ライフサイエンスコーパス: matrix metalloprotease

1 stent with the properties of a membrane type matrix metalloprotease.

2 analysis suggests that the enzyme was a non-matrix metalloprotease.

3 wo compounds known as specific inhibitors of matrix metalloproteases.

4 ored precursor by incompletely characterized matrix metalloproteases.

5 cleavage takes place on the cell surface by matrix metalloproteases.

6 n of p87 and was suppressed by inhibitors of matrix metalloproteases.

7 cluding decorin, collagens, fibronectin, and matrix metalloproteases.

8 epend on actin cytoskeletal dynamics but not matrix metalloproteases.

9 d to inflammatory response and inhibition of matrix metalloproteases.

10 grading the matrix through the activation of matrix metalloproteases.

11 ttractants, leukocyte adhesion proteins, and matrix metalloproteases.

12 lation of miR-34a also altered expression of matrix metalloproteases 1 and 2, the mediators involved

13 potential and led to increased expression of matrix metalloproteases 1 and 9 (MMP1 and MMP9).

14 roles of the upstream proteases thrombin and matrix metalloprotease-1 (MMP-1) in triggering PAR1-medi

15 In the present study, we found that matrix metalloprotease-1 (MMP-1) robustly activates the

16 It was recently shown that matrix metalloprotease-1 (MMP1) activation of the G prot

17 Matrix metalloprotease-1 (MMP1) is an important mediator

18 Matrix metalloprotease-1 (MMP1), a collagenase and activ

19 ased levels of mRNA for two PAR1 activators, matrix metalloprotease-1 and Factor Xa, suggesting a mec

20 r necrosis factor-alpha-induced collagenase (matrix metalloprotease-1) gene expression in dermal fibr

21 in the expression of alpha1 type I collagen, matrix metalloprotease-1, and platelet-derived growth fa

22 fficiently secreted (>80%); are cleaved with matrix metalloprotease-1; inhibit NF-kappaB driven trans

23 ividuals with detectable tissue inhibitor of matrix-metalloprotease-1 (TIMP-1) had a 3.5-fold greater

24 Matrix metalloprotease 11 (MMP-11), a protease associate

25 Matrix metalloprotease 12 plays a significant role in ai

26 RXP470.1 phosphinic peptide inhibitor toward matrix metalloprotease-12 (MMP-12) remain elusive.

27 obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneu

28 igands CXCL5, CXCL1 and CCL3, cathepsins and matrix metalloprotease-12.

29 Further, MAC colocalized with matrix metalloprotease 13 (MMP13) and with activated ext

30 dependent fashion, whereas it down-regulated matrix metalloprotease-13 (MMP13), thus favoring scarrin

31 ion markers, including alkaline phosphatase, matrix metalloproteases-13, osteocalcin, and runx2, and

32 at L1 interacts with the ANT binding partner matrix metalloprotease 14 (MMP14) and that the ANT prote

33 of ADAM17 (TNF-alpha converting enzyme) and matrix metalloprotease 14 caused by a reduction in the e

34 including Cadherin 6, CollagenXXValpha1, and Matrix metalloprotease 17, that are selectively expresse

35 Matrix metalloprotease 2 (MMP-2) and cathepsin S were pr

36 h the activated form of purified recombinant matrix metalloprotease 2 (MMP-2) and had type IV collage

37 lts from the up-regulation and activation of matrix metalloprotease 2 (MMP-2) in tumor cells.

38 to a bioactive variant by incorporation of a matrix metalloprotease 2 (MMP-2) specific cleavage site

39 ed invadopodium function via upregulation of matrix metalloprotease 2 (MMP2) and MMP9 expression leve

40 loprotease 9 (MMP9) as well as activation of matrix metalloprotease 2 (MMP2) and MMP9, whereas the ED

41 MMP-12 inhibitor, was derived from a potent matrix metalloprotease 2 and 13 inhibitor via lead optim

42 sulted in decreased alphavbeta3 integrin and matrix metalloprotease 2, suggesting that the leptin sig

43 ion kinase phosphorylation and expression of matrix metalloproteases 2 and 9, both downstream mediato

44 We demonstrate that matrix metalloproteases 2, 8, and 15 were able to releas

45 tric oxide (NO) production, which stimulates matrix metalloprotease-2 (MMP-2) and MMP-9 activity in t

46 te an annexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the e

47 gments (Fn-f) associated with the proform of matrix metalloprotease-2 (MMP-2) in conditioned medium o

48 Ang2 was overexpressed, increased levels of matrix metalloprotease-2 (MMP-2) were also apparent.

49 es glioma invasion through the activation of matrix metalloprotease-2 (MMP-2).

