ライフサイエンスコーパス: matricellular

1 Periostin, a matricellular adapter protein highly expressed by period

2 d and uninfected devices, and these included matricellular and inflammatory proteins.

3 The matricellular angiogenesis inhibitor, thrombospondin (TS

4 Mice that lack the matricellular angiogenesis inhibitor, thrombospondin-2 (

5 GF and NOV) family of proteins is a group of matricellular biomolecules involved in both physiologica

6 lting from cardiomyocyte-TrkA recognition by matricellular connective tissue growth factor (CTGF/CCN2

7 These included several proteoglycans and matricellular ECM proteins composed of common repetitive

8 epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with high epi

9 ing promotes tumor progression by increasing matricellular fibrosis and tissue tension.

10 he findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mu

11 r lesion formation, we examined whether this matricellular gene cluster was also coordinately regulat

12 Human thrombospondin 1 (hTSP-1) is a matricellular glycoprotein facilitating bacterial adhere

13 f angiogenesis is thrombospondin-1 (TSP1), a matricellular glycoprotein known to influence adhesion,

14 The matricellular glycoprotein SPARC (secreted protein acidi

15 The matricellular glycoprotein SPARC (secreted protein acidi

16 e (SPARC) is an extracellular Ca(2+)-binding matricellular glycoprotein that associates with cell pop

17 in, acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that is capable of inhibiting

18 d Protein Acidic and Rich in Cysteine), is a matricellular glycoprotein that is produced by tumor and

19 The human matricellular glycoprotein thrombospondin-1 (hTSP-1) is

20 hibition of some angiogenic responses by the matricellular glycoprotein thrombospondin-1 and is there

21 e necessary for some T cell responses to the matricellular glycoprotein thrombospondin-1.

22 Tenascin C (TNC) is a matricellular glycoprotein whose expression in adult tis

23 Thrombospondin (TSP)-1 is a matricellular glycoprotein with immunoregulatory propert

24 at SPARC/osteonectin, a small ECM-associated matricellular glycoprotein, can induce MMP-2 activation

25 tential role for thrombospondin-2 (TSP-2), a matricellular glycoprotein, in the regulation of primary

26 SPARC, a 32-kDa matricellular glycoprotein, mediates interactions betwee

27 ted protein, acidic and rich in cysteine), a matricellular glycoprotein, modulates the interaction of

28 ich in cysteine (SPARC) is a multifunctional matricellular glycoprotein.

29 interaction of Streptococcus pneumoniae with matricellular hTSP-1.

30 CCN1 (CYR61) is a matricellular inducer of angiogenesis essential for succ

31 ed as a cell scaffold to study the effect of matricellular interactions in vitro.

32 ealing in skin fibroblasts and establish its matricellular mode of action through integrin receptors.

33 uch as CCN1, an immediate-early gene-encoded matricellular molecule critical for vascular development

34 CCN6 is a secreted cysteine-rich matricellular protein (36.9 kDa) that exerts growth-inhi

35 ficantly, we found that the TGF-beta-induced matricellular protein (TGFBI) was similarly biphasically

36 CCN1 is a matricellular protein and a member of the CCN family of

37 In PDAC patient biopsies, higher matricellular protein and activated STAT3 were associate

38 ed, cooperative interaction between the CCN1 matricellular protein and canonical TGF-beta1/SMAD3 sign

39 Hevin is a matricellular protein and the result of a gene duplicati

40 ed protein acidic and rich in cysteine) is a matricellular protein associated with the extracellular

41 Previous studies showed that the matricellular protein CCN1 (CYR61) is induced during hep

42 The matricellular protein CCN1 (CYR61) regulates multiple ce

43 The matricellular protein CCN1 (formerly named CYR61) regula

44 The matricellular protein CCN1 enhances TGF-beta1/SMAD3-depe

45 Here we show that the matricellular protein CCN1/CYR61 can unmask the cytotoxi

46 titative mass spectrometry, we find that the matricellular protein CCN1/CYR61 is highly regulated by

47 ecently provided the first evidence that the matricellular protein CCN3 (official symbol NOV) functio

48 re, we determined that the expression of the matricellular protein CCN3 is strongly reduced in rodent

49 ght to interact with BMP-2: collagen IIA and matricellular protein CCN3.

50 The matricellular protein CCN5/WISP-2 represents a promising

51 The matricellular protein connective tissue growth factor (C

52 Thrombospondin 2 (TSP2) is a matricellular protein controlling the apoptosis-prolifer

53 cytes with keratinocytes upregulates CCN3, a matricellular protein critical to maintenance of normal

54 everal microarray databases suggest that the matricellular protein Cyr61 is highly induced by LPA.

