ライフサイエンスコーパス: matrilin-1

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1 that were homozygous for V194D and null for matrilin 1.

2 ed aggregates and caused the co-retention of matrilin 1.

3 nt on the formation of hetero-oligomers with matrilin 1.

4 ndrocytes in the cartilage anlagen expresses matrilin-1.

5 directed toward the cartilage matrix protein matrilin-1.

6 de corresponding to the C-terminal domain of matrilin-1.

7 sults indicate a molecular stoichiometry of (matrilin-1)2(matrilin-3)2.

8 One potential antigen is matrilin-1, a cartilage matrix protein found uniquely in

9 Matrilin-1 and epiphycan were specific for rib and trach

10 not dependent on hetero-oligomerization with matrilin 1, and that the total ablation of matrilin 1 ex

11 ain organization to cartilage matrix protein/matrilin-1, but information on the protein structure is

12 ss of this domain occurs as a consequence of matrilin-1 deficiency.

13 Matrilin-1 displays a multiphasic expression during zebr

14 region, matrilin-2 will form a homotrimer as matrilin-1 does.

15 on zone, in addition to its co-assembly with matrilin-1 during endochondral ossification.

16 h matrilin 1, and that the total ablation of matrilin 1 expression has no impact on disease severity

17 n of early chondrocytes that do not activate matrilin-1 expression rather than by redifferentiation f

18 that, in primary chondrocyte cultures, CMP (matrilin-1) forms a filamentous network, which is made u

19 c molecule with a noncollagenous A domain of matrilin-1 fused to the N terminus of NC1.

20 nase gene has been targeted to exon 1 of the matrilin-1 gene (Matn1) to investigate the origins of ar

21 e chondrocytes did not turn on expression of matrilin-1 in contrast to the other chondrocytes of the

22 However, gene targeting of matrilin-1 in mouse did not lead to pronounced phenotype

23 appears to function in the matrix linked to matrilin-1 in the form of disulfide-bonded heteromeric m

24 Later, when the skeleton develops, matrilin-1 is expressed mainly in cartilage.

25 The results show that matrilin-1 is indispensible for zebrafish cartilage form

26 expression at about 15 h post-fertilization, matrilin-1 is present throughout the zebrafish embryo wi

27 Matrilin-1 is the prototypical member of the matrilin pr

28 During the early expression phase the matrilin-1 knockdown had no effects on cell morphology,

29 us angiogenesis inhibitors, we have purified matrilin-1 (MATN-1) and have demonstrated, for the first

30 Matrilin-1, matrilin-4, epiphycan, and thrombospondin-4

31 of matrilin 1 would abolish the formation of matrilin 1/matrilin 3 hetero-oligomers, eliminate the se

32 with that of the mature chondrocyte-abundant matrilin-1 mRNA.

33 Morpholino knockdown of matrilin-1 results both in overall growth defects and in

34 Matrilin-3 and CMP (matrilin-1) were prominent in equimolar amounts in fetal

35 derived from cells that have never expressed matrilin-1 whereas the remainder of the chondrocytes in

36 investigate the hypothesis that deletion of matrilin 1 would abolish the formation of matrilin 1/mat

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