating-type loci as the causal origin of bipolar mating

148 In tetrapolar species, two unlinked mating-type loci exist (A and B), whereas in bipolar spe

149 hes transcriptional silencing at the cryptic mating-type loci HMR and HML (HM loci) by recruiting the

150 ced heterochromatin formation at the cryptic mating-type loci HMR and HML via Rif1, a telomere regula

151 chromatin occurs at telomeres and the silent mating-type loci HMR and HML.

152 chromosomal fusion underlying the linkage of mating-type loci in fungi and provided evidence for mult

153 The telomeres and mating-type loci of budding yeast adopt a condensed, het

154 he genomic location and DNA sequences of the mating-type loci of S. japonicus differ vastly from thos

155 ream of the MRA cassette, deletion of silent mating-type loci, and utilization of alpha-type instead

156 ides near yeast telomeres and at the cryptic mating-type loci, HML and HMR, where it silences transcr

157 binds to core X sequences in addition to the mating-type loci, HML and HMR.

158 of whether the cells express the a- or alpha-mating-type loci, which control the expression of other,

159 omeres, ribosomal DNA (rDNA) and the cryptic mating-type loci.

160 ochromatin found at telomeres and the silent mating-type loci.

161 r alternative allele combinations at the two mating-type loci.

162 stitutive heterochromatin at centromeric and mating-type loci.

163 chromatin structures at telomeres and silent mating-type loci.

164 hich is independent of the regulation of the mating type locus (MTL).

165 Candida albicans strains homozygous at the mating type locus can switch from white to opaque, and m

166 The germline mating type locus consists of a tandem array of incomple

167 We report here that the somatic mating type locus contains a pair of genes arranged head

168 n Candida albicans that positively regulates mating type locus MTLalpha gene expression and thereby r

169 Here, we characterized the mating type locus of M. irregularis and the mating type

170 ient fork movement in the ribosomal DNA, the mating type locus, tRNA, 5S ribosomal RNA genes, and gen

171 formation at centromeres, telomeres, and the mating type locus.

172 actions between the Aa and Da alleles of the mating type locus.

173 te new gene pair is assembled at the somatic mating type locus; the incomplete genes of one gene pair

174 Pheromone receptors encoded by the mating-type locus (MAT) mediate reciprocal pheromone sen

175 howed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast.

176 , controlled by the alternate alleles of the mating-type locus (mat1).

177 cell-size regulatory gene(s) to an ancestral mating-type locus as a possible step in the evolution of

178 ectopic spread of silencing from the silent mating-type locus HMRa into flanking euchromatin.

179 in's ability to bind and silence the cryptic mating-type locus HMRa requires a protein-protein intera

180 At the HMR mating-type locus of budding yeast, cohesin associates w

181 The mating-type locus of C. disseminatus is similar to the A

182 we report the discovery and analysis of the mating-type locus of the model organism Dictyostelium di

183 locus of C. disseminatus is similar to the A mating-type locus of the model species Coprinopsis ciner

184 f recombination cessation in stages from the mating-type locus toward the pseudoautosomal regions was

185 ize--anisogamy--involves genes linked to the mating-type locus, as was predicted theoretically.

186 tromeric repeats, telomeric regions, and the mating-type locus, consistent with inhibition of the his

187 The establishment of silencing at the silent mating-type locus, HMR, in Saccharomyces cerevisiae requ

188 However, at the mating-type locus, Swi6 recruitment is defective in the

189 At the mating-type locus, the loss of jmj2 or substitution of j

190 generate heterochromatin at telomeres and a mating-type locus.

191 pathways to silence transgenes at the silent mating-type locus.

192 utation from the HMalpha locus into the MAT (mating type) locus has provided the genetic evidence tha

193 identity is determined by genes at the MAT (mating-type) locus; mating occurs between MATa and MATal

194 NA-strand-specific epigenetic imprint at the mating-type locus1 initiates the recombination event, wh

195 viously identified a mutation, suppressor of mating type locus3 15-1 (smt15-1), that partially suppre

196 ubstitutions at a faster rate than the other mating type (mat A) and thus may be in the early stages

197 e bipolar mating systems with a single large mating type (MAT) locus that represents a derived state

198 s at least 6 Mbp ( approximately 63%) of the mating-type (mat) chromosome in N. tetrasperma and is as