55 tion by these agonists and revealed that the matricellular protein cysteine-rich 61 (Cyr61/CCN1) is s

56 lammatory mediator cyclooxygenase 2, and the matricellular protein cysteine-rich angiogenic inducer 6

57 Periostin is a matricellular protein essential for tissue integrity and

58 duction by reporting a novel function of the matricellular protein Fibulin-5 (Fbln5).

59 vel downstream target Sparc, which encodes a matricellular protein found in PDAC stroma that has been

60 ervations suggest an important role for this matricellular protein in the local regulation of inflamm

61 CCN1 is a matricellular protein involved in normal vascular develo

62 Previously, we showed that periostin, a matricellular protein involved in tissue repair, is mark

63 th factor (CTGF) is a cysteine-rich secreted matricellular protein involved in wound healing and tiss

64 bospondin-1 (TSP) is a transiently expressed matricellular protein known to promote chemotaxis of leu

65 Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of ch

66 ein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular ma

67 Here we identify the matricellular protein Nephroblastoma Overexpressed (Nov,

68 Here we show that CCN6 (WISP3), a secreted matricellular protein of the CCN (CYR61/CTGF/NOV) family

69 Here we show that CCN1, a matricellular protein of the CCN (CYR61/CTGF/NOV) family

70 r CCN1 (cysteine-rich 61, CYR61), a secreted matricellular protein of the CCN family, is a ligand of

71 CN3 (NOV, nephroblastoma overexpressed) is a matricellular protein of the CCN family, which also incl

72 CCN3 (NOV) is a matricellular protein of the CCN family, which also incl

73 Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulate

74 SPARC is a matricellular protein often associated with fibrosis.

75 The matricellular protein osteopontin (OPN, Spp-1) is widely

76 are the first to show that induction of the matricellular protein osteopontin facilitates DMBA/TPA-i

77 hat Wnt-1 strongly induced the expression of matricellular protein osteopontin, and modestly enhanced

78 cretion of profibrotic proteins, such as the matricellular protein periostin.

79 Periostin (Postn) is a matricellular protein preferentially expressed by osteoc

80 Connective tissue growth factor (CTGF) is a matricellular protein presumed to be involved in the pat

81 ers of fibrinolysis, endothelial activation, matricellular protein release, and tissue damage and wit

82 , fibrinolysis, endothelial cell activation, matricellular protein release, and tissue damage were me

83 ered the role of thrombospondin-1 (TSP-1), a matricellular protein released in abundance from activat

84 otein 61 (Cyr61) is a dynamically expressed, matricellular protein required for proper angiogenesis a

85 secreted cysteine-rich and integrin-binding matricellular protein required for proper cardiovascular

86 The matricellular protein secreted protein acidic and rich i

87 le of which was the evolutionarily conserved matricellular protein Secreted Protein Acidic and Rich i

88 and rich in cysteine)/BM 40/osteonectin is a matricellular protein shown to function as a counteradhe

89 The matricellular protein SMOC (Secreted Modular Calcium bin

90 r-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important conseque

91 Arntl2 partner and functionally validate the matricellular protein Smoc2 as a pro-metastatic secreted

92 The matricellular protein SPARC (secreted protein acidic and

93 observed in the presence and absence of the matricellular protein SPARC (secreted protein, acidic an

94 This study identifies the stromal-derived matricellular protein SPARC as a novel regulator of isle

95 We show that the matricellular protein SPARC contributes to the BM stroma

96 The matricellular protein SPARC is expressed at high levels

97 The gene encoding the matricellular protein SPARCL1 was most strongly upregula

98 In addition, interstitial deposition of the matricellular protein tenascin, a marker of active remod

99 SPARC, a matricellular protein that affects cellular adhesion and

100 rowth factor (CCN2, also known as CTGF) is a matricellular protein that appears to play an important

101 Fibulin-5 (Fbln5) is a matricellular protein that blocks fibronectin-integrin i

102 We show that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fi

103 Thrombospondin-1 (TSP1) is a matricellular protein that differentially promotes the a

104 Thrombospondin-1 (TSP1) is a matricellular protein that displays both pro- and anti-a

105 CCN1 is a matricellular protein that has been implicated in angiog

106 Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and cau

107 d Protein, Acidic and Rich in Cysteine) is a matricellular protein that inhibits mesangial cell proli

108 reported that fibulin-5, an integrin-binding matricellular protein that is essential for elastic fibe

109 CCN1 (CYR61) is a matricellular protein that is highly expressed at sites

110 SPARC is a matricellular protein that is highly expressed in remode

111 ed connective tissue growth factor (CTGF), a matricellular protein that is highly expressed in the br

112 ein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for the regulati

113 SPARC is a matricellular protein that is involved in both pancreati

114 Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibro

115 Connective tissue growth factor (CTGF) is a matricellular protein that mediates cell-matrix interact

116 d protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and p

117 protein acidic rich in cysteine (SPARC) is a matricellular protein that modulates the activity of gro