50 We have shown that matrix metalloprotease-2 (MMP2) cleaves laminin-5 (Ln-5)

51 Specific cleavage of laminin-5 (Ln-5) by matrix metalloprotease-2 (MMP2) was shown to induce migr

52 he extracellular matrix, including Twist and matrix metalloprotease-2 (MMP2).

53 s of angiogenesis, including angiopoietin-1, matrix metalloprotease-2, and hypoxia-inducible factor 1

54 tified five common targets: tenascin-C(TNC), matrix metalloprotease-2, collagen-6-A1, mannosidase-alp

55 xpression of alpha-SMA, collagen alpha1 (I), matrix metalloprotease-2, or tissue inhibitor of metallo

56 he protease responsible for IAP cleavage was matrix metalloprotease-2.

57 growth factor, matrix metalloprotease-9, and matrix metalloprotease-2.

58 Matrix metalloprotease-20 (Mmp20) is the predominant enz

59 MMP23 (matrix metalloprotease 23) contains a domain (MMP23(TxD)

60 n is critically regulated by the activity of matrix metalloprotease 3 (MMP-3), in contrast to NMDAR-d

61 Here, we identify matrix metalloprotease 7 (MMP7) as a key downstream effe

62 ted by the use of inhibitors directed toward matrix metalloprotease 8, matrix metalloprotease 9, or p

63 The enzymes responsible for generating PGP, matrix metalloproteases 8 and -9 and prolyl endopeptidas

64 d in PGP generation from collagen, involving matrix metalloproteases 8 and 9 and prolyl endopeptidase

65 We report that matrix metalloprotease-8 (MMP8) depletion or inhibition

66 The collagenase matrix metalloprotease 9 (MMP-9), which is increased in

67 LPS also induced expression of matrix metalloprotease 9 (MMP9) and failed to induce CD2

68 production, NO-dependent S-nitrosylation of matrix metalloprotease 9 (MMP9) as well as activation of

69 f NF-kappaB and the expression of its target matrix metalloprotease 9 (MMP9).

70 , and is mediated by proteolytic activity of matrix metalloprotease 9 (MMP9).

71 ed an angiogenic response by upregulation of matrix metalloprotease 9 and endothelial and mesangial m

72 creased expression of NF-kappaB target genes matrix metalloprotease 9 and interleukin 6.

73 on, activation of p38MAPK, and production of matrix metalloprotease 9 are possible mechanisms for pro

74 (1607)-T(1608) peptide bond; cathepsin G and matrix metalloprotease 9 cleave VWF substrates at the Y(

75 ancer cells with a corresponding increase in matrix metalloprotease 9 enhanced hypoxia-induced GLUT1

76 IL-8, thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release.

77 , anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased

78 Expression of gelatinase B (matrix metalloprotease 9) in human placenta is developme

79 , c-myc, vascular endothelial growth factor, matrix metalloprotease 9).

80 y response genes, including TNF-alpha, CCL3, matrix metalloprotease 9, integrin alpha(M), and Bcl-X i

81 rs directed toward matrix metalloprotease 8, matrix metalloprotease 9, or prolyl endopeptidase.

82 alloprotease activity, including activity of matrix metalloprotease 9.

83 regulating the Mr 92,000 type IV collagenase matrix metalloprotease-9 (MMP-9) and in vitro invasivene

84 d using BrdU incorporation and both TrkA and matrix metalloprotease-9 (MMP-9) expression were measure

85 r differentially expressed transcript, mouse matrix metalloprotease-9 (MMP-9).

86 ressed the DMBA-induced cyclooxygenase-2 and matrix metalloprotease-9 expression in the breast tumor.

87 gulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression.

88 Infected Wsh mice had reduced amounts of matrix metalloprotease-9 in BALF and were resistant to e

89 vivo, sIL-6R and LPS augmented amniochorion matrix metalloprotease-9 release, whereas sgp130 opposed

90 l and LPS-stimulated release of amniochorion matrix metalloprotease-9 was tested ex vivo.

91 [VEGF-A], stromal cell-derived factor-1, and matrix metalloprotease-9) and proangiogenic macrophage/m

92 M-1, vascular endothelial growth factor, and matrix metalloprotease-9) gene products.

93 ar endothelial growth factor), and invasion (matrix metalloprotease-9).

94 sential for the efficient early induction of matrix metalloprotease-9, a known mediator of extracellu

95 xpression of basic fibroblast growth factor, matrix metalloprotease-9, and matrix metalloprotease-2.