199 However, using knowledge of mating-type (MAT) gene organization, we now describe con

200 elevated temperature, srs2, rad51-I345T, and mating-type (MAT) heterozygosity resulted in almost comp

201 Different gene combinations reside at these mating-type (MAT) loci and confer sexual identity; invar

202 elucidate the structure and functions of the mating-type (MAT) locus and establish that C. lusitaniae

203 id cells, requiring the genome to have three mating-type (MAT)-like loci and a mechanism for silencin

204 Duplication of the mating type matA(HMG) gene in this haploid organism trig

205 Haploid opaque cells of opposite mating type mate efficiently to regenerate the diploid f

206 and the mean of gamete size (volume) of each mating type measured agree closely with the prediction f

207 long been known to present a wide variety of mating type numbers and modes of inheritance, but only r

208 the sibling species Paramecium septaurelia, mating type O is determined by coding-sequence deletions

209 isiae has a complex system for switching the mating type of haploid cells, requiring the genome to ha

210 we show that HAP2 is expressed in all seven mating types of T. thermophila and that fertility is onl

211 ts evolution, we sequenced 12 genomes (6 per mating type) of this species and identified the genomic

212 es in sexual fertility, and the influence of mating type on the severity of cutaneous infection.

213 strains were then used to test the impact of mating type on virulence.

214 Most ascomycetes have two mating types: one (called alpha in yeasts and MAT1-1 in

215 ention, self-incompatibility systems such as mating types or sexes appear to be derived limitations t

216 uding outbreeding systems with more than two mating types or sexes, unisexual selfing, and even examp

217 etermined the multilocus sequence type (ST), mating type, ploidy, and allelic profile.

218 In sexual crosses with spa19 as the mating type plus parent, however, PS+ genomes are transm

219 GP genes analyzed (SAG1 and SAD1) encode the mating-type plus and minus sexual agglutinins, displayed

220 mating type locus of M. irregularis and the mating type ratio of 17 clinical isolates in China.

221 a haplo-lethal allele that is linked to one mating type region.

222 ition, we show that the N. tetrasperma mat a mating-type region appears to be accumulating deleteriou

223 sed for recombination in the heterochromatic mating-type region during meiosis and several mutants de

224 e, assembly of heterochromatin at the silent mating-type region is critical for cell fate determinati

225 ion was strongly silenced in the relocalized mating-type region through mechanisms that differ from t

226 ocalization of a heterochromatic region, the mating-type region, from its natural location at the spi

227 but in M cells it spreads across the silent mating-type region, including mat2-P.

228 Crosstalk between UPR and the b mating-type regulated developmental program adapts ER ho

229 The mechanism of haploid selection is mating-type-regulated auxotrophy (MRA), by which prototr

230 or its association with target promoters was mating-type-regulated.

231 Surprisingly, the mating-type regulatory function of Sum1 was conserved in

232 acting to determine the alternate A1 and A2 mating types required for mating in Microbotryum.

233 m1, contributed by gametes of plus and minus mating types respectively, physically interact and trans

234 e important for telomeric silencing, but not mating type silencing, and that Rif1 and Rif2 interactio

235 We observed mating type-specific differences in chloroplast DNA meth

236 We identified 361 gametic genes with mating type-specific expression patterns and 627 genes t

237 Each gene encodes a mating type-specific segment and a transmembrane domain

238 um has A1 and A2 mating types, determined by mating-type-specific 'sex chromosomes' that contain 1-2

239 not significantly different between the two mating-type-specific chromosomes nor between the non-rec

240 g state are derepressed to establish the new mating-type-specific gene expression program coincident

241 etylation of nucleosomes in the promoters of mating-type-specific genes requires the corepressor Ssn6

242 imilar levels of genetic degeneration in the mating-type-specific regions of the non-recombining 'sex

243 ysis of the processes in the non-recombining mating-type-specific regions of the smut fungus Microbot

244 Our data show genetic continuity between the mating-type specification and sex determination pathways

245 om its ancestral role in C. reinhardtii as a mating-type specifier, to become a determinant of sperm

246 In budding yeast, these signals include mating-type status, nutrient starvation, and respiration

247 ontributions, a pair of congenic a and alpha mating type strains was generated by a series of 11 back

248 s involving forced heterokaryons of opposite mating-type strains show that presence of one receptor a

249 g-4 behave normally in crosses with opposite mating-type strains.