118 (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in normal tissue

119 ue growth factor (CTGF/CCN2) is an inducible matricellular protein that plays a major role in fibropr

120 ytes with keratinocytes up-regulated CCN3, a matricellular protein that we subsequently found to be c

121 The matricellular protein thrombospondin (TSP) stimulates st

122 to test the hypothesis that the prototypical matricellular protein thrombospondin (TSP)-1, a potent a

123 We hypothesized that the matricellular protein thrombospondin (TSP)-1, a potent i

124 The matricellular protein thrombospondin 1 (TSP1) regulates

125 The matricellular protein thrombospondin 2 (TSP2) regulates

126 We tested the hypothesis that the matricellular protein thrombospondin-1 (TSP1), through b

127 We reported previously that the matricellular protein thrombospondin-1 is upregulated in

128 Because levels of the matricellular protein thrombospondin-4 (TSP4) rapidly ri

129 ng Protein-2 (Smoc-2) is a broadly-expressed matricellular protein which contributes to mitogenesis v

130 We recently noted that the matricellular protein WISP1 contributes to sepsis induce

131 Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct expression pattern

132 Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating

133 otein acidic and rich in cysteine (SPARC), a matricellular protein with counteradhesive properties, i

134 Periostin is considered to be a matricellular protein with expression typically confined

135 Osteopontin (OPN) is a matricellular protein with proinflammatory and profibrot

136 Periostin is a matricellular protein with roles in tissue repair follow

137 bospondin-1 (TSP-1), a potent proatherogenic matricellular protein, as a putative link between hyperg

138 The matricellular protein, connective tissue growth factor (

139 , acidic and rich in cysteine (SPARC) family matricellular protein, during invasive phases of prostat

140 ests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of

141 ne), although primarily known as a secreted, matricellular protein, has also been identified in uroth

142 Periostin, a matricellular protein, has an important role during reep

143 Periostin (PN), a novel fasciclin-related matricellular protein, has been implicated in cardiac de

144 The matricellular protein, thrombospondin-1 (TSP-1), is prom

145 The matricellular protein, thrombospondin-2 (TSP-2), has bee

146 lved in extracellular matrix remodeling, and matricellular protein-protein and protein-cholangiocarci

147 and rich in cysteine), or osteonectin, is a matricellular protein.

148 e CCN family of proteins, is a cysteine-rich matricellular protein.

149 ster analysis, we identified a subset of six matricellular proteins (eg, osteopontin and plasminogen

150 small leucin-rich repeat proteoglycans, and matricellular proteins affecting both the composition an

151 lecular signature composed of an ensemble of matricellular proteins and remodeling enzymes they provi

152 Given that matricellular proteins are expressed in response to inju

153 Matricellular proteins are extracellular matrix proteins

154 Matricellular proteins are induced in fibrotic condition

155 The three matricellular proteins considered here might each prefer

156 Furthermore, a role for matricellular proteins in the regulation skin blood flow

157 Matricellular proteins mediate pleiotropic effects durin

158 Deposition of matricellular proteins modulates growth factor signaling

159 y, we demonstrate that the presence of these matricellular proteins results in significantly stiffer

160 Matricellular proteins such as SPARC, thrombospondin 1 a

161 They comprise a diverse group of matricellular proteins that confer antiadhesive properti

162 e 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the r

163 Thrombospondin-1 (TSP1) and TSP2 are matricellular proteins that have been shown to regulate

164 1) is a member of the CCN family of secreted matricellular proteins that includes connective tissue g

165 -adhesion is induced by the highly regulated matricellular proteins TSP1 and 2, tenascin-C, and SPARC

166 e we show that CCN1 (CYR61) and CCN2 (CTGF), matricellular proteins upregulated at sites of inflammat

167 ediators of extracellular matrix remodeling, matricellular proteins, and cardiac integrins compared w

168 d SPARC, two homologs of the SPARC family of matricellular proteins, in the foreign body response.

169 ndly decreased gene expression of a group of matricellular proteins, of which periostin was prominent

170 Matricellular proteins, secreted macromolecules that int

171 Whereas major matricellular proteins, such as osteopontin, tenascin or

172 C-2 is a novel member of the SPARC family of matricellular proteins.

173 otensin axis, matrix metalloproteinases, and matricellular proteins.

174 ysiologic significance of this action of the matricellular proteins?

175 rograms and circulating osteopontin (OPN), a matricellular regulator of arteriosclerosis.

176 The matricellular secreted protein connective tissue growth

177 Matricellular Secreted Protein, Acidic and Rich in Cyste

178 Ab) that is directed against the pleiotropic matricellular signaling protein connective tissue growth

179 The matricellular SPARC family member hevin (SPARC-like 1/SP

180 r to the classical PspC molecule, with human matricellular thrombospondin-1 (hTSP-1).