96 ced NF-kappaB-dependent reporter gene and of matrix metalloprotease-9, cyclooxygenase-2, and cyclin D

97 as also necessary for TNF-induced release of matrix metalloprotease-9, thought to be an essential reg

98 Known LRP1 ligands, including matrix metalloprotease-9, tissue-type plasminogen activa

99 (CCL-2), and RANTES (CCL-5), as well as the matrix metalloprotease-9.

100 ducts cyclin D1, cyclooxygenase (COX)-2, and matrix metalloprotease-9.

101 Consistently, IL-17 upregulated matrix-metalloprotease-9 and neutrophil elastase express

102 pwise cascade of protease activation wherein matrix metalloproteases activate effector caspases, lead

103 uring invasion in Matrigel, the secretion of matrix metalloprotease activity and migration in a modif

104 Because osteonectin specifically enhances matrix metalloprotease activity in prostate and breast c

105 ficantly reduced tumor cell invasiveness and matrix metalloprotease activity in the coculture superna

106 Treatment with IL-1 significantly increased matrix metalloprotease activity in the conditioned media

107 astic fiber disruption with age, and vaginal matrix metalloprotease activity was increased significan

108 nse to TSP1 or its EGF-like repeats required matrix metalloprotease activity, including activity of m

109 aneurysm by enhancing cellular apoptosis and matrix metalloprotease activity.

110 The EGFR ligands are known substrates of the matrix metalloprotease ADAM17, suggesting stretch activa

111 joints as well as by increased expression of matrix metalloproteases and bone-specific proteases.

112 Both SF-resident matrix metalloproteases and cathepsins have been implica

113 th fibrosis and tissue remodeling, including matrix metalloproteases and collagen, were upregulated i

114 innate immune cells, elevated activities of matrix metalloproteases and increased angiogenesis and v

115 oactivator p300, preventing the induction of matrix metalloproteases and other p300-dependent genes r

116 facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (

117 gment is generated at the plasma membrane by matrix metalloproteases and transferred to the cell nucl

118 en engineered requirements for activation by matrix metalloproteases and urokinase plasminogen activa

119 ystems-BMP-1/TLD (tolloid) (astacins), MMPs (matrix metalloproteases) and the ADAMs (disintegrin/meta

120 inly in the connective tissue (predominantly matrix metalloproteases) and, to some extent, in the epi

121 of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology.

122 tin, TGF-beta1, collagen I, fibronectin, and matrix metalloproteases, and plasma PAI-1 levels correla

123 n and LPS up-regulate chemokines, cytokines, matrix metalloproteases, and PTGS/COX2, consistent with

124 expression of the M-CSF receptor c-Fms by a matrix metalloprotease- and MAPK-dependent mechanism.

125 ace expression on human neutrophils, whereas matrix metalloproteases are dispensable.

126 nitiate dendrite breakage, and extracellular matrix metalloproteases are required to degrade the seve

127 We observe increased expression of matrix metalloproteases as well as decreased expression

128 g., for the thrombin receptor, inhibition of matrix metalloproteases blocked IL-8-mediated cell migra

129 ue-specific proteases, including complement, matrix metalloproteases, caspases, and granzymes, and ca

130 eness of the tumor cells in a TNF-alpha- and matrix metalloprotease-dependent manner.

131 ted through an autocrine mechanism involving matrix metalloprotease-dependent release of heparin-bind

132 rends and selectivity profiles against other matrix metalloproteases despite their close structural s

133 promoted invasiveness indirectly by inducing matrix metalloprotease enzyme 9 production, whereas drug

134 is a glycosylphosphatidyl inositol-anchored matrix metalloprotease expressed on the surface of cance

135 geting metastatic spread using inhibitors of matrix metalloproteases failed to deliver the promise of

136 os-dependent transcriptional activation of a matrix metalloprotease gene mmp1 downstream of JNK.

137 r--as well as the wide-spectrum inhibitor of matrix metalloproteases, GM6001.

138 gh the role of selected serine proteases and matrix metalloproteases in chemokine processing has long

139 ermore, RNF213 down-regulated expressions of matrix metalloproteases in endothelial cells, but not in

140 strated that TWEAK induced the production of matrix metalloproteases in human chondrocytes and potent

141 uggest that although activation of all known matrix metalloproteases in vitro is accomplished by prot

142 nally, studies using selective inhibitors of matrix metalloproteases indicated that they and heparin-

143 y mediators that stimulate the production of matrix metalloprotease, inflammatory cell recruitment, a

144 -plasmin, an inhibitor of plasmin, or by the matrix metalloprotease inhibitor 1,10 phenanthroline.