250 RG1) is a catalytic subunit of the switch in mating type/sucrose nonfermentation complex and plays an

251 ient limitation via the transcription factor mating type switch 1 (Mts1).

252 acers and a region immediately preceding the mating type switch locus Mat1, and the mechanism of pola

253 Our results suggest that the frequency of mating type switch might control the trade-off between d

254 ological processes, such as budding, mating, mating type switch, consumption of nutrients, and cell d

255 We further show that the mating type switch-activating protein Sap1 is a GRF in S

256 lencing" is found in the yeast S. cerevisiae mating-type switch [1, 2].

257 latory transcription factors ensures a rapid mating-type switch.

258 bits ascospore dimorphism and unidirectional mating type switching - self-fertile strains derived fro

259 Thus, mechanisms for mating type switching have evolved multiple times, indic

260 lactis, a DNA rearrangement associated with mating type switching requires a domesticated transposas

261 encing phenomena observed in fungi including mating type switching, telomere position effect (TPE), s

262 s DSB, created by the HO endonuclease during mating type switching.

263 ylation of histone H3 tails affects SWI/SNF (mating type switching/ sucrose non fermenting) and RSC (

264 elta) resulted in decreased viability during mating-type switching and conferred shorter cell cycle d

265 the studies that deciphered the mechanism of mating-type switching and revealed the phenomenon of gen

266 h genetically diverse partners, as inhibited mating-type switching causes mother cells to shun their

267 Kat1 induces mating-type switching from mating type a (MATa) to MATal

268 general question in the specific context of mating-type switching in budding yeast, which is a model

269 at a single chromosomal break, we monitored mating-type switching in Saccharomyces cerevisiae strain

270 gene transposition model as the mechanism of mating-type switching in the budding yeast Saccharomyces

271 Mating-type switching is induced by a DNA double-strand

272 Saccharomyces cerevisiae mating-type switching is initiated by a double-strand br

273 Saccharomyces mating-type switching occurs through a double-strand bre

274 Here, we propose a quantitative model of mating-type switching predicated on the assumption of DS

275 t these factors must be rapidly removed upon mating-type switching to allow the master regulators of

276 /3 heterochromatin, the origin of ascomycete mating-type switching, and panascomycete synteny at the

277 A novel mating-type switching-defective mutant showed a highly u

278 l for cell fate determination in the form of mating-type switching.

279 cycle delays and decreased viability during mating-type switching.

280 la, a ciliated protozoan with seven sexes or mating types that bypasses the production of male gamete

281 from two N. tetrasperma strains of opposite mating type to determine whether structural rearrangemen

282 tor IME4 allows cells expressing the haploid mating type to sporulate with kinetics that are indistin

283 ones that stimulate opaque cells of opposite mating type to undergo mating.

284 me aid in simultaneous dissemination of both mating types to new locations in the environment.

285 en serotypes A and D, and the combination of mating types to the virulence potential of AD hybrids ha

286 t importantly, our data provide evidence for mating-type transcription factor functions that reach fa

287 d Th-1, Th-2 and Th-17 cells numbers in each mating type treated mice showed that the severity and di

288 ty and disease progress were enhanced in (+) mating type treated mice.

289 le genetic locus specify this species' three mating types: two versions of the locus are entirely dif

290 Differences in gamete size between the two mating types underlie sexual selection.

291 ound in South American isolates but only one mating type was found in Central American isolates, supp

292 A single mating type was found in the new species Aspergillus pse

293 ) as the average sequence divergence between mating types was only 2% in the SR region.

294 ism: the Microbotryum sequences from a given mating type were all more similar to the pheromone recep

295 e pairs of interactions in cells of opposite mating type were revealed by this study, including bilat

296 Interestingly, both mating types were found in South American isolates but o

297 Two A and B alleles but only two mating types were identified.

298 dinutans, but in Aspergillus parafelis, both mating types were present.

299 genes are sufficient to determine two of the mating types, whereas homologs of both these genes are r

300 iven by sexual conflict or by association of mating types with ecological differences.

301 lonial genera from this group have classical mating types with equal-sized gametes, while larger mult