ライフサイエンスコーパス: matricellular protein

1 and rich in cysteine), or osteonectin, is a matricellular protein.

2 e CCN family of proteins, is a cysteine-rich matricellular protein.

3 C-2 is a novel member of the SPARC family of matricellular proteins.

4 otensin axis, matrix metalloproteinases, and matricellular proteins.

5 ysiologic significance of this action of the matricellular proteins?

6 CCN6 is a secreted cysteine-rich matricellular protein (36.9 kDa) that exerts growth-inhi

7 small leucin-rich repeat proteoglycans, and matricellular proteins affecting both the composition an

8 CCN1 is a matricellular protein and a member of the CCN family of

9 In PDAC patient biopsies, higher matricellular protein and activated STAT3 were associate

10 ed, cooperative interaction between the CCN1 matricellular protein and canonical TGF-beta1/SMAD3 sign

11 Hevin is a matricellular protein and the result of a gene duplicati

12 lecular signature composed of an ensemble of matricellular proteins and remodeling enzymes they provi

13 ediators of extracellular matrix remodeling, matricellular proteins, and cardiac integrins compared w

14 Given that matricellular proteins are expressed in response to inju

15 Matricellular proteins are extracellular matrix proteins

16 Matricellular proteins are induced in fibrotic condition

17 bospondin-1 (TSP-1), a potent proatherogenic matricellular protein, as a putative link between hyperg

18 ed protein acidic and rich in cysteine) is a matricellular protein associated with the extracellular

19 Previous studies showed that the matricellular protein CCN1 (CYR61) is induced during hep

20 The matricellular protein CCN1 (CYR61) regulates multiple ce

21 The matricellular protein CCN1 (formerly named CYR61) regula

22 The matricellular protein CCN1 enhances TGF-beta1/SMAD3-depe

23 Here we show that the matricellular protein CCN1/CYR61 can unmask the cytotoxi

24 titative mass spectrometry, we find that the matricellular protein CCN1/CYR61 is highly regulated by

25 ecently provided the first evidence that the matricellular protein CCN3 (official symbol NOV) functio

26 re, we determined that the expression of the matricellular protein CCN3 is strongly reduced in rodent

27 ght to interact with BMP-2: collagen IIA and matricellular protein CCN3.

28 The matricellular protein CCN5/WISP-2 represents a promising

29 The matricellular protein connective tissue growth factor (C

30 The matricellular protein, connective tissue growth factor (

31 The three matricellular proteins considered here might each prefer

32 Thrombospondin 2 (TSP2) is a matricellular protein controlling the apoptosis-prolifer

33 cytes with keratinocytes upregulates CCN3, a matricellular protein critical to maintenance of normal

34 everal microarray databases suggest that the matricellular protein Cyr61 is highly induced by LPA.

35 tion by these agonists and revealed that the matricellular protein cysteine-rich 61 (Cyr61/CCN1) is s

36 lammatory mediator cyclooxygenase 2, and the matricellular protein cysteine-rich angiogenic inducer 6

37 , acidic and rich in cysteine (SPARC) family matricellular protein, during invasive phases of prostat

38 ster analysis, we identified a subset of six matricellular proteins (eg, osteopontin and plasminogen

39 Periostin is a matricellular protein essential for tissue integrity and

40 duction by reporting a novel function of the matricellular protein Fibulin-5 (Fbln5).

41 vel downstream target Sparc, which encodes a matricellular protein found in PDAC stroma that has been

42 ests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of

43 ne), although primarily known as a secreted, matricellular protein, has also been identified in uroth

44 Periostin, a matricellular protein, has an important role during reep

45 Periostin (PN), a novel fasciclin-related matricellular protein, has been implicated in cardiac de

46 ervations suggest an important role for this matricellular protein in the local regulation of inflamm

47 Furthermore, a role for matricellular proteins in the regulation skin blood flow

48 d SPARC, two homologs of the SPARC family of matricellular proteins, in the foreign body response.

49 CCN1 is a matricellular protein involved in normal vascular develo

50 Previously, we showed that periostin, a matricellular protein involved in tissue repair, is mark

51 th factor (CTGF) is a cysteine-rich secreted matricellular protein involved in wound healing and tiss

52 bospondin-1 (TSP) is a transiently expressed matricellular protein known to promote chemotaxis of leu

53 Thrombospondin-1 (TSP1) is a multifunctional matricellular protein known to promote progression of ch

54 ein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular ma

55 Matricellular proteins mediate pleiotropic effects durin

56 Deposition of matricellular proteins modulates growth factor signaling

57 Here we identify the matricellular protein Nephroblastoma Overexpressed (Nov,

58 Here we show that CCN6 (WISP3), a secreted matricellular protein of the CCN (CYR61/CTGF/NOV) family

59 Here we show that CCN1, a matricellular protein of the CCN (CYR61/CTGF/NOV) family

60 r CCN1 (cysteine-rich 61, CYR61), a secreted matricellular protein of the CCN family, is a ligand of

61 CN3 (NOV, nephroblastoma overexpressed) is a matricellular protein of the CCN family, which also incl

62 CCN3 (NOV) is a matricellular protein of the CCN family, which also incl

63 Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulate

64 ndly decreased gene expression of a group of matricellular proteins, of which periostin was prominent

65 SPARC is a matricellular protein often associated with fibrosis.

66 The matricellular protein osteopontin (OPN, Spp-1) is widely

67 are the first to show that induction of the matricellular protein osteopontin facilitates DMBA/TPA-i

68 hat Wnt-1 strongly induced the expression of matricellular protein osteopontin, and modestly enhanced

69 cretion of profibrotic proteins, such as the matricellular protein periostin.