145 A key intermediate in the synthesis of a matrix metalloprotease inhibitor has been achieved using

146 Endogenous matrix metalloprotease inhibitor TIMP-3 inhibited activi

147 The general matrix metalloprotease inhibitor, GM6001, blocked agonis

148 X-73-4 or by 1,10-phenanthroline, but not by matrix metalloprotease inhibitors.

149 e relationship of Pneumocystis colonization, matrix metalloprotease levels in sputum, and airway obst

150 regulatory pathways involving inhibition of matrix metalloproteases, liver X receptor/retinoid X rec

151 urther analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matr

152 cells also led to increased secretion of the matrix metalloprotease MMP-9.

153 olar septal cell apoptosis and activation of matrix metalloproteases MMP-9 and MMP-2.

154 showed that exogenous addition of activated matrix metalloprotease (MMP) 2 stimulates migration onto

155 lox/flox) mice is characterized by excessive matrix metalloprotease (MMP) activity, reduced lung elas

156 onents of the plasminogen activator (PA) and matrix metalloprotease (MMP) cascade have been character

157 cleavage site motifs for six enzymes in the matrix metalloprotease (MMP) family.

158 Young and aged mice were treated with a matrix metalloprotease (MMP) inhibitor and systemic sFas

159 howed that cold causes actin disassembly and matrix metalloprotease (MMP) secretion by SEC, we also q

160 g site-masking peptide to the antibody via a matrix metalloprotease (MMP) susceptible linker.

161 We now identify the metalloprotease MT1-matrix metalloprotease (MMP), an integral membrane prote

162 vity caused the expression and activation of matrix metalloprotease (MMP)-1 and MMP-9, which in turn

163 Surface expression of matrix metalloprotease (MMP)-14 on ovarian cancer cells

164 Although matrix metalloprotease (MMP)-2 and -9 are involved in bo

165 The type IV collagenases matrix metalloprotease (MMP)-2 and MMP-9 are linked with

166 on of angiogenesis ( approximately 40%) in a matrix metalloprotease (MMP)-2-deficient mouse compared

167 oth the expression and enzymatic activity of matrix metalloprotease (MMP)-9 and MMP-2, two pro-angiog

168 mpromised elastic fibers and upregulation of matrix metalloprotease (MMP)-9.

169 onths and were analysed for a panel of novel matrix metalloprotease (MMP)-degraded ECM proteins, by E

170 cell interfaces accompanied by inhibition of matrix metalloprotease (MMP)-dependent shedding of the D

171 In response to PR-induced Wnt-1 signaling, matrix metalloprotease (MMP)-mediated membrane-proximal

172 ole of biomaterial design in BMP delivery, a matrix metalloprotease (MMP)-sensitive hyaluronic acid (

173 VEGF, nitrotyrosine, and membrane-type (MT1) matrix metalloprotease (MMP).

174 Here, we examined the expression of matrix metalloproteases (MMP) -2, -3, -9, -12, and -13 a

175 sites of ECM degradation where activation of matrix metalloproteases (MMP) occurs.

176 ibition results in a significant increase in matrix metalloproteases (MMP)-2 and membrane-type 1-MMP

177 Matrix metalloproteases (MMP)-9 and cathepsin B have bee

178 sed their phagocytic rate, without affecting matrix metalloproteases (MMP)2 and MMP9 activity.

179 Further, we show that the matrix metalloprotease, MMP-1, functions as a protease a

180 ion, and also downregulates the pro-invasive matrix metalloprotease, MMP-2.

181 increase in the activity of membrane type-1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeri

182 ribes the characterization of the Drosophila matrix metalloprotease Mmp2 as an extracellular inhibito

183 markers FN, Snail, N-cadherin, vimentin, the matrix metalloprotease MMP2, alpha-smooth muscle actin a

184 matory responses such as upregulation of the matrix metalloprotease MMP9, and increases angiogenesis

185 tential, by decreasing the expression of the matrix metalloprotease MMP9.

186 ulated induction, in cardiac fibroblasts, of matrix metalloproteases (MMPs) 9 and 13-MMPs linked to g

187 in a process that requires ECM remodeling by matrix metalloproteases (MMPs) [2-4].

188 atrix-degrading enzyme expression, including matrix metalloproteases (MMPs) and a disintegrin-like an

189 Matrix metalloproteases (MMPs) are a group of zinc-depen

190 Matrix Metalloproteases (MMPs) are an important family o

191 Matrix metalloproteases (MMPs) are endopeptidases that r

192 Matrix metalloproteases (MMPs) are responsible for the b

193 Matrix metalloproteases (MMPs) are typically associated

194 Matrix metalloproteases (MMPs) are Zn-containing endopep

195 ffect of their interaction on the release of matrix metalloproteases (MMPs) from chondrocytes.

196 Matrix metalloproteases (MMPs) have attracted considerab

197 Matrix metalloproteases (MMPs) have recently emerged as

198 Conversely, the activity of matrix metalloproteases (MMPs) is essential for the late

199 The group of matrix metalloproteases (MMPs) is responsible for multip

200 Matrix metalloproteases (MMPs) MMP-2 and MMP-9 have been

201 Matrix metalloproteases (MMPs) play a role in remodeling

202 Matrix metalloproteases (MMPs) play important roles in n

203 Matrix metalloproteases (MMPs) regulate innate immunity

204 ACE inhibition, but reducing potency against matrix metalloproteases (MMPs) thus increasing overall s

205 Applied to matrix metalloproteases (MMPs) with highly conserved cat

206 We examined the role of matrix metalloproteases (Mmps), and found that reducing

207 been synthesized, evaluated as inhibitors of matrix metalloproteases (MMPs), and found to display rem

208 Integrins, matrix metalloproteases (MMPs), and the cytokine TGF-bet

209 rface of cells is sensitive to cleavage with matrix metalloproteases (MMPs), this study examined whet

210 Matrix metalloproteases (MMPs), which are induced by tra

211 arge variety of mediators, including several matrix metalloproteases (MMPs), which participate in fib

212 he ECM, and cleavage of VEGF from the ECM by matrix metalloproteases (MMPs).

213 microtubule track for localized secretion of matrix metalloproteases (MMPs).

214 , fibrillar collagen is degraded by specific matrix metalloproteases (MMPs).

215 ate the extracellular levels of gelatinases (matrix metalloproteases, MMPs) and potentially influence

216 anges in macrophage cytokine, chemokine, and matrix metalloprotease mRNA, and protein-inducing mediat

217 Membrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major ac

218 crovesicle cargo such as the membrane-type 1 matrix metalloprotease (MT1-MMP) to shedding microvesicl

219 n secretion from the cell by membrane type 1 matrix metalloprotease (MT1-MMP), affording the 8 and 5

220 ity, dependent on the enzyme membrane type I matrix metalloprotease (MT1-MMP), and that DC transientl

221 s (EECs) of critical cargos (membrane-type 1 matrix metalloprotease [MT1-MMP] and beta3 integrin) req

222 b27-dependent recycling of the transmembrane matrix metalloprotease, MT1-MMP to promote invasive beha

223 cleavage of an intact mannose receptor by a matrix metalloprotease or ADAM metalloprotease.

224 ificantly inhibit the 10 most abundant human matrix metalloproteases or complement-mediated cell lysi

225 y 12-fold) the TNF-specific peptide over the matrix metalloproteases peptide in vitro.

226 rotubule integrity, as well as by modulating matrix metalloprotease processing.

227 mitogenesis of articular cells and stimulate matrix metalloprotease production, thus promoting degrad

228 Matrix metalloproteases promote tumor cell invasion, epi

229 in vivo and that inhibition of ROCK but not matrix-metalloproteases reduces cancer cell motility in

230 Matrix metalloproteases regulate both physiological and

231 nalogous to the cysteine switch mechanism of matrix metalloprotease regulation.

232 ptides, peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloi

233 Metastasizing tumor cells use matrix metalloproteases, such as the transmembrane colla

234 Matrilysin is a matrix metalloprotease that is overexpressed in cancer c

235 Type IV 72-kDa collagenase is one of the matrix metalloproteases that has been implicated in diff

236 t) decreased, consistent with an increase in matrix metalloproteases throughout the leaflet.

237 imilar to that found in tissue inhibitors of matrix metalloproteases (TIMPs) and in complement factor

238 I), as well as by an endogenous inhibitor of matrix metalloproteases, tissue inhibitor of metalloprot

239 ate that NG2+ cells, but not astrocytes, use matrix metalloproteases to extend across a region of inh

240 Matrix metalloprotease type 9 (MMP-9) has been functiona

241 s, including chemokines, growth factors, and matrix metalloproteases, was increased, a signature rese

242 Because TIMP-1 inhibits most matrix metalloproteases, which are responsible for colla

243 phosphorylation of DDRs is known to activate matrix metalloproteases, which in turn cleave the ECM.

244 ealed that the protrusion is enriched in the matrix metalloprotease ZMP-1 and transiently expands AC