70 Periostin (Postn) is a matricellular protein preferentially expressed by osteoc

71 Connective tissue growth factor (CTGF) is a matricellular protein presumed to be involved in the pat

72 lved in extracellular matrix remodeling, and matricellular protein-protein and protein-cholangiocarci

73 ers of fibrinolysis, endothelial activation, matricellular protein release, and tissue damage and wit

74 , fibrinolysis, endothelial cell activation, matricellular protein release, and tissue damage were me

75 ered the role of thrombospondin-1 (TSP-1), a matricellular protein released in abundance from activat

76 otein 61 (Cyr61) is a dynamically expressed, matricellular protein required for proper angiogenesis a

77 secreted cysteine-rich and integrin-binding matricellular protein required for proper cardiovascular

78 y, we demonstrate that the presence of these matricellular proteins results in significantly stiffer

79 le of which was the evolutionarily conserved matricellular protein Secreted Protein Acidic and Rich i

80 The matricellular protein secreted protein acidic and rich i

81 Matricellular proteins, secreted macromolecules that int

82 and rich in cysteine)/BM 40/osteonectin is a matricellular protein shown to function as a counteradhe

83 The matricellular protein SMOC (Secreted Modular Calcium bin

84 r-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important conseque

85 Arntl2 partner and functionally validate the matricellular protein Smoc2 as a pro-metastatic secreted

86 The matricellular protein SPARC (secreted protein acidic and

87 observed in the presence and absence of the matricellular protein SPARC (secreted protein, acidic an

88 This study identifies the stromal-derived matricellular protein SPARC as a novel regulator of isle

89 We show that the matricellular protein SPARC contributes to the BM stroma

90 The matricellular protein SPARC is expressed at high levels

91 The gene encoding the matricellular protein SPARCL1 was most strongly upregula

92 Matricellular proteins such as SPARC, thrombospondin 1 a

93 Whereas major matricellular proteins, such as osteopontin, tenascin or

94 In addition, interstitial deposition of the matricellular protein tenascin, a marker of active remod

95 ficantly, we found that the TGF-beta-induced matricellular protein (TGFBI) was similarly biphasically

96 SPARC, a matricellular protein that affects cellular adhesion and

97 rowth factor (CCN2, also known as CTGF) is a matricellular protein that appears to play an important

98 Fibulin-5 (Fbln5) is a matricellular protein that blocks fibronectin-integrin i

99 We show that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fi

100 Thrombospondin-1 (TSP1) is a matricellular protein that differentially promotes the a

101 Thrombospondin-1 (TSP1) is a matricellular protein that displays both pro- and anti-a

102 CCN1 is a matricellular protein that has been implicated in angiog

103 Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and cau

104 d Protein, Acidic and Rich in Cysteine) is a matricellular protein that inhibits mesangial cell proli

105 reported that fibulin-5, an integrin-binding matricellular protein that is essential for elastic fibe

106 CCN1 (CYR61) is a matricellular protein that is highly expressed at sites

107 SPARC is a matricellular protein that is highly expressed in remode

108 ed connective tissue growth factor (CTGF), a matricellular protein that is highly expressed in the br

109 ein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for the regulati

110 SPARC is a matricellular protein that is involved in both pancreati

111 Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibro

112 Connective tissue growth factor (CTGF) is a matricellular protein that mediates cell-matrix interact

113 d protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and p

114 protein acidic rich in cysteine (SPARC) is a matricellular protein that modulates the activity of gro

115 (osteonectin) (SPARC) gene, which encodes a matricellular protein that participates in normal tissue

116 ue growth factor (CTGF/CCN2) is an inducible matricellular protein that plays a major role in fibropr

117 ytes with keratinocytes up-regulated CCN3, a matricellular protein that we subsequently found to be c

118 They comprise a diverse group of matricellular proteins that confer antiadhesive properti

119 e 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the r

120 Thrombospondin-1 (TSP1) and TSP2 are matricellular proteins that have been shown to regulate

121 1) is a member of the CCN family of secreted matricellular proteins that includes connective tissue g

122 The matricellular protein thrombospondin (TSP) stimulates st

123 to test the hypothesis that the prototypical matricellular protein thrombospondin (TSP)-1, a potent a

124 We hypothesized that the matricellular protein thrombospondin (TSP)-1, a potent i

125 The matricellular protein thrombospondin 1 (TSP1) regulates

126 The matricellular protein thrombospondin 2 (TSP2) regulates

127 We tested the hypothesis that the matricellular protein thrombospondin-1 (TSP1), through b

128 We reported previously that the matricellular protein thrombospondin-1 is upregulated in

129 Because levels of the matricellular protein thrombospondin-4 (TSP4) rapidly ri

130 The matricellular protein, thrombospondin-1 (TSP-1), is prom

131 The matricellular protein, thrombospondin-2 (TSP-2), has bee

132 -adhesion is induced by the highly regulated matricellular proteins TSP1 and 2, tenascin-C, and SPARC

133 e we show that CCN1 (CYR61) and CCN2 (CTGF), matricellular proteins upregulated at sites of inflammat

134 ng Protein-2 (Smoc-2) is a broadly-expressed matricellular protein which contributes to mitogenesis v

135 We recently noted that the matricellular protein WISP1 contributes to sepsis induce

136 Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct expression pattern

137 Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating

138 otein acidic and rich in cysteine (SPARC), a matricellular protein with counteradhesive properties, i

139 Periostin is considered to be a matricellular protein with expression typically confined

140 Osteopontin (OPN) is a matricellular protein with proinflammatory and profibrot

141 Periostin is a matricellular protein with roles in tissue repair